Role of Smoking Status on Long-Term Survival in Patients Operated for Non-Small Cell Lung Cancer
Öz
Abstract:
Aim: This present study aimed to evaluate both the frequency of non-smoking patients and the impact of smoking status to the long-term survival of patients operated for NSCLC in our institutional cohort. Although tobacco smoking is one of the major causes of lung cancer the correlation between smoking status and the survival of patients is uncertain.
Materials and Method: Medical records of 249 patients who underwent pulmonary resection for NSCLC were retrospectively reviewed. Patients were divided into smokers and never-smokers. Annual frequency, demographic and clinical characteristics and overall survival were compared between the groups.
Results: The annual frequency of never-smokers between the years 2002 and 2012 was 33.2, 24, 37.5, 25, 34.3, 35.4, 29.4, 22.7, 22.2, 35.7 and 28.5%, respectively. There were no statistically significant difference in terms of the distribution of age (p=0.993), FEV1 measurement (p=0.476), type of resection performed (p=0.564) and tumor histology (p=0.920) between the groups. The median survival time was similar in both groups (72 vs 76 months, smokers vs. never-smokers. Log-rank test; P=0.654).
Conclusion: The proportion of never-smokers were approximately 30% in our cohort. In long follow-up, smoking status was not an independent risk factor for a poorer prognosis in patients operated for NSCLC.
Anahtar Kelimeler
Non-small cell lung cancer, tobacco smoking, survival
Destekleyen Kurum
No
Etik Beyan
The Authors declare that there is no conflict of interest.
Kaynakça
- 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011:61; 69-90
- 2. Thun MJ, Henley SJ, Burns D, Jemal A, Shanks TG, Calle EE. Lung cancer death rates in lifelong nonsmokers. J Natl Cancer Inst 2006:98;691-9
- 3. Cufari ME, Proli C, De Sousa P, Raubenheimer H, Al Sahaf M, Chavan H, et al. Increasing frequency of non-smoking lung cancer: Presentation of patients with early disease to a tertiary institution in the UK. European journal of cancer 2017:84;55-9
- 4. Rissanen E, Heikkinen S, Seppä K, Ryynänen H, Eriksson JG et al. METCA Study Group. Incidence trends and risk factors of lung cancer in never smokers: Pooled analyses of seven cohorts. Int J Cancer. 2021:15;149(12):2010-2019
- 5. Lee SJ, Lee J, Park YS, Lee CH, Lee SM, Yim JJ, et al. Impact of smoking on mortality of patients with non-small cell lung cancer. Thorac Cancer 2014:5;43-9
- 6. Meguid RA, Hooker CM, Harris J, Xu L, Westra WH, Sherwood JT, et al. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest 2010:138;500-9
- 7. Sardari Nia P, Weyler J, Colpaert C, Vermeulen P, Van Marck E, Van Schil P. Prognostic value of smoking status in operated non-small cell lung cancer. Lung Cancer 2005:47;351-9
- 8. Ferketich AK, Niland JC, Mamet R, Zornosa C, D'Amico TA, Ettinger DS, et al. Smoking status and survival in the National Comprehensive Cancer Network non-small cell lung cancer cohort. Cancer 2013:119;847-53
- 9. Nakamura H, Haruki T, Adachi Y, Fujioka S, Miwa K, Taniguchi Y. Smoking affects prognosis after lung cancer surgery. Surg Today 2008:38;227-31
- 10. Pelosof L, Ahn C, Gao A, Horn L, Madrigales A, Cox J, et al. Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions. J Natl Cancer Inst 2017:109;1-6