Klinik Araştırma
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A Retrospective Analysis of Interventional Flexible Bronchoscopic Procedures in Pediatric Patients

Yıl 2025, Cilt: 35 Sayı: 5, 1020 - 1031, 28.10.2025
https://doi.org/10.54005/geneltip.1741443

Öz

Background: Pediatric interventional pulmonology has significantly advanced in recent years with the integration of minimally invasive techniques such as cryotherapy, balloon dilation, and endobronchial biopsies. Flexible bronchoscopy, once primarily a diagnostic tool, has now become an essential therapeutic modality in managing complex pediatric airway and pulmonary conditions. This study aimed to retrospectively evaluate interventional procedures performed using flexible bronchoscopy in pediatric patients over a one-year period. Methods:
A retrospective review was conducted on pediatric patients who underwent interventional flexible bronchoscopy between June 2024 and June 2025. Data collected included demographic information, indications for bronchoscopy, types of interventional procedures performed, bronchoscopic findings, and observed complications. All procedures were conducted under sedation or general anesthesia by experienced pediatric pulmonologists using age-appropriate bronchoscopes. Results: A total of 24 patients (13 males) with a mean age of 91 months underwent interventional bronchoscopic procedures. The most common indications included subglottic stenosis (16.7%), suspected primary ciliary dyskinesia (16.7%), interstitial lung disease (20.8%), and foreign body aspiration (16.7%). A total of 27 procedures were performed, including balloon dilatation (22.2%), cryobiopsy (37.0%), foreign body removal (14.8%), and cryodevitalization (11.1%). The complication rate was low, with only mild bleeding in two patients and moderate bleeding in one; no pneumothorax was reported. Conclusion: Pediatric flexible bronchoscopy is a safe and effective method for both diagnosis and therapy in children with complex respiratory conditions. With the availability of thinner instruments and increased expertise, advanced interventional techniques are now more accessible and applicable in pediatric populations. Structured training programs and interdisciplinary collaboration are essential to further develop and standardize pediatric interventional pulmonology practices.

Kaynakça

  • 1-X. Tao, S. Li, H. Wu, F. Jin, G. Jin, L. Wu. Progress in the Application of Bronchoscopic Cryotherapy in Pediatric Pulmonary Diseases. Children 11, no. 9 (2024): 1130.
  • 2. Schramm D. Integrating novel interventional techniques into pediatric pulmonology training. Pediatr Pulmonol. 2025 Mar; 60 Suppl 1(Suppl 1): S8-S10.
  • 3. E. Hysinger and J. Piccione, “Advanced Diagnostic and Therapeutic Bronchoscopy in Pediatrics,” Clinics in Chest Medicine 45, no. 3 (2024): 555–567.
  • 4. A. Corcoran, D. Shore, R. P. Boesch, Chopra M, Das S, DiBardino D, Goldfarb S et al., “Practices and Perspectives on Advanced Diagnostic and Interventional Bronchoscopy Among Pediatric Pulmonologists in the United States,” Pediatric Pulmonology 59, no. 6 (2024): 1708–1715.
  • 5- Schramm D, Freitag N, Kötz K, Iglesias-Serrano I, Culebras-Amigo M, Koblizek V et al. Cryotherapy in the paediatric airway: indications, indications, success and safety. Respirology. 2022; 27: 966‐974.
  • 6- Schramm D, Freitag N, Nicolai T, Wiemers A, Hinrichs B, Amrhein P, et al. Special Interest Group on Pediatric Bronchoscopy of the Society for Pediatric Pneumology (GPP) and invited Societies involved in pediatric airway endoscopy. Pediatric Airway Endoscopy: Recommendations of the Society for Pediatric Pneumology. Respiration. 2021; 100: 1128-1145.
  • 7- Dhochak N. Interventional Bronchoscopy in Children: The Way Forward. Indian J Pediatr. 2023; 90: 806-810. 8- Januska MN, Kaspy K, Bozkanat KM, Vicencio AG. Pediatric interventional bronchoscopy: from early limitations to achievable opportunities. Curr Opin Pulm Med. 2024 ;30:107-117.
  • 9- Eber E, Antón-Pacheco JL, de Blic J, Doull I, Faro A, Nenna R, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J. 2017; 50: 1700901.
  • 10- Korevaar D.A, Colella S, Fally M, Camuset J, Colby T.V, Hagmeyer L, et al. European Respiratory Society guidelines on transbronchial lung cryobiopsy in the diagnosis of interstitial lung diseases. Eur. Respir. J. 2022, 60, 2200425
  • 11- Moslehi M.A. Transbronchial lung cryobiopsy in children. Expert. Rev. Respir. Med. 2022, 16, 333–339
  • 12- Lee J.C, Kim M.S, Kim D.J, Park D.H, Lee I.W, Roh H.J, et al. Subglottic stenosis in children: Our experience at a pediatric tertiary center for 8 years in South Korea. Int. J. Pediatr. Otorhinolaryngol. 2019, 121,64–67.
  • 13- Yılmaz Aİ, Schramm D. Developments in Paediatric Interventional Pulmonology: Recent Experience in Turkiye with Broad Implications for the Field. Respirology. 2025; 30: 535-536.
  • 14- Goldfarb S, Piccione J. Diagnostic and interventional bronchoscopy in children. Springer; 2021.
  • 15- Dhochak N, Mittal S, Mohan A, Jain D, Jat K.R, Jana M, et al. Transbronchial lung cryobiopsy for diffuse lung diseases in children: A case series. Pediatr. Pulmonol. 2022, 57, 2851–2854.
  • 16- Thomas RJ, Yerkovich ST, Goyal V, Chang AB, Rutter C, Masters IB et al. The utility of elective flexible bronchoscopy to improve quality of life and clinical outcomes for children: A systematic review. Pediatr Pulmonol. 2024; 59: 1589-1595.
  • 17- Jiao A, Liu F, Lerner AD, Rao X, Guo Y, Meng C et al. Effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy. Pediatr Investig. 2019; 3: 9-16.
  • 18- Lee P, Mehta A.C, Mathur P.N. Management of complications from diagnostic and interventional bronchoscopy. Respirology 2009, 14, 940–953

Pediatrik Hastalarda Girişimsel Fleksible Bronkoskopik İşlemlerin Retrospektif Analizi

Yıl 2025, Cilt: 35 Sayı: 5, 1020 - 1031, 28.10.2025
https://doi.org/10.54005/geneltip.1741443

Öz

Giriş: Pediatrik girişimsel pulmonoloji, kriyoterapi, balon dilatasyonu ve endobronşiyal biyopsi gibi minimal invaziv tekniklerin entegrasyonu ile son yıllarda önemli ölçüde ilerleme kaydetmiştir. Başlangıçta yalnızca tanısal amaçlarla kullanılan fleksibl bronkoskopi, artık karmaşık pediatrik hava yolu ve akciğer hastalıklarının tedavisinde vazgeçilmez bir yöntem hâline gelmiştir. Bu çalışmanın amacı, bir yıllık süre içerisinde pediatrik hastalara uygulanan girişimsel fleksibl bronkoskopik işlemleri retrospektif olarak değerlendirmektir. Yöntem:
Haziran 2024 ile Haziran 2025 tarihleri arasında girişimsel fleksibl bronkoskopi uygulanan pediatrik hastalar retrospektif olarak incelendi. Hastalara ait demografik bilgiler, bronkoskopi endikasyonları, uygulanan girişimsel işlem türleri, bronkoskopik bulgular ve gözlenen komplikasyonlar kaydedildi. Tüm işlemler, yaşa uygun bronkoskoplar kullanılarak, deneyimli pediatrik göğüs hastalıkları uzmanları tarafından, sedasyon veya genel anestezi altında gerçekleştirildi. Bulgular: Toplam 24 hasta (13’ü erkek), ortalama 91 ay yaşında idi. En sık bronkoskopi endikasyonları; subglottik stenoz (%16,7), primer siliyer diskinezi şüphesi (%16,7), interstisyel akciğer hastalığı (%20,8) ve yabancı cisim aspirasyonu (%16,7) olarak belirlendi. Toplam 27 girişimsel işlem uygulandı. Bu işlemler arasında balon dilatasyonu (%22,2), kriyobiyopsi (%37,0), yabancı cisim çıkarılması (%14,8) ve kriyodevitalizasyon (%11,1) yer aldı. Komplikasyon oranı düşüktü; iki hastada hafif, bir hastada ise orta düzeyde kanama görüldü. Pnömotoraks vakası saptanmadı. Sonuç: Pediatrik fleksibl girişimsel bronkoskopi, karmaşık solunum yolu hastalıklarının tanı ve tedavisinde güvenli ve etkili yöntemlerdir. Daha ince enstrümanlara olan erişim ve artan uzmanlık sayesinde, ileri girişimsel teknikler artık çocuk hastalarda daha yaygın ve uygulanabilir hâle gelmiştir. Bu alanın gelişimi için yapılandırılmış eğitim programları ve disiplinler arası iş birliği büyük önem taşımaktadır.

Kaynakça

  • 1-X. Tao, S. Li, H. Wu, F. Jin, G. Jin, L. Wu. Progress in the Application of Bronchoscopic Cryotherapy in Pediatric Pulmonary Diseases. Children 11, no. 9 (2024): 1130.
  • 2. Schramm D. Integrating novel interventional techniques into pediatric pulmonology training. Pediatr Pulmonol. 2025 Mar; 60 Suppl 1(Suppl 1): S8-S10.
  • 3. E. Hysinger and J. Piccione, “Advanced Diagnostic and Therapeutic Bronchoscopy in Pediatrics,” Clinics in Chest Medicine 45, no. 3 (2024): 555–567.
  • 4. A. Corcoran, D. Shore, R. P. Boesch, Chopra M, Das S, DiBardino D, Goldfarb S et al., “Practices and Perspectives on Advanced Diagnostic and Interventional Bronchoscopy Among Pediatric Pulmonologists in the United States,” Pediatric Pulmonology 59, no. 6 (2024): 1708–1715.
  • 5- Schramm D, Freitag N, Kötz K, Iglesias-Serrano I, Culebras-Amigo M, Koblizek V et al. Cryotherapy in the paediatric airway: indications, indications, success and safety. Respirology. 2022; 27: 966‐974.
  • 6- Schramm D, Freitag N, Nicolai T, Wiemers A, Hinrichs B, Amrhein P, et al. Special Interest Group on Pediatric Bronchoscopy of the Society for Pediatric Pneumology (GPP) and invited Societies involved in pediatric airway endoscopy. Pediatric Airway Endoscopy: Recommendations of the Society for Pediatric Pneumology. Respiration. 2021; 100: 1128-1145.
  • 7- Dhochak N. Interventional Bronchoscopy in Children: The Way Forward. Indian J Pediatr. 2023; 90: 806-810. 8- Januska MN, Kaspy K, Bozkanat KM, Vicencio AG. Pediatric interventional bronchoscopy: from early limitations to achievable opportunities. Curr Opin Pulm Med. 2024 ;30:107-117.
  • 9- Eber E, Antón-Pacheco JL, de Blic J, Doull I, Faro A, Nenna R, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J. 2017; 50: 1700901.
  • 10- Korevaar D.A, Colella S, Fally M, Camuset J, Colby T.V, Hagmeyer L, et al. European Respiratory Society guidelines on transbronchial lung cryobiopsy in the diagnosis of interstitial lung diseases. Eur. Respir. J. 2022, 60, 2200425
  • 11- Moslehi M.A. Transbronchial lung cryobiopsy in children. Expert. Rev. Respir. Med. 2022, 16, 333–339
  • 12- Lee J.C, Kim M.S, Kim D.J, Park D.H, Lee I.W, Roh H.J, et al. Subglottic stenosis in children: Our experience at a pediatric tertiary center for 8 years in South Korea. Int. J. Pediatr. Otorhinolaryngol. 2019, 121,64–67.
  • 13- Yılmaz Aİ, Schramm D. Developments in Paediatric Interventional Pulmonology: Recent Experience in Turkiye with Broad Implications for the Field. Respirology. 2025; 30: 535-536.
  • 14- Goldfarb S, Piccione J. Diagnostic and interventional bronchoscopy in children. Springer; 2021.
  • 15- Dhochak N, Mittal S, Mohan A, Jain D, Jat K.R, Jana M, et al. Transbronchial lung cryobiopsy for diffuse lung diseases in children: A case series. Pediatr. Pulmonol. 2022, 57, 2851–2854.
  • 16- Thomas RJ, Yerkovich ST, Goyal V, Chang AB, Rutter C, Masters IB et al. The utility of elective flexible bronchoscopy to improve quality of life and clinical outcomes for children: A systematic review. Pediatr Pulmonol. 2024; 59: 1589-1595.
  • 17- Jiao A, Liu F, Lerner AD, Rao X, Guo Y, Meng C et al. Effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy. Pediatr Investig. 2019; 3: 9-16.
  • 18- Lee P, Mehta A.C, Mathur P.N. Management of complications from diagnostic and interventional bronchoscopy. Respirology 2009, 14, 940–953
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Klinik Araştırma
Yazarlar

Aslı İmran Yılmaz 0000-0003-2689-7904

Dirk Schramm 0000-0002-0440-4737

Sevgi Pekcan 0000-0002-8059-902X

Gönderilme Tarihi 13 Temmuz 2025
Kabul Tarihi 8 Eylül 2025
Yayımlanma Tarihi 28 Ekim 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 35 Sayı: 5

Kaynak Göster

Vancouver Yılmaz Aİ, Schramm D, Pekcan S. A Retrospective Analysis of Interventional Flexible Bronchoscopic Procedures in Pediatric Patients. Genel Tıp Derg. 2025;35(5):1020-31.