65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması

Rabia Bağ Soytaş; Suna Avcı; Hakan Yavuzer; Serdar Özkök; Alper Döventaş; Deniz Suna Erdinçler

doi:10.15321/GenelTipDer.2021.300

EN TR

Comparison Side Effects of Denosumab and Zoledronic Acid in Osteoporosis Patients Over 65 Years Old

Öz

Objective: We aimed to compare the rates of denosumab and zoledronic acid in patients receiving osteoporosis treatment and the side effects of these drugs. Material and Method: In our study, the files of the applicants were searched between January 2016-December 2017; those with denosumab and zoledronic acid. Clinical and demographic data, laboratory values of beginning of treatment, 6 months and 1 year and side effects were recorded. Results: 171 patients were included. Denosumab group was older, their urea and creatinine levels were higher and GFRs were lower. Hypocalcemia was observed only in denosumab group (1 (1.23%) patient). Acut renal failure occured in 4 (% 5,19) patients with denosumab and 2 (%2,12) patients with the other group during 1 month follow up. Flu-like symptomps were observed only in zoledronic asit group (2 (%2,12) patients). Bilateral spontaneous fracture of the ischium pubis was observed in 1 (1.29%) of the former, spontaneous 6 teeth loss in 1 (1.06%) of the latter group. Conclusion: There were no significant differences between two groups in terms of side effects. Side effects were lower than those reported in the literature; in addition to comorbidity, multiple drug use and rare side effects should be kept in mind.

Anahtar Kelimeler

Geriatric, Zoledronic acid, Denosumab, Side effect

65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması

Öz

Amaç: Osteoporoz tedavisi alan hastalarda, zoledronik asit ve denosumab kullanım oranları ile bu iki ilacın yan etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamızda Ocak 2016-Aralık 2017 tarihleri arasında başvuran hastaların dosyaları taranarak, osteoporoz tanısıyla zoledronik asit ve denosumab almış olanlar belirlendi. Klinik ve demografik verileri, tedavi başlangıcı, 6. ay ve 1. yıl laboratuvar değerleri ile ilaç yan etkileri kaydedildi. Bulgular: Çalışmaya 171 hasta dâhil edildi. Denosumab alanlar daha yaşlı, üre ve kreatinin değerleri daha yüksek, kreatinin klirensleriyse daha düşüktü. Yan etki açısından değerlendirildiğinde hipokalsemi, denosumab verilenlerin 1’inde (%1,29) görülürken; zoledronik asit verilenlerde rastlanmadı. Denosumab alanların 4’ünde (% 5,19), zoledronik asit alanların ise 2’sinde (% 2,12) 1 aylık takipte akut böbrek yetmezliği gelişti. Zoledronik asit alanların 2’sinde (% 2,12) grip benzeri semptomlar görülürken; denosumab alanlarda gözlenmedi. Ayrıca zoledronik asit alanların 1’inde (% 1,06) tedavi sonrası çene osteonekrozu olmaksızın, 6 dişinde kendiliğinden dökülme; denosumab alanların 1’inde (% 1,29) ise iskium pubiste bilateral spontan kırık tespit edildi. Sonuç: İki ajan karşılaştırıldığında, yan etki açısından iki grup arasında anlamlı fark olmadığı; gelişen yan etkilerin ise literatürde belirtilenden daha az olduğu; kullanılacak ajanın seçiminde komorbidite yanı sıra, çoklu ilaç kullanımı ve nadir yan etkilerin akılda tutulması gerektiği kanısına varıldı.

Anahtar Kelimeler

Geriatri, Zoledronik asit, Denosumab, Yan Etki

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Rabia Bağ Soytaş Bu kişi benim
Türkiye

Suna Avcı
Türkiye

Hakan Yavuzer
Türkiye

Serdar Özkök Bu kişi benim
Türkiye

Alper Döventaş
Türkiye

Deniz Suna Erdinçler
Türkiye

Yayımlanma Tarihi

30 Haziran 2021

Gönderilme Tarihi

21 Ekim 2019

Kabul Tarihi

22 Ağustos 2020

Yayımlandığı Sayı

Yıl 2021 Cilt: 31 Sayı: 2

DOI

https://doi.org/10.15321/GenelTipDer.2021.300

IZ

https://izlik.org/JA62GA22GD

APA

Soytaş, R. B., Avcı, S., Yavuzer, H., Özkök, S., Döventaş, A., & Suna Erdinçler, D. (2021). 65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması. Genel Tıp Dergisi, 31(2), 135-139. https://doi.org/10.15321/GenelTipDer.2021.300

AMA

1.Soytaş RB, Avcı S, Yavuzer H, Özkök S, Döventaş A, Suna Erdinçler D. 65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması. Genel Tıp Derg. 2021;31(2):135-139. doi:10.15321/GenelTipDer.2021.300

Chicago

Soytaş, Rabia Bağ, Suna Avcı, Hakan Yavuzer, Serdar Özkök, Alper Döventaş, ve Deniz Suna Erdinçler. 2021. “65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması”. Genel Tıp Dergisi 31 (2): 135-39. https://doi.org/10.15321/GenelTipDer.2021.300.

EndNote

Soytaş RB, Avcı S, Yavuzer H, Özkök S, Döventaş A, Suna Erdinçler D (01 Haziran 2021) 65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması. Genel Tıp Dergisi 31 2 135–139.

IEEE

[1]R. B. Soytaş, S. Avcı, H. Yavuzer, S. Özkök, A. Döventaş, ve D. Suna Erdinçler, “65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması”, Genel Tıp Derg, c. 31, sy 2, ss. 135–139, Haz. 2021, doi: 10.15321/GenelTipDer.2021.300.

ISNAD

Soytaş, Rabia Bağ - Avcı, Suna - Yavuzer, Hakan - Özkök, Serdar - Döventaş, Alper - Suna Erdinçler, Deniz. “65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması”. Genel Tıp Dergisi 31/2 (01 Haziran 2021): 135-139. https://doi.org/10.15321/GenelTipDer.2021.300.

JAMA

1.Soytaş RB, Avcı S, Yavuzer H, Özkök S, Döventaş A, Suna Erdinçler D. 65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması. Genel Tıp Derg. 2021;31:135–139.

MLA

Soytaş, Rabia Bağ, vd. “65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması”. Genel Tıp Dergisi, c. 31, sy 2, Haziran 2021, ss. 135-9, doi:10.15321/GenelTipDer.2021.300.

Vancouver

1.Rabia Bağ Soytaş, Suna Avcı, Hakan Yavuzer, Serdar Özkök, Alper Döventaş, Deniz Suna Erdinçler. 65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması. Genel Tıp Derg. 01 Haziran 2021;31(2):135-9. doi:10.15321/GenelTipDer.2021.300

Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.

Comparison Side Effects of Denosumab and Zoledronic Acid in Osteoporosis Patients Over 65 Years Old

Öz

Anahtar Kelimeler

65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster