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Kırım Kongo Kanamalı Ateşinde Hemogram Parametrelerinin Tanısal Değeri

Yıl 2021, Cilt: 31 Sayı: 2, 101 - 104, 30.06.2021
https://doi.org/10.15321/GenelTipDer.2021.293

Öz

Giriş: Ülkemizde son yıllarda Kırım Kongo kanamalı ateşi (KKKA), yüksek mortalitesi nedeni ile dikkat çekmektedir.

Amaç: KKKA’da meydana gelen inflamatuar sürecin, tam kan parametreleri üzerine olan etkisini araştırmaktır.

Gereç ve Yöntem:01.01.2010 – 31.12.2011 tarihleri arasında acil servisimize, kene ile temas şikayetiyle başvuran toplam 5260 hasta retrospektif olarak incelendi. Klinik olarak şüpheli 80 vakaya yapılan serolojik inceleme sonunda KKKA tanısı için 40 hastada pozitif ve 40 hastada negatif sonuç bulundu. Sağlıklı gönüllü 40 kişiden kontrol grubu oluşturuldu. Hastalardan başvuru sırasında alınan tüm hemogram parametreleri, hasta ve kontrol grubu ile ayrı ayrı karşılaştırıldı.

Bulgular: KKKA pozitif ve negatif olan hasta grubu, kontrol grubu ile kıyaslandığında; lökosit, nötrofil, red cell distribution width (RDW), mean platelet volume (MPV), nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) değerleri sadece KKKA pozitif olan grupta anlamlı tespit edildi. Oysa lenfosit ve platelet değerleri her iki grupta da anlamlı bulunmuştur (p≤0.01).

Sonuç: Bu çalışmada elde edilen verilere göre özellikle acil servislerde ucuz, kolay ve yaygın olarak kullanılabilecek bu tam kan parametreleri KKKA tanısında klinisyenlere yardımcı olabilir.

Kaynakça

  • Whitehouse, C.A. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004:64;145-160.
  • Ergönül Ö. Kırım Kongo kanamalı ateşi tedavisi ve ribavirin kullanımı. Klimik Dergisi. 2016;29:2-9
  • Burt F.J, Swanepoel R, Shieh W.J, et al. Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Arch. Pathol. Lab. Med. 1997: 121; 839-846.
  • Feldmann H, Jones S, Klenk H.D, Schnittler H.J. Ebola virus: From discovery to vaccine. Nat. Rev. Immunol. 2003: 3; 677-685.
  • Öngürü P, Bodur H. Crimean-congo haemorrhagic fever. J. Exp. Clin. Med. 2012; 29: S175-S181
  • Sonmez O, Ertas G, Bacaksız A, Tasal A, Erdogan E, Asoglu E. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease. An observational study. Anadolu Kardiyol Derg. 2013;13:662e7
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S. The platelet functions in patients with ankylosing spondylitis, antiTNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets 2010;21:126e31.
  • Azab B, Shah N, Akerman M, McGinn Jr JT. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326e34
  • Ertekin B, Kara H, Erdemir E, Doğan E, Acar T, Demir L.S. Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis. Eurasian J Emerg Med 2017; 16: 29-33
  • Uyar Y, Chrıstova I, Papa A. Current situation of Crimean Congo hemorrhagic fever (CCHF) in Anatolia and Balkan Peninsula. Türk Hijyen ve Deneysel Biyoloji Dergisi 2011; 68: 139 – 151
  • Yilmaz GR, Buzgan T, Irmak H. The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002–2007. Int J Infect Dis 2009;13:380-6.
  • Ozkurt Z, Kiki I, Erol S et al. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect 2006: 52; 207–215.
  • Bastug A, Kayaaslan B, Kazancioglu S, et al. Crimean-Congo hemorrhagic fever: Prognostic factors and the association of leukocyte counts with mortality. Jpn J Infect Dis 2016: 69; 51–55
  • Eren S. H, Zengin S, Büyüktuna S.A, Gözel M.G. Clinical severity in forecasting platelet to lymphocyte ratio in Crimean–Congo hemorrhagic fever patients. J Med Microbiol 2016: 65;1100–1104
  • Akıncı E, Bodur H, Leblebicioglu H. Pathogenesis of Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis 2013;13: 429–437.
  • Ertürk A, Cüre E, Parlak E, Cüre M.C. Yüce S, Özkurt Z. Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. JMID 2015;5:51-56
  • Vorou R, Pierroutsakos I. N. Maltezou H. C. CrimeanCongo hemorrhagic fever. Curr Opin Infect Dis. 2007; 20: 495–500.
  • Inci A. Increased Mean Platelet Volume in Patients with Crimean Congo Hemorrhagic Fever. J Clin Anal Med 2015;6:1-3.
  • Turkdogan K.A, Eren S.H, Coskun A, Engın A, Sonmez E, Cıvelek C. Ratio of neutrophil to lymphocyte Counts in Crimean Congo Hemorrhagic Fever. J Clin Anal Med 2016;7: 10-3
  • Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
  • Beyan C. Is mean platelet volume a predictive marker in patients with venous thrombosis? Clin Appl Thromb Hemost 2012;18:670-1.
  • Ekiz F, Gürbüz Y, Basar Ö, et al. Mean platelet volume in the diagnosis and prognosis of Crimean-Congo hemorrhagic fever. Clin Appl Thromb Hemost 2013;19:441-4.
  • Alan S, Tuna S, Turkoğlu E.B. The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet’s syndrome. Kaohsiung J Med Sci 2015; 31: 626-631
  • Harmanci O, Kav T, Sivri B. Red cell distribution width can predict intestinal atrophy in selected patients with celiac disease. J Clin Anal Med 2012;26:497–502
  • Tanoglu A, Karagoz E, Ulcay A, Turhan V, Kara M, Yazgan Yusuf. Clinical Significance of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume for Predicting the Severity of Hepatic Fibrosis in Patients with Chronic Hepatitis B. Medicine Science 2016;5:147-59
  • Koseoglu HI, Altunkas F, Doruk S, Etikan I, Demir O, Kanbay A. Plateletelymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome. J Thromb Thrombolysis 2015;39:179e85
  • Macey M, Hagi-Pavli E, Stewart J, et al. Age, gender and disease related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behcet’s disease. Rheumatology 2011;50: 1849-59.
  • Proctor MJ, Morrison DS, Talwar D, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 2011;47:2633-41.
  • Cho K.I, Ann S.H, Singh G.B, Her A.Y, Shin E.S. Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One 2015: Jul 24;10:e0133934.
  • Sadaka F, O’Brien J, Prakash S. Red Cell Distribution Width and Outcome in Patients With Septic Shock. J Intensive Care Med. 2013;28:307-13.
  • Şenol K, Saylam B, Kocaay F, Tez M. Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med 2013; 31: 687-9.
  • Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009; 104: 868–72
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M; for the Cholesterol and Recurrent Events (CARE) Trial Investigators: Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation 2008; 117: 163–68
  • Ku NS, Kim HW, Oh HJ, et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia. Shock 2012; 38: 123–27

Diagnostic Value of Hemogram Parameters in Crimean-Congo Hemorrhagic Fever

Yıl 2021, Cilt: 31 Sayı: 2, 101 - 104, 30.06.2021
https://doi.org/10.15321/GenelTipDer.2021.293

Öz

Introduction: Crimean-Kongo hemorrhagic fever (CKHF) has pulled attention in recent years due to its high mortality rate.

Objective: To investigate the effect of the inflammatory process in Crimean-Kongo hemorrhagic fever on the complete blood count parameters.

Material and Methods: A total of 5260 patients who had presented to theemergency room of our hospital due to tick contact between 01 January 2010 and 31 December 2011 were analyzed retrospectively. Serological examination yielded 40 positive and 40 negative results for 80 cases with suspicion of CKHF. Forty healthy volunteers constituted the control group. All of the complete blood cell count parameters that were examined on admission were compared separately with the patient and the control group.

Results: When CKHF positive and negative patient groups were compared with the control group, the neutrophil, red cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) values were found to be significant in the CKHF-positive group only. However, the lymphocyte and the platelet values were found to be significant in both groups (p≤0.01).

Conclusion: The results of the present study suggest that complete blood count parameters, which are inexpensive, easy and widely used, may be useful for the diagnosis of Crimean-Kongo hemorrhagic fever in the emergency room.

Kaynakça

  • Whitehouse, C.A. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004:64;145-160.
  • Ergönül Ö. Kırım Kongo kanamalı ateşi tedavisi ve ribavirin kullanımı. Klimik Dergisi. 2016;29:2-9
  • Burt F.J, Swanepoel R, Shieh W.J, et al. Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Arch. Pathol. Lab. Med. 1997: 121; 839-846.
  • Feldmann H, Jones S, Klenk H.D, Schnittler H.J. Ebola virus: From discovery to vaccine. Nat. Rev. Immunol. 2003: 3; 677-685.
  • Öngürü P, Bodur H. Crimean-congo haemorrhagic fever. J. Exp. Clin. Med. 2012; 29: S175-S181
  • Sonmez O, Ertas G, Bacaksız A, Tasal A, Erdogan E, Asoglu E. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease. An observational study. Anadolu Kardiyol Derg. 2013;13:662e7
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S. The platelet functions in patients with ankylosing spondylitis, antiTNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets 2010;21:126e31.
  • Azab B, Shah N, Akerman M, McGinn Jr JT. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326e34
  • Ertekin B, Kara H, Erdemir E, Doğan E, Acar T, Demir L.S. Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis. Eurasian J Emerg Med 2017; 16: 29-33
  • Uyar Y, Chrıstova I, Papa A. Current situation of Crimean Congo hemorrhagic fever (CCHF) in Anatolia and Balkan Peninsula. Türk Hijyen ve Deneysel Biyoloji Dergisi 2011; 68: 139 – 151
  • Yilmaz GR, Buzgan T, Irmak H. The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002–2007. Int J Infect Dis 2009;13:380-6.
  • Ozkurt Z, Kiki I, Erol S et al. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect 2006: 52; 207–215.
  • Bastug A, Kayaaslan B, Kazancioglu S, et al. Crimean-Congo hemorrhagic fever: Prognostic factors and the association of leukocyte counts with mortality. Jpn J Infect Dis 2016: 69; 51–55
  • Eren S. H, Zengin S, Büyüktuna S.A, Gözel M.G. Clinical severity in forecasting platelet to lymphocyte ratio in Crimean–Congo hemorrhagic fever patients. J Med Microbiol 2016: 65;1100–1104
  • Akıncı E, Bodur H, Leblebicioglu H. Pathogenesis of Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis 2013;13: 429–437.
  • Ertürk A, Cüre E, Parlak E, Cüre M.C. Yüce S, Özkurt Z. Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. JMID 2015;5:51-56
  • Vorou R, Pierroutsakos I. N. Maltezou H. C. CrimeanCongo hemorrhagic fever. Curr Opin Infect Dis. 2007; 20: 495–500.
  • Inci A. Increased Mean Platelet Volume in Patients with Crimean Congo Hemorrhagic Fever. J Clin Anal Med 2015;6:1-3.
  • Turkdogan K.A, Eren S.H, Coskun A, Engın A, Sonmez E, Cıvelek C. Ratio of neutrophil to lymphocyte Counts in Crimean Congo Hemorrhagic Fever. J Clin Anal Med 2016;7: 10-3
  • Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
  • Beyan C. Is mean platelet volume a predictive marker in patients with venous thrombosis? Clin Appl Thromb Hemost 2012;18:670-1.
  • Ekiz F, Gürbüz Y, Basar Ö, et al. Mean platelet volume in the diagnosis and prognosis of Crimean-Congo hemorrhagic fever. Clin Appl Thromb Hemost 2013;19:441-4.
  • Alan S, Tuna S, Turkoğlu E.B. The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet’s syndrome. Kaohsiung J Med Sci 2015; 31: 626-631
  • Harmanci O, Kav T, Sivri B. Red cell distribution width can predict intestinal atrophy in selected patients with celiac disease. J Clin Anal Med 2012;26:497–502
  • Tanoglu A, Karagoz E, Ulcay A, Turhan V, Kara M, Yazgan Yusuf. Clinical Significance of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume for Predicting the Severity of Hepatic Fibrosis in Patients with Chronic Hepatitis B. Medicine Science 2016;5:147-59
  • Koseoglu HI, Altunkas F, Doruk S, Etikan I, Demir O, Kanbay A. Plateletelymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome. J Thromb Thrombolysis 2015;39:179e85
  • Macey M, Hagi-Pavli E, Stewart J, et al. Age, gender and disease related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behcet’s disease. Rheumatology 2011;50: 1849-59.
  • Proctor MJ, Morrison DS, Talwar D, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 2011;47:2633-41.
  • Cho K.I, Ann S.H, Singh G.B, Her A.Y, Shin E.S. Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One 2015: Jul 24;10:e0133934.
  • Sadaka F, O’Brien J, Prakash S. Red Cell Distribution Width and Outcome in Patients With Septic Shock. J Intensive Care Med. 2013;28:307-13.
  • Şenol K, Saylam B, Kocaay F, Tez M. Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med 2013; 31: 687-9.
  • Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009; 104: 868–72
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M; for the Cholesterol and Recurrent Events (CARE) Trial Investigators: Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation 2008; 117: 163–68
  • Ku NS, Kim HW, Oh HJ, et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia. Shock 2012; 38: 123–27
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Original Article
Yazarlar

Emine Doğan Bu kişi benim 0000-0002-8789-6705

Sadık Girişgin 0000-0003-2669-0532

Birsen Ertekin 0000-0002-0630-8634

Osman Lütfi Demirci Bu kişi benim

Yayımlanma Tarihi 30 Haziran 2021
Gönderilme Tarihi 18 Mayıs 2019
Yayımlandığı Sayı Yıl 2021 Cilt: 31 Sayı: 2

Kaynak Göster

Vancouver Doğan E, Girişgin S, Ertekin B, Demirci OL. Kırım Kongo Kanamalı Ateşinde Hemogram Parametrelerinin Tanısal Değeri. Genel Tıp Derg. 2021;31(2):101-4.