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Transfusion Transmitted Virüs TTV Prevalansı İnaktif Hepatit B Taşıyıcılarında Hemodiyalizden Etkileniyor Mu?

Yıl 2018, Cilt: 28 Sayı: 2, 45 - 47, 01.03.2018

Şua Sümer Nazlım Aktuğ Demir Servet Kölgelier Lütfi Saltuk Demir Abdullah Arpacı Onur Ural

Öz

Amaç: Bu çalışmada, hemodiyaliz tedavisi uygulanan ve uygulanmayan inaktif hepatit B taşıyıcılarında Transfusion Transmitted Virus TTV prevalansının saptanması amaçlandı.Gereç ve Yöntem: Bu çalışma, hemodiyaliz tedavisi uygulanan 50 inaktif hepatit B hastası ve renal fonksiyonları normal olan 40 inaktif hepatit B olgusu üzerinde yapıldı. Hastalardan alınan serum örneklerinden ELİSA kiti ile Anti TTV IGG çalışıldı. Veriler Ki-kare testi ile değerlendirildi.Bulgular: 50 hemodiyaliz hastasının 39’unda %78 Anti TTV IGG pozitif saptanırken, 40 hemodiyaliz tedavisi uygulanmayan inaktif hepatit B hastasının 8’inde %20 Anti TTV IGG pozitifliği saptandı. Bu fark istatistiki olarak anlamlı idi p=0.001 .Sonuç: Hemodiyaliz tedavisi uygulanan hastalarda TTV seropozitifliğinin yüksek olması nedeniyle, hepatit virüslerinin bulaşının önlenmesi için bu ünitelerde temizlik, dezenfeksiyon ve enfeksiyon kontrolüne yönelik standart önlemlerin daha dikkatli uygulanması gerektiğini düşünüyoruz

Anahtar Kelimeler

Hemodiyaliz inaktif hepatit b transfusion transmitted virüs

Kaynakça

  • Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Mi- yakawa Y, Mayumi M. A novel DNA virüs (TTV) associ- ated with elevated transaminase levels in post transfusion hepatitis of unknown etiology. Biochem Biophys Res Com- mun1997;24:92-7.
  • Özener Çİ, Türe F, Koç M,Avşar E. SAPD Hastalarında TT Virüs (TTV) Enfeksiyonu ve Prevelansı.Turk Neph Dial Transpl 2001;10:93-7.
  • Tanaka H, Okamoto H, Luengrojanakul P, et al.Infecti- on with an unenveloped DNA virus (TTV) associated with posttransfusion non-A to G hepatitis in hepatitis patients and healthy blood donors in Thailand. J Med Virol 1998;56:234-8.
  • Kheradpezhouh M, Taremi M, Gachkar L. Presence and- significance of transfusion-transmitted virus infection in Iranian patients on maintenance hemodialysis. J Microbiol Immunol Infect 2007;40:106-11.
  • Chan YJ, Hsu YH, Chen MC et al. TT virus infection among hemodialysis patients at a medical center in Taiwan. J Microbiol Immunol Infect 2000;33:14-8.
  • Yılmaz N, Çiftçi A, Balcı M, et al.Hemodiyaliz Hastalarında Hepatit E, Hepatit G Ve TTV Seroprevalansı. Ortadogu- Med J 2017;9:6-11.
  • Rivanera D, Lozzi MA, Idili C, Lilli D. Prevalence of TT virus infection in Italian dialysis patients. Pathol Biol 2009;57:97-100.
  • Valtuille R, Frankel F, Gomez F, et al. The role of transfusi- on-transmitted virus in patients undergoing hemodialysis. J Clin Gastroenterol 2002;34:86-8.
  • Schroter M, Feucht HH, Zollner B, Schafer P, Laufs R. Pre- valence of a novel DNA virus (TTV) among patients on maintenance hemodialysis. Nephron 2001;87:139-42.
  • Chattopadhyay S, Rao S, Das BC, Singh NP, Kar P. Preva- lence of transfusion-transmitted virus infection in patients on maintenance hemodialysis from New Delhi, India. Hemodial Int 2005;9:362-6.
  • Türkoğlu S. TTV'nin farklı hasta gruplarında araştırılması. Türk Mikrobiol Cem Derg 2001;31:259-61.
  • Simmonds P, Davidson F, Lycett C, et al.Detection of a no- vel DNA virus (TTV) in blood donors and blood products. Lancet 1998;352:191-5.
  • Prescott LE, Simmonds P. Global distribution of transfusi- on-transmitted virus. N Engl J Med 1998;339:776–7.
  • Ukita M, Okamoto H, Kato N, Miyakawa Y, Mayumi M.Excretion in to bile of a novelunenveloped DNA virus (TTV virus) associated with acute and chronic non-A-G hepatitis. J Infect Dis 1999;179:1245-8.
  • Prescott LE, Simmonds P. Global distribution of transfusi- on-transmitted virus. N Engl J Med 1998;339: 776-7.
  • Desai SM, Muerhoff AS, Leary TP, et al. Prevalence of TT virus infection in US blood donors and populations at risk for acquiring parenterally transmitted viruses. J Infect Dis 1999;179:1242-4.
  • Tunçbilek S, Coşkun D, Çetinkaya F, Hizel N, Tahtakılıç P. İstanbul'da kan donörlerinde TT virusu (TTV) prevalansı- nın araştırılması. Flora 1999;4:273-7.
  • Usta M, Dilek K, Ersoy A, et al. Prevalence of transfusion transmitted virus infection and its effect on renal graftsur- vival in renal transplant recipients. Scand J Urol Nephrol 2002;36:473-7.
  • Savaş MC, Güney Ç, Kadayıfçı A, et al. High prevalence of transfusion-transmitted virüs infection in patients with chronic liver diseases in an endemic area of hepatitis B and C virüs. Med Prin Pract Med 2003;12:176-9.
  • Yenice N, Gökden Y, Erdem L, Türkmen S, Arican N. Transfusional transmitted virüs seroprevalence in asympto- matic HBsAg (+) hepatitis B carriers. Scand J Gastroenterol 2004;39:174-7.
  • Irshad M, Mandal K, Singh S, Agarwal SK. Torqueteno vi- rus infection in hemodialysis patients in North India. Int Urol Nephrol 2010;42:1077-83.

Yıl 2018, Cilt: 28 Sayı: 2, 45 - 47, 01.03.2018

Şua Sümer Nazlım Aktuğ Demir Servet Kölgelier Lütfi Saltuk Demir Abdullah Arpacı Onur Ural

Öz

Objective: Inthisstudy, it was aimed to determine the prevalence of Transfusion Transmitted Virus TTV virus in inactivated hepatitis B carriers with and without hemodialysis treatment.Materials and Methods: This study was conducted on 50 inactive hepatitis B patients treated with hemodialysis and 40 inactive hepatitis B patients with normal renal function. Anti-TTV IGG was studied with ELISA kit from serum samples taken from patients. Data were evaluated by Chi-square test.Results: Anti-TTV IGG positivity was detected in 39 78% of 50 hemodialysis patients while Anti-TTV IGG positivity was detected in 8 20% of 40 inactivated hepatitis B patients without hemodialysis. This difference was statistically significant p=0.001 .Conclusion: We think that standard measures for cleaning, disinfection and infection control should be applied more carefully in these units in order to prevent transmission of hepatitis viruses because of the high TTV seropositivity in hemodialysis patients

Anahtar Kelimeler

Hemodialysis inactive hepatitis b transfusion transmitted virus

Kaynakça

  • Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Mi- yakawa Y, Mayumi M. A novel DNA virüs (TTV) associ- ated with elevated transaminase levels in post transfusion hepatitis of unknown etiology. Biochem Biophys Res Com- mun1997;24:92-7.
  • Özener Çİ, Türe F, Koç M,Avşar E. SAPD Hastalarında TT Virüs (TTV) Enfeksiyonu ve Prevelansı.Turk Neph Dial Transpl 2001;10:93-7.
  • Tanaka H, Okamoto H, Luengrojanakul P, et al.Infecti- on with an unenveloped DNA virus (TTV) associated with posttransfusion non-A to G hepatitis in hepatitis patients and healthy blood donors in Thailand. J Med Virol 1998;56:234-8.
  • Kheradpezhouh M, Taremi M, Gachkar L. Presence and- significance of transfusion-transmitted virus infection in Iranian patients on maintenance hemodialysis. J Microbiol Immunol Infect 2007;40:106-11.
  • Chan YJ, Hsu YH, Chen MC et al. TT virus infection among hemodialysis patients at a medical center in Taiwan. J Microbiol Immunol Infect 2000;33:14-8.
  • Yılmaz N, Çiftçi A, Balcı M, et al.Hemodiyaliz Hastalarında Hepatit E, Hepatit G Ve TTV Seroprevalansı. Ortadogu- Med J 2017;9:6-11.
  • Rivanera D, Lozzi MA, Idili C, Lilli D. Prevalence of TT virus infection in Italian dialysis patients. Pathol Biol 2009;57:97-100.
  • Valtuille R, Frankel F, Gomez F, et al. The role of transfusi- on-transmitted virus in patients undergoing hemodialysis. J Clin Gastroenterol 2002;34:86-8.
  • Schroter M, Feucht HH, Zollner B, Schafer P, Laufs R. Pre- valence of a novel DNA virus (TTV) among patients on maintenance hemodialysis. Nephron 2001;87:139-42.
  • Chattopadhyay S, Rao S, Das BC, Singh NP, Kar P. Preva- lence of transfusion-transmitted virus infection in patients on maintenance hemodialysis from New Delhi, India. Hemodial Int 2005;9:362-6.
  • Türkoğlu S. TTV'nin farklı hasta gruplarında araştırılması. Türk Mikrobiol Cem Derg 2001;31:259-61.
  • Simmonds P, Davidson F, Lycett C, et al.Detection of a no- vel DNA virus (TTV) in blood donors and blood products. Lancet 1998;352:191-5.
  • Prescott LE, Simmonds P. Global distribution of transfusi- on-transmitted virus. N Engl J Med 1998;339:776–7.
  • Ukita M, Okamoto H, Kato N, Miyakawa Y, Mayumi M.Excretion in to bile of a novelunenveloped DNA virus (TTV virus) associated with acute and chronic non-A-G hepatitis. J Infect Dis 1999;179:1245-8.
  • Prescott LE, Simmonds P. Global distribution of transfusi- on-transmitted virus. N Engl J Med 1998;339: 776-7.
  • Desai SM, Muerhoff AS, Leary TP, et al. Prevalence of TT virus infection in US blood donors and populations at risk for acquiring parenterally transmitted viruses. J Infect Dis 1999;179:1242-4.
  • Tunçbilek S, Coşkun D, Çetinkaya F, Hizel N, Tahtakılıç P. İstanbul'da kan donörlerinde TT virusu (TTV) prevalansı- nın araştırılması. Flora 1999;4:273-7.
  • Usta M, Dilek K, Ersoy A, et al. Prevalence of transfusion transmitted virus infection and its effect on renal graftsur- vival in renal transplant recipients. Scand J Urol Nephrol 2002;36:473-7.
  • Savaş MC, Güney Ç, Kadayıfçı A, et al. High prevalence of transfusion-transmitted virüs infection in patients with chronic liver diseases in an endemic area of hepatitis B and C virüs. Med Prin Pract Med 2003;12:176-9.
  • Yenice N, Gökden Y, Erdem L, Türkmen S, Arican N. Transfusional transmitted virüs seroprevalence in asympto- matic HBsAg (+) hepatitis B carriers. Scand J Gastroenterol 2004;39:174-7.
  • Irshad M, Mandal K, Singh S, Agarwal SK. Torqueteno vi- rus infection in hemodialysis patients in North India. Int Urol Nephrol 2010;42:1077-83.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Original Article
Yazarlar

Şua Sümer Bu kişi benim

Nazlım Aktuğ Demir Bu kişi benim

Servet Kölgelier Bu kişi benim

Lütfi Saltuk Demir Bu kişi benim

Abdullah Arpacı Bu kişi benim

Onur Ural Bu kişi benim

Yayımlanma Tarihi 1 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 28 Sayı: 2

Kaynak Göster

Vancouver Sümer Ş, Demir NA, Kölgelier S, Demir LS, Arpacı A, Ural O. Transfusion Transmitted Virüs TTV Prevalansı İnaktif Hepatit B Taşıyıcılarında Hemodiyalizden Etkileniyor Mu?. Genel Tıp Derg. 2018;28(2):45-7.

Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.