Öz
Soliterfibröz tümörler SFT , genellikle plevra yerleşimli, nadir görülen spindle hücreli neoplazmlardır. Fakat bu tümörler ekstraplevral bölgelerde de nadir olarak görülebilirler. Ürogenital lokalizasyon ise oldukça nadirdir. Biz, ürogenital yerleşimli 2 olgu sunacağız. İlk olgumuz, 33yaşında erkek hastada ürogenital sistemde mesane yerleşimli, ikinci olgumuz ise 49 yaşında bayan hastada böbrekte perirenal yağ doku yerleşimlidir. Her iki olguda da tümör iyi sınırlı olup, spindle hücrelerden oluşmakta idi. Bu tümörler immünhistokimyasal olarak CD-34, BCL-2 ve CD-99 ile pozitif, sitokeratin, CD-117, S-100 ve kas markerları ile negatif ekspresyon göstermekte idi. %90 olgu benign seyirli olup, immünhistokimyasal çalışmalar tanıda anahtar rol oynamaktadır
Anahtar Kelimeler
Soliter fibröz tümör ürogenital sistem immünhistokimyasal çalışmalar nadir
Kaynakça
- Cerda-Nikolas M, Lopez-Giners C, Gilbenso R, et al. Soli- tary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Neuropathology 2006; 26:557-63.
- Znati K, Chbani L, El FatemiH, et al.Solitary fibrous tumor of the kidney: A case report and review of the literature. Rev Urol 2007;9:36-40.
- Hanau CA, Miettinen M. Solitary fibrous tumor: histo- logical and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995; 26: 440-9.
- Sfoungaristos S, Papatheodorou M, Kavouras A, Permenis P. Solitary fibrous tumor of the kidney with massive retro- peritoneal recurrence. A case presentation. Prague Med. Rep 2012;113:246-50.
- Corti B, Carella R, Gabusi E, et al. Solitary fibrous tumour of the urinary bladder with expression of BCL-2, CD34, and insulin-like growth factor type II. Eur Urol 2001;39: 484-8.
- Hsieh TY, ChangChien YC, ChenWH,et al. De novoma- lignant solitary fibrous tumor of the kidney. Diagn Pathol 2011;6:96.
- Fine SW, McCarthy DM, Chan TY, Epstein JI, Argani P. Malignant solitary fibrous tumor of thekidney. Report of a case and comprehensi vereview of the literature. Arch Pat- hol Lab Med 2006; 130: 857-61.
- Yamaguchi T, Takimoto T, Yamashita T, et al. Fat containing variant of solitary fibrous tumor (lipomatous hemangiope- ricytoma) arising on surface of kidney. Urology 2005; 65: 175.
- Guillou L, Fletcher JA, Fletcher CMD. Extrapleural Soli- tary fibrous tumor and haemangiopericytoma. In: Fletcher CMD, Unni KK, Mertens F (eds). Pathology and Genetics of Tumours of Soft Tissue and Bone (WHO Classification of Tumors). Lyon: IARC Press 2002: 86-90.
- Goldblum JR, FCAP, FASCP, et al. Soft Tissue Tumors of Intermediate Malignancy of uncertain Type. In: Weiss SW, Goldblum JR (eds). SoftTissueTumors. 2014; 969-1027.
Öz
A solitary fibrous tumor SFT is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the urogenital system is rare. We report a two cases arising in the urogenital system. The first case, 33-year-old male patient bladder located in the urogenital system, while the second case is a 49-year- old female patient with kidney perirenal fat tissue localization. In the two cases the tumor was well-circumscribed and composed of a spindle cells. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. This tumors are benign in up to 90% of cases. The immunohistochemical study is the key to diagnosis
Anahtar Kelimeler
Solitary fibrous tumor urogenital system immunohistochemical study rare
Kaynakça
- Cerda-Nikolas M, Lopez-Giners C, Gilbenso R, et al. Soli- tary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Neuropathology 2006; 26:557-63.
- Znati K, Chbani L, El FatemiH, et al.Solitary fibrous tumor of the kidney: A case report and review of the literature. Rev Urol 2007;9:36-40.
- Hanau CA, Miettinen M. Solitary fibrous tumor: histo- logical and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995; 26: 440-9.
- Sfoungaristos S, Papatheodorou M, Kavouras A, Permenis P. Solitary fibrous tumor of the kidney with massive retro- peritoneal recurrence. A case presentation. Prague Med. Rep 2012;113:246-50.
- Corti B, Carella R, Gabusi E, et al. Solitary fibrous tumour of the urinary bladder with expression of BCL-2, CD34, and insulin-like growth factor type II. Eur Urol 2001;39: 484-8.
- Hsieh TY, ChangChien YC, ChenWH,et al. De novoma- lignant solitary fibrous tumor of the kidney. Diagn Pathol 2011;6:96.
- Fine SW, McCarthy DM, Chan TY, Epstein JI, Argani P. Malignant solitary fibrous tumor of thekidney. Report of a case and comprehensi vereview of the literature. Arch Pat- hol Lab Med 2006; 130: 857-61.
- Yamaguchi T, Takimoto T, Yamashita T, et al. Fat containing variant of solitary fibrous tumor (lipomatous hemangiope- ricytoma) arising on surface of kidney. Urology 2005; 65: 175.
- Guillou L, Fletcher JA, Fletcher CMD. Extrapleural Soli- tary fibrous tumor and haemangiopericytoma. In: Fletcher CMD, Unni KK, Mertens F (eds). Pathology and Genetics of Tumours of Soft Tissue and Bone (WHO Classification of Tumors). Lyon: IARC Press 2002: 86-90.
- Goldblum JR, FCAP, FASCP, et al. Soft Tissue Tumors of Intermediate Malignancy of uncertain Type. In: Weiss SW, Goldblum JR (eds). SoftTissueTumors. 2014; 969-1027.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 27 Sayı: 2 |
Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.