Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1

Yıl 2016, Cilt: 26 Sayı: 4, 121 - 126, 01.12.2016

Ümmügülsüm Can

Öz

Oksidatif stres fazla oksidant bileşiğin yapılması ve antioksidant koruma mekanizmasının azlığı sonucu oluşarak doku hasarlarına yol açar. Oksidatif stres sonucu oluşan okside-düşük dansiteli lipoprotein oxidized low-density lipoprotein ox-LDL , reseptörü lektin benzeri ox-LDL reseptör-1 lectin-like receptor for ox-LDL-1 LOX-1 ’e bağlanır. ox-LDL ve LOX-1 endotel disfonksiyonu, monosit adezyonu, düz kas hücre proliferasyon, migrasyon ve apoptozis, yağ hücre yapımı ve trombosit aktivasyonu ile ilgili mekanizmalarda görev alır. ox-LDL, ateroskleroz, diabetes mellitus, yaşlanma, metabolik sendrom, kardiovasküler, ve serebrovasküler, böbrek ve karaciğer hastalıklarında artarak hastalıkların patogenezlerinde aktif rol alır. Bu derlemede, ox-LDL ve reseptörü LOX-1 etkileri incelenmiştir

Anahtar Kelimeler

Okside-LDL, lektin benzeri okside-LDL reseptör-1, kardiyovasküler hastalıklar

Kaynakça

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