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Alopesi Areata Hastalarında Nötrofil/Lenfosit Oranının ve Diğer İnflamatuar Parametrelerin Normal Popülasyon İle Karşılaştırılması

Yıl 2016, Cilt: 26 Sayı: 2, 46 - 49, 01.06.2016

Mehmet Emin Yanık Gamze Erfan Hülya Albayrak Pınar Sonat Kara Dilek Solmaz Mustafa Kulaç

Öz

Amaç: Bu çalışmanın amacı; alopesi areata AA hastalarında nötrofil/lenfosit oranını NLR , Eritrosit sedimentasyon hızı ESR , C reaktif protein CRP gibi inflamatuar parametreleri normal populasyon ile kıyaslayarak bu parametrelerin AA hastalarında inflamasyonun şiddetini ölçebilecek bir marker olarak kullanılabilirliğini değerlendirmektir.Yöntem: Çalışmaya klinik olarak AA tanısı konmuş 234 hasta dahil edildi. 37 sağlıklı kişi alındı. Hasta dosyalarından lökosit, nötrofil ve lenfosit sayıları ile ESR ve CRP sonuçları kaydedildi. NLR ise hesaplanarak bulunup kaydedilmiştir. Bulgular: Hasta ve kontrol grubu arasında Lökosit, Nötrofil, ,Hb ve Esr değerleri ile NLR açısından anlamlı fark saptanmazken p>0.05 Lenfosit sayıları p=0,02 ve Crp P

Anahtar Kelimeler

Alopesi areata İnflamatuar parametreler NLR

Kaynakça

  • Sperling L. Alopecias. In: Bolognia J, Jorizzo J, Rapini R, eds. Dermatology. New York: Mosby Elsevier; 2008: 992–5.
  • Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549–566; quiz 567–70.
  • Van der Steen P, Traupe H, Happle R, Boezeman J, Sträter R, Hamm H. The genetic risk for alopecia areata in first deg- ree relatives of severely affected patients. An estimate. Acta Derm Venereol 1992; 72(5):373-5.
  • Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inf- lammation in prevalent chronic diseases in Asian populati- on. Int Arch Med 2012 26;5(1):2.
  • Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardio- vasc Ther 2013;11:55-9.
  • Ozturk ZA, Kuyumcu ME, Yesil Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest 2013;36:593-9.
  • Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, Mc- Millan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218-30.
  • Ahsen A, Ulu MS, Yuksel S, et al. As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-ly- mphocyte ratio. Inflammation 2013;36:1357-62.
  • Celikbilek M, Dogan S, Ozbakır O, et al. Neutrophil- lym- phocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013;27:72-6.
  • Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Ma- ter Sociomed 2014;26:231-3.
  • Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neut- rophil to lymphocyte ratio as a measure of systemic inflam- mation in psoriasis. Cutan Ocul Toxicol 2014;33:223.
  • Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: Part I. Clinical picture, histopatho- logy, and pathogenesis. J Am Acad Dermatol 2010;62:177- 88.
  • Matzer F, Egger JW, Kopera D. Psychosocial stress and coping in alopecia areata: a questionnaire survey and qu- alitative study among 45 patients. Acta Derm Venereol 2011;91:318-27.
  • Ozlu E, Karadag AS, Akdeniz N, Uzuncakmak TK. Acit- retin-induced alopecia areata: a case report. Cutan Ocul Toxicol 2015;34:248-50.
  • ong J, Lim SW. Alopecia areata as a paraneoplastic synd- rome of Hodgkin's lymphoma: A case report. Mol Clin Oncol 2014;2:596-8.
  • Qiao J, Zhou G, Ding Y, Zhu D, Fang H. Multiple parane- oplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma. J Neurol Sci 2011;308:177-9.
  • Rifaioglu EN, Şen BB, Ekiz O, Dogramaci AC. Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disea- se activity. Acta Dermatovenerol 2014;23:65-7.
  • Li L, Xia Y, Chen C, Cheng P, Peng C. Neutrophil-lymp- hocyte ratio in systemic lupus erythematosus disease: a retrospective study. International Journal of Clinical and Experimental Medicine 2015;8:11026-31.
  • Paramanathan A, Saxena A2, Morris DL3. A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol 2014; 23:31-9.
  • Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002;105:2462-4.
  • Yousefi M, Namazi MR, Rahimi H, Younespour S, Ehsani AH, Shakoei S. Evaluation of Serum Homocysteine, Hi- gh-Sensitivity CRP, and RBC Folate in Patients with Alope- cia Areata. Indian J Dermatol 2014; 59:630.
  • Kalish RS, Johnson KL, Hordinsky MK. Alopecia areata. Autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood. Arch Dermatol 1992;128:1072- 7.

Yıl 2016, Cilt: 26 Sayı: 2, 46 - 49, 01.06.2016

Mehmet Emin Yanık Gamze Erfan Hülya Albayrak Pınar Sonat Kara Dilek Solmaz Mustafa Kulaç

Öz

Objective: The objective of this study is to calculate the neutrophil-lymphocyte ratio NLR and other inflamatory paramaters like erythrocyte sedimentation rate ECR and C-reactive protein results CRP in Alopecia areata AA patients and determine the association between thoose laboratory values and AA.Method: 234 patients with AA and 37 healthy subjects were enrolled in the study. Number of neutrophil, lymphocyte, leucocyte, ESR and CRP were ascertained from patient’s medical records. NLR was calculated and recorded.Results: While the difference between patient and control groups in terms of value of Neutrophils, Leukocytes, Hb and Esr were found to be insignificant p>0.05 , numbers of Lymphocyte p=0,02 and value of Crp P

Anahtar Kelimeler

Alopecia areata Inflamatory parameters NLR

Kaynakça

  • Sperling L. Alopecias. In: Bolognia J, Jorizzo J, Rapini R, eds. Dermatology. New York: Mosby Elsevier; 2008: 992–5.
  • Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549–566; quiz 567–70.
  • Van der Steen P, Traupe H, Happle R, Boezeman J, Sträter R, Hamm H. The genetic risk for alopecia areata in first deg- ree relatives of severely affected patients. An estimate. Acta Derm Venereol 1992; 72(5):373-5.
  • Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inf- lammation in prevalent chronic diseases in Asian populati- on. Int Arch Med 2012 26;5(1):2.
  • Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardio- vasc Ther 2013;11:55-9.
  • Ozturk ZA, Kuyumcu ME, Yesil Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest 2013;36:593-9.
  • Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, Mc- Millan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218-30.
  • Ahsen A, Ulu MS, Yuksel S, et al. As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-ly- mphocyte ratio. Inflammation 2013;36:1357-62.
  • Celikbilek M, Dogan S, Ozbakır O, et al. Neutrophil- lym- phocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013;27:72-6.
  • Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Ma- ter Sociomed 2014;26:231-3.
  • Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neut- rophil to lymphocyte ratio as a measure of systemic inflam- mation in psoriasis. Cutan Ocul Toxicol 2014;33:223.
  • Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: Part I. Clinical picture, histopatho- logy, and pathogenesis. J Am Acad Dermatol 2010;62:177- 88.
  • Matzer F, Egger JW, Kopera D. Psychosocial stress and coping in alopecia areata: a questionnaire survey and qu- alitative study among 45 patients. Acta Derm Venereol 2011;91:318-27.
  • Ozlu E, Karadag AS, Akdeniz N, Uzuncakmak TK. Acit- retin-induced alopecia areata: a case report. Cutan Ocul Toxicol 2015;34:248-50.
  • ong J, Lim SW. Alopecia areata as a paraneoplastic synd- rome of Hodgkin's lymphoma: A case report. Mol Clin Oncol 2014;2:596-8.
  • Qiao J, Zhou G, Ding Y, Zhu D, Fang H. Multiple parane- oplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma. J Neurol Sci 2011;308:177-9.
  • Rifaioglu EN, Şen BB, Ekiz O, Dogramaci AC. Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disea- se activity. Acta Dermatovenerol 2014;23:65-7.
  • Li L, Xia Y, Chen C, Cheng P, Peng C. Neutrophil-lymp- hocyte ratio in systemic lupus erythematosus disease: a retrospective study. International Journal of Clinical and Experimental Medicine 2015;8:11026-31.
  • Paramanathan A, Saxena A2, Morris DL3. A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol 2014; 23:31-9.
  • Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002;105:2462-4.
  • Yousefi M, Namazi MR, Rahimi H, Younespour S, Ehsani AH, Shakoei S. Evaluation of Serum Homocysteine, Hi- gh-Sensitivity CRP, and RBC Folate in Patients with Alope- cia Areata. Indian J Dermatol 2014; 59:630.
  • Kalish RS, Johnson KL, Hordinsky MK. Alopecia areata. Autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood. Arch Dermatol 1992;128:1072- 7.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Original Article
Yazarlar

Mehmet Emin Yanık Bu kişi benim

Gamze Erfan Bu kişi benim

Hülya Albayrak Bu kişi benim

Pınar Sonat Kara Bu kişi benim

Dilek Solmaz Bu kişi benim

Mustafa Kulaç Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 26 Sayı: 2

Kaynak Göster

Vancouver Yanık ME, Erfan G, Albayrak H, Kara PS, Solmaz D, Kulaç M. Alopesi Areata Hastalarında Nötrofil/Lenfosit Oranının ve Diğer İnflamatuar Parametrelerin Normal Popülasyon İle Karşılaştırılması. Genel Tıp Derg. 2016;26(2):46-9.


Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.