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Laparoskopik kolesistektomide karbondioksit pnömoperitoneumun beyin natriüretik peptid ve troponin I üzerine etkileri

Yıl 2015, Cilt: 25 Sayı: 3, 85 - 88, 01.09.2015

Öz

Bu çalışmanın amacı, LK sırasında CO2 pnömoperitoneumun BNP ve cTnI içeren kardiyak belirteçler üzerine etkisini araştırmaktır.Amaç: Bu çalışmanın amacı laparoskopik kolesistektomi sırasında karbondioksit pnömoperitoneumun beyin natriüretik peptid BNP ve troponin I’yı cTnI içeren kardiyak belirteçler üzerine etkisini araştırmaktır. Gereç ve yöntem: Hastalar; laparoskopik kolesistektomi uygulanan hastalar Grup I ve genel anestezi altında diğer cerrahi işlem uygulanan hastalar Grup II olarak iki gruba ayrıldı. Kan örnekleri preoperatif, peroperatif dönemde ve ameliyatın 24. saatinde alındı. Troponin I ve BNP düzeyleri ölçüldü. Bulgular: Hiçbir hastada ameliyat sırasında elektrokardiyografide akut ST değişikliği saptanmadı. Grup I’de ameliyattın 24. saatindeki BNP düzeyleri hem preoperatif hem de peroperatif dönem BNP düzeylerinden anlamlı yüksek bulundu. Grup II’nin BNP düzeyleri değerlendirildiğinde aralarında anlamlı fark saptanmadı. Grup I ve II’de cTnI düzeyleri arasında anlamlı fark saptanmadı. Sonuç: Laparoskopik kolesistektomiye bağlı pnömoperitoneum kardiyak iskemik olaya yol açmadan hemodinamik değişlikliğe yol açmaktadır

Kaynakça

  • Ekici Y, Bozbas H, Karakayali F, et al. Effect of different intra-ab- dominal pressure levels on QT dispersion in patients undergoing laparoscopic cholecystectomy. Surg Endosc 2009;23:2543-9.
  • Sare M, Yürekli M, Kurukahvecioğlu O, et al. The effects of carbon dioxide pneumoperitoneum on tyrosine hydroxylase activity. Surg Laparosc Endosc Percutan Tech 2006;16:25-8.
  • Williams MD, Murr PC, Laparoscopic insufflation of the abdomen depresses cardiopulmonary function, Surg Endosc 1993;7:12-6.
  • Marathe US, Lilly RE, Silvestry SC, et al. Alterations in hemod- ynamics and left ventricular contractility during carbon dioxide pneumoperitoneum. Surg Endosc 1996;10:974-8.
  • Kaklamanos IG, Condos S, Merrell RC. Time-related changes in hemodynamic parameters and pressure-derived indices of left ventricular function in a porcine model of prolonged pneumope- ritoneum. Surg Endosc 2000;14:834-8.
  • Bickel A, Yahalom M, Roguin N, et al. Power spectral analysis of heart rate variability during positive pressure pneumoperitoneum: the significance of increased cardiac sympathetic expression. Surg Endosc 2002;16:1341-4.
  • Ferguson JI, Beckett GJ, Stoddart M, Walker SW, Fox KA. Myocar- dial infarction redefined: the new ACC/ESC definition, based on cardiac troponin, increases the apparent incidence of infarction. Heart 2002;88:343-5.
  • Nageh T, Sherwood RA, Haris BM, Byrne JA, Thomas MR. Cardi- ac troponin T and I and creatine kinase-MB as markers of myo- cardial injury and predictors of outcome following percutaneous coronary intervention. Int J Cardiol 2003;92:285-93.
  • Yee KC, Mukherjee D, Smith DE, et al. Prognostic significance of an elevated creatine kinase in the absence of an elevated tropo- nin I during an acute coronary syndrome. Am J Cardiol 2003;92: 1442-4.
  • Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans, Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and bra- in natriuretic peptide. J Clin Invest 1991;87:1402-12.
  • Yoshimura M, Yasue H, Morita E, et al. Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in pa- tients with congestive heart failure. Circulation 1991;84:1581-8.
  • Joris JL, Noirot DP, Legrand MJ, Jacquet NJ, Lamy ML. Hemod- ynamic changes during laparoscopic cholecystectomy. Anesth Analg 1993;76:1067-71.
  • Goodale RL, Beebe DS, McNevin MP, et al. Haemodynamic, respi- ratory, and metabolic effects of laparoscopic cholecystectomy. Am J Surg 1993;166:533–7.
  • Brantly JC, Riley PM. Cardiovascular collapse during laparoscopy: a report of two cases. Am J Obstet Gynecol 1998;159:735–7.
  • Westerband A, Van De Water J, Amzallag M, et al. Cardiovascular changes during laparoscopic cholecystectomy. Surg Gynecol Obs- tet 1992;175:535–8.
  • Janseen H, Treviño C, Williams D. Hemodynamic alterations in venous blood flow produced by external pneumatic compression. J Cardiovasc Surg 1993;34:441–7.
  • Ishizaki Y, Bandai Y, Shimomura K, Abe H, Ohtomo Y, Idezuki Y. Changes in splanchnic blood flow and cardiovascular effects following peritoneal insufflation of carbon dioxide. Surg Endosc 1993;7:420–3.
  • Jakimowicz J, Stultiëns G, Smulders F. Laparoscopic insufflation of abdomen reduces portal venous flow. Surg Endosc 1998;12: 129–32.
  • Nishikimi T, Yoshihara F, Morimoto A, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension 1996;28:22-30.
  • de Bold AJ. Cardiac natriuretic peptides gene expression and sec- retion in inflammation. J Investig Med 2009;57:29-32.

The role of tumor markers including CA125, CA19.9 and carcinoembriyonic antigen in acute appendicitis

Yıl 2015, Cilt: 25 Sayı: 3, 85 - 88, 01.09.2015

Öz

Objectives: The purpose of this study is to investigate the effects of carbondioxide pneumoperitoneum on brain natriuretic peptide BNP and cardiac markers including troponin I TnI during laparoscopic cholecystectomy LC . Material and methods: Patients performed LC were grouped as Group I and patients performed different surgical procedures under general anesthesia were grouped as Group II. Blood samples were obtained in preoperative and peroperative periods and 24 hours after the surgery, Troponin I and BNP levels were measured. Results: Acute ST segment changes in the electrocardiography were not determined in any patient during the operation. For Group I, the BNP levels at the 24th hour of the operation was significantly higher than both preoperative and peroperative periods whereas there were no significant differences in BNP levels in Group II. Between Group I and II no significant differences in cTnI levels were determined. Conclusion: Pneumoperitoneum due to LC causes hemodynamic changes without lead- ing to any cardiac ischemic conditions

Kaynakça

  • Ekici Y, Bozbas H, Karakayali F, et al. Effect of different intra-ab- dominal pressure levels on QT dispersion in patients undergoing laparoscopic cholecystectomy. Surg Endosc 2009;23:2543-9.
  • Sare M, Yürekli M, Kurukahvecioğlu O, et al. The effects of carbon dioxide pneumoperitoneum on tyrosine hydroxylase activity. Surg Laparosc Endosc Percutan Tech 2006;16:25-8.
  • Williams MD, Murr PC, Laparoscopic insufflation of the abdomen depresses cardiopulmonary function, Surg Endosc 1993;7:12-6.
  • Marathe US, Lilly RE, Silvestry SC, et al. Alterations in hemod- ynamics and left ventricular contractility during carbon dioxide pneumoperitoneum. Surg Endosc 1996;10:974-8.
  • Kaklamanos IG, Condos S, Merrell RC. Time-related changes in hemodynamic parameters and pressure-derived indices of left ventricular function in a porcine model of prolonged pneumope- ritoneum. Surg Endosc 2000;14:834-8.
  • Bickel A, Yahalom M, Roguin N, et al. Power spectral analysis of heart rate variability during positive pressure pneumoperitoneum: the significance of increased cardiac sympathetic expression. Surg Endosc 2002;16:1341-4.
  • Ferguson JI, Beckett GJ, Stoddart M, Walker SW, Fox KA. Myocar- dial infarction redefined: the new ACC/ESC definition, based on cardiac troponin, increases the apparent incidence of infarction. Heart 2002;88:343-5.
  • Nageh T, Sherwood RA, Haris BM, Byrne JA, Thomas MR. Cardi- ac troponin T and I and creatine kinase-MB as markers of myo- cardial injury and predictors of outcome following percutaneous coronary intervention. Int J Cardiol 2003;92:285-93.
  • Yee KC, Mukherjee D, Smith DE, et al. Prognostic significance of an elevated creatine kinase in the absence of an elevated tropo- nin I during an acute coronary syndrome. Am J Cardiol 2003;92: 1442-4.
  • Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans, Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and bra- in natriuretic peptide. J Clin Invest 1991;87:1402-12.
  • Yoshimura M, Yasue H, Morita E, et al. Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in pa- tients with congestive heart failure. Circulation 1991;84:1581-8.
  • Joris JL, Noirot DP, Legrand MJ, Jacquet NJ, Lamy ML. Hemod- ynamic changes during laparoscopic cholecystectomy. Anesth Analg 1993;76:1067-71.
  • Goodale RL, Beebe DS, McNevin MP, et al. Haemodynamic, respi- ratory, and metabolic effects of laparoscopic cholecystectomy. Am J Surg 1993;166:533–7.
  • Brantly JC, Riley PM. Cardiovascular collapse during laparoscopy: a report of two cases. Am J Obstet Gynecol 1998;159:735–7.
  • Westerband A, Van De Water J, Amzallag M, et al. Cardiovascular changes during laparoscopic cholecystectomy. Surg Gynecol Obs- tet 1992;175:535–8.
  • Janseen H, Treviño C, Williams D. Hemodynamic alterations in venous blood flow produced by external pneumatic compression. J Cardiovasc Surg 1993;34:441–7.
  • Ishizaki Y, Bandai Y, Shimomura K, Abe H, Ohtomo Y, Idezuki Y. Changes in splanchnic blood flow and cardiovascular effects following peritoneal insufflation of carbon dioxide. Surg Endosc 1993;7:420–3.
  • Jakimowicz J, Stultiëns G, Smulders F. Laparoscopic insufflation of abdomen reduces portal venous flow. Surg Endosc 1998;12: 129–32.
  • Nishikimi T, Yoshihara F, Morimoto A, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension 1996;28:22-30.
  • de Bold AJ. Cardiac natriuretic peptides gene expression and sec- retion in inflammation. J Investig Med 2009;57:29-32.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Original Article
Yazarlar

Hande Köksal Bu kişi benim

Sevil Kurban Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 25 Sayı: 3

Kaynak Göster

Vancouver Köksal H, Kurban S. Laparoskopik kolesistektomide karbondioksit pnömoperitoneumun beyin natriüretik peptid ve troponin I üzerine etkileri. Genel Tıp Derg. 2015;25(3):85-8.