Akut İskemik İnmede Yeni Bir Biyobelirteç Olan Serum NR2 Düzeyinin İnmenin Şiddeti ve Prognozu ile İlişkisi

Yıl 2013, Cilt: 23 Sayı: 4, 114 - 119, 01.01.2013

Ersin Kasım Ulusoy Erdem Gürkaş Cevdet Zungun Mehmet İlker Yön Sevilay Sezer Fikri Ak

Öz

Giriş: Akut iskemik inme tanısı için klinik deneyim ve görüntüleme bulgularını destekleyecek kan testine ihtiyaç vardır. Bu çalışma- da serum NR2 antikor düzeyinin akut iskemik inme tanısındaki değerinin ortaya konması amaçlandı. Gereç ve yöntem: Çalışmaya prosfektif olarak, çalışmaya alınma kriterlerini dolduran 64 iskemik inmeli hasta ile 68 sağlıklı gönüllü dahil edildi. İskemik inmenin akut döneminde serum NR2 anikor düzeyi ELİSA yöntemi ile ölçüldü. İnmenin şiddeti ve prognozu, giriş NIH İnme Skalası, 3. Ay modifiye Rankin Skalası ve Barthel indexi skorları ile, enfarkt hacmi AXBXC/2 hesaplamasıyla belirlendi. Sonuçlar Kolmogorov Smirnov, Tukey HSD, Wilcoxon ve Mann-Whitney U Testi kullanılarak NR2 düzeyi ile kıyaslandı. Bulgular: Ortalama serum NR2 antikor düzeyi iskemik inme grubunda 2.64±1.43 iken, kontrol grubunda 2.28±1.13 idi. Gruplar arasındaki fark istatistiksel olarak anlamlı değildi. S100B değerlerinin yaş, cinsiyet, koroner arter hastalığı, diyabetes mellitus, hiperlipidemi, hipertansiyon, periferik damar hastalığı, sigara içiminden etkilenmediği görülmüştür. Sonuç: Bu çalışma sonuçları NR2 antikor düzeyinin akut iskemik inmeli hastalardaki serum düzeylerinin normal kontrollere göre farklı olmadığını gösterdi. Bu verilere göre iskemik inmede NR2 antikor düzeyinin etkili bir rol almadığını düşünüyoruz

Anahtar Kelimeler

İskemik inme, biyobelirteç, serum NR2 antikor düzeyi

The relationship between serum levels of a novel biomarker NR2 antibody and acute ıschemic stroke prognosis and severity

Öz

Objectives: A blood test supporting the clinical and radiological findings used for the diagnosis of acute ischemic stroke AIS is nee- ded. The aim was to demonstrate the value of serum NR2 antibody levels for the differential diagnosis of AIS. Material and method: Sixtyfour ischemic stroke patients and 68 healthy volunteers who fulfilled the study criteria are included to our study prospectively. Serum NR2 antibody levels calculated by ELISA method at period of the acute ischemic stroke. Severity and prognosis of stroke are determined by on admission NIHSS score, third month MRS and Barthel index scores, infarction volume with AXBXC/2 calculation. Results are compared with NR2 antibody levels by using Kolmogorov Smirnov, Tukey HSD, Wilcoxon and Mann-Whitney U tests. Results: Average serum NR2 antibody levels are 2.64±1.43 and 2.28±1.13 in ischemic stroke and control groups respectively. The dif- ference between two groups is found statistically insignificant. It is understood that S100B levels are not affected by age, gender, coro- nary artery diseases, diabetes mellitus, hyperlipidemia, hypertension, peripheral artery disease or smoking. Conclusion: These results suggest that serum NR2 antibody levels in the patients with acute ischemic stroke do not show a statistically significant difference when compared to healthy controls. We conclude that serum NR2 antibody levels have no important effect on the ischemic stroke

Anahtar Kelimeler

Ischemıc stroke, biomarkers, serum NR2 antibody levels

Kaynakça

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