Arı sokmalarına karşı oluşan reaksiyonlar

Yıl 2012, Cilt: 22 Sayı: 3, 102 - 108, 01.01.2012

Deniz Gezer Engin Şenel İclal Süslü

Öz

Arı venomlarına karşı gelişen reaksiyonlar, ciddi sonuçlarının olabilmesi nedeniyle önemli bir sağlık sorunu oluşturmaktadır. Reaksiyonlar arı sokmasının olduğu bölgede, lokal veya sistemik olarak ortaya çıkabilir. Reaksiyonlar IgE bağımlı veya IgE bağımsız mekanizmalara bağlı olabilir. Bu derlemede, arı sokmalarında oluşan lezyonların ve reaksiyonların sınıflandırılması, tanı ve tedavi yöntemleri sunulmaktadır

Anahtar Kelimeler

Arı venomu, venom aşırı duyarlılığı, venom hipersensitivitesi, alerjik reaksiyonlar

Reactions caused by bee stings

Öz

Reactions to hymenoptera venoms are major health problems because of their serious consequences. Reactions to hymenoptera venoms can develop locally or systemically and may be mediated by IgE-dependent or non-IgE- dependent mechanisms. In this review we aimed to discuss the classification, diagnosis and the management of the lesions and reactions caused by hymenoptera venomhypersensitivity

Anahtar Kelimeler

hymenoptera venom, venom hypersensitivity, allergic reactions

Kaynakça

• Schwartz MW, Pool WR, Bieber AL. Mojave rattlesnake (Crotalus scutulatus scutulatus) venom: enzyme activities and purification 1984;22:327-38. ester hydrolases. Toxicon
• Navarro LA, Pelaez A, de la Torre F, Tenias Burillo JM, Megias J, Martinez I. Epidemiological factors on hymenoptera venom allergy in a Spanish adult population. J Investig Allergol Clin Immunol 2004;14:134-41.
• Fernandez J, Blanca M, Soriano V, Sanchez J, Juarez C. Epidemiological study of the prevalence of allergic reactions to Hymenoptera in a rural population in the Mediterranean area. Clin Exp Allergy 1999;29:1069-74.
• Golden DB. Insect sting allergy and venom immunotherapy: A model and a mystery. J Allergy Clin Immunol 2005;115:439-47.
• Golden DB, Marsh DG, Kagey-Sobotka A, et al. Epidemiology of insect venom sensitivity. JAMA 1989;262: 240-4. Arı sokmalarındaki reaksiyonlar, Gezer ve ark.
• Ebo DG, Hagendorens MM, Stevens WJ. Hymenoptera venom allergy. Expert Rev Clin Immunol 2005;1:169-75.
• . Johansson S G, Hourihane J O, Bousquet J, et al. A revised nomenclature for allergy. An EAACI position statement fromthe EAACI nomenclature task force. Allergy 2001;56: 813-24.
• . Incorvaia C, Mauro M, Pastorello E A. Hymenoptera stings in conscripts. Allergy 1997;52:680-1.
• Barnard JH. Studies of 400 Hymenoptera sting deaths in the United States. J Allergy Clin Immunol 1973;52:259-64.
• . Sin B. Allerjik Hastalıklar ve Bronşial Astma. İstanbul: Özlem Grafik: 1998.
• . Aytekin AM. Arılar ve yaban arıları. Astım Allerji İmmünol 2006;4:5-9.
• Kalyoncu AF. Honey allergy and rhinitis in Ankara, Turkey. Allergy 1997;52:876-7.
• . Severino M, Bonadonna P, Passalacqua G. Large local reactions from stinging insects: from epidemiology to management. Curr Opin Allergy Clin Immunol 2009;9:334-7.
• . Bilo BM, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink J N. Diagnosis of Hymenoptera venom allergy. Allergy 2005;60:1339-49.
• . Antonicelli L, Bilo MB, Bonifazi F. Epidemiology of Hymenoptera allergy. Curr Opin Allergy Clin Immunol 2002;2:341-6.
• . Golden DB, Kagey-Sobotka A, Norman PS, Hamilton RG, Lichtenstein LM. Insect sting allergy with negative venom skin test responses. J Allergy Clin Immunol 2001;107:897- 901.
• . Golden DB. Insect sting anaphylaxis. Immunol Allergy Clin North Am 2007;27:261-72.
• . Hogan AD, Schwartz LB. Markers of mast cell degranulation. Methods 1997;13:43-52.
• . Reisman RE. Insect stings. N Engl J Med 1994;331:523-7.
• . Muller U. Insect sting allergy-clinical aspects, diagnosis and therapy. Wien Med Wochenschr 1989;139:150-6.
• . Sasvary T, Muller U. Fatalities from insect stings in Switzerland 1978 to 1987. Schweiz Med Wochenschr
• . Kettner A, Hughes G J, Frutiger S, et al. Api m 6: a new bee venom allergen. J Allergy Clin Immunol 2001;107:914-20.
• . Zhang R, Meleg-Smith S, Batuman V. Acute tubulointerstitial nephritis after wasp stings. Am J Kidney Dis 2001;38:33.
• . Pucci S, Antonicelli L, Bilo MB, Garritani MS, Bonifazi F. Shortness of interval between two stings as risk factor for developing Hymenoptera venom allergy. Allergy 1994;49: 894-6.
• . Valentine M D, Schuberth K C, Kagey-Sobotka A, et al. The value of immunotherapy with venom in children with allergy to insect stings. N Engl J Med 1990;323:1601-3.
• . Engel T, Heinig J H, Weeke E R. Prognosis of patients reacting with urticaria to insect sting. Results of an in-hospital sting challenge. Allergy 1988: 43: 289-293.
• Annila IT, Annila PA, Morsky P. Risk assessment in determining systemic reactivity to honeybee stings in beekeepers. Ann Allergy Asthma Immunol 1997;78:473-7.
• . Lockey RF, Turkeltaub PC, Baird-Warren IA. The Hymenoptera venom study I, 1979-1982: Demographics and history-sting data. J Allergy Clin Immunol 1988;82:370-81.
• . Lantner R, Reisman RE. Clinical and immunologic features and subsequent course of patients with severe insect-sting anaphylaxis. J Allergy Clin Immunol 1989;84:900-6.
• . Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio FJ, Lichtenstein LM. A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med 1978;299:157-61.
• . Ludolph-Hauser D, Rueff F, Fries C, Schopf P, Przybilla B. Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 2001;357:361-2.
• . Muller UR. Hymenoptera venom hypersensitivity: An update. Clin Exp Allergy 1998;28:4-6.
• Muller U, Helbling A, Berchtold E. Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety. J Allergy Clin Immunol 1992;89:529-35.
• . Chiang BL. Molecular mechanisms of allergen-specific immunotherapy for atopic diseases. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1998;39:293-6.
• Kowalski ML, Jutel M. Mechanisms of specific immunotherapy of allergic diseases. Allergy 1998;53:485-92.
• Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J, Saloga J. Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997;27:1131-9.
• Akdis CA, Blesken T, Akdis M, Wuthrich B, Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998;102:98-106.
• Yang X. Does allergen immunotherapy alter the natural course of allergic disorders? Drugs 2001;61:365-74.
• Jutel M, Akdis M, Budak F, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003:33:1205-14.
• King TP, Spangfort MD. Structure and biology of stinging insect venom allergens. Int Arch Allergy Immunol 2000;123:99-106.
• Muller UR. Epidemiology of insect sting allergy. Monogr Allergy 1993;31:131-46.
• Moffitt JE, Golden D B, Reisman R E, et al. Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol 2004;114:869-86.