The Efficacy Of Preemptive Pregabalİn Administration on Pre-and Postoperative Anxiety and Postoperative Analgesia in Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study

Yıl 2022, Cilt: 32 Sayı: 1, 12 - 18, 28.02.2022

Faruk Çiçekci , Mehmet Sargın , Ahmet Yıldırım , Muslu Kazım Körez , Göksun Günaydın İnci Kara

https://doi.org/10.54005/geneltip.999386

Cited By: 1

Öz

Aim: Few studies have investigated pregabalin use as preemptive analgesia in the management of acute pain and anxiety following arthroscopic shoulder surgery. We hypothesized that the preemptive use of oral pregabalin might decrease pain and postoperative anxiety on arthroscopic shoulder surgery pain during the initial 48 hours.
Patients and methods: In this prospective, randomized, double-blind, placebo-controlled study, 65 eligible patients were randomly divided into two groups, the preemptive pregabalin 150 mg (group P) and the control group (group C). The primary outcomes were pain levels measured both rest and during active motion based on a visual analog scale (VAS). Secondary outcomes were the level of anxiety (STAI-S and STAI-T), patient satisfaction, and complications.
Results: Group P showed lower pain (p < 0.001), better opioid consumption (p < 0.001), longer time to first requirement of analgesia (p < 0.001), and lower rescue analgesic dose (p < 0.001) than the control group at postoperative 48 h follow-up. Also, group P showed less preoperative and postoperative anxiety (p < 0.001) and greater patient satisfaction (p < 0.001) than group C. The rate of postoperative adverse effects was similar between the groups (p > 0.05).
Conclusion: The preemptive use of oral pregabalin received 150 mg daily for 2 days before surgery provided postoperative analgesia in both rest and active motion, and improved preoperative and postoperative anxiety levels and greater patient satisfaction in patients undergoing arthroscopic surgery.

Anahtar Kelimeler

Analgesia, anxiety, preemptive, pregabalin, orthopedic surgery

ARTROSKOPİK OMUZ CERRAHİSİNDE PREEMPTİF PREGABALİN YÖNETİMİNİN POSTOPERATİF VE POSTOPERATİF ANKSİYETE VE POSTOPERATİF ANALJEZİ ÜZERİNE ETKİNLİĞİ: PROSPEKTİF, RANDOMİZE, ÇİFT KÖR, PLASEBO KONTROLLÜ BİR KLİNİK ÇALIŞMA

Öz

Amaç: Artroskopik omuz cerrahisini takiben akut ağrı ve anksiyete tedavisinde pregabalinin preemptif analjezi olarak kullanımını araştıran az sayıda çalışma bulunmaktadır. Oral pregabalinin preemptif kullanımının, ilk 48 saat boyunca artroskopik omuz cerrahisi ağrısına bağlı ağrıyı ve postoperatif anksiyeteyi azaltabileceğini varsaydık.
Hastalar ve yöntemler: Bu prospektif, randomize, çift kör, plasebo kontrollü çalışmada, 65 uygun hasta rastgele iki gruba, preemptif pregabalin 150 mg (grup P) ve kontrol grubu (grup C) olarak ayrıldı. Birincil sonuçlar, görsel analog skalaya (VAS) dayalı olarak hem dinlenme hem de aktif hareket sırasında ölçülen ağrı seviyeleriydi. İkincil sonuçlar kaygı düzeyi (STAI-S ve STAI-T), hasta memnuniyeti ve komplikasyonlardı.
Bulgular: Grup P, kontrol grubuna göre daha düşük ağrı (p < 0.001), daha az opioid tüketimi (p < 0.001), ilk analjezi ihtiyacına kadar daha uzun süre (p < 0.001) ve daha düşük kurtarma analjezik dozu (p < 0.001) gösterdi. postoperatif 48 saat takip. Ayrıca grup P, grup C'ye göre daha az preoperatif ve postoperatif anksiyete (p < 0.001) ve daha fazla hasta memnuniyeti (p < 0.001) gösterdi. Postoperatif yan etkilerin oranı gruplar arasında benzerdi (p > 0.05).
Sonuç: Ameliyattan 2 gün önce günde 150 mg oral pregabalinin preemptif kullanımı, artroskopik cerrahi geçiren hastalarda hem istirahat hem de aktif harekette postoperatif analjezi sağladı ve preoperatif ve postoperatif anksiyete düzeylerini iyileştirdi ve hasta memnuniyetini artırdı.

Anahtar Kelimeler

Analjezi, anksiyete, preemptif, pregabalin, ortopedik cerrahi

Kaynakça

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