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Multiple Sklerozda Sakkadik Göz Hareketleri ile elde edilen Devinime İlişkin Kortikal Potansiyeller

Yıl 2022, Cilt: 32 Sayı: 3, 238 - 244, 01.08.2022
https://doi.org/10.54005/geneltip.1032373

Öz

Amaç: Devinime İlişkin Kortikal Potansiyellerin (DİP) sakkadik göz hareketleriyle Multipl Skleroz’(MS) lu hasta grubunda elde edilmesi amaçlandı.
Gereç ve Yöntem: Çalışma Multiple Skleroz polikliniğinde takipli Mc Donalds kriterlerine uygun olarak multipl skleroz tanısı almış,18-55 yaş aralığında, EDSS 0-5 arasında olan çalışmaya uyum sağlayabileceği düşünülen, bilişsel fonksiyonları iyi olan, 25 MS hastası ve benzer yaş aralığında 20 sağlıklı gönüllü ile yapıldı. Horizontal istemli konjuge bakış ile DİP kayıtlaması ve averajı işlemi Micromed, Brainquick, 32 kanallı EEG cihazında yapıldı.
Bulgular: Hasta ve kontrol grubunda yaptığımız kayıtlamalarda DİP’in daha önce bildirilmiş tüm komponentlerinin net ayrımı yapılamadı. Ancak her iki grubun BP (Bereitshaftpotential, hazırlık potansiyelinin başlangıcı) latans değerleri literatürde bildirilen değerlerle uyumlu bulunduğu halde hasta grubunda latansın daha uzun olduğu gözlendi. NS (Negative slope) ve MP’(Motor potansiyel) in bileşeni olarak kabul edilebilecek olan TÇ’ (tepe-çukur) nin amplitüdü ise hasta grubunda daha yüksek bulundu ve hasta grubunda hedefin daha zor bulunduğuna işaret edebileceği düşünüldü.
Sonuç: Multipl sklerozda kognitif bozulma ile ilgili çalışmalar genel olarak nöropsikolojik testler üzerinden yürütülmüştür. Bizim çalışmamız MS tanısı ile takip edilen hastalarda kognitif bozulmayı nörofizyolojik testlerle objektif olarak ortaya koyması bakımından değerlidir ancak daha anlamlı sonuçlar elde edebilmek için yüksek sayıda hasta ve kontrol grubunda, EDSS ile kolerasyonun değerlendirildiği , farklı hareket paternlerine dayanan devinme ilişkin kortikal potansiyel çalışmalarının geliştirilmesi planlanmalıdır.

Kaynakça

  • References 1. Barrett G, Shibasaki H, Neshige R. Cortical potential shifts preceding voluntary movement are normal in parkinsonism. Electroencephalogr Clin Neurophysiol. 1986;63(4):340-8. PMID: 2419091.
  • 2. Mutluer M, Güney F, Ilhan S. Devinime İlişkin Kortikal Potansiyellerin Hafif Bilişsel Bozukluk ve Orta Evre Alzheimer Hastalığı’nı Değerlendirmede Nöropsikolojik Testler ile Korelasyonu [Correlation with neuropsychological tests and movement related cortical potentials in assesing mild cognitive impairment and middle stage Alzheimer's disease]. Noro Psikiyatr Ars. 2013;50:9-14. doi: 10.4274/npa.y6036.
  • 3. Brunia CH, Voorn FJ, Berger MP. Movement related slow potentials. A contrast between finger and foot movements in left handed subjects. Electroencephalogr Clin Neurophysiol. 1985;60(2):135-45. PMID: 2578365. 4. Altıntas A. Immunopathogenesis and Pathology of Multiple Sclerosis. Turkiye Klinikleri J Neurol-Special Topics 2009;2(2):1-8 http://www.turkiyeklinikleri.com/journal/noroloji-ozel-konular/1308-1039/issue/2009/2/2-0/multipl-skleroz-ozel-sayisi/tr-index.html
  • 5. Miller AE, Lublin FD. Multipl skleroz ve santral sinir sisteminin diğer demiyelinizan hastalıkları: Bradly WG, Daroff RB, Fenichel GM, Jankovic J, editors. Neurology in Clinical Practice. 5th ed. Philadelphia: Butterworth-Heinemann; 2008. p. 1583-613.
  • 6. Saud A. Sadiq. Multipl skleroz. In: Rowland LP (ed) Merrit’s Neurology. 11th ed. Istanbul: Gunes Tıp Kitapevleri; 2008. p. 939-62.
  • 7. Eraksoy M, Akman-Demir G. Merkezi sinir sisteminin miyelin hastalıkları: Öge AE, Baykan B, editors. Nöroloji. İstanbul: Nobel Tıp Kitapevleri; 2011. p. 603-29.
  • 8. Boz C. Clinical Findings and Symptoms of Multiple Sclerosis. Turkiye Klinikleri J Neurol-Special Topics 2009;2(2):9-14 http://www.turkiyeklinikleri.com/journal/noroloji-ozel-konular/1308-1039/issue/2009/2/2-0/multipl-skleroz-ozel-sayisi/tr-index.html
  • 9. Calabrese P. Neuropsychology of multiple sclerosis—an overview. J Neurol. 2006;253 Suppl 1:I10-5. PMID: 16477479; doi: 10.1007/s00415-006-1103-1.
  • 10. Akpınar Z, Gunduz ZB. Multipl skleroz ve kognitif bozulma [Multiple Sclerosis and Cognitive Impairment]. Selçuk Tıp Derg 2012;28(1):75-9
  • 11. Karaman T. Şizofrenide klinik nörofizyoloji. Şizofreni dizisi. 1999;3:102-7.
  • 12. Shibasaki H, Hallett M. What is the Bereitschaftpotential? Clin Neurophysiol. 2006;117(11): 2341-56. PMID: 16876476; doi: 10.1016/j.clinph.2006.04.025.
  • 13. Lang W, Beisteiner R, Lindinger G, Deecke L. Changes of cortical activity when executing learned motor sequences. Exp Brain Res. 1992;89(2):435–40. PMID: 1623985.
  • 14. Tarkka IM, Hallett M. Cortical topography of premotor and motor potentials preceding self-paced, voluntary movement of dominant and non-dominant hands. Electroencephalogr Clin Neurophysiol. 1990;75(2):36–43. PMID: 1688771.
  • 15. Deecke L, Grözinger B, Kornhuber HH. Voluntary finger movement in man: Cerebral potentials and theory. Biol Cybern. 1976;23(2):99-119. PMID: 949512.
  • 16. Satow T, Ikeda A, Yamamoto J, et al. Role of primary sensorimotor cortex and supplamantary motor area in volitional swallowing: A movement related cortical potential study. Am J Physiol Gastrointest Liver Physiol. 2004;287(2):G459-70. PMID: 14701719; doi: 10.1152/ajpgi.00323.2003.
  • 17. Fave AP, Bathien N, Rondot P. Movement-related cortical potentials in aged subjects. Neurophysiol Clin. 1991;21(4):281-91. PMID: 1795694.
  • 18. Wright DJ, Holmes PS, Smith D. Using the movement-related cortical potential to study motor skill learning. J Mot Behav. 2011;43(3):193-201. PMID: 21462065; doi: 10.1080/00222895.2011.557751.
  • 19. Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010;109:923-33. PMID: 20306270; doi: 10.1007/s00421-010-1432-8.
  • 20. Deecke L, Englitz HG, Kornhuber HH, Scmidt G. Cerebral potantials preceding voluntary movement in patients with bilateral or unilateral parkinsonian akinesia. In: Desmedt JE, editors Progress in Clinical Neurophysiology. Basel: Karger; 1977.p. 151-3.
  • 21. Jahanshahi M, Dirnberger G, Liasis A, Towell A, Boyd S. Does the pre-frontal cortex contribute to movement related potentialis? Recordings from subdural electrodes. Neurocase. 2001;7(6):495-501 PMID: 11788741; doi: 10.1093/neucas/7.6.495.
  • 22. Rektor I, Bares M, Brázdil M, et al. Cognitive- and movement-related potentials recorded in the human basal ganglia. Mov Disord. 2005;20(5):562-8. PMID: 15666424; doi: 10.1002/mds.20368.
  • 23. Yamamoto J, Ikeda A, Satow T, et al. Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials. Brain. 2004;127(Pt 4):873-87. PMID: 14960503; doi: 10.1093/brain/awh110.

Movement Releated Cortical Potentials Obtained by Saccadic Eye Movements In Multiple Sclerosis

Yıl 2022, Cilt: 32 Sayı: 3, 238 - 244, 01.08.2022
https://doi.org/10.54005/geneltip.1032373

Öz

Background
Movement-related cortical potentials (MRCPs) are electrophysiological activities that reflect neurological mechanisms that occur in the cortex during the planning of and preparation for movement. We aimed to evaluate the MRCPs that occur due to saccadic eye movement in multiple sclerosis (MS).
Methods
Twenty-five patients aged 18–55 years with good cognitive functions who were diagnosed with MS according to the McDonald criteria and scored 0–5 on the Expanded Disability Status Scale (EDSS) were included. Twenty healthy volunteers in a similar age range also participated. Voluntary horizontal conjugate gaze and MRCPs were recorded and averaged.
Results
It was observed that the latency of the Bereitshaftpotential (BP; preparation potential) was longer in the patient group, and the latency values were consistent with the values reported in the literature. The peak-pit (PP) amplitude, which can be regarded as a component of the negative slope (NS) and motor potential (MP), was higher in the patient group and may indicate that the target movement was more difficult for the patient group.
Conclusion
Studies on cognitive impairment in MS have generally been conducted using neuropsychological tests. Although we could not obtain a record that corresponded to the typical MRCP pattern reported in the literature, our findings make a contribution to the field of MCRP-based studies by raising new questions about the measurement and use of MRCP values.

Kaynakça

  • References 1. Barrett G, Shibasaki H, Neshige R. Cortical potential shifts preceding voluntary movement are normal in parkinsonism. Electroencephalogr Clin Neurophysiol. 1986;63(4):340-8. PMID: 2419091.
  • 2. Mutluer M, Güney F, Ilhan S. Devinime İlişkin Kortikal Potansiyellerin Hafif Bilişsel Bozukluk ve Orta Evre Alzheimer Hastalığı’nı Değerlendirmede Nöropsikolojik Testler ile Korelasyonu [Correlation with neuropsychological tests and movement related cortical potentials in assesing mild cognitive impairment and middle stage Alzheimer's disease]. Noro Psikiyatr Ars. 2013;50:9-14. doi: 10.4274/npa.y6036.
  • 3. Brunia CH, Voorn FJ, Berger MP. Movement related slow potentials. A contrast between finger and foot movements in left handed subjects. Electroencephalogr Clin Neurophysiol. 1985;60(2):135-45. PMID: 2578365. 4. Altıntas A. Immunopathogenesis and Pathology of Multiple Sclerosis. Turkiye Klinikleri J Neurol-Special Topics 2009;2(2):1-8 http://www.turkiyeklinikleri.com/journal/noroloji-ozel-konular/1308-1039/issue/2009/2/2-0/multipl-skleroz-ozel-sayisi/tr-index.html
  • 5. Miller AE, Lublin FD. Multipl skleroz ve santral sinir sisteminin diğer demiyelinizan hastalıkları: Bradly WG, Daroff RB, Fenichel GM, Jankovic J, editors. Neurology in Clinical Practice. 5th ed. Philadelphia: Butterworth-Heinemann; 2008. p. 1583-613.
  • 6. Saud A. Sadiq. Multipl skleroz. In: Rowland LP (ed) Merrit’s Neurology. 11th ed. Istanbul: Gunes Tıp Kitapevleri; 2008. p. 939-62.
  • 7. Eraksoy M, Akman-Demir G. Merkezi sinir sisteminin miyelin hastalıkları: Öge AE, Baykan B, editors. Nöroloji. İstanbul: Nobel Tıp Kitapevleri; 2011. p. 603-29.
  • 8. Boz C. Clinical Findings and Symptoms of Multiple Sclerosis. Turkiye Klinikleri J Neurol-Special Topics 2009;2(2):9-14 http://www.turkiyeklinikleri.com/journal/noroloji-ozel-konular/1308-1039/issue/2009/2/2-0/multipl-skleroz-ozel-sayisi/tr-index.html
  • 9. Calabrese P. Neuropsychology of multiple sclerosis—an overview. J Neurol. 2006;253 Suppl 1:I10-5. PMID: 16477479; doi: 10.1007/s00415-006-1103-1.
  • 10. Akpınar Z, Gunduz ZB. Multipl skleroz ve kognitif bozulma [Multiple Sclerosis and Cognitive Impairment]. Selçuk Tıp Derg 2012;28(1):75-9
  • 11. Karaman T. Şizofrenide klinik nörofizyoloji. Şizofreni dizisi. 1999;3:102-7.
  • 12. Shibasaki H, Hallett M. What is the Bereitschaftpotential? Clin Neurophysiol. 2006;117(11): 2341-56. PMID: 16876476; doi: 10.1016/j.clinph.2006.04.025.
  • 13. Lang W, Beisteiner R, Lindinger G, Deecke L. Changes of cortical activity when executing learned motor sequences. Exp Brain Res. 1992;89(2):435–40. PMID: 1623985.
  • 14. Tarkka IM, Hallett M. Cortical topography of premotor and motor potentials preceding self-paced, voluntary movement of dominant and non-dominant hands. Electroencephalogr Clin Neurophysiol. 1990;75(2):36–43. PMID: 1688771.
  • 15. Deecke L, Grözinger B, Kornhuber HH. Voluntary finger movement in man: Cerebral potentials and theory. Biol Cybern. 1976;23(2):99-119. PMID: 949512.
  • 16. Satow T, Ikeda A, Yamamoto J, et al. Role of primary sensorimotor cortex and supplamantary motor area in volitional swallowing: A movement related cortical potential study. Am J Physiol Gastrointest Liver Physiol. 2004;287(2):G459-70. PMID: 14701719; doi: 10.1152/ajpgi.00323.2003.
  • 17. Fave AP, Bathien N, Rondot P. Movement-related cortical potentials in aged subjects. Neurophysiol Clin. 1991;21(4):281-91. PMID: 1795694.
  • 18. Wright DJ, Holmes PS, Smith D. Using the movement-related cortical potential to study motor skill learning. J Mot Behav. 2011;43(3):193-201. PMID: 21462065; doi: 10.1080/00222895.2011.557751.
  • 19. Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010;109:923-33. PMID: 20306270; doi: 10.1007/s00421-010-1432-8.
  • 20. Deecke L, Englitz HG, Kornhuber HH, Scmidt G. Cerebral potantials preceding voluntary movement in patients with bilateral or unilateral parkinsonian akinesia. In: Desmedt JE, editors Progress in Clinical Neurophysiology. Basel: Karger; 1977.p. 151-3.
  • 21. Jahanshahi M, Dirnberger G, Liasis A, Towell A, Boyd S. Does the pre-frontal cortex contribute to movement related potentialis? Recordings from subdural electrodes. Neurocase. 2001;7(6):495-501 PMID: 11788741; doi: 10.1093/neucas/7.6.495.
  • 22. Rektor I, Bares M, Brázdil M, et al. Cognitive- and movement-related potentials recorded in the human basal ganglia. Mov Disord. 2005;20(5):562-8. PMID: 15666424; doi: 10.1002/mds.20368.
  • 23. Yamamoto J, Ikeda A, Satow T, et al. Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials. Brain. 2004;127(Pt 4):873-87. PMID: 14960503; doi: 10.1093/brain/awh110.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Article
Yazarlar

Zahide Betül Gündüz 0000-0002-6421-1857

Tomris Ugur Egercioglu Bu kişi benim 0000-0002-8189-1612

Osman Serhat Tokgöz Bu kişi benim 0000-0002-4919-0285

Zehra Akpınar Bu kişi benim 0000-0003-1106-2867

Yayımlanma Tarihi 1 Ağustos 2022
Gönderilme Tarihi 13 Aralık 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 32 Sayı: 3

Kaynak Göster

Vancouver Gündüz ZB, Egercioglu TU, Tokgöz OS, Akpınar Z. Movement Releated Cortical Potentials Obtained by Saccadic Eye Movements In Multiple Sclerosis. Genel Tıp Derg. 2022;32(3):238-44.