BibTex RIS Kaynak Göster

Effects of four week coenzyme Q10 supplementation on exercise-induced muscle damage in sedentary young men

Yıl 2012, Cilt: 22 Sayı: 1, 11 - 15, 01.01.2012

Öz

Objective: The purpose of this study was to investigate the effects of coenzyme Q10 CoQ10 supplementation on eccentric exercise-induced muscle damage in sedentary young males. Methods: Twenty-one sedentary and healthy young male participated to the study. The height, body weight and body fat percentages of the participants were measured and their blood samples were taken at rest. Eleven participants were given 200 mg CoQ10 and ten participants were given placebo orally as a single dosage for four weeks then measurements and blood sampling were repeated. After that eccentric exercise protocol were applied in all participants in isokinetic exercise dynamometry, then their blood samples were taken at 24th and 48th hours after exercise. Plasma coenzyme Q10 levels, serum creatine kinase activities and myoglobin levels were measured in blood samples. Results: Plasma CoQ10 levels were higher in CoQ10 supplemented group compared to placebo group. Creatine kinase activities and miyoglobin levels increased in both groups after exercise but there was no significant difference between the groups. Conclusion: While four weeks of coenzyme Q10 supplementation increase plasma coenzyme Q10 levels, it does not affect creatine kinase activities and myoglobin levels in exerciseinduced muscle damage

Kaynakça

  • Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, et al. Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res 2006;171:9-16.
  • Greenberg S, Frishman WH. Co-enzymeQ10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
  • Linnane AW, Kopsidas G, Zhang C, Yarovaya N, Kovalenko S, Papakostopoulos P, et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic Res 2002;36:445-53.
  • Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician 2005;72:1065-70.
  • Brown S, Day S, Doneelly A. Indirect evidence of human skeletal muscle damage and collegen breakdown eccentric muscle action. J Sport Sci 1999;17:397-402.
  • Urso ML, Clarkson PM. Oxidative stress, exercise and antioxidant supplementation. Toxicology. 2003;189:41-54.
  • Villa-Caballero L, Nava-Ocampo AA, Frati-Munari AC, Rodríguez de León SM, Becerra-Pérez AR, Ceja RM, et al. Hemodynamic and oxidative stress profile after exercise in type 2 diabetes. Diabetes Res Clin Pract 2007;75:285-91.
  • Zhou S, Zhang Y, Davie A, Marshall GS, Hu H, Wang J, et al. Muscle and plasma coenzyme Q10 concentration aerobic power and exercise economy of healthy men in response to four weeks of supplemantation. J Sports Med Phys Fitness 2005;45:337-46.
  • Gökbel H, Gül I, Belviranli M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 2010;24:97-102.
  • Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr 2008;100:903-9.
  • Byrne C, Eston R. The effect of exercise induced muscle damage on isometric and dynamic knee extensor strenght and vertical jump performance. J Sports Sci 2002;20:417-25.
  • Gojanovic B, Feihl F, Liaudet L, Gremion G, Waeber B. Whole body vibration training elevates cratine kinase levels in sedentary subjects. Swiss Med Wkly 2011;141:13222.
  • Chapman D, Newton M, Sacco P, Nosaka K. Greater muscle damage induced by fastversus slow velocity eccentric exercise. Int J Sport Med 2006;27:591-8.
  • Croiser JL, Camus G, Venneman I, Deby-Dupont G, Juchmes A, Lamy M, et al. Effects of training on exercise induced muscle damage and interleukin-6 production. Muscle Nerve 1999;22:208-12.
  • Paschalis V, Giakas G, Baltzopoulos V, Jamurtas AZ, Theoharis V, Kotzamanidis C, et al. The effects of muscle damage following eccentric exercise on gait biomechanics. Gait Posture 2007; 25: 236-42.
  • Knechtle B, Knechtle P, Mrazek C, Senn O, Roseman T, Imoberdorf R, et al. No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra runners a randomized controlled trial. J Int Soc Sports Nutr 2011;8:6.
  • Michihiro K, Fimunori K, Takayuki A, Kai T, Yosuke M, Sachiko I, et al. Effect of CoQ10 supplemention on exercise- induced muscular injury of rats. Exerc Immunol Rev 2007;13:76-88.
  • Kaikkonen J, Nyyssonen K, Porkkala –Sarataho E, Poulsen HE, Metsa-Ketala T, Hayn M, et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 2002;22:1195-202.

DÖRT HAFTALIK KOENZİM Q10 DESTEĞİNİN SEDANTER GENÇ ERKEKLERDE EGZERSİZLE OLUŞAN KAS HASARI ÜZERİNE ETKİLERİ

Yıl 2012, Cilt: 22 Sayı: 1, 11 - 15, 01.01.2012

Öz

Amaç: Bu çalışmanın amacı, sedanter genç erkeklerde ekzantrik egzersizin neden olduğu kas hasarında koenzim Q10 CoQ10 takviyesinin etkilerini incelemekti. Yöntem: Çalışmaya 21 sağlıklı sedanter genç erkek katıldı. Tüm katılımcıların boyları, vücut ağırlıkları ve vücut yağ yüzdeleri ölçüldü ve istirahat kanları alındı. Dört hafta süreyle 11 katılımcıya oral yolla günde tek doz 200 mg CoQ10, 10 katılımcıya plasebo verildikten sonra ölçümler ve kan alımı tekrarlandı. Daha sonra bütün katılımcılara izokinetik egzersiz dinamometresinde ekzantrik egzersiz protokolü uygulandı ve egzersiz sonrası 24. ve 48. saatte kan örnekleri alındı. Alınan kan örneklerinde plazma koenzim Q10 seviyesi, serum kreatin kinaz aktivitesi ve serum miyoglobin seviyesi tayin edildi. Bulgular: Plazma CoQ10 seviyesi CoQ10 takviyesi yapılan grupta plasebo grubuna göre daha yüksekti. Kreatin kinaz aktivitesi ve miyoglobin seviyesi egzersiz sonrası 24. ve 48. saatte her iki grupta da arttı, ama her iki grup arasında anlamlı fark yoktu. Sonuç: Dört haftalık koenzim Q10 takviyesi kan koenzim Q10 seviyesini artırırken egzersizle oluşan kas hasarını etkilemez

Kaynakça

  • Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, et al. Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res 2006;171:9-16.
  • Greenberg S, Frishman WH. Co-enzymeQ10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
  • Linnane AW, Kopsidas G, Zhang C, Yarovaya N, Kovalenko S, Papakostopoulos P, et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic Res 2002;36:445-53.
  • Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician 2005;72:1065-70.
  • Brown S, Day S, Doneelly A. Indirect evidence of human skeletal muscle damage and collegen breakdown eccentric muscle action. J Sport Sci 1999;17:397-402.
  • Urso ML, Clarkson PM. Oxidative stress, exercise and antioxidant supplementation. Toxicology. 2003;189:41-54.
  • Villa-Caballero L, Nava-Ocampo AA, Frati-Munari AC, Rodríguez de León SM, Becerra-Pérez AR, Ceja RM, et al. Hemodynamic and oxidative stress profile after exercise in type 2 diabetes. Diabetes Res Clin Pract 2007;75:285-91.
  • Zhou S, Zhang Y, Davie A, Marshall GS, Hu H, Wang J, et al. Muscle and plasma coenzyme Q10 concentration aerobic power and exercise economy of healthy men in response to four weeks of supplemantation. J Sports Med Phys Fitness 2005;45:337-46.
  • Gökbel H, Gül I, Belviranli M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 2010;24:97-102.
  • Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr 2008;100:903-9.
  • Byrne C, Eston R. The effect of exercise induced muscle damage on isometric and dynamic knee extensor strenght and vertical jump performance. J Sports Sci 2002;20:417-25.
  • Gojanovic B, Feihl F, Liaudet L, Gremion G, Waeber B. Whole body vibration training elevates cratine kinase levels in sedentary subjects. Swiss Med Wkly 2011;141:13222.
  • Chapman D, Newton M, Sacco P, Nosaka K. Greater muscle damage induced by fastversus slow velocity eccentric exercise. Int J Sport Med 2006;27:591-8.
  • Croiser JL, Camus G, Venneman I, Deby-Dupont G, Juchmes A, Lamy M, et al. Effects of training on exercise induced muscle damage and interleukin-6 production. Muscle Nerve 1999;22:208-12.
  • Paschalis V, Giakas G, Baltzopoulos V, Jamurtas AZ, Theoharis V, Kotzamanidis C, et al. The effects of muscle damage following eccentric exercise on gait biomechanics. Gait Posture 2007; 25: 236-42.
  • Knechtle B, Knechtle P, Mrazek C, Senn O, Roseman T, Imoberdorf R, et al. No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra runners a randomized controlled trial. J Int Soc Sports Nutr 2011;8:6.
  • Michihiro K, Fimunori K, Takayuki A, Kai T, Yosuke M, Sachiko I, et al. Effect of CoQ10 supplemention on exercise- induced muscular injury of rats. Exerc Immunol Rev 2007;13:76-88.
  • Kaikkonen J, Nyyssonen K, Porkkala –Sarataho E, Poulsen HE, Metsa-Ketala T, Hayn M, et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 2002;22:1195-202.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Original Article
Yazarlar

Savaş Torlak Bu kişi benim

Nilsel Okudan Bu kişi benim

Hakkı Gökbel Bu kişi benim

Muaz Belviranlı Bu kişi benim

Aysel Kıyıcı Bu kişi benim

Yayımlanma Tarihi 1 Ocak 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 22 Sayı: 1

Kaynak Göster

Vancouver Torlak S, Okudan N, Gökbel H, Belviranlı M, Kıyıcı A. DÖRT HAFTALIK KOENZİM Q10 DESTEĞİNİN SEDANTER GENÇ ERKEKLERDE EGZERSİZLE OLUŞAN KAS HASARI ÜZERİNE ETKİLERİ. Genel Tıp Derg. 2012;22(1):11-5.