Association of Impulsivity with Rheumatoid Factor Seropositivity in Rheumatoid Arthritis

Yıl 2024, Cilt: 34 Sayı: 5, 719 - 726, 30.10.2024

Çağrı Öğüt , Alper Yıldırım

Öz

Background: Impulsivity is the propensity to make judgments and take action without sufficient planning or foreseeing consequences. Impulsivity is one of the main symptoms of several mental disorders. Studies supporting the association between inflammation and impulsivity are increasing in number. This study aimed to assess the association between impulsivity and rheumatoid factor (RF) in rheumatoid arthritis.
Methods: Thirty rheumatoid arthritis patients with RF+ and 22 rheumatoid arthritis patients with RF- were enrolled in this study. Impulsivity was measured using the Barratt Impulsivity Scale (BIS). In addition, Beck Depression Inventory, Beck Anxiety Inventory, Morisky Medication Adherence Scale, Intuitive Eating Scale-2, Health Assessment Questionnaire, and Disease Activity Score-28 were used to evaluate the individuals' clinical features.
Results: In this study, patients with RF+ had higher BIS impulsivity scores than those with RF-. In addition, smoking rates, which may be associated with impulsive behavior, were higher in the RF+ group than in the RF group. Regarding the Morisky Medication Adherence Scale, Beck Anxiety Inventory, Beck Depression Inventory, and Intuitive Eating Scale-2, there was no significant difference between the groups. However, higher scores on impulsivity were positively correlated with higher lymphocyte counts.
Conclusions: These results indicate that RF seropositivity in rheumatoid arthritis is associated with impulsivity. The high impulsivity detected in RF+ patients may be the reason why risky behaviors such as smoking are seen more frequently in this group.

Anahtar Kelimeler

rheumatoid arthritis, rheumatoid factor, inflammation, impulsivity

Etik Beyan

Usak University Medical Ethics Committee for Clinical Studies, Uşak, Turkey (82-82-06) approved the study

Destekleyen Kurum

none

Romatoid Artritte Dürtüselliğin Romatoid Faktör Seropozitifliği ile İlişkisi

Öz

Amaç: Dürtüsellik, yeterli planlama yapmadan veya sonuçlarını öngörmeden yargıda bulunma ve harekete geçme eğilimidir. Dürtüsellik, farklı ruhsal bozuklukların temel belirtilerinden biridir. Enflamasyon ve dürtüsellik arasındaki ilişkiyi destekleyen çalışmaların sayısı giderek artmaktadır. Bu çalışmada romatoid artritte dürtüsellik ve romatoid faktör arasındaki ilişkinin değerlendirilmesi amaçlanmıştır.
Materyal-Metot: Bu çalışmaya romatoid faktör + olan 30 romatoid artrit hastası ve romatoid faktör - olan 22 romatoid artrit hastası dahil edilmiştir. Dürtüsellik Barratt Dürtüsellik Ölçeği (BDÖ) kullanılarak ölçülmüştür. Ayrıca, bireylerin klinik özelliklerini değerlendirmek için Beck Depresyon Ölçeği, Beck Anksiyete Ölçeği, Morisky Tedavi Uyum Ölçeği, Sezgisel Yeme Ölçeği-2, Sağlık Değerlendirme Anketi ve Hastalık Aktivite Skoru-28 kullanılmıştır.
Bulgular: Bu çalışmada, romatoid faktör + olan hastaların toplam BDÖ dürtüsellik skorları romatoid faktör - olanlara göre daha yüksek olarak saptandı. Ayrıca, dürtüsel davranışla ilişkili olabilecek sigara içme oranları romatoid faktör + olan grupta daha yüksekti. Morisky İlaç Uyum Ölçeği, Beck Anksiyete Envanteri, Beck Depresyon Envanteri ve Sezgisel Yeme Ölçeği-2 toplam puanları açısından gruplar arasında anlamlı bir fark bulunmadı. Toplam dürtüsellik puanları ile lenfosit sayıları arasında pozitif yönde korelasyon olduğu saptandı.
Sonuç: Bu sonuçlar romatoid artritte romatoid faktör seropozitifliğinin dürtüsellik ile ilişkili olduğunu göstermektedir. Romatoid faktör + hastalarda saptanan yüksek dürtüsellik, sigara kullanımı gibi riskli davranışların bu grupta daha sık görülmesinin sebebi olabilir.

Anahtar Kelimeler

romatoid artrit, romatoid faktör, inflamasyon, dürtüsellik

Kaynakça

• Krijbolder DI, Verstappen M, van Dijk BT, Dakkak YJ, Burgers LE, Boer AC, et al. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet. 2022;400:283-94.
• Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev. 2021;20:102776.
• Trabelsi M, Romand X, Gilson M, Vaillant M, Guerne PA, Hayem G, et al. Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review. J Clin Med. 2020;9.
• Alexander SK, Di Cicco M, Pohl U, Cifelli A. Rheumatoid disease: an unusual cause of relapsing meningoencephalitis. BMJ Case Rep. 2018;2018.
• Inan AS, Masatlioglu S, Ozyurek SC, Engin D, Erdem I. Unusual central nervous system involvement of rheumatoid arthritis: successful treatment with steroid and azathioprine. Rheumatol Int. 2011;31:1383-5.
• Markenson JA, McDougal JS, Tsairis P, Lockshin MD, Christian CL. Rheumatoid meningitis: a localized immune process. Ann Intern Med. 1979;90:786-9.
• Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094-108.
• Tillmann T, Krishnadas R, Cavanagh J, Petrides KV. Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study. Arthritis Res Ther. 2013;15:R45.
• Ho RC, Fu EH, Chua AN, Cheak AA, Mak A. Clinical and psychosocial factors associated with depression and anxiety in Singaporean patients with rheumatoid arthritis. Int J Rheum Dis. 2011;14:37-47.
• Stanciu I, Anderson J, Siebert S, Mackay D, Lyall DM. Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank. Sci Rep. 2022;12:19844.
• Vitturi BK, Nascimento BAC, Alves BR, de Campos FSC, Torigoe DY. Cognitive impairment in patients with rheumatoid arthritis. J Clin Neurosci. 2019;69:81-7.
• Jackson NA, Jabbi MM. Integrating biobehavioral information to predict mood disorder suicide risk. Brain Behav Immun Health. 2022;24:100495.
• Vallee A. Neuroinflammation in Schizophrenia: The Key Role of the WNT/beta-Catenin Pathway. Int J Mol Sci. 2022;23.
• Thomas M, Savitz J, Zhang Y, Burrows K, Smith R, Figueroa-Hall L, et al. Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life (Basel). 2021;12.
• Coccaro EF, Sripada CS, Yanowitch RN, Phan KL. Corticolimbic function in impulsive aggressive behavior. Biol Psychiatry. 2011;69:1153-9.
• Wohleb ES. Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse". Front Immunol. 2016;7:544.
• Mora S, Martin-Gonzalez E, Prados-Pardo A, Moreno J, Lopez MJ, Pilar-Cuellar F, et al. Increased vulnerability to impulsive behavior after streptococcal antigen exposure and antibiotic treatment in rats. Brain Behav Immun. 2020;89:675-88.
• Coryell W, Wilcox H, Evans SJ, Pandey GN, Jones-Brando L, Dickerson F, et al. Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior. J Psychiatr Res. 2018;106:38-42.
• Gassen J, Prokosch ML, Eimerbrink MJ, Proffitt Leyva RP, White JD, Peterman JL, et al. Inflammation Predicts Decision-Making Characterized by Impulsivity, Present Focus, and an Inability to Delay Gratification. Sci Rep. 2019;9:4928.
• Madison AA, Kiecolt-Glaser JK. Are sick people really more impulsive?: Investigating inflammation-driven impulsivity. Psychoneuroendocrinology. 2022;141:105763.
• Dalley JW, Everitt BJ, Robbins TW. Impulsivity, compulsivity, and top-down cognitive control. Neuron. 2011;69:680-94.
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition ed. Washington: American Psychiatric Association,; 2013.
• Benard M, Bellisle F, Kesse-Guyot E, Julia C, Andreeva VA, Etile F, et al. Impulsivity is associated with food intake, snacking, and eating disorders in a general population. Am J Clin Nutr. 2019;109:117-26.
• Belzeaux R, Boyer L, Mazzola-Pomietto P, Michel P, Correard N, Aubin V, et al. Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients. J Affect Disord. 2015;184:60-6.
• Kim YS, Cha B, Lee D, Kim SM, Moon E, Park CS, et al. The Relationship between Impulsivity and Quality of Life in Euthymic Patients with Bipolar Disorder. Psychiatry Investig. 2013;10:246-52.
• Cormier BM, Wittkower ED. Psychological aspects of rheumatoid arthritis. Can Med Assoc J. 1957;77:533-41.
• Kowalec K, Carney H, Patel M, Hitchon C, Bolton JM, Patten SB, et al. Prevalence and Risk Factors of Substance Use Disorder in Rheumatoid Arthritis. ACR Open Rheumatol. 2021;3:889-96.
• Tektonidou MG, Dasgupta A, Ward MM. Suicidal ideation among adults with arthritis: prevalence and subgroups at highest risk. Data from the 2007-2008 National Health and Nutrition Examination Survey. Arthritis Care Res (Hoboken). 2011;63:1322-33.
• Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford). 2012;51 Suppl 6:vi5-9.
• van Riel PL. The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28). Clin Exp Rheumatol. 2014;32:S-65-74.
• Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51:768-74.
• Güleç H, Tamam L, Yazıcı Güleç M, Tuhan M, Karakuş G, Zengin M, et al. Psychometric Properties of the Turkish Version of the Barratt Impulsiveness Scale-11. Klinik Psikofarmakoloji Bülteni 2008;18:251-8.
• Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56:893-7.
• Ulusoy M, Sahin N, Erkmen H. Turkish Version of the Beck Anxiety Inventory. Journal of Cognitive Psychotherapy 1998;12:163-72.
• Beck AT, Ward CH, Mendelson M, Mock J, J. E. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-71.
• Hisli N. Beck depresyon envanterinin üniversite öğrencileri için geçerliği, güvenirliği. Psikoloji Dergisi. 1988;6:3-13.
• Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10:348-54.
• Hacihasanoglu Asilar R, Gozum S, Capik C, Morisky DE. Reliability and validity of the Turkish form of the eight-item Morisky medication adherence scale in hypertensive patients. Anadolu Kardiyol Derg. 2014;14:692-700.
• Tylka TL, Kroon Van Diest AM. The Intuitive Eating Scale-2: item refinement and psychometric evaluation with college women and men. J Couns Psychol. 2013;60:137-53.
• Ramalho SM, Saint-Maurice PF, Felix S, Conceicao E. Intuitive eating Scale-2: Factor structure and associations with disordered eating, impulsivity and quality of life in adolescents with overweight/obesity. Eat Behav. 2022;44:101593.
• Bas M, Karaca KE, Saglam D, Aritici G, Cengiz E, Koksal S, et al. Turkish version of the Intuitive Eating Scale-2: Validity and reliability among university students. Appetite. 2017;114:391-7.
• Fries JF, Spitz P, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis Rheum. 1980;23:137-45.
• Kucukdeveci AA, Sahin H, Ataman S, Griffiths B, Tennant A. Issues in cross-cultural validity: example from the adaptation, reliability, and validity testing of a Turkish version of the Stanford Health Assessment Questionnaire. Arthritis Rheum. 2004;51:14-9.
• Wu CY, Yang HY, Luo SF, Lai JH. From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis. Int J Mol Sci. 2021;22.
• Sopori ML, Kozak W. Immunomodulatory effects of cigarette smoke. J Neuroimmunol. 1998;83:148-56.
• Balevich EC, Wein ND, Flory JD. Cigarette smoking and measures of impulsivity in a college sample. Subst Abus. 2013;34:256-62.
• Flory JD, Manuck SB. Impulsiveness and cigarette smoking. Psychosom Med. 2009;71:431-7.
• Kale D, Stautz K, Cooper A. Impulsivity related personality traits and cigarette smoking in adults: A meta-analysis using the UPPS-P model of impulsivity and reward sensitivity. Drug Alcohol Depend. 2018;185:149-67.
• Lwin MN, Serhal L, Holroyd C, Edwards CJ. Rheumatoid Arthritis: The Impact of Mental Health on Disease: A Narrative Review. Rheumatol Ther. 2020;7:457-71.
• Margaretten M, Julian L, Katz P, Yelin E. Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheumtol. 2011;6:617-23.
• Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, et al. Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry. 2021;26:7393-402.
• Moustafa AA, Tindle R, Frydecka D, Misiak B. Impulsivity and its relationship with anxiety, depression and stress. Compr Psychiatry. 2017;74:173-9.
• van Delft MAM, Huizinga TWJ. An overview of autoantibodies in rheumatoid arthritis. J Autoimmun. 2020;110:102392.
• Herman AM, Pilcher N, Duka T. Deter the emotions: Alexithymia, impulsivity and their relationship to binge drinking. Addict Behav Rep. 2020;12:100308.
• Dunne EM, Cook RL, Ennis N. Non-planning Impulsivity But Not Behavioral Impulsivity is Associated with HIV Medication Non-adherence. AIDS Behav. 2019;23:1297-305.
• Orr CK, Najm A, Young F, McGarry T, Biniecka M, Fearon U, et al. The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis. Front Med (Lausanne). 2018;5:185.