Do Peripheral Blood Inflammation Indices Differ Among Schizophrenia Patients with Clozapine Treatment? A cross-secfional investigation.

Yıl 2024, Cilt: 34 Sayı: 6, 846 - 852, 31.12.2024

İhsan Aksoy , Hüseyin Uçar

https://doi.org/10.54005/geneltip.1538269

Öz

Background/Aims: There remains a need to investigate alternative pathophysiological processes in schizophrenia such as neuroinflammatory processes. We aimed to compare blood count levels, with a particular focus on peripheral blood inflammatory cell levels, among three distinct groups of participants: schizophrenia patients taking clozapine, schizophrenia patients taking antipsychotics other than clozapine, and healthy controls. We also evaluated the relationship between these findings and clinical characteristics.
Methods: The SC group included 47, the SA group included 61 patients and the HC group included 65 healthy controls. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were calculated by dividing the respective cell counts from white blood cell count (WBC). The relationship between these measures and clinical characteristics are done with the Positive and Negative Syndrome Scale (PANSS).
Results: WBC counts were significantly higher in the SC group than in the SA and HC groups. The log transformed NLR (LnNLR) was significantly higher in the SC group than the HC group and SA group, but there were no difference between the the SA and HC groups. LnNLR was significantly correlated with PANSS positive, general and total scores, but not significantly correlated with PANNS negative score. LnNLR was significantly different between groups after adjusting for age and gender using ANCOVA.
Conclusions: The current study sheds light on the potential immunological alterations associated with schizophrenia and its treatment with clozapine. The elevated NLR in individuals receiving clozapine treatment underscores the need for further research to elucidate the underlying mechanisms and clinical implications of this observation.

Anahtar Kelimeler

Schizophrenia, clozapine, inflammation, neutrophil-lymphocyte ratio

Etik Beyan

It was approved by the institutional ethics committee of Ankara Atatürk Sanatory Education and Research Hospital in accordance with the Declaration of Helsinki [Protocol No: 2023-2865].

Klozapin Tedavisi Gören Şizofreni Hastalarında Periferik Kan İnflamasyon İndeksleri Farklılaşır mı? Kesitsel bir Çalışma.

Öz

Amaç: Şizofrenide nöroinflamatuar süreçler gibi alternatif patofizyolojik süreçlerin araştırılması önemlidir. Ayrıca antipsikotik ilaçların inflamatuar etkilerine dair yayınlar mevcuttur. Bu çalışmada, klozapin kullanan (SC) ve kullanmayan (SA) şizofreni hastalarını ve sağlıklı kişileri (HC), periferik kan inflamatuar indeksleri açısından karşılaştırmayı ve klinik özellikler ile ilişkilerini araştırmayı amaçladık.
Gereç ve Yöntem: SC grubunda 47, SA grubunda 61 hasta ve HC grubunda 65 sağlıklı kontrol yer aldı. Nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve monosit-lenfosit oranı (MLR), son 6 aydaki tam kan sayımlarından retrospektif olarak taranarak hesaplandı. Bu ölçümler ile klinik özellikler arasındaki ilişki Pozitif ve Negatif Sendrom Ölçeği (PANSS) ile araştırıldı.
Bulgular: Beyaz küre (BK) sayıları SC grubunda, SA ve HC gruplarına göre anlamlı derecede yüksekti. Log dönüştürülmüş NLR (LnNLR), SC grubunda HC grubu ve SA grubuna göre anlamlı derecede yüksekti ancak SA ve HC grupları arasında fark yoktu. LnNLR, PANSS pozitif, genel ve toplam puanlarıyla anlamlı düzeyde korelasyon gösterirken PANNS negatif puanıyla ilişkili bulunmadı. ANCOVA kullanılarak yaş ve cinsiyet etkisi arındırıldıktan sonra LnNLR halen SC grubunda anlamlı olarak yüksek tespit edildi.
Sonuç: Bu çalışmanın sonuçları şizofreni etyolojisinde immünolojik süreçlerin rolüne, ve klozapinin periferik kan inflamatuar indeksleri üzerine etkisine ışık tutmaktadır. Retrospektif ve kesitsel dizaynı nedeniyle nedensellik bağı kurulamamıştır, ancak prospektif çalışmalara olan ihtiyacı göstermektedir.

Anahtar Kelimeler

Şizofreni, klozapin, inflamasyon, nötrofil-lenfosit oranı

Kaynakça

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