Yıl 2025,
Cilt: 35 Sayı: 1, 16 - 20, 28.02.2025
Bilge Tuna
,
Gökhan Tüzemen
Kaynakça
- 1. Upadhya I, Datar J. Treatment options in otitis media with effusion. Indian J Otolaryngol Head Neck Surg 2014;66:191-197
- 2. Park CW, Han JH, Jeong JH, et al. Detection rates of bacteria in chronic otitis media with effusion in children. J Korean Med Sci 2004;19:735-738
- 3. Ha R, Lim BW, Kim DH, Park JW, Cho CH, Lee JH. Predictive values of neutrophil to lymphocyte ratio (NLO), platelet to lymphocyte ratio (TLO), and MPVer prognostic factors in pediatric idiopathic sudden sensorineural hearing loss. Int J Pediatric Otorhinolaryngol 2019;120:134-139
- 4. Doğan A, Apaydın E, Özcan KM, Dere H. New diagnostic indicators in chronic otitis media with effusion: neutrophil to lymphocyte ratio and thrombocyte lymphocyte ratio. ENT Updates 2016;6:12-15
- 5. Yükkaldıran A, Erdoğan O, Kaplama ME. NLO and TLO in otitis media with effusion in children: diagnostic role and audiological correlation. Int J Clin Pract 2021;75:e13805
- 6. Boztepe OF, Demir M, Gün T, Bilal N, Ensari NA, Doğru H. A novel predictive marker for the viscosity of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2015;79:2355-2358
- 7. Elbistanlı MS, Koçak HE, Acıpayam H, Yiğider AP, Keskin M, Kayhan FT. The Predictive Value of NLO and TLO for the effusion viscosity in otitis media. J Craniofac Surg 2017;28:e244-e247
- 8. Marcano-Acuna ME, Carrasco-Llatas M, Tortajada-Girbes M, Dalmau-Galofre J, Codoner-Franch P. Clin Otolaryngol 2019;44(6):983-988
- 9. Hızalan İ. Ed. Önerci M, part ed. Güneri A. Book Ear Nose Throat Diseases Head Neck Surgery 2021:223-240
- 10. Kim TH, Chae SW, Kim HJ, et al. Effect of recombinant vascular endothelial growth factor on experimental otitis media with effusion. Acta Otolaryngol 2009;125:256-259
- 11. Vanneste P, Page C. Otitis media with effusion in children: Pathophysiology, diagnosis, and treatment. A review. J Otol 2019;14:33-39
- 12. Matkovic S, Vojvodic D, Baljosevic I. Cytokine levels in groups of patients with different duration of chronic secretory otitis. Eur Arch Otorhinolaryngol 2007;264:1283-1287
- 13. Rasheed AM, Abbas AM, Hilal SA, Homadi NJ. Adenoidectomy and Endoscopic Myringotomy with and without ventilation tube insertion for Treatment of Otitis Media with Effusion in 6-12-year-old children. Int Tinnitus J. 2023 Dec 4;27(1):27-33.
- 14. Tao J, Luo R, Chen Y, Hou C, Qin H. Myringotomy or tympanostomy tube insertion, comparison of surgical treatment of adenoid hypertrophy and otitis media with effusion in children. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg). 2020;34(3):207-10.
- 15. Zhang Y, Fu Y. Different treatment methods and efficacy analysis of otitis media with effusion in children with different hearing loss. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg). 2022;36(10):731-5.
- 16. Chung MH, Choi JY, Lee WS, et al. The compositional difference in middle ar effusion: Mucous Versus Serous 2002;112:152-155
- 17. Seth R, Discolo CM, Palcczewska GM, et al. Ultrasound characterization of Middle ear Effusion. Am J Otolaryngol 2013;34:44-50
- 18. Bucak A, Ulu S, Oruc S, et al. Neutrophil to Lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-1681
- 19. Kum RO, Ozca M, Baklacı D, et al. Elevated neutrophil to lymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev 2014;15:7351-7355
- 20. Boztepe OF, Gun T, Demir M, et al. A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery. Eur Arch Otorhinolaryngol 2016;273:1439-1444
- 21. Guo Y, Liu J. The Roles Played by Blood Inflammatory Parameters in Sudden Sensorineural Hearing Loss. Ear Nose Throat J 2021 Oct 18;145561320960355
- 22. Kum RO, Özcan M, Baklacı D, Kum NY, Yılmaz YF, Unal A, et al. Investigation of NLO and MPV in sudden hearing loss. Braz J Otorhinolaryngol 2015;81:636-641
- 23. Ulu Ş, Kınar A, Bucak A, Özdemir M. SII of patients with idiopathic SSHL: comparison of NLO and TLO values. Ear Nose Throat J 2021;100:726-730
- 24. Tian H, Zhang H, Chen Y, Zhong C. A Study of the Influence of Meteorological and Environmental Factors on Otitis Media with Effusion in Lanzhou. Indian J Otolaryngol Head Neck Surg. 2024;76(6):5234-5247.
The Role of Blood Inflammatory Parameters in the Evaluation of Otitis Media with Effusion in Children with Obstructive Adenoid Hypertrophy: Retrospective study
Yıl 2025,
Cilt: 35 Sayı: 1, 16 - 20, 28.02.2025
Bilge Tuna
,
Gökhan Tüzemen
Öz
Introduction: It has been reported that inflammatory parameters of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), eosinophil basophil ratio (EBR), systemic immune index (SII) and mean platelet volume (MPV) in the blood have prognostic and diagnostic values in diseases accompanied by inflammation. Serous/Mucoid differentiation of otitis media with effusion (OME) and the decision to apply a ventilation tube (VT) can be difficult. Our study aimed to examine the importance of blood inflammatory parameters in the evaluation of effusion character in OME with obstructive adenoid hypertrophy (OAH).
Materials and Methods: Preoperative blood tests of 215 pediatric patients who were operated with the diagnosis of OAH in our clinic between January 1 and December 31, 2022 were scanned. Patients with OME were grouped as Serous OME (Group 1, n:33) and Mucoid OME (Group 2, n:69). Children without accompanying OME were considered as control group (Group 3, n:113). NLR, PLR, EBR, SII and MPV values of the groups were compared.
Results: NLR value was found to be significantly lower in Group 1 than in Group 3 (p=0.023). MPV values were found to be significantly lower in Group 2 compared to Group 3 (p=0.015). No significant difference was detected between the groups in terms of other parameters.
Conclusion: The low NLR may suggest that the effusion may be of serous character. In patients with low MPV, it should be taken into account that mucoid EOM increases.
Etik Beyan
Bursa Şehir Eğitim ve Araştırma Hastanesi Etik Kurulu’ndan onay alınmıştır (Karar no:2023-5/2, 05.04.2023).
Kaynakça
- 1. Upadhya I, Datar J. Treatment options in otitis media with effusion. Indian J Otolaryngol Head Neck Surg 2014;66:191-197
- 2. Park CW, Han JH, Jeong JH, et al. Detection rates of bacteria in chronic otitis media with effusion in children. J Korean Med Sci 2004;19:735-738
- 3. Ha R, Lim BW, Kim DH, Park JW, Cho CH, Lee JH. Predictive values of neutrophil to lymphocyte ratio (NLO), platelet to lymphocyte ratio (TLO), and MPVer prognostic factors in pediatric idiopathic sudden sensorineural hearing loss. Int J Pediatric Otorhinolaryngol 2019;120:134-139
- 4. Doğan A, Apaydın E, Özcan KM, Dere H. New diagnostic indicators in chronic otitis media with effusion: neutrophil to lymphocyte ratio and thrombocyte lymphocyte ratio. ENT Updates 2016;6:12-15
- 5. Yükkaldıran A, Erdoğan O, Kaplama ME. NLO and TLO in otitis media with effusion in children: diagnostic role and audiological correlation. Int J Clin Pract 2021;75:e13805
- 6. Boztepe OF, Demir M, Gün T, Bilal N, Ensari NA, Doğru H. A novel predictive marker for the viscosity of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2015;79:2355-2358
- 7. Elbistanlı MS, Koçak HE, Acıpayam H, Yiğider AP, Keskin M, Kayhan FT. The Predictive Value of NLO and TLO for the effusion viscosity in otitis media. J Craniofac Surg 2017;28:e244-e247
- 8. Marcano-Acuna ME, Carrasco-Llatas M, Tortajada-Girbes M, Dalmau-Galofre J, Codoner-Franch P. Clin Otolaryngol 2019;44(6):983-988
- 9. Hızalan İ. Ed. Önerci M, part ed. Güneri A. Book Ear Nose Throat Diseases Head Neck Surgery 2021:223-240
- 10. Kim TH, Chae SW, Kim HJ, et al. Effect of recombinant vascular endothelial growth factor on experimental otitis media with effusion. Acta Otolaryngol 2009;125:256-259
- 11. Vanneste P, Page C. Otitis media with effusion in children: Pathophysiology, diagnosis, and treatment. A review. J Otol 2019;14:33-39
- 12. Matkovic S, Vojvodic D, Baljosevic I. Cytokine levels in groups of patients with different duration of chronic secretory otitis. Eur Arch Otorhinolaryngol 2007;264:1283-1287
- 13. Rasheed AM, Abbas AM, Hilal SA, Homadi NJ. Adenoidectomy and Endoscopic Myringotomy with and without ventilation tube insertion for Treatment of Otitis Media with Effusion in 6-12-year-old children. Int Tinnitus J. 2023 Dec 4;27(1):27-33.
- 14. Tao J, Luo R, Chen Y, Hou C, Qin H. Myringotomy or tympanostomy tube insertion, comparison of surgical treatment of adenoid hypertrophy and otitis media with effusion in children. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg). 2020;34(3):207-10.
- 15. Zhang Y, Fu Y. Different treatment methods and efficacy analysis of otitis media with effusion in children with different hearing loss. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg). 2022;36(10):731-5.
- 16. Chung MH, Choi JY, Lee WS, et al. The compositional difference in middle ar effusion: Mucous Versus Serous 2002;112:152-155
- 17. Seth R, Discolo CM, Palcczewska GM, et al. Ultrasound characterization of Middle ear Effusion. Am J Otolaryngol 2013;34:44-50
- 18. Bucak A, Ulu S, Oruc S, et al. Neutrophil to Lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-1681
- 19. Kum RO, Ozca M, Baklacı D, et al. Elevated neutrophil to lymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev 2014;15:7351-7355
- 20. Boztepe OF, Gun T, Demir M, et al. A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery. Eur Arch Otorhinolaryngol 2016;273:1439-1444
- 21. Guo Y, Liu J. The Roles Played by Blood Inflammatory Parameters in Sudden Sensorineural Hearing Loss. Ear Nose Throat J 2021 Oct 18;145561320960355
- 22. Kum RO, Özcan M, Baklacı D, Kum NY, Yılmaz YF, Unal A, et al. Investigation of NLO and MPV in sudden hearing loss. Braz J Otorhinolaryngol 2015;81:636-641
- 23. Ulu Ş, Kınar A, Bucak A, Özdemir M. SII of patients with idiopathic SSHL: comparison of NLO and TLO values. Ear Nose Throat J 2021;100:726-730
- 24. Tian H, Zhang H, Chen Y, Zhong C. A Study of the Influence of Meteorological and Environmental Factors on Otitis Media with Effusion in Lanzhou. Indian J Otolaryngol Head Neck Surg. 2024;76(6):5234-5247.