Küçük Hücreli Dışı Akciğer Kanseri Nedeniyle Ameliyat Edilen Hastalarda Sigara İçme Durumunun Uzun Dönem Sağkalım Üzerindeki Rolü

Yıl 2025, Cilt: 35 Sayı: 4, 667 - 672, 29.08.2025

Serkan Uysal , Ulaş Kumbasar , Erkan Dikmen , Metin Demircin , Rıza Doğan

https://doi.org/10.54005/geneltip.1670826

Öz

Öz:
Amaç: Bu çalışmanın amacı küçük hücreli dışı akciğer kanseri (KHDAK) nedeniyle akciğer rezeksiyonu uygulanan hastalarda sigara kullanmayan hastaların sıklığının ve sigara kullanımının mortalite üzerine olan etkisini araştırmaktır. Sigara kullanımı akciğer kanserinin en önemli nedenlerinden biri iken sigara içimi ile sağkalım arasındaki ilişki belirsizdir.
Gereç ve Yöntem: KHDAK nedeniyle akciğer rezeksiyonu uygulanan 249 hastanın dosya verileri incelendi. Hastalar sigara içmiş olanlar ve hiç sigara içmemiş olanlar olmak üzere iki gruba ayrıldı ve gruplar sigara içmeyen hastaların yıllık oranı, demografik, klinik özellikler ve uzun dönem sağkalım açısından karşılaştırıldı.
Bulgular: Sigara içmeyen hastaların 2002-2012 yılları arasındaki oranları sırası ile %33.2, 24, 37.5, 25, 34.3, 35.4, 29.4, 22.7, 22.2, 35.7 ve 28.5 olarak hesaplandı. Sigara içmeyen grupta kadın hastaların oranı daha yüksek bulundu (p=0.022). Sigara içmeyen ve içen hasta gruplarında yaş (p=0.993), zorlu ekspirasyonun birinci saniyesinde atılan volümler (p=0.476), uygulanan cerrahi rezeksiyonlar (p=0.564) ve tümörün histolojik tipi (p=0.920) açısından istatistiksel olarak farklılık saptanmadı. Ortanca sağkalım sigara içmeyen grupta 76 ay, sigara içen grupta ise 72 ay olarak hesaplandı (p=0.654). Sigara içmeyen hatalar kohortumuzun %30’unu oluşturmaktadır.
Sonuçlar: Çalışmamızdan elde edilen veriler, KHDAK nedeniyle rezeksiyon uygulanan hasta grubunda sigara kullanımının hastaların total sağkalımı üzerine etkisi olmadığını göstermektedir.

Anahtar Kelimeler

Küçük hücreli dışı akciğer kanseri , sigara kullanımı , sağ kalım

Etik Beyan

Yazarların çıkar çatışması bulunmamaktadır.

Destekleyen Kurum

Yok

Role of Smoking Status on Long-Term Survival in Patients Operated for Non-Small Cell Lung Cancer

Öz

Abstract:
Aim: This present study aimed to evaluate both the frequency of non-smoking patients and the impact of smoking status to the long-term survival of patients operated for NSCLC in our institutional cohort. Although tobacco smoking is one of the major causes of lung cancer the correlation between smoking status and the survival of patients is uncertain.
Materials and Method: Medical records of 249 patients who underwent pulmonary resection for NSCLC were retrospectively reviewed. Patients were divided into smokers and never-smokers. Annual frequency, demographic and clinical characteristics and overall survival were compared between the groups.
Results: The annual frequency of never-smokers between the years 2002 and 2012 was 33.2, 24, 37.5, 25, 34.3, 35.4, 29.4, 22.7, 22.2, 35.7 and 28.5%, respectively. There were no statistically significant difference in terms of the distribution of age (p=0.993), FEV1 measurement (p=0.476), type of resection performed (p=0.564) and tumor histology (p=0.920) between the groups. The median survival time was similar in both groups (72 vs 76 months, smokers vs. never-smokers. Log-rank test; P=0.654).
Conclusion: The proportion of never-smokers were approximately 30% in our cohort. In long follow-up, smoking status was not an independent risk factor for a poorer prognosis in patients operated for NSCLC.

Anahtar Kelimeler

Non-small cell lung cancer , tobacco smoking , survival

Etik Beyan

The Authors declare that there is no conflict of interest.

Destekleyen Kurum

No

Kaynakça

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