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İşlenmiş Et ve Kanser Bağlantısı: Araştırma Eğilimleri ve Sağlık Etkilerinin Bibliyometrik Analizi

Yıl 2025, Cilt: 35 Sayı: 4, 681 - 695, 29.08.2025
https://doi.org/10.54005/geneltip.1684769

Öz

Amaç: Kanser, dünya çapında önde gelen bir ölüm nedenidir ve özellikle işlenmiş et tüketimi gibi diyet faktörleri artan kanser riski ile ilişkilendirilmektedir. Bu çalışma, bibliyometrik bir yaklaşım kullanarak işlenmiş et ve kanser üzerine yapılan araştırmaların genel görünümünü sistematik bir şekilde analiz etmeyi, araştırma trendlerini, önemli katkıda bulunanları ve ortaya çıkan temaları değerlendirmeyi amaçlamıştır.
Yöntemler: Web of Science Core Collection veri tabanı kullanılarak 1982'den 2025'e kadar yayımlanan 1.536 yayını içeren bir bibliyometrik analiz gerçekleştirilmiştir. "İşlenmiş et," "kürlenmiş et," "emülsifiye et," "kanser," "tümör," "karsinom," "malign" ve "kanserojen etki" gibi anahtar kelimeler kullanılmıştır. Analiz, atıf haritalaması, trend belirleme ve önde gelen ülkelerin, dergilerin ve yazarların katkılarını içermiştir.
Bulgular: Epidemiyolojik çalışmalar araştırmaya hâkim olmuş ve işlenmiş et tüketimi ile özellikle kolorektal kanser riski arasında tutarlı bir ilişki gösterilmiştir. Belirlenen anahtar konular arasında nitrozaminler, N-nitroso bileşikleri ve yüksek sıcaklıkta pişirme yöntemleri yer almıştır. Amerika Birleşik Devletleri en yüksek yayın oranına (yüzde 23,1) sahip ülke olmuştur. Son dönem trendleri, nedensellik çıkarımı için Mendel rastgeleleştirme çalışmalarının kullanımını ve diyet kılavuzlarında sürdürülebilirliğe artan odaklanmayı ortaya koymuştur.
Sonuçlar: İşlenmiş et tüketimi, artan kanser riski ile tutarlı şekilde ilişkilendirilmekte olup, bütüncül diyet kalıplarının önemini vurgulamaktadır. Gelecekteki araştırmaların sürdürülebilir et üretimine, yenilikçi koruma yöntemlerine ve dengeli diyet müdahalelerine odaklanarak halk sağlığı ve çevresel sürdürülebilirliğin teşvik edilmesi gerektiği belirtilmiştir.

Kaynakça

  • 1. Zhang X, Liang S, Chen X, Yang J, Zhou Y, Du L, et al. Red/processed meat consumption and non-cancer-related outcomes in humans: Umbrella review. Br. J. Nutr. 2023;130(3):484–94.
  • 2. Lim W, Moon S, Lee NR, Shin HG, Yu SY, Lee JE, et al. Group I pharmaceuticals of IARC and associated cancer risks: systematic review and meta-analysis. Sci Rep. 2024;14(1):413.
  • 3. Dean E, Xu J, Jones AYM, Vongsirinavarat M, Lomi C, Kumar P, et al. An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides. Nutr. J. 2024;23(1):1-30.
  • 4. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021;133:285–96.
  • 5. Ross SA, Milner JA. Epigenetic modulation and cancer: Effect of metabolic syndrome? Am. J. Clin. Nutr. 2007;86(3):872S-877S.
  • 6. Sinha R, Kulldorff M, Chow WH, Denobile J, Rothman N. Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas. Cancer Epidemiol. Biomarkers Prev. 2001;10(5),559-562.
  • 7. Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Laure Preterre A, Iqbal K, et al. Food groups and risk of colorectal cancer. Int. J. Cancer. 2018;142(9),1748-1758.
  • 8. Babaoğlu AS. Assessing the Formation of Polycyclic Aromatic Hydrocarbons in Grilled Beef Steak and Beef Patty with Different Charcoals by the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Method with Gas Chromatography–Mass Spectrometry. Food Sci Anim Resour. 2023;43(5):826–39.
  • 9. Akansel B, Yılmaz Oral ZF, Sallan S, Kaban G, Kaya M. Effect of Black Garlic on Microbiological Properties, Lipid Oxidation, Residual Nitrite, Nitrosamine Formation and Sensory Characteristics in a Semi-Dry Fermented Sausage. Foods. 2023;12(7):1545.
  • 10. Babaoğlu AS, Karakaya M. Monitoring of the physicochemical, microbial, textural, and sensory properties of clean label sucuk produced with natural curing agents during the ripening period. Int. J. Gastronomy Food Sci. 2022;29,100570.
  • 11. Dilek NM, Karakaya M. Investigations on the usage of sugar beet molasses as nitrate alternative in sucuk. Fleischwirtschaft. 2022;102(4):161-170.
  • 12. Serdaroğlu M, Can H, Sarı B, Kavuşan HS, Yılmaz FM. Effects of natural nitrite sources from arugula and barberry extract on quality characteristics of heat-treated fermented sausages. Meat Sci. 2023;198:109090.
  • 13. Yılmaz Oral ZF., Kaya M, Kaban G. Using Celery Powder in a Semi-Dry Fermented Sausage ‘Heat-Treated Sucuk’: Nitrosamine Formation, Lipid Oxidation, and Volatile Compounds. Foods. 2024;13(20):3306.
  • 14. Awney H. The effect of green tea and olive oil on the mutagenic activity of heterocyclic amines extracted from common food consumed in Saudi Arabia. Int J Food Sci Nutr. 2011;62(3):295–302.
  • 15. Bogueva D, McClements DJ. Safety and Nutritional Risks Associated with Plant-Based Meat Alternatives. Sustainability. 2023;15(19):14336.
  • 16. Aoudeh E, Oz E, Oz F. Effect of beef patties fortification with black garlic on the polycyclic aromatic hydrocarbons (PAHs) content and toxic potency. Food Chem. 2023;428:136763.
  • 17. Unal K, Karakaya M, Oz F. The effects of different spices and fat types on the formation of heterocyclic aromatic amines in barbecued sucuk. J Sci Food Agric. 2018;98(2):719–25.
  • 18. Yılmaz Oral ZF, Kaya M, Kaban G. Using Celery Powder in a Semi-Dry Fermented Sausage ‘Heat-Treated Sucuk’: Nitrosamine Formation, Lipid Oxidation, and Volatile Compounds. Foods. 2024;13(20):3306.
  • 19. Clinton SK, Giovannucci EL, Hursting SD. The world cancer research fund/american ınstitute for cancer research third expert report on diet, nutrition, physical activity, and cancer: ımpact and future directions. J. Nutr. 2020;150(4):663-671.
  • 20. Lee SY, Yim DG, Lee DY, Kim OY, Kang HJ, Kim HS, et al. Overview of the effect of natural products on the reduction of potential carcinogenic substances in meat products. Trends Food Sci. Technol. 2020;99:568-579.
  • 21. Higgs JD. The changing nature of red meat: 20 years of improving nutritional quality. Trends Food Sci. Technol. 2000;11(3),85-95.
  • 22. Bryant C, Couture A, Ross E, Clark A, Chapman T. A review of policy levers to reduce meat production and consumption. Appetite. 2024;107684.
  • 23. Trumbo PR, Glass KA, Lee SY, Moshfegh A, Welling PA, Zecca P. North American considerations, strategies, and practices in reducing the sodium content in processed foods. J. Food Sci. 2024;89(10):6086-6097.
  • 24. Inguglia ES, Zhang Z, Tiwari BK, Kerry JP, Burgess CM. Salt reduction strategies in processed meat products – A review. Trends Food Sci. Technol. 2017;59:70-78.
  • 25. Rasheed HA, Rehman A, Karim A, Al-Asmari F, Cui H, Lin L. A comprehensive insight into plant-derived extracts/bioactives: Exploring their antimicrobial mechanisms and potential for high-performance food applications. Food Biosci. 2024,104035.
  • 26. Assaf S, Park J, Chowdhry N, Ganapuram M, Mattathil S, Alakeel R, et al. Unraveling the Evolutionary Diet Mismatch and Its Contribution to the Deterioration of Body Composition. Metabolites. 2024;14(7):379.
  • 27. Dave LA, Hodgkinson SM, Roy NC, Smith NW, McNabb WC. The role of holistic nutritional properties of diets in the assessment of food systems and dietary sustainability. Crit. Rev. Food Sci. Nutr. 2023; 63(21):5117-5137.
  • 28. Menichetti G, Ravandi B, Mozaffarian D, Barabási AL. Machine learning prediction of the degree of food processing. Nat Commun. 2023;14(1): 2312.
  • 29. Ma NL, Peng W, Soon CF, Noor Hassim MF, Misbah S, Rahmat Z, et al. COVID-19 pandemic through the lens of food safety and security. Environ Res. 2021;193:110405.
  • 30. Arokiyaraj S, Dinakarkumar Y, Shin H. A comprehensive overview of the preservation techniques and packaging of processed meat products: Emphasis on natural derivatives. J. King Saud Univ. Sci. 2024; 36(1):103032.
  • 31. Babaoğlu AS, Unal K, Dilek NM, Poçan HB, Karakaya M. Antioxidant and antimicrobial effects of blackberry, black chokeberry, blueberry, and red currant pomace extracts on beef patties subject to refrigerated storage. Meat Sci. 2022;187:108765.
  • 32. Dilek NM, Karakaya M. Natural Alternative Curing Agent in Fermented Sucuk Production: Sugar beet (Beta vulgaris var. saccharifera L.) Molasses. Selcuk J. Agric. Food Sci. 2022; 36(3): 380-386.
  • 33. Ateş E, Unal K. The effects of deep-frying, microwave, oven, and sous vide cooking on the acrylamide formation of gluten-free chicken nuggets. Int J Gastron Food Sci. 2023;31:100666.
  • 34. Flore G, Deledda A, Lombardo M, Armani A, Velluzzi F. Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer. Antioxidants. 2023;12(10):1845.
  • 35. Hussain A, Bourguet-Kondracki ML, Hussain F, Rauf A, Ibrahim M, Khalid M, et al. The potential role of dietary plant ingredients against mammary cancer: a comprehensive review. Crit. Rev. Food Sci. Nutr. 2022;62(10):2580-2605. 36. Zhang H, Fan Y, Li H, Feng X, Yue D. Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis. PLoS One. 2024;19(5):e0301752.
  • 37. Wang F, Chandler PD, Zeleznik OA, Wu K, Wu Y, Yin K, et al. Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk. Nutrients. 2022;14(5):978.
  • 38. Caini S, Chioccioli S, Pastore E, Fontana M, Tortora K, Caderni G, et al. Fish Consumption and Colorectal Cancer Risk: Meta-Analysis of Prospective Epidemiological Studies and Review of Evidence from Animal Studies. Cancers (Basel). 2022;14(3):640.

Processed Meat and Cancer Connection: A Bibliometric Analysis of Research Trends and Health Implications

Yıl 2025, Cilt: 35 Sayı: 4, 681 - 695, 29.08.2025
https://doi.org/10.54005/geneltip.1684769

Öz

Aim: Cancer is a leading cause of mortality worldwide, with dietary factors, particularly processed meat consumption, being associated with an increased cancer risk. This study aimed to systematically analyze the research landscape on processed meat and cancer through a bibliometric approach, evaluating research trends, key contributors, and emerging themes.
Methods: A bibliometric analysis was conducted using data from the Web of Science Core Collection, including 1,536 publications from 1982 to 2025. Keywords such as "processed meat," "cured meat," "emulsified meat," "cancer," "tumor," "carcinoma," "malignant," and "carcinogenic effect" were used. The analysis included citation mapping, trend identification, and contributions from leading countries, journals, and authors.
Results: Epidemiological studies dominated the research, consistently showing associations between processed meat consumption and cancer risk, particularly colorectal cancer. Key topics identified included nitrosamines, N-nitroso compounds, and high-temperature cooking methods. The United States contributed the highest number of publications (23.1%). Recent trends highlighted the use of Mendelian randomization studies for causal inference and increased focus on sustainability in dietary guidelines.
Conclusions: Processed meat consumption is consistently associated with increased cancer risk, emphasizing the importance of holistic dietary patterns. Future research should focus on sustainable meat production, innovative preservation methods, and balanced dietary interventions to promote public health and environmental sustainability.

Etik Beyan

There is no need for an ethics committee report.

Kaynakça

  • 1. Zhang X, Liang S, Chen X, Yang J, Zhou Y, Du L, et al. Red/processed meat consumption and non-cancer-related outcomes in humans: Umbrella review. Br. J. Nutr. 2023;130(3):484–94.
  • 2. Lim W, Moon S, Lee NR, Shin HG, Yu SY, Lee JE, et al. Group I pharmaceuticals of IARC and associated cancer risks: systematic review and meta-analysis. Sci Rep. 2024;14(1):413.
  • 3. Dean E, Xu J, Jones AYM, Vongsirinavarat M, Lomi C, Kumar P, et al. An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides. Nutr. J. 2024;23(1):1-30.
  • 4. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021;133:285–96.
  • 5. Ross SA, Milner JA. Epigenetic modulation and cancer: Effect of metabolic syndrome? Am. J. Clin. Nutr. 2007;86(3):872S-877S.
  • 6. Sinha R, Kulldorff M, Chow WH, Denobile J, Rothman N. Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas. Cancer Epidemiol. Biomarkers Prev. 2001;10(5),559-562.
  • 7. Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Laure Preterre A, Iqbal K, et al. Food groups and risk of colorectal cancer. Int. J. Cancer. 2018;142(9),1748-1758.
  • 8. Babaoğlu AS. Assessing the Formation of Polycyclic Aromatic Hydrocarbons in Grilled Beef Steak and Beef Patty with Different Charcoals by the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Method with Gas Chromatography–Mass Spectrometry. Food Sci Anim Resour. 2023;43(5):826–39.
  • 9. Akansel B, Yılmaz Oral ZF, Sallan S, Kaban G, Kaya M. Effect of Black Garlic on Microbiological Properties, Lipid Oxidation, Residual Nitrite, Nitrosamine Formation and Sensory Characteristics in a Semi-Dry Fermented Sausage. Foods. 2023;12(7):1545.
  • 10. Babaoğlu AS, Karakaya M. Monitoring of the physicochemical, microbial, textural, and sensory properties of clean label sucuk produced with natural curing agents during the ripening period. Int. J. Gastronomy Food Sci. 2022;29,100570.
  • 11. Dilek NM, Karakaya M. Investigations on the usage of sugar beet molasses as nitrate alternative in sucuk. Fleischwirtschaft. 2022;102(4):161-170.
  • 12. Serdaroğlu M, Can H, Sarı B, Kavuşan HS, Yılmaz FM. Effects of natural nitrite sources from arugula and barberry extract on quality characteristics of heat-treated fermented sausages. Meat Sci. 2023;198:109090.
  • 13. Yılmaz Oral ZF., Kaya M, Kaban G. Using Celery Powder in a Semi-Dry Fermented Sausage ‘Heat-Treated Sucuk’: Nitrosamine Formation, Lipid Oxidation, and Volatile Compounds. Foods. 2024;13(20):3306.
  • 14. Awney H. The effect of green tea and olive oil on the mutagenic activity of heterocyclic amines extracted from common food consumed in Saudi Arabia. Int J Food Sci Nutr. 2011;62(3):295–302.
  • 15. Bogueva D, McClements DJ. Safety and Nutritional Risks Associated with Plant-Based Meat Alternatives. Sustainability. 2023;15(19):14336.
  • 16. Aoudeh E, Oz E, Oz F. Effect of beef patties fortification with black garlic on the polycyclic aromatic hydrocarbons (PAHs) content and toxic potency. Food Chem. 2023;428:136763.
  • 17. Unal K, Karakaya M, Oz F. The effects of different spices and fat types on the formation of heterocyclic aromatic amines in barbecued sucuk. J Sci Food Agric. 2018;98(2):719–25.
  • 18. Yılmaz Oral ZF, Kaya M, Kaban G. Using Celery Powder in a Semi-Dry Fermented Sausage ‘Heat-Treated Sucuk’: Nitrosamine Formation, Lipid Oxidation, and Volatile Compounds. Foods. 2024;13(20):3306.
  • 19. Clinton SK, Giovannucci EL, Hursting SD. The world cancer research fund/american ınstitute for cancer research third expert report on diet, nutrition, physical activity, and cancer: ımpact and future directions. J. Nutr. 2020;150(4):663-671.
  • 20. Lee SY, Yim DG, Lee DY, Kim OY, Kang HJ, Kim HS, et al. Overview of the effect of natural products on the reduction of potential carcinogenic substances in meat products. Trends Food Sci. Technol. 2020;99:568-579.
  • 21. Higgs JD. The changing nature of red meat: 20 years of improving nutritional quality. Trends Food Sci. Technol. 2000;11(3),85-95.
  • 22. Bryant C, Couture A, Ross E, Clark A, Chapman T. A review of policy levers to reduce meat production and consumption. Appetite. 2024;107684.
  • 23. Trumbo PR, Glass KA, Lee SY, Moshfegh A, Welling PA, Zecca P. North American considerations, strategies, and practices in reducing the sodium content in processed foods. J. Food Sci. 2024;89(10):6086-6097.
  • 24. Inguglia ES, Zhang Z, Tiwari BK, Kerry JP, Burgess CM. Salt reduction strategies in processed meat products – A review. Trends Food Sci. Technol. 2017;59:70-78.
  • 25. Rasheed HA, Rehman A, Karim A, Al-Asmari F, Cui H, Lin L. A comprehensive insight into plant-derived extracts/bioactives: Exploring their antimicrobial mechanisms and potential for high-performance food applications. Food Biosci. 2024,104035.
  • 26. Assaf S, Park J, Chowdhry N, Ganapuram M, Mattathil S, Alakeel R, et al. Unraveling the Evolutionary Diet Mismatch and Its Contribution to the Deterioration of Body Composition. Metabolites. 2024;14(7):379.
  • 27. Dave LA, Hodgkinson SM, Roy NC, Smith NW, McNabb WC. The role of holistic nutritional properties of diets in the assessment of food systems and dietary sustainability. Crit. Rev. Food Sci. Nutr. 2023; 63(21):5117-5137.
  • 28. Menichetti G, Ravandi B, Mozaffarian D, Barabási AL. Machine learning prediction of the degree of food processing. Nat Commun. 2023;14(1): 2312.
  • 29. Ma NL, Peng W, Soon CF, Noor Hassim MF, Misbah S, Rahmat Z, et al. COVID-19 pandemic through the lens of food safety and security. Environ Res. 2021;193:110405.
  • 30. Arokiyaraj S, Dinakarkumar Y, Shin H. A comprehensive overview of the preservation techniques and packaging of processed meat products: Emphasis on natural derivatives. J. King Saud Univ. Sci. 2024; 36(1):103032.
  • 31. Babaoğlu AS, Unal K, Dilek NM, Poçan HB, Karakaya M. Antioxidant and antimicrobial effects of blackberry, black chokeberry, blueberry, and red currant pomace extracts on beef patties subject to refrigerated storage. Meat Sci. 2022;187:108765.
  • 32. Dilek NM, Karakaya M. Natural Alternative Curing Agent in Fermented Sucuk Production: Sugar beet (Beta vulgaris var. saccharifera L.) Molasses. Selcuk J. Agric. Food Sci. 2022; 36(3): 380-386.
  • 33. Ateş E, Unal K. The effects of deep-frying, microwave, oven, and sous vide cooking on the acrylamide formation of gluten-free chicken nuggets. Int J Gastron Food Sci. 2023;31:100666.
  • 34. Flore G, Deledda A, Lombardo M, Armani A, Velluzzi F. Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer. Antioxidants. 2023;12(10):1845.
  • 35. Hussain A, Bourguet-Kondracki ML, Hussain F, Rauf A, Ibrahim M, Khalid M, et al. The potential role of dietary plant ingredients against mammary cancer: a comprehensive review. Crit. Rev. Food Sci. Nutr. 2022;62(10):2580-2605. 36. Zhang H, Fan Y, Li H, Feng X, Yue D. Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis. PLoS One. 2024;19(5):e0301752.
  • 37. Wang F, Chandler PD, Zeleznik OA, Wu K, Wu Y, Yin K, et al. Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk. Nutrients. 2022;14(5):978.
  • 38. Caini S, Chioccioli S, Pastore E, Fontana M, Tortora K, Caderni G, et al. Fish Consumption and Colorectal Cancer Risk: Meta-Analysis of Prospective Epidemiological Studies and Review of Evidence from Animal Studies. Cancers (Basel). 2022;14(3):640.
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Original Article
Yazarlar

Gamze Demirel 0000-0001-6037-378X

Nazik Meziyet Dilek 0000-0003-2506-2067

Erken Görünüm Tarihi 29 Ağustos 2025
Yayımlanma Tarihi 29 Ağustos 2025
Gönderilme Tarihi 26 Nisan 2025
Kabul Tarihi 7 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 35 Sayı: 4

Kaynak Göster

Vancouver Demirel G, Dilek NM. Processed Meat and Cancer Connection: A Bibliometric Analysis of Research Trends and Health Implications. Genel Tıp Derg. 2025;35(4):681-95.