Triglyceride-Glucose Index in Central Retinal Artery Occlusion: A Metabolic Risk Factor?

Yıl 2025, Cilt: 35 Sayı: 5, 965 - 972, 28.10.2025

Ali Osman Gündoğan , Refik Oltulu , Selman Belviranlı , Ali Tezcan , Enver Mirza , Mehmet Adam , Mehmet Okka

Öz

Aim: To evaluate the triglyceride glucose index (TGI) in patients with central retinal artery occlusion (CRAO) compared with controls and to determine its prognostic significance.
Methods: A total of 54 CRAO patients and 54 healthy controls participated in this retrospective study. The TGI was calculated based on fasting plasma triglyceride and glucose levels and the results were evaluated between the different groups. To determine the optimal TGI threshold, ROC curve analysis was performed and its sensitivity and specificity were determined between the CRAO and control groups.
Results: No statistically meaningful difference across the groups in terms of age and sex (p = 0.547 and p = 1.000, respectively). The TGI was identified as 8.46 [8.37, 8.59] in the control group and 8.86 [8.55, 9.10] in the CRAO group (p<0.001). The optimal ROC cutoff value for TGI distinguishing CRAO and control groups was determined as 8.68, with 63% sensitivity and 98% specificity (AUC: 0.865, p<0.001, 95% CI 0.800–0.931).
Conclusion: Higher levels of TGI appear to be associated with the occurrence of CRAO. TGI may be a potential marker for CRAO. Because of the association of elevated TGI with increased metabolic and cardiovascular risk, patients with CRAO should be carefully evaluated.

Anahtar Kelimeler

Central Retinal Artery Occlusion , Triglyceride , Glucose , Triglyceride-Glucose Index , Blood Lipid Profile

Santral Retinal Arter Tıkanıklığında Trigliserit-Glikoz İndeksi: Metabolik Bir Risk Faktörü mü?

Öz

ÖZ
Amaç: Santral retinal arter tıkanıklığı (SRAT) olan hastalarda trigliserid glukoz indeksini (TGI) kontrol grubuyla karşılaştırmalı olarak değerlendirmek ve prognostik önemini belirlemek.
Gereç ve Yöntemler: Bu retrospektif çalışmaya toplam 54 SRAT hastası ve 54 sağlıklı kontrol katıldı. TGI, açlık plazma trigliseritleri ve glukoz seviyeleri kullanılarak belirlenmiş ve sonuçlar gruplar arasında karşılaştırılmıştır. ROC eğrisi, SRAT ve kontrol grupları arasındaki duyarlılık ve özgüllüğün yanı sıra optimum TGI cut-off değerini belirlemek için uygulandı.
Bulgular: Cinsiyet ve yaş bakımından gruplar karşılaştırıldığında anlamlı bir farklılık saptanmadı (sırasıyla p = 0.547 ve p = 1.000). TGI değeri kontrol grubunda 8.46 [8.37, 8.59] ve SRAT grubunda 8.86 [8.55, 9.10] olarak tespit edilmiştir (p<0.001). SRAT ve kontrol gruplarını ayırt eden TGI için optimal ROC cutoff değeri %63 duyarlılık ve %98 özgüllük ile 8.68 olarak hesaplanmıştır (AUC: 0.865, p<0.001, %95 CI 0.800-0.931).
Sonuçlar: Daha yüksek TGI seviyeleri SRAT oluşumu ile ilişkili görünmektedir. TGI, SRAT için potansiyel bir belirteç olabilir. Yüksek TGI'nın artmış metabolik ve kardiyovasküler risk ile ilişkisi nedeniyle, SRAT'lı hastalar dikkatle değerlendirilmelidir.

Anahtar Kelimeler

Santral Retinal Arter Tıkanıklığı , Trigliserid , Glukoz , Trigliserid-Glukoz İndeksi , Kan Lipid Profili

Kaynakça

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