Yaşlı Farelerde Florür Maruziyetinin Motor Performans, Depresyon ve Hafıza Üzerine Etkileri

Öz

Amaç: Florürün yaşlanma döneminde motor fonksiyonlar, davranışsal ve bilişsel işlevler üzerine etkilerini gösteren yeterli kanıt yoktur. Bu çalışmada yaşlı farelere oral gavaj yolu ile verilen sodyum florürün motor fonksiyonları, davranışsal ve bilişsel işlevleri etkileyip etkilemediğinin araştırılması amaçlanmıştır.

 

Gereç ve Yöntemler: Balb-C fareleri rastgele seçilmiş ve kontrol, düşük ve yüksek doz (sırası ile 3 ve 9 mg / L sodyum florür) olma üzere 3 gruba ayrılmıştır. Tüm gruplara 28 gün süreyle sodyum florür maruziyeti sonrasında lokomotor aktivite testi, zorlu yüzme testi ve yeni nesne tanıma testi uygulanmıştır.

 

Bulgular: Hem düşük hem de yüksek doz sodyum florür gruplarında yaşlı farelerin, lokomotor aktivitelerinde azalma meydana gelmiş ancak anlamlı bir fark gözlenememiştir. Gruplar arasında, zorunlu yüzme testinde hareketsiz kalma süresinde meydana gelen artış, istatistiksel olarak anlamlı bulunmamıştır. Ancak, yeni obje tanıma testi sonuçları, yüksek doz (9 mg / L) grubunda, düşük doz (3 mg / L) ve kontrol grubuna kıyasla, fark indeksine göre istatistiksel olarak anlamlı bir fark olduğunu göstermiştir.

 

Sonuç: Bulgularımız, yaşlı farelerde yüksek doz sodyum florür maruziyetinin yeni obje tanıma testi sonuçlarına göre bilişsel işlev bozukluklarını artırabileceğini göstermektedir.  

Anahtar Kelimeler

• Anahtar Kelimeler: Florür,yaşlı,hafıza,kognitif fonksiyon

Effects of Fluoride Exposure on Motor Performance, Depression and Memory in Elderly Mice

Öz

Aim: There is insufficient evidence to support the effect of sodium fluoride on motor, behavioral and cognitive functions in the aging period. We aimed to investigate whether sodium fluoride exposure by oral gavage affected the locomotor activity, behavioral and memory functions in elderly mice.

 

Material and Methods: Balb-C mice were randomly divided into three groups: control, low and high (3 and 9 mg/L sodium fluoride, respectively) dose groups. Locomotor activity test, forced swim test and novel object recognition test were performed after 28 days of feeding in all groups.

 

Results: Older mice in both low and high sodium fluoride dose groups exhibited decreased locomotor activity but no statistically significant difference was observed. The increase in the immobility time in the forced swim test was also not statistically significant among the groups. However, the novel object recognition test results showed significant difference in high dose (9 mg/L) group when compared to low dose (3 mg/L) and control groups regarding to discrimination index.

 

Conclusion: Our findings indicate that high dose sodium fluoride may induce impairments in cognitive function based on the object recognition test results in elderly mice. 

Anahtar Kelimeler

• Fluoride,geriatric,memory,cognitive function

Kaynakça

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