Tip 2 Diabetes Mellitus ve Alzheimer Hastalığı Ortak Tedavi Edilebilir Mi?

Yıl 2018, Cilt: 1 Sayı: 1, 20 - 27, 15.05.2018

Beril Kadıoğlu Turgay Çelik

Öz

Klinik,
biyokimyasal ve görüntüleme araştırmaları, Tip 2 Diabetes Mellitus (T2DM)’de
yüksek glikoz düzeylerinin, Alzheimer Hastalığı’ndaki (AH) bilişsel işlev
bozukluğuyla ilişkili olabileceğini göstermiştir. İki hastalık arasında
obezite, dislipidemi, insülin direnci ve sedanter yaşam alışkanlıkları ortak
risk ve etiyolojik faktörler olarak tanımlanmıştır. Bu durumda, yaşam tarzı
değişiklikleri ve farmakolojik ajanların kullanılması ile bu iki hastalığın
ilerlemesi önlenebilir veya geciktirilebilir. T2DM tedavisinde kullanılan başta
İnsülin, Metformin, Peroksizom Proliferatör-Aktive Reseptörler (PPAR)
agonistleri, Glukagon Benzeri Peptid-1 Reseptör agonistleri ve Dipeptidil Peptidaz-4
inhibitörleri gibi farmakolojik ajanların, AH’de ortaya çıkan bilişsel
bozukluklar üzerine koruyucu etkiler gösterdikleri gözlenmiştir.

Anahtar Kelimeler

İnsülin Rezistansı, Alzheimer HastalığI

Kaynakça

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