Geriatrik Bir Olguda D Vitamini İntoksikasyonuna Bağlı Gelişen Akut Mental Değişiklik

Yıl 2018, Cilt: 1 Sayı: 2, 73 - 78, 29.10.2018

Ali Ekrem Aydın Özge Dokuzlar

Öz

Son
yıllarda D vitamini ile immün sistem, kardiyovasküler sağlık ve hatta kanserin
önlenmesi arasındaki ilişkiyi ortaya koyan çalışmalar sonucu kullanımına olan
ilgi artmıştır. Yanlış kullanımlar sonucu D vitamini intoksikasyonu
gelişebilmekle beraber nadir görülmektedir. D vitamini intoksikasyonu,
hiperkalsemi, hiperkalsiüri, hiperfosfatemiye ve de uzun dönemde yumuşak doku,
vasküler kalsifikasyonlar, nefrolitiyazise neden olabilmektedir. Bu yazıda D
vitamininin yanlış kullanımı sonrası akut mental değişiklik tablosuyla acil
servise getirilen 75 yaşında bir kadın olgu sunulmuştur.

Anahtar Kelimeler

D vitamini, intoksikasyon, akut mental değişiklik, yaşlı

Kaynakça

• Holick MF. Vitamin D Status: Measurement, Interpretation, and Clinical Application. Annals of Epidemiology. 2009.
• Hossein-Nezhad A, Holick MF. Vitamin D for health: A global perspective. In: Mayo Clinic Proceedings. 2013.
• Sahota O. Understanding vitamin D deficiency. Age and Ageing. 2014;
• Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: Modulator of the immune system. Current Opinion in Pharmacology. 2010.
• Pérez-Barrios C, Hernández-Álvarez E, Blanco-Navarro I, Pérez-Sacristán B, Granado-Lorencio F. Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. Clin Nutr. 2016;
• Koul PA, Ahmad SH, Ahmad F, Jan RA, Shah SU, Khan UH. Vitamin D toxicity in adults: A case series from an area with endemic Hypovitaminosis D. Oman Med J. 2011;
• Lee JP, Tansey M, Jetton JG, Krasowski MD. Vitamin D Toxicity: A 16-Year Retrospective Study at an Academic Medical Center. Lab Med. 2018;
• Bringhurst FR, Demay MB, Kronenberg HM. Hormones and Disorders of Mineral Metabolism. In: Williams Textbook of Endocrinology. 2011.
• Shoback D, Marcus R, Bikle D. Metabolic bone disease. New York: Lange Medical Books/McGraw-Hill; 2004. 324-30 p.
• Wang C. Role of vitamin D in cardiometabolic diseases. Journal of Diabetes Research. 2013.
• Reddy Vanga S, Good M, Howard PA, Vacek JL. Role of Vitamin D in Cardiovascular Health. Am J Cardiol. 2010;
• Klontz KC, Acheson DW. Dietary Supplement–Induced Vitamin D Intoxication. N Engl J Med. 2007;
• Herrera Martinez A, Vinals Torras M, Munoz Jimenez MC, Arenas de Larriva AP, Molina Puerta MJ, Manzano Garcia G, et al. Metabolic encephalopathy secondary to vitamin D intoxication. Nutr Hosp. 2014 Oct;31(3):1449–51.
• Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;
• Kaptein S, Risselada AJ, Boerma EC, Egbers PHM, Nieboer P. Life-threatening complications of vitamin D intoxication due to over-the-counter supplements. Clin Toxicol. 2010;
• Araki T, Holick MF, Alfonso BD, Charlap E, Romero CM, Rizk D, et al. Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. In: Journal of Clinical Endocrinology and Metabolism. 2011.
• National Institute for Health and Care Excellence (NICE): Public health guideline on vitamin D – Supplement use in specific population groups, updated 2017. 2014.