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Relationship Between Dementia and Comorbid Diseases

Yıl 2018, Cilt: 1 Sayı: 2, 32 - 39, 29.10.2018

Öz

Aim: Dementia
is an increasingly frequent health problem worldwide. It is known that comorbid
disease prevelance is high in dementia patients. Dementia can challenge the
management of comorbid diseases and the ability of patients to manage chronic
conditions. The aim of this study is to assess the relationship between
dementia and comorbidity.

Methods: 2264 patients aged 60 years and over were included
in the study. Patients were divided into 2 groups who have dementia
and
no dementia. Chronic disease
information, socio-demographic data, drug numbers were evaluated
retrospectively from patient follow-up files.
The results obtained were
compared among the patient groups.

Results: The
mean age of 1767 non-demented patients was 74.36 ± 8.5, and the mean age of 497
demented patients was 78.06 ± 8.48. Hypertension was the most common chronic
disease in both groups of patients. The total number of comorbid diseases in the
non-demented group was 3.06, and in demented group was 2.69. The Charlson
Comorbidity Index was significantly higher in the demented patient group (p
<0.001).



Conclusion: It is known that comorbid diseases such as
diabetes, hypertension and hypercholesterolemia play role in dementia risk, but
these findings suggest that vascular risk factors in etiopathogenesis of
dementia might not be forefront and other risk factors may take part of disease
development.

Kaynakça

  • Alzheimer's Disease International. Policy Brief for G8 Heads of Government. The Global Impact of Dementia 2013-2050. London: Alzheimer's Disease International; 2013.
  • Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ. Prevalence and impact of medical comorbidity in Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2002; 57:M173–M177.
  • Leon J, Cheng CK, Neumann PJ. Alzheimer’s disease care: costs and potential savings. Health Aff (Millwood). 1998; 17:206.
  • Schubert CC, Boustani M, Callahan CM, Perkins AJ, Carney CP, Fox C, Unverzagt F, Hui S, Hendrie HC: Comorbidity profile of dementia patients in primary care: are they sicker? J Am Geriatr Soc. 2006;54:104–109.
  • Kuo TC, Zhao Y, Weir S, Kramer MS, Ash AS. Implications of comorbidity on costs for patients with Alzheimer disease. Med Care. 2008;46:839–846.
  • Richards M, Brayne C. What do we mean by Alzheimer’s disease? BMJ. 2010; 341:c4670.
  • Skoog I. Vascular aspects in Alzheimer’s disease. J Neural Transm Suppl. 2000; 59:37.
  • Barnett K, Mercer SW, Norbury M, Watt G, et al. Epidemiology of multimorbidity and implications for healthcare, research, and medical education: A cross-sectional study, Lancet. 2012; 380:37–43.
  • Savva GM, Stephan BC. Alzheimer’s Society Vascular Dementia Systematic Review Group: Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke. 2010; 41:e41–e46.
  • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006; 5:64–74.
  • Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA. 2009; 301:1565–1572.
  • Sampson EL, Blanchard MR, Jones L, Tookman A, King M. Dementia in the acute hospital: prospective cohort study of prevalence and mortality. Br J Psychiatry. 2009; 195:61–66.
  • Keenan TD, Goldacre R, Goldacre MJ. Associations between age-related macular degeneration, Alzheimer disease, and dementia: record linkage study of hospital admissions. JAMA Ophthalmol. 2014; 132:63–68.
  • Sinclair AJ, Girling AJ, Bayer AJ. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. Diabetes Res Clin Pract. 2000; 50:203–212.
  • Bakker C, de Vugt ME, van Vliet D, et al. Predictors of the time to institutionalization in young- versus late-onset dementia: Results from the Needs in Young Onset Dementia (NeedYD) study. J Am Med Dir Assoc. 2013;14:248e253.
  • Ory MG, Hoffman RR 3rd, Yee JL, et al. Prevalence and impact of caregiving: A detailed comparison between dementia and nondementia caregivers. Gerontologist. 1999;39:177e185.
  • Pinquart M, Sorensen S. Correlates of physical health of informal caregivers: A meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2007;62:P126eP137.
  • Charlson ME, Pompei P. Ales KL, MacKenzie R. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987; 40 (5): 373-383.
  • Babacan-Yildiz G, Isik AT, Ur E, Aydemir E, Ertas C, Cebi M, Soysal P, Gursoy E, Kolukisa M, Kocaman G, Celebi A. COST: Cognitive State Test, a brief screening battery for Alzheimer disease in illiterate and literate patients. Int Psychogeriatr. 2013;25(3):403-12.
  • Poblador-Plou B, Calderón-Larrañaga A, Marta-Moreno J, Hancco-Saavedra J, et al. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry. 2014;14:84.
  • Sanderson M, Wang J, Davis DR, Lane MJ, et al. Co-morbidity associated with dementia. Am J Alzheimers Dis Other Demen. 2002; 17:73–78.
  • Duthie A, Chew D, Soiza RL. Non-psychiatric comorbidity associated with Alzheimer's disease. QJM. 2011;104:913–920.
  • Chen TB, Yiao SY, Sun Y, Lee HJ, et al. Comorbidity and dementia: A nationwide survey in Taiwan. PLoS ONE. 12(4):e0175475.
  • Wolf-Klein GP, Siverstone FA, Brod MS, et al. Are Alzheimer patients healthier? J Am Geriatr Soc. 1988; 36: 219–24.
  • Holstein J, Chatellier G, Piette F, et al. Prevalence of associated diseases in different types of dementia among elderly institutionalized patients: analysis of 3447 records. JAmGeriatr Soc. 1994; 42: 972–7.
  • Landi F, Onder G, Cattel C, et al. Functional status and clinical correlates in cognitively impaired community-living older people. J GeriatrPsychiatry Neurol. 2001; 14: 21–7.
  • Landi F, Gambassi G, Lapane KL, et al. Comorbidity and drug use in cognitively impaired elderly living in long-term care. Dement Geriatr Cogn Disord. 1998; 9: 347–56.
  • Zekry D, Herrmann FR, Grandjean R, Meynet MP, et al. Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age and Ageing. 2008; 37: 83–89.
  • Lopponen MK, Isoaho RE, Raiha IJ, et al. Undiagnosed diseases in patients with dementia-a potential target group for intervention. Dement Geriatr Cogn Disord. 2004; 18: 321–9.
  • Hill JW, Futterman R, Duttagupta S, et al. Alzheimer’s disease and related dementias increase costs of comorbidities in managed Medicare. Neurology. 2002; 58: 62–70.
  • Tirumalasetti F, Han L, Birkett DP. The relationship between cancer and Alzheimer’s disease. J Am Geriatr Soc. 1991; 39: 840.
  • Desouky LA. The relationship between cancer and Alzheimer’s disease. J Am Geriatr Soc. 1992; 40: 1075.
  • Işık AT. Demans, Editörler; Işık AT, Çelik T, Geriatri Pratiğinde İlaç Tedavisi, 1. baskı, İzmir, O Tıp Kitabevi, 2015, 84-112.
  • Ateş Bulut E, Soysal P, Işık AT. Demans. Editörler: Soysal P, Işık AT. Geriatri Pratiğinde Geriatrik Sendromlar, 1. Baskı, İzmir, US Akademi Yayınevi, 2018, 73-133.

Demans ve Komorbid Hastalıklarla İlişkisi

Yıl 2018, Cilt: 1 Sayı: 2, 32 - 39, 29.10.2018

Öz

Amaç: Demans,
dünya genelinde sıklığı giderek artan bir sağlık problemidir. Demans
hastalarında komorbid hastalık sıklığının yüksek olduğu bilinmektedir. Demans
varlığı, komorbid hastalıkların yönetimini ve hastaların kronik durumu yönetme
becerisini zorlaştırabilir. Bu çalışmanın amacı, demans ve komorbidite
ilişkisini değerlendirmektir.

Metod: Çalışmaya,
60
yaş ve üstü, 2264
hasta
alındı. Hastalar demansı
olan ve olmayan olmak üzere 2 gruba ayrıldı. Kronik hastalık bilgileri,
sosyo-demografik verileri, ilaç sayılarına dair veriler
hasta takip dosyalarından elde edilerek retrospektif
olarak değerlendirildi. Elde edilen sonuçlar hasta grupları arasında
karşılaştırıldı.

Bulgular:
Çalışmaya
dahil edilen demansı olmayan 1767 hastanın yaş ortalaması 74,36 ± 8,5, demansı
olan 497 hastanın yaş ortalaması ise 78.06 ± 8,48 idi. Her iki hasta grubunda
en sık görülen kronik hastalık hipertansiyondu. Demansı olan hastalarda ortalama komorbid hastalık
sayısı ise
2,69, demansı olmayanlarda ise 3,06 idi. Demansı olan hastalarda
Charlson Komorbidite
İndeksi anlamlı olarak daha yüksek bulundu (
p<0.001).



Sonuç:
Bu bulgular, demans gelişiminde diyabet,
hipertansiyon, hiperkolesterolemi gibi komorbid hastalıkların risk faktörü
olarak rol oynadığı bilinse de etiyopatogenezde vasküler risk faktörlerinin ön
planda yer almadığı, hastalık gelişiminde başka faktörlerin de yer aldığını
düşündürmektedir.

Kaynakça

  • Alzheimer's Disease International. Policy Brief for G8 Heads of Government. The Global Impact of Dementia 2013-2050. London: Alzheimer's Disease International; 2013.
  • Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ. Prevalence and impact of medical comorbidity in Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2002; 57:M173–M177.
  • Leon J, Cheng CK, Neumann PJ. Alzheimer’s disease care: costs and potential savings. Health Aff (Millwood). 1998; 17:206.
  • Schubert CC, Boustani M, Callahan CM, Perkins AJ, Carney CP, Fox C, Unverzagt F, Hui S, Hendrie HC: Comorbidity profile of dementia patients in primary care: are they sicker? J Am Geriatr Soc. 2006;54:104–109.
  • Kuo TC, Zhao Y, Weir S, Kramer MS, Ash AS. Implications of comorbidity on costs for patients with Alzheimer disease. Med Care. 2008;46:839–846.
  • Richards M, Brayne C. What do we mean by Alzheimer’s disease? BMJ. 2010; 341:c4670.
  • Skoog I. Vascular aspects in Alzheimer’s disease. J Neural Transm Suppl. 2000; 59:37.
  • Barnett K, Mercer SW, Norbury M, Watt G, et al. Epidemiology of multimorbidity and implications for healthcare, research, and medical education: A cross-sectional study, Lancet. 2012; 380:37–43.
  • Savva GM, Stephan BC. Alzheimer’s Society Vascular Dementia Systematic Review Group: Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke. 2010; 41:e41–e46.
  • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006; 5:64–74.
  • Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA. 2009; 301:1565–1572.
  • Sampson EL, Blanchard MR, Jones L, Tookman A, King M. Dementia in the acute hospital: prospective cohort study of prevalence and mortality. Br J Psychiatry. 2009; 195:61–66.
  • Keenan TD, Goldacre R, Goldacre MJ. Associations between age-related macular degeneration, Alzheimer disease, and dementia: record linkage study of hospital admissions. JAMA Ophthalmol. 2014; 132:63–68.
  • Sinclair AJ, Girling AJ, Bayer AJ. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. Diabetes Res Clin Pract. 2000; 50:203–212.
  • Bakker C, de Vugt ME, van Vliet D, et al. Predictors of the time to institutionalization in young- versus late-onset dementia: Results from the Needs in Young Onset Dementia (NeedYD) study. J Am Med Dir Assoc. 2013;14:248e253.
  • Ory MG, Hoffman RR 3rd, Yee JL, et al. Prevalence and impact of caregiving: A detailed comparison between dementia and nondementia caregivers. Gerontologist. 1999;39:177e185.
  • Pinquart M, Sorensen S. Correlates of physical health of informal caregivers: A meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2007;62:P126eP137.
  • Charlson ME, Pompei P. Ales KL, MacKenzie R. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987; 40 (5): 373-383.
  • Babacan-Yildiz G, Isik AT, Ur E, Aydemir E, Ertas C, Cebi M, Soysal P, Gursoy E, Kolukisa M, Kocaman G, Celebi A. COST: Cognitive State Test, a brief screening battery for Alzheimer disease in illiterate and literate patients. Int Psychogeriatr. 2013;25(3):403-12.
  • Poblador-Plou B, Calderón-Larrañaga A, Marta-Moreno J, Hancco-Saavedra J, et al. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry. 2014;14:84.
  • Sanderson M, Wang J, Davis DR, Lane MJ, et al. Co-morbidity associated with dementia. Am J Alzheimers Dis Other Demen. 2002; 17:73–78.
  • Duthie A, Chew D, Soiza RL. Non-psychiatric comorbidity associated with Alzheimer's disease. QJM. 2011;104:913–920.
  • Chen TB, Yiao SY, Sun Y, Lee HJ, et al. Comorbidity and dementia: A nationwide survey in Taiwan. PLoS ONE. 12(4):e0175475.
  • Wolf-Klein GP, Siverstone FA, Brod MS, et al. Are Alzheimer patients healthier? J Am Geriatr Soc. 1988; 36: 219–24.
  • Holstein J, Chatellier G, Piette F, et al. Prevalence of associated diseases in different types of dementia among elderly institutionalized patients: analysis of 3447 records. JAmGeriatr Soc. 1994; 42: 972–7.
  • Landi F, Onder G, Cattel C, et al. Functional status and clinical correlates in cognitively impaired community-living older people. J GeriatrPsychiatry Neurol. 2001; 14: 21–7.
  • Landi F, Gambassi G, Lapane KL, et al. Comorbidity and drug use in cognitively impaired elderly living in long-term care. Dement Geriatr Cogn Disord. 1998; 9: 347–56.
  • Zekry D, Herrmann FR, Grandjean R, Meynet MP, et al. Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age and Ageing. 2008; 37: 83–89.
  • Lopponen MK, Isoaho RE, Raiha IJ, et al. Undiagnosed diseases in patients with dementia-a potential target group for intervention. Dement Geriatr Cogn Disord. 2004; 18: 321–9.
  • Hill JW, Futterman R, Duttagupta S, et al. Alzheimer’s disease and related dementias increase costs of comorbidities in managed Medicare. Neurology. 2002; 58: 62–70.
  • Tirumalasetti F, Han L, Birkett DP. The relationship between cancer and Alzheimer’s disease. J Am Geriatr Soc. 1991; 39: 840.
  • Desouky LA. The relationship between cancer and Alzheimer’s disease. J Am Geriatr Soc. 1992; 40: 1075.
  • Işık AT. Demans, Editörler; Işık AT, Çelik T, Geriatri Pratiğinde İlaç Tedavisi, 1. baskı, İzmir, O Tıp Kitabevi, 2015, 84-112.
  • Ateş Bulut E, Soysal P, Işık AT. Demans. Editörler: Soysal P, Işık AT. Geriatri Pratiğinde Geriatrik Sendromlar, 1. Baskı, İzmir, US Akademi Yayınevi, 2018, 73-133.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Saadet Koç Okudur 0000-0001-5034-3720

Özge Dokuzlar

Pınar Soysal

Ahmet Turan Işık

Yayımlanma Tarihi 29 Ekim 2018
Gönderilme Tarihi 31 Ağustos 2018
Kabul Tarihi 29 Ekim 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 1 Sayı: 2

Kaynak Göster

APA Koç Okudur, S., Dokuzlar, Ö., Soysal, P., Işık, A. T. (2018). Demans ve Komorbid Hastalıklarla İlişkisi. Geriatrik Bilimler Dergisi, 1(2), 32-39.
AMA Koç Okudur S, Dokuzlar Ö, Soysal P, Işık AT. Demans ve Komorbid Hastalıklarla İlişkisi. GBD. Ekim 2018;1(2):32-39.
Chicago Koç Okudur, Saadet, Özge Dokuzlar, Pınar Soysal, ve Ahmet Turan Işık. “Demans Ve Komorbid Hastalıklarla İlişkisi”. Geriatrik Bilimler Dergisi 1, sy. 2 (Ekim 2018): 32-39.
EndNote Koç Okudur S, Dokuzlar Ö, Soysal P, Işık AT (01 Ekim 2018) Demans ve Komorbid Hastalıklarla İlişkisi. Geriatrik Bilimler Dergisi 1 2 32–39.
IEEE S. Koç Okudur, Ö. Dokuzlar, P. Soysal, ve A. T. Işık, “Demans ve Komorbid Hastalıklarla İlişkisi”, GBD, c. 1, sy. 2, ss. 32–39, 2018.
ISNAD Koç Okudur, Saadet vd. “Demans Ve Komorbid Hastalıklarla İlişkisi”. Geriatrik Bilimler Dergisi 1/2 (Ekim 2018), 32-39.
JAMA Koç Okudur S, Dokuzlar Ö, Soysal P, Işık AT. Demans ve Komorbid Hastalıklarla İlişkisi. GBD. 2018;1:32–39.
MLA Koç Okudur, Saadet vd. “Demans Ve Komorbid Hastalıklarla İlişkisi”. Geriatrik Bilimler Dergisi, c. 1, sy. 2, 2018, ss. 32-39.
Vancouver Koç Okudur S, Dokuzlar Ö, Soysal P, Işık AT. Demans ve Komorbid Hastalıklarla İlişkisi. GBD. 2018;1(2):32-9.

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