Yaşlılarda Serum Homosistein Düzeyi ile Osteoporoz Arasında İlişki Var mı?

Yıl 2021, Cilt: 4 Sayı: 1, 9 - 14, 30.04.2021

Mehmet Selman Öntan , Özge Dokuzlar

https://doi.org/10.47141/geriatrik.919473

Cited By: 1

Öz

Amaç: Osteoporoz ilerleyen yaşla sıklığı artan, çok sayıda morbidite, mortalite ve artan sağlık harcamalarına yol açan bir sorundur. Homosistinüri hastalarında erken yaşta görülen osteoporoz serum homosistein düzeyi ile osteoporoz arasında ilişki olabileceğini düşündürmüştür. Bu çalışmanın amacı, yaşlı erişkinlerde serum homosistein düzeyi ile osteoporoz arasında herhangi bir ilişki olup olmadığının araştırılmasıdır.

Gereç ve Yöntemler: Çalışmaya 65 yaş ve üzeri dosyalarında eş zamanlı dual enerji X-ray absorbsiyometri (DEXA) ve serum homosistein seviyesi olan 168 hasta dahil edildi. Hastaların dosyalarında yer alan demografik veriler, DEXA ölçümleri, serum homosistein düzeyi ve laboratuvar analizleri kaydedildi. Retrospektif ve kesitsel bir çalışma olarak dizayn edildi.

Bulgular: Katılımcıların yaş ortalaması 75,79±7,40 yıl ve %74,4’ü kadın idi. 67 hastada osteoporoz, 80 hastada osteopeni saptandı. Kontrol, osteopeni ve osteoporoz gruplarında serum homosistein düzeyleri sırası ile 15,01±5,84, 15,42±7,09 ve 15,61±7,88 mmol/L idi. Vitamin B12, Folat, Vitamin D ve TSH düzeyleri gruplar arasında anlamlı fark yoktu. Gruplar arasında yaş, cinsiyet ve vücut kitle indekslerinin karıştırıcı etkileri ortadan kaldırıldıktan sonra artmış serum homosistein düzeyleri ile osteoporoz arasında anlamlı ilişki saptandı (OR:1,114; p<0,05). Diğer sonuçlarda ise istatistiksel anlamlı bir değişiklik olmadı.

Sonuç: Yüksek serum homosistein düzeylerinin yaşlı erişkinlerde sık ve önemli bir sorun olan osteoporoz riskini artırdığı saptanmıştır. Bu sonuçların desteklenmesi ve nedenlerinin aydınlatılması için prospektif çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

homosistein, osteopeni, osteoporoz, yaşlı

Destekleyen Kurum

yoktur

Is There a Relationship Between Serum Homocysteine Level and Osteoporosis in Older Adults?

Öz

Aim: Osteoporosis is an important clinical condition that is quite common in older adults and is related to many morbidities, mortality, and increased healthcare costs. Early osteoporosis in patients with homocystinuria suggests that there may be a relationship between serum homocysteine level and osteoporosis. The aim of this study is to investigate whether there is any relationship between serum homocysteine level and osteoporosis in older adults.

Material and Methods: The study included 168 patients aged 65 years and older who have simultaneous dual-energy X-ray absorptiometry (DEXA) and serum homocysteine levels. Demographic data, DEXA measurements, serum homocysteine level, and laboratory analysis in the patients' files were recorded. The study was designed as a retrospective and cross-sectional study.

Results: The average age of the participants was 75.79 ± 7.40 years, and 74.4% of them were women. Osteoporosis and osteopenia were diagnosed in 67 and 80 patients, respectively. Serum homocysteine levels in the control, osteopenia, and osteoporosis groups were 15.01 ± 5.84, 15.42 ± 7.09, and 15.61 ± 7.88 mmol/L, respectively. There was no significant difference in Vitamin B12, Folate, Vitamin D, and TSH levels between the groups. After the confounding effects of age, gender, and body mass index were eliminated between the groups, a significant relationship was found between increased serum homocysteine levels and osteoporosis (OR:1.114; p <0.05). There was no statistically significant change in other results.

Conclusion: It has been determined that high serum homocysteine levels increase the risk of osteoporosis, which is a common and significant problem in older adults. Prospective studies are needed to support these results and clarify the reasons.

Anahtar Kelimeler

Homocysteine, older adults, osteopenia, osteoporosis

Kaynakça

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