The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Davut Bozkaya; Ebru Ergenekon; Aysegul Yucel; Sengul Ozdek; İbrahim Hirfanoglu; Ozden Turan; Canan Turkyilmaz; Esra Onal; Esin Koc; Yıldız Atalay

doi:10.16899/gopctd.535602

The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Öz

Introduction: Most important factors in retinopathy of prematurity (ROP) are prematurity and oxygen toxicity although blood transfusions, insulin like growth factor-1 ( IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular endothelial growth factor (VEGF) also have important roles.

The objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm newborns before and after blood transfusion and assess if the effect of transfusion in development of ROP is via these mediators, and to investigate whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA) were different in preterm newborns with and without ROP.

Material and Methods: Preterm newborns with gestational age ≤34 weeks were included and blood samples were obtained before and after red blood cell (RBC) transfusion.

Results: Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2: n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC tranfusion. Excluding the patient with stage 3 ROP all ROP patients were referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3 levels of the patients with and without mild ROP. Patients with mild ROP had significantly more number of transfusions.

Conclusions: Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and IGF-1 were not associated of ROP.

Anahtar Kelimeler

Retinopathy of prematurity,IGF-1,IGFBP-3

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Davut Bozkaya ^*
0000-0001-5548-7387
Türkiye

Ebru Ergenekon Bu kişi benim

Aysegul Yucel Bu kişi benim

Sengul Ozdek Bu kişi benim

İbrahim Hirfanoglu Bu kişi benim

Ozden Turan

Canan Turkyilmaz Bu kişi benim

Esra Onal Bu kişi benim

Esin Koc

Yıldız Atalay Bu kişi benim

Yayımlanma Tarihi

27 Mart 2019

Gönderilme Tarihi

4 Mart 2019

Kabul Tarihi

12 Mart 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 9 Sayı: 1

DOI

https://doi.org/10.16899/gopctd.535602

IZ

https://izlik.org/JA49GH67CX

Kaynak Göster

RIS / Bibtex

APA

Bozkaya, D., Ergenekon, E., Yucel, A., Ozdek, S., Hirfanoglu, İ., Turan, O., Turkyilmaz, C., Onal, E., Koc, E., & Atalay, Y. (2019). The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi, 9(1), 9-14. https://doi.org/10.16899/gopctd.535602

AMA

1.Bozkaya D, Ergenekon E, Yucel A, vd. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 2019;9(1):9-14. doi:10.16899/gopctd.535602

Chicago

Bozkaya, Davut, Ebru Ergenekon, Aysegul Yucel, vd. 2019. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi 9 (1): 9-14. https://doi.org/10.16899/gopctd.535602.

EndNote

Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y (01 Mart 2019) The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi 9 1 9–14.

IEEE

[1]D. Bozkaya vd., “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”, J Contemp Med, c. 9, sy 1, ss. 9–14, Mar. 2019, doi: 10.16899/gopctd.535602.

ISNAD

Bozkaya, Davut - Ergenekon, Ebru - Yucel, Aysegul - Ozdek, Sengul - Hirfanoglu, İbrahim - Turan, Ozden - Turkyilmaz, Canan - Onal, Esra - Koc, Esin - Atalay, Yıldız. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi 9/1 (01 Mart 2019): 9-14. https://doi.org/10.16899/gopctd.535602.

JAMA

1.Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 2019;9:9–14.

MLA

Bozkaya, Davut, vd. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi, c. 9, sy 1, Mart 2019, ss. 9-14, doi:10.16899/gopctd.535602.

Vancouver

1.Davut Bozkaya, Ebru Ergenekon, Aysegul Yucel, Sengul Ozdek, İbrahim Hirfanoglu, Ozden Turan, Canan Turkyilmaz, Esra Onal, Esin Koc, Yıldız Atalay. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 01 Mart 2019;9(1):9-14. doi:10.16899/gopctd.535602