Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review.

Cilt: 4 Sayı: 2 EK 11 Eylül 2014
  • Sharmila Dudani
  • Shivani Kalhan
  • Sonia Sharma
  • Anshu Gupta
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Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review.

Öz

 Gastrointestinal stromal tumours ( GISTs) are the most common  mesenchymal tumours of the GI tract. They occur most frequently in stomach (60-70%), or small intestine(SI) ( 25-30%). Rare sites include colon, rectum, appendix and esophagus (<10%). On histology their appearance varies from cellular spindle cell tumours to epithelioid to pleomorphic tumours. Traditionally, three criteria have been used to determine malignancy, which include site of origin (SI and rectal tumours  are more aggressive than stomach tumours), tumour size( >5 cm) and mitotic rate.(>5/50 hpf ).GISTs are characterized by gain of function mutation in c kit (CD117) proto oncogene most commonly involving exon 11. GISTs without c kit mutation show mutations in  platelet derived growth factor receptor alpha( PDGFRα).Surgery has been the standard treatment for resectable GISTs, but  metastatic and unresectable GISTs had a poor prognosis. Recent molecular advances have opened new vistas leading to the development of specific molecular targeted therapies which stabilize the disease and reduce the frequency of disease recurrence. This review summarizes our existing knowledge, recent advances regarding histogenesis, pathology, molecular biology, and targeted cancer therapies which has revolutionized the management of these diseases.

 

 

Anahtar Kelimeler

Kaynakça

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  6. 6. Goettsch WG, Bos SD, Breekveldt- Postma N, Casparie M, Herings RM, Hoogendoorn PC. Incidence of gastrointestinal stromal tumours is underestimated. Results of a nationwide study. Eur J Cancer 2005; 41: 2868-2872.
  7. 7. Long KB, Butryuski JE, Blank SD, Ebrahim KS, Dressel DM, Heinrich MC et al. Primary extra gastrointestinal tumour of the pleura. Report of a unique case with genetic confirmation. Am J Surg Pathol 2010; 34: 907-12.
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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Sharmila Dudani Bu kişi benim

Shivani Kalhan Bu kişi benim

Sonia Sharma Bu kişi benim

Anshu Gupta Bu kişi benim

Yayımlanma Tarihi

11 Eylül 2014

Gönderilme Tarihi

11 Eylül 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2014 Cilt: 4 Sayı: 2 EK

IZ

https://izlik.org/JA84UR68JY

Kaynak Göster

RIS / Bibtex
APA
Dudani, S., Kalhan, S., Sharma, S., & Gupta, A. (2014). Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review. Çağdaş Tıp Dergisi, 4(2 EK), 100-90. https://izlik.org/JA84UR68JY
AMA
1.Dudani S, Kalhan S, Sharma S, Gupta A. Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review. J Contemp Med. 2014;4(2 EK):100-90. https://izlik.org/JA84UR68JY
Chicago
Dudani, Sharmila, Shivani Kalhan, Sonia Sharma, ve Anshu Gupta. 2014. “Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review”. Çağdaş Tıp Dergisi 4 (2 EK): 100-90. https://izlik.org/JA84UR68JY.
EndNote
Dudani S, Kalhan S, Sharma S, Gupta A (01 Ekim 2014) Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review. Çağdaş Tıp Dergisi 4 2 EK 100–90.
IEEE
[1]S. Dudani, S. Kalhan, S. Sharma, ve A. Gupta, “Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review”., J Contemp Med, c. 4, sy 2 EK, ss. 100–90, Eki. 2014, [çevrimiçi]. Erişim adresi: https://izlik.org/JA84UR68JY
ISNAD
Dudani, Sharmila - Kalhan, Shivani - Sharma, Sonia - Gupta, Anshu. “Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review”. Çağdaş Tıp Dergisi 4/2 EK (01 Ekim 2014): 100-90. https://izlik.org/JA84UR68JY.
JAMA
1.Dudani S, Kalhan S, Sharma S, Gupta A. Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review. J Contemp Med. 2014;4:100–90.
MLA
Dudani, Sharmila, vd. “Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review”. Çağdaş Tıp Dergisi, c. 4, sy 2 EK, Ekim 2014, ss. 100-90, https://izlik.org/JA84UR68JY.
Vancouver
1.Sharmila Dudani, Shivani Kalhan, Sonia Sharma, Anshu Gupta. Gastrointestinal stromal tumours (GIST)- Pathology and clinical applications of recent molecular advances --A perspective review. J Contemp Med [Internet]. 01 Ekim 2014;4(2 EK):100-90. Erişim adresi: https://izlik.org/JA84UR68JY