LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ

Serkan Yiğitkan; Abdulselam Ertaş; Mehmet Fırat; Yeter Yeşil; İlkay Erdoğan Orhan

LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ

Öz

3-Hidroksi-3-metil-glutaril-koenzim A (HMG-KoA) redüktaz enzimi kolesterol biyosentezinde görev alan anahtar enzimdir. Dolayısıyla HMG-KoA redüktaz inhibisyonu hiperkolesterolemi tedavisi için en önemli hedeflerden biridir. Diğer yandan, yeni ilaç keşfi araştırmalarında tıbbi bitkiler ve bunlardan izole edilen moleküller önemli bir yer tutmaktadır. Bu çalışmada, Türkiye’de yetişen ve daha önce bu enzime yönelik olarak üzerinde araştırma yapılmamış olan Lamiaceae familyasına ait 37 bitki taksonunun etanol ekstrelerinin in vitro HMG-KoA redüktaz enzim inhibisyon aktiviteleri ELISA mikroplak yöntemi kullanılarak araştırılmıştır. Taramamız sonucunda Salvia inhibitör etkili bulunan ekstreler, Salvia multicaulis Vahl. (% 61,66 ± 1,52) ve Salvia blepharochlaena Hedge & Hub.Mor. (% 55,21 ± 1,12) olarak tespit edilmiştir.

Anahtar Kelimeler

Destekleyen Kurum

Gazi Üniversitesi

Proje Numarası

02/2018-16

Teşekkür

Çalışmamızı 02/2018-16 proje kodu ile destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri Birimine teşekkür ederiz.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Serkan Yiğitkan Bu kişi benim
Türkiye

Abdulselam Ertaş
Türkiye

Mehmet Fırat
Türkiye

Yeter Yeşil Bu kişi benim
Türkiye

İlkay Erdoğan Orhan ^*
0000-0002-7379-5436
Türkiye

Yayımlanma Tarihi

31 Aralık 2020

Gönderilme Tarihi

18 Aralık 2020

Kabul Tarihi

6 Ocak 2021

Yayımlandığı Sayı

Yıl 2020 Cilt: 5 Sayı: 3

IZ

https://izlik.org/JA37AG22CP

Kaynak Göster

RIS / Bibtex

APA

Yiğitkan, S., Ertaş, A., Fırat, M., Yeşil, Y., & Erdoğan Orhan, İ. (2020). LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ. Gazi Sağlık Bilimleri Dergisi, 5(3), 24-33. https://izlik.org/JA37AG22CP

AMA

1.Yiğitkan S, Ertaş A, Fırat M, Yeşil Y, Erdoğan Orhan İ. LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ. Gazi Sağlık Bil. 2020;5(3):24-33. https://izlik.org/JA37AG22CP

Chicago

Yiğitkan, Serkan, Abdulselam Ertaş, Mehmet Fırat, Yeter Yeşil, ve İlkay Erdoğan Orhan. 2020. “LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ”. Gazi Sağlık Bilimleri Dergisi 5 (3): 24-33. https://izlik.org/JA37AG22CP.

EndNote

Yiğitkan S, Ertaş A, Fırat M, Yeşil Y, Erdoğan Orhan İ (01 Aralık 2020) LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ. Gazi Sağlık Bilimleri Dergisi 5 3 24–33.

IEEE

[1]S. Yiğitkan, A. Ertaş, M. Fırat, Y. Yeşil, ve İ. Erdoğan Orhan, “LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ”, Gazi Sağlık Bil, c. 5, sy 3, ss. 24–33, Ara. 2020, [çevrimiçi]. Erişim adresi: https://izlik.org/JA37AG22CP

ISNAD

Yiğitkan, Serkan - Ertaş, Abdulselam - Fırat, Mehmet - Yeşil, Yeter - Erdoğan Orhan, İlkay. “LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ”. Gazi Sağlık Bilimleri Dergisi 5/3 (01 Aralık 2020): 24-33. https://izlik.org/JA37AG22CP.

JAMA

1.Yiğitkan S, Ertaş A, Fırat M, Yeşil Y, Erdoğan Orhan İ. LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ. Gazi Sağlık Bil. 2020;5:24–33.

MLA

Yiğitkan, Serkan, vd. “LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ”. Gazi Sağlık Bilimleri Dergisi, c. 5, sy 3, Aralık 2020, ss. 24-33, https://izlik.org/JA37AG22CP.

Vancouver

1.Serkan Yiğitkan, Abdulselam Ertaş, Mehmet Fırat, Yeter Yeşil, İlkay Erdoğan Orhan. LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ. Gazi Sağlık Bil [Internet]. 01 Aralık 2020;5(3):24-33. Erişim adresi: https://izlik.org/JA37AG22CP