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Obezite Paradoksu

Yıl 2022, Cilt: 7 Sayı: 1, 164 - 172, 21.03.2022
https://doi.org/10.52881/gsbdergi.972930

Öz

Obezite, günümüzde gelişmekte olan ülkeler için tıpkı gelişmiş ülkeler gibi, bulaşıcı olmayan hastalıklar için bir risk faktörüdür. Obezite başta kardiyovasküler hastalıklar olmak üzere kanser, diyabet ve diğer bulaşıcı olmayan hastalıklar (BOH) ile birlikte bir prognoz izlemektedir. Yakın geleceğe kadar yapılan çalışmalarda BKİ değeri arttıkça risk faktörünün arttığını ve obezite ile birlikte BOH için zemin oluşturduğu saptanmıştır. Ancak son yapılan çalışmalar da görüyoruz ki Beden Kitle İndeksi (BKİ) 30’dan fazla olmasına rağmen aktif ve hareketli yaşayanlar, düşük BKİ’ye sahip ancak sedanter yaşayanlara kıyasla kronik hastalıklara daha az yakalanmaktadırlar. Bu durum ‘obezite paradoksu’ olarak tanımlanmaktadır. Obezite paradoksu teriminin literatürdeki yeri tartışmalı olup hastalıklar ile ilişkiler ve ortaya çıkışını etkileyen etmenler hakkında daha fazla çalışmaya ihtiyaç duyulmaktadır.

Kaynakça

  • 1. Flegal, Katherine; Kit, Brian; Orpana, Heather (2 January 2013). "Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories". Journal of the American Medical Association. 309 (1): 71–82.
  • 2. Carnethon, Mercedes; De Chaves, Peter John; Biggs, Mary (8 August 2012). "Association of Weight Status with Mortality in Adults with Incident Diabetes". Journal of the American Medical Association. 308 (6): 581–90.
  • 3. Schmidt, Darren S.; Salahudeen, Abdulla K. (2007). "Cardıovascular And Survıval Paradoxes In Dıalysıs Patıents: Obesity-Survival Paradox-Still a Controversy?". Seminars in Dialysis. 20 (6): 486–92.
  • 4. Kalantar-Zadeh, Kamyar; Block, Gladys; Horwich, Tamara; Fonarow, Gregg C (2004). "Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure". Journal of the American College of Cardiology. 43 (8): 1439–44.
  • 5. Sharma, A; Lavie, CJ; Borer, JS; Vallakati, A; Goel, S; Lopez-Jimenez, F; Arbab-Zadeh, A; Mukherjee, D; Lazar, JM (15 May 2015). "Meta-analysis of the relation of body mass index to all-cause and cardiovascular mortality and hospitalization in patients with chronic heart failure" (PDF). The American Journal of Cardiology. 115 (10): 1428–34.
  • 6. Padwal, R; McAlister, F A; McMurray, J J V; Cowie, M R; Rich, M; Pocock, S; Swedberg, K; Maggioni, A; Gamble, G; Ariti, C; Earle, N; Whalley, G; Poppe, K K; Doughty, R N; Bayes-Genis, A (31 October 2013). "The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data". International Journal of Obesity. 38 (8): 1110–1114.
  • 7. Wang, L; Liu, W; He, X; Chen, Y; Lu, J; Liu, K; Cao, K; Yin, P (4 September 2015). "Association of overweight and obesity with patient mortality after acute myocardial infarction: A meta-analysis of prospective studies". International Journal of Obesity. 40 (2): 220–8.
  • 8. Niedziela, J; Hudzik, B; Niedziela, N; Gąsior, M; Gierlotka, M; Wasilewski, J; Myrda, K; Lekston, A; Poloński, L; Rozentryt, P (November 2014). "The obesity paradox in acute coronary syndrome: a meta-analysis". European Journal of Epidemiology. 29 (11): 801–12.
  • 9. Cao, Chao; Wang, Ran; Wang, Jianmiao; Bunjhoo, Hansvin; Xu, Yongjian; Xiong, Weining; Simpson, Colin (24 August 2012). "Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis". PLOS ONE. 7 (8): e43892.
  • 10. Gruberg, L., Weissman, N. J., Waksman, R., Fuchs, S., Deible, R., Pinnow, E. E., ... & Satler, L. F. (2002). The impact of obesity on the short-term andlong-term outcomes after percutaneous coronary intervention: the obesity paradox?. Journal of the American College of Cardiology, 39(4), 578-584.
  • 11. Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Normal weight obesity: A risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2010;31:737–746.
  • 12. Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA. Body mass index and mortality in heart failure: a meta-analysis. Am Heart J 2008;156(1):13-22.
  • 13. Fonarow GC, Srikanthan P, Costanzo MR, et al. An obesity paradox in acute heart failure: Analysis of body mass index and inhospital mortality for 108,927 patients in the Acute Decompensated Heart Failure National Registry. Am Heart J. 2007;153:74–81.
  • 14. Lee, S. Y., Kim, H. L., Kim, M. A., Park, J. J., Choi, D. J., Kim, J. J., ... & Cho, M. C. (2021). Obesity paradox in Korean male and female patients with heart failure: a report from the Korean Heart Failure Registry. International Journal of Cardiology, 325, 82-88.
  • 15. Rodríguez-Reyes, H., Lara-Vaca, S., Ochoa-Guzmán, A., Chiquete, E., Abundes-Velasco, A., Acevedo-Zepeda, C., ... & Zúñiga-Sedano, J. G. (2021). Obesity paradox and 12 month outcome in patients with atrial fibrillation. Archives of Medical Research, 52(2), 233-239.
  • 16. Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308:581–590.
  • 17. Kokkinos P., Myers J., Faselis C., Doumas M, Kheirbek R.,and Nylen, E., BMI–Mortality Paradox and Fitness in African American and Caucasian Men With Type 2 Diabetes, Diabetes Care. 2012 May;35(5):1021-7.
  • 18. Tseng, C. H. (2013). Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis, 226(1), 186-192.
  • 19. Thomas, G., Khunti, K., Curcin, V., Molokhia, M., Millett, C., Majeed, A., & Paul, S. (2014). Obesity paradox in people newly diagnosed with type 2 diabetes with and without prior cardiovascular disease. Diabetes, Obesity and Metabolism, 16(4), 317-325.
  • 20. Lee, E. Y., Lee, Y. H., Yi, S. W., Shin, S. A., & Yi, J. J. (2017). BMI and all-cause mortality in normoglycemia, impaired fasting glucose, newly diagnosed diabetes, and prevalent diabetes: a cohort study. Diabetes Care, 40(8), 1026-1033.
  • 21. Martinez-Tapia, C., Diot, T., Oubaya, N., Paillaud, E., Poisson, J., Gisselbrecht, M., ... & Canouï-Poitrine, F. (2021). The obesity paradox for mid-and long-term mortality in older cancer patients: a prospective multicenter cohort study. The American Journal of Clinical Nutrition, 113(1), 129-141.
  • 22. Chung, I. Y., Lee, J. W., Lee, J. S., Park, Y. R., Min, Y. H., Lee, Y., ... & Ahn, S. H. (2017). Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer. PLoS One, 12(3), e0170311.
  • 23. Parker, A. S., Lohse, C. M., Cheville, J. C., Thiel, D. D., Leibovich, B. C., & Blute, M. L. (2006). Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology, 68(4), 741-746.
  • 24. Choi, Y., Park, B., Jeong, B. C., Seo, S. I., Jeon, S. S., Choi, H. Y., ... & Lee, H. M. (2013). Body mass index and survival in patients with renal cell carcinoma: a clinical‐based cohort and meta‐analysis. International journal of cancer, 132(3), 625-634.
  • 25. Ferro, M., Vartolomei, M. D., Russo, G. I., Cantiello, F., Farhan, A. R. A., Terracciano, D., ... & Lucarelli, G. (2019). An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer. World journal of urology, 37(3), 507-514.
  • 26. Lam, V. K., Bentzen, S. M., Mohindra, P., Nichols, E. M., Bhooshan, N., Vyfhuis, M., ... & Feliciano, J. L. (2017). Obesity is associated with long-term improved survival in definitively treated locally advanced non-small cell lung cancer (NSCLC). Lung Cancer, 104, 52-57.
  • 27. Zhang, X., Liu, Y., Shao, H., & Zheng, X. (2017). Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications. Journal of Thoracic Oncology, 12(10), 1478-1488.
  • 28. Ferguson, M. K., Im, H. K., Watson, S., Johnson, E., Wigfield, C. H., & Vigneswaran, W. T. (2014). Association of body mass index and outcomes after major lung resection. European Journal of Cardio-Thoracic Surgery, 45(4), e94-e99.
  • 29. Carson, K. R., Bartlett, N. L., McDonald, J. R., Luo, S., Zeringue, A., Liu, J., ... & Colditz, G. A. (2012). Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma. Journal of Clinical Oncology, 30(26), 3217.
  • 30. Weiss, L., Melchardt, T., Habringer, S., Boekstegers, A., Hufnagl, C., Neureiter, D., ... & Egle, A. (2014). Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma. Annals of oncology, 25(1), 171-176.
  • 31. Brunner, A. M., Sadrzadeh, H., Feng, Y., Drapkin, B. J., Ballen, K. K., Attar, E. C., ... & Fathi, A. T. (2013). Association between baseline body mass index and overall survival among patients over age 60 with acute myeloid leukemia. American journal of hematology, 88(8), 642-646.
  • 32. Amankwah, E. K., Saenz, A. M., Hale, G. A., & Brown, P. A. (2016). Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis. Leukemia & lymphoma, 57(5), 1140-1148.

Obesity Paradox

Yıl 2022, Cilt: 7 Sayı: 1, 164 - 172, 21.03.2022
https://doi.org/10.52881/gsbdergi.972930

Öz

Obesity is a risk factor for non-communicable diseases for developing countries today, just like developed countries. Obesity follows a prognosis with cancer, diabetes and other non-communicable diseases (NCD), especially cardiovascular diseases. In studies conducted until the near future, it has been determined that as BMI value increases, the risk factor increases and creates a basis for NCD with obesity. However, in recent studies, we see that although the Body Mass Index (BMI) is more than 30, those who live active and active, have less chronic diseases compared to those who have low BMI but live sedentary. This situation is defined as "obesity paradox". The place of the term obesity paradox in the literature is controversial, and more studies are needed on the relationships with diseases and the factors affecting their occurrence.

Kaynakça

  • 1. Flegal, Katherine; Kit, Brian; Orpana, Heather (2 January 2013). "Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories". Journal of the American Medical Association. 309 (1): 71–82.
  • 2. Carnethon, Mercedes; De Chaves, Peter John; Biggs, Mary (8 August 2012). "Association of Weight Status with Mortality in Adults with Incident Diabetes". Journal of the American Medical Association. 308 (6): 581–90.
  • 3. Schmidt, Darren S.; Salahudeen, Abdulla K. (2007). "Cardıovascular And Survıval Paradoxes In Dıalysıs Patıents: Obesity-Survival Paradox-Still a Controversy?". Seminars in Dialysis. 20 (6): 486–92.
  • 4. Kalantar-Zadeh, Kamyar; Block, Gladys; Horwich, Tamara; Fonarow, Gregg C (2004). "Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure". Journal of the American College of Cardiology. 43 (8): 1439–44.
  • 5. Sharma, A; Lavie, CJ; Borer, JS; Vallakati, A; Goel, S; Lopez-Jimenez, F; Arbab-Zadeh, A; Mukherjee, D; Lazar, JM (15 May 2015). "Meta-analysis of the relation of body mass index to all-cause and cardiovascular mortality and hospitalization in patients with chronic heart failure" (PDF). The American Journal of Cardiology. 115 (10): 1428–34.
  • 6. Padwal, R; McAlister, F A; McMurray, J J V; Cowie, M R; Rich, M; Pocock, S; Swedberg, K; Maggioni, A; Gamble, G; Ariti, C; Earle, N; Whalley, G; Poppe, K K; Doughty, R N; Bayes-Genis, A (31 October 2013). "The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data". International Journal of Obesity. 38 (8): 1110–1114.
  • 7. Wang, L; Liu, W; He, X; Chen, Y; Lu, J; Liu, K; Cao, K; Yin, P (4 September 2015). "Association of overweight and obesity with patient mortality after acute myocardial infarction: A meta-analysis of prospective studies". International Journal of Obesity. 40 (2): 220–8.
  • 8. Niedziela, J; Hudzik, B; Niedziela, N; Gąsior, M; Gierlotka, M; Wasilewski, J; Myrda, K; Lekston, A; Poloński, L; Rozentryt, P (November 2014). "The obesity paradox in acute coronary syndrome: a meta-analysis". European Journal of Epidemiology. 29 (11): 801–12.
  • 9. Cao, Chao; Wang, Ran; Wang, Jianmiao; Bunjhoo, Hansvin; Xu, Yongjian; Xiong, Weining; Simpson, Colin (24 August 2012). "Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis". PLOS ONE. 7 (8): e43892.
  • 10. Gruberg, L., Weissman, N. J., Waksman, R., Fuchs, S., Deible, R., Pinnow, E. E., ... & Satler, L. F. (2002). The impact of obesity on the short-term andlong-term outcomes after percutaneous coronary intervention: the obesity paradox?. Journal of the American College of Cardiology, 39(4), 578-584.
  • 11. Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Normal weight obesity: A risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2010;31:737–746.
  • 12. Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA. Body mass index and mortality in heart failure: a meta-analysis. Am Heart J 2008;156(1):13-22.
  • 13. Fonarow GC, Srikanthan P, Costanzo MR, et al. An obesity paradox in acute heart failure: Analysis of body mass index and inhospital mortality for 108,927 patients in the Acute Decompensated Heart Failure National Registry. Am Heart J. 2007;153:74–81.
  • 14. Lee, S. Y., Kim, H. L., Kim, M. A., Park, J. J., Choi, D. J., Kim, J. J., ... & Cho, M. C. (2021). Obesity paradox in Korean male and female patients with heart failure: a report from the Korean Heart Failure Registry. International Journal of Cardiology, 325, 82-88.
  • 15. Rodríguez-Reyes, H., Lara-Vaca, S., Ochoa-Guzmán, A., Chiquete, E., Abundes-Velasco, A., Acevedo-Zepeda, C., ... & Zúñiga-Sedano, J. G. (2021). Obesity paradox and 12 month outcome in patients with atrial fibrillation. Archives of Medical Research, 52(2), 233-239.
  • 16. Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308:581–590.
  • 17. Kokkinos P., Myers J., Faselis C., Doumas M, Kheirbek R.,and Nylen, E., BMI–Mortality Paradox and Fitness in African American and Caucasian Men With Type 2 Diabetes, Diabetes Care. 2012 May;35(5):1021-7.
  • 18. Tseng, C. H. (2013). Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis, 226(1), 186-192.
  • 19. Thomas, G., Khunti, K., Curcin, V., Molokhia, M., Millett, C., Majeed, A., & Paul, S. (2014). Obesity paradox in people newly diagnosed with type 2 diabetes with and without prior cardiovascular disease. Diabetes, Obesity and Metabolism, 16(4), 317-325.
  • 20. Lee, E. Y., Lee, Y. H., Yi, S. W., Shin, S. A., & Yi, J. J. (2017). BMI and all-cause mortality in normoglycemia, impaired fasting glucose, newly diagnosed diabetes, and prevalent diabetes: a cohort study. Diabetes Care, 40(8), 1026-1033.
  • 21. Martinez-Tapia, C., Diot, T., Oubaya, N., Paillaud, E., Poisson, J., Gisselbrecht, M., ... & Canouï-Poitrine, F. (2021). The obesity paradox for mid-and long-term mortality in older cancer patients: a prospective multicenter cohort study. The American Journal of Clinical Nutrition, 113(1), 129-141.
  • 22. Chung, I. Y., Lee, J. W., Lee, J. S., Park, Y. R., Min, Y. H., Lee, Y., ... & Ahn, S. H. (2017). Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer. PLoS One, 12(3), e0170311.
  • 23. Parker, A. S., Lohse, C. M., Cheville, J. C., Thiel, D. D., Leibovich, B. C., & Blute, M. L. (2006). Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology, 68(4), 741-746.
  • 24. Choi, Y., Park, B., Jeong, B. C., Seo, S. I., Jeon, S. S., Choi, H. Y., ... & Lee, H. M. (2013). Body mass index and survival in patients with renal cell carcinoma: a clinical‐based cohort and meta‐analysis. International journal of cancer, 132(3), 625-634.
  • 25. Ferro, M., Vartolomei, M. D., Russo, G. I., Cantiello, F., Farhan, A. R. A., Terracciano, D., ... & Lucarelli, G. (2019). An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer. World journal of urology, 37(3), 507-514.
  • 26. Lam, V. K., Bentzen, S. M., Mohindra, P., Nichols, E. M., Bhooshan, N., Vyfhuis, M., ... & Feliciano, J. L. (2017). Obesity is associated with long-term improved survival in definitively treated locally advanced non-small cell lung cancer (NSCLC). Lung Cancer, 104, 52-57.
  • 27. Zhang, X., Liu, Y., Shao, H., & Zheng, X. (2017). Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications. Journal of Thoracic Oncology, 12(10), 1478-1488.
  • 28. Ferguson, M. K., Im, H. K., Watson, S., Johnson, E., Wigfield, C. H., & Vigneswaran, W. T. (2014). Association of body mass index and outcomes after major lung resection. European Journal of Cardio-Thoracic Surgery, 45(4), e94-e99.
  • 29. Carson, K. R., Bartlett, N. L., McDonald, J. R., Luo, S., Zeringue, A., Liu, J., ... & Colditz, G. A. (2012). Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma. Journal of Clinical Oncology, 30(26), 3217.
  • 30. Weiss, L., Melchardt, T., Habringer, S., Boekstegers, A., Hufnagl, C., Neureiter, D., ... & Egle, A. (2014). Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma. Annals of oncology, 25(1), 171-176.
  • 31. Brunner, A. M., Sadrzadeh, H., Feng, Y., Drapkin, B. J., Ballen, K. K., Attar, E. C., ... & Fathi, A. T. (2013). Association between baseline body mass index and overall survival among patients over age 60 with acute myeloid leukemia. American journal of hematology, 88(8), 642-646.
  • 32. Amankwah, E. K., Saenz, A. M., Hale, G. A., & Brown, P. A. (2016). Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis. Leukemia & lymphoma, 57(5), 1140-1148.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Kübra Kılıç 0000-0002-3501-5275

Yahya Özdoğan 0000-0002-4697-8042

Erken Görünüm Tarihi 18 Mart 2022
Yayımlanma Tarihi 21 Mart 2022
Gönderilme Tarihi 30 Temmuz 2021
Kabul Tarihi 29 Ekim 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 7 Sayı: 1

Kaynak Göster

APA Kılıç, K., & Özdoğan, Y. (2022). Obezite Paradoksu. Gazi Sağlık Bilimleri Dergisi, 7(1), 164-172. https://doi.org/10.52881/gsbdergi.972930
AMA Kılıç K, Özdoğan Y. Obezite Paradoksu. Gazi Sağlık Bil. Mart 2022;7(1):164-172. doi:10.52881/gsbdergi.972930
Chicago Kılıç, Kübra, ve Yahya Özdoğan. “Obezite Paradoksu”. Gazi Sağlık Bilimleri Dergisi 7, sy. 1 (Mart 2022): 164-72. https://doi.org/10.52881/gsbdergi.972930.
EndNote Kılıç K, Özdoğan Y (01 Mart 2022) Obezite Paradoksu. Gazi Sağlık Bilimleri Dergisi 7 1 164–172.
IEEE K. Kılıç ve Y. Özdoğan, “Obezite Paradoksu”, Gazi Sağlık Bil, c. 7, sy. 1, ss. 164–172, 2022, doi: 10.52881/gsbdergi.972930.
ISNAD Kılıç, Kübra - Özdoğan, Yahya. “Obezite Paradoksu”. Gazi Sağlık Bilimleri Dergisi 7/1 (Mart 2022), 164-172. https://doi.org/10.52881/gsbdergi.972930.
JAMA Kılıç K, Özdoğan Y. Obezite Paradoksu. Gazi Sağlık Bil. 2022;7:164–172.
MLA Kılıç, Kübra ve Yahya Özdoğan. “Obezite Paradoksu”. Gazi Sağlık Bilimleri Dergisi, c. 7, sy. 1, 2022, ss. 164-72, doi:10.52881/gsbdergi.972930.
Vancouver Kılıç K, Özdoğan Y. Obezite Paradoksu. Gazi Sağlık Bil. 2022;7(1):164-72.