Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi

Sinem Çolak

doi:10.5281/zenodo.4843549

Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi

Öz

Tütüne özgü nitrozaminler (TSNA) nikotinin kimyasal reaksiyonları sonucu oluşmaktadır ve çoğu kanserojendir. Biyolojik örneklerde bu nitrozamin miktarlarının takibi, hastalık ve kanser riski için önemli bilgiler sağlayabilir. Ancak, TSNA’ların biyolojik örneklerdeki konsantrasyonlarının düşük olması ve örneklerde matris etkisinin fazlalığı hassas ektraksiyon ve analiz yöntemleri gerektirmektedir. Bu çalışma, şu anda mevcut olan yöntem ve kullanılan cihazlara genel bir bakış açısı sunmaktadır. Ayrıca, farklı biyolojik matrislerde TSNA ölçen çeşitli çalışmalar için analitik prosedürlerin kapsamlı bir özetini sağlamaktadır. Her yöntemin avantaj ve dezavantajlarının yanı sıra biyolojik örneklerdeki analitik zorluklar da çalışmada vurgulanmış ve bunların giderilmesi için benimsenen yaklaşımlar tartışılmıştır. Geleneksel yöntemlerin yanında yeni geliştirilen nanomalzemeler ve biyosensörler de çalışmada sunulmuştur.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Sinem Çolak ^*
0000-0001-6731-327X
Türkiye

Yayımlanma Tarihi

1 Mayıs 2021

Gönderilme Tarihi

11 Nisan 2021

Kabul Tarihi

9 Mayıs 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 2 Sayı: 1

DOI

https://doi.org/10.5281/zenodo.4843549

IZ

https://izlik.org/JA63LU59ER

Kaynak Göster

RIS / Bibtex

APA

Çolak, S. (2021). Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. Gazi Üniversitesi Fen Fakültesi Dergisi, 2(1), 77-92. https://doi.org/10.5281/zenodo.4843549

AMA

1.Çolak S. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. 2021;2(1):77-92. doi:10.5281/zenodo.4843549

Chicago

Çolak, Sinem. 2021. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi 2 (1): 77-92. https://doi.org/10.5281/zenodo.4843549.

EndNote

Çolak S (01 Mayıs 2021) Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. Gazi Üniversitesi Fen Fakültesi Dergisi 2 1 77–92.

IEEE

[1]S. Çolak, “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”, GÜFFD, c. 2, sy 1, ss. 77–92, May. 2021, doi: 10.5281/zenodo.4843549.

ISNAD

Çolak, Sinem. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi 2/1 (01 Mayıs 2021): 77-92. https://doi.org/10.5281/zenodo.4843549.

JAMA

1.Çolak S. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. 2021;2:77–92.

MLA

Çolak, Sinem. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 2, sy 1, Mayıs 2021, ss. 77-92, doi:10.5281/zenodo.4843549.

Vancouver

1.Sinem Çolak. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. 01 Mayıs 2021;2(1):77-92. doi:10.5281/zenodo.4843549