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Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi

Yıl 2021, Cilt: 2 Sayı: 1, 77 - 92, 01.05.2021
https://doi.org/10.5281/zenodo.4843549

Öz

Tütüne özgü nitrozaminler (TSNA) nikotinin kimyasal reaksiyonları sonucu oluşmaktadır ve çoğu kanserojendir. Biyolojik örneklerde bu nitrozamin miktarlarının takibi, hastalık ve kanser riski için önemli bilgiler sağlayabilir. Ancak, TSNA’ların biyolojik örneklerdeki konsantrasyonlarının düşük olması ve örneklerde matris etkisinin fazlalığı hassas ektraksiyon ve analiz yöntemleri gerektirmektedir. Bu çalışma, şu anda mevcut olan yöntem ve kullanılan cihazlara genel bir bakış açısı sunmaktadır. Ayrıca, farklı biyolojik matrislerde TSNA ölçen çeşitli çalışmalar için analitik prosedürlerin kapsamlı bir özetini sağlamaktadır. Her yöntemin avantaj ve dezavantajlarının yanı sıra biyolojik örneklerdeki analitik zorluklar da çalışmada vurgulanmış ve bunların giderilmesi için benimsenen yaklaşımlar tartışılmıştır. Geleneksel yöntemlerin yanında yeni geliştirilen nanomalzemeler ve biyosensörler de çalışmada sunulmuştur.

Kaynakça

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Toplam 49 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Sinem Çolak 0000-0001-6731-327X

Yayımlanma Tarihi 1 Mayıs 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 1

Kaynak Göster

APA Çolak, S. (2021). Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. Gazi Üniversitesi Fen Fakültesi Dergisi, 2(1), 77-92. https://doi.org/10.5281/zenodo.4843549
AMA Çolak S. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. Mayıs 2021;2(1):77-92. doi:10.5281/zenodo.4843549
Chicago Çolak, Sinem. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi 2, sy. 1 (Mayıs 2021): 77-92. https://doi.org/10.5281/zenodo.4843549.
EndNote Çolak S (01 Mayıs 2021) Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. Gazi Üniversitesi Fen Fakültesi Dergisi 2 1 77–92.
IEEE S. Çolak, “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”, GÜFFD, c. 2, sy. 1, ss. 77–92, 2021, doi: 10.5281/zenodo.4843549.
ISNAD Çolak, Sinem. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi 2/1 (Mayıs 2021), 77-92. https://doi.org/10.5281/zenodo.4843549.
JAMA Çolak S. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. 2021;2:77–92.
MLA Çolak, Sinem. “Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 2, sy. 1, 2021, ss. 77-92, doi:10.5281/zenodo.4843549.
Vancouver Çolak S. Tütüne Özgü Kanserojen Nitrozaminlerin Biyolojik Örneklerde Tayini için Kullanılan Analitik Yöntemlerin İncelenmesi. GÜFFD. 2021;2(1):77-92.