Biyouyumlu Kolajen /PVA /TiO2 Nanokompozit Filmlerden 5-FU Kanser İlacının Salımı

Öz

Bir ilaç salım sistemi, verimliliği ve güvenliği artırmak için salım hızını, miktarını, zamanını ve yerini kontrol edebilen terapötik bir maddenin vücudumuza girmesine yönelik bir formülasyondur. İlaç salım sistemlerinde kullanılacak olan materyalin iyi bir biyouyumluluğa sahip olması, toksik ve zararlı maddeler içermemesi gerekmektedir Bu çalışmada, biyouyumlu poli(vinil alkol)/kolajen/TiO2 (PVA/Col/TiO2) membranları döküm yöntemi ile hazırlanmıştır. Membranların 5-florourasil (5-FU) kanser ilacı etken maddesinin in vitro çalışması franz difüzyon hücreleri ile değerlendirilmiştir. Hazırlanan membranların çapraz bağlaması, yeşil bir çapraz bağlayıcı sitrik asitin ile gerçekleştirildi. Membranlar diferansiyel tarama kalorimetresi (DSC) ve X Işını Kırınım (XRD) analiz yöntemleri ile gerçekleştirildi. Hazırlanan membranlarda Col : PVA karışım oranı, Membran kalınlığının ve sıcaklığın membranlardan 5-FU salımı üzerindeki etkileri incelendi. 5-FU salımında hazırlanan membranlarda en iyi aktarımın PVA/Col/TiO2 (4:4) membranlarında %90,3 (m/m) olarak elde edildiği ve artan membran kalınlığı ile 5-FU salımının azaldığı görülmüştür. Bu çalışma ile hazırlanan kompozit membranların, doğa dostu ve uzun süreli tedavisi olan kanser için, kanser ilaçlarının salımında kullanılabilecek umut verici bir materyal olabileceği düşünülmektedir.

Anahtar Kelimeler

• Biyobozunur Kompozit Membran
• Yeşil Çapraz Bağlayıcı
• Franz Difüzyon

Release of 5-FU Cancer Drug from Biocompatible Collagen/PVA/TiO2 Nanocomposite Films

Abstract

A drug delivery system is a formulation for introducing a therapeutic agent into the body to control the release rate, amount, time, and location to increase efficiency and safety. The material used in drug delivery systems should have good biocompatibility and not contain toxic and harmful substances. In this study, biocompatible poly(vinyl alcohol)/collagen/TiO2 (PVA/Col/TiO2) membranes were prepared using the casting method. In vitro study of 5-fluorouracil (5-FU), a cancer drug active substance, of the membranes was evaluated with Franz diffusion cells. The prepared membranes were cross-linked with a green cross-linker, citric acid. Membranes were performed using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis methods. The effects of Col: PVA mixing ratio, membrane thickness, and temperature on 5-FU release from the membranes were investigated. It was observed that the best transfer in the prepared membranes for 5-FU release was obtained as 90.3% (m/m) in PVA/Col/TiO2 (4:4) membranes, and 5-FU release decreased with increasing membrane thickness. It is thought that the composite membranes prepared in this study can be a promising material that can be used in the release of cancer drugs for cancer, which has an environmentally friendly and long-term treatment.

Keywords

• Biodegradable Composite Membrane
• Green Crosslinker
• Franz Diffusion

Kaynakça

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