Medyan ve Aralık Olarak Raporlanan Çalışmaların Meta-analizi: Erken Evre Meme Kanserinde Cerrahi Yöntem Tercihinde Yaş Faktörünün İncelenmesi

Yıl 2018, Cilt: 8 Sayı: 2, 175 - 184, 31.07.2018

Esin Avcı

https://doi.org/10.17714/gumusfenbil.331912

Öz

Sürekli verilere
ait çalışmaların birleştirilmesinde meta-analiz uygulanabilmesi için ortalama
ve standart sapmaya gerek olmaktadır. Bu çalışmada, yayımlanan çalışmaların
medyan, aralık ve örneklem hacmi olarak verilmesi durumunda ortalama ve
standart sapmanın tahmin edilmesi için geliştirilen dönüşüm yöntemleri ele
alınmıştır. Uygulama olarak erken evre meme kanserli hastalara en çok uygulanan
iki tedavi yönteminin tercihinde yaş faktörünün etkisi incelenmiştir. Ele
alınan dönüşüm yöntemleri kullanılarak meta-analizine dahil edilen çalışma
sayısı 9'dan 17'ye çıkarılmış ve örneklem hacmi arttırılarak daha etkin
meta-analizi elde edilmiştir. Analiz sonucunda, yaş faktörünün tedavi yöntemi
tercihinde önemli olmadığı sonucuna varılmıştır.

Anahtar Kelimeler

Aralık, Erken evre meme kanseri, Meta-analizi, Örneklem ortalaması, Standart sapma

Meta-analysis of Median and Range Reported Studies: Examination of Age Factor in the preference of Surgical Method in Early Stage Breast Cancer

Öz

To perform meta-analysis of continuous data,
meta-analyses need the mean and the standart deviation. In this paper, the
conversion methods that improved to estimate the mean and the standart
deviation from published studies that report median, range and sample size were
discussed. The impact of age on preferring the most used surgery type for early
stage breast cancer patients was analyzed. Using the conversion methods, the
number of studies included in the meta-analysis was increased from 9 to 17 and
the sample volume was increased to obtain more efficient meta-analysis. As a
result of the analysis, it was concluded that the age factor was not
significant in the choice of treatment.

Anahtar Kelimeler

, Range, Early Stage Breast Cancer, Meta-analysis, Sample mean, Standart deviation

Kaynakça

• Acil, H., Cavdar, I., 2014. Comparison of Quality of Life of Turkish Breast Cancer Patients Receiving Breast Conserving Surgery or Modified Radical Mastectomy. Asian Pacific Journal of Cancer Prevention, 15, 5377-5388.
• Begg, C.B., Mazumdar, M., 1994. Operating Characteristics af a Rank Correlation Test for Publication Bias, Biometrics, 50(4), 1088-101.
• Bloom, G., 1958. Statistical Estimates and Transformed Beta Variables. New York: John Wiley and Sons. Inc.
• Borenstein, M., Hedges, L.V., Higgins, J.P.T., Rothstein, H.R., 2009. Introduction to Meta-Analysis, Chichester: Wiley, UK.
• Chen, Z., Xu, Y., Shu, J., Xu, N., 2015. Breast‑Conserving Surgery Versus Modified Radical Mastectomy in Treatment of Early Stage Breast Cancer: A Retrospective Study of 107 Cases. Journal of Cancer Research and Therapeutics, 11, 29-31.
• Cohen, L.M., Manion, L., Morrison. K., 2007. Research Methods in Education. London: Routledge.
• Cooper, H., 1998. Synthesizing Research. Thousand Oaks. CA:Sage. Cooper, H., Hedges, L.V., 1994. Handbook of Research Synthesis. Washington, DC: American Psychological Association.
• Çolak, T., Alimoğlu, E., Mesci, A., Peştereli, E., Kabaalioğlu, A., Karaveli, Ş., Akaydın, M., 2008. Meme Kanserli Kadınlarda Cerrahi Yöntemin Seçimini Etkileyen Faktörler. Meme Sağlığı Dergisi, 4(1), 29-33.
• Egger, M., Davey, S.G., Schneider, M., Minder, C., 1997. Bias in Meta-Analysis Detected By a Simple Graphical Test, British Medical Journal, 315(7109), 629-34.
• Fentiman, I.S., 2000. Long-term follow-up of the first breast conservation trial: Guy’ wide excision study. The Breast, 9, 5–8.
• Glass, G.V., 1976. Primary, Secondary,and Meta-Analysis of Research. American Educational Research Association, 5(10), 3-8.
• Gully, S., Incalcaterra, K., Joshi, A., Beaubien, J., 2002. A Meta Analysis of Team Efficiency, Potency, Andperformance, Journal Of Applied Psychology, 87 (5), 819–832.
• Gumus, M., Ustaalioglu, B.O., Garip, M., Kiziltan, E., Bilici, A., Seker, M., Erkol, B., Salepci, T., Mayadagli, A., Turhal, N.S., 2010. Factors that Affect Patients’ Decision-Making about Mastectomy or Breast Conserving Surgery, and the Psychological Effect of this Choice on Breast Cancer Patients. Breast Care, 5, 164–168.
• Halsted, W.S., 1898. A Clinical and Histological Study of Certain Adenocarcinoma of the Breast: and a Brief Consideration of the Supraclavicular Operation and of the Results of Operations for Cancer of the Breast from 1889 to 1898 at the Johns Hopkins Hospital. Annals of Surgery, 28, 557–576.
• Harbord, R.M., Egger, M., Sterne, J.A., 2006. A Modified Test for Small-Study Effects in Meta Analyses of Controlled Trials With Binary Endpoints, Statistics in Medicine, 25(20), 3443-57.
• Hedges, L.V., Olkin, I., 1985. Statistical Method for Meta-Analysis. San Diego, CA: Academic Press.
• Holmberg, L., Omne-Ponten, M., Burns, T., Adamı, H.O., Bergstrom, R., 1989. Psychosocial Adjustment After Mastectomy and Breast-Conserving Treatment. Cancer, 64, 969-974.
• Horiguchi, J., Lino, Y., Koibuchi, Y., Yokoe, T., Takei, H., Yamakawa, M., Nakajima, T., Oyama, T., Ando, T., Ishida, T., Endo, K., Takai, Y., Suzuki, H., Fujii, T., Yokomori, T., Morishita, Y., 2002. Breast-Conserving Therapy Versus Modified Radical Mastectomy in the Treatment of Early Breast Cancer in Japan. Breast Cancer, 9(2), 160-165.
• Hozo, S.P., Djulbegovic, B., Hozo, I., 2005. Estimating the Mean and Variance from the Median, Range, and the Size of a Sample. BMC Medical research Methodology, 5(13), 1-10.
• Judge, T.A., Colberet, A., Illies, R., 2004. Intelligence and Leadership. Journal of Applied Psychology, 89 (3), 542–552.
• Kelemen III, J.J., Poulton, T., Swartz, M.T., Jatoi, I., 2001. Surgical Treatment of Early-Stage Breast Cancer in the Department of Defense Healthcare System. American College of Surgeons, 192(3), 293-297.
• Lee, H.D., Yoon, D.S., Koo, J.Y., Suh, C.O., Jung, W.H., Oh, K.K., 1997. Breast Conserving Therapy in Stage I & II Breast Cancer in Korea. Breast Cancer Research and Treatment, 44 (3), 193–199.
• Light, R.J., Pillemer, D.B., 1984. Summing Up: The Science of Reviewing Research. Cambridge, MA: Harvard University Press.
• Litière, S., Werutsky, G., Fentiman, I.S., Rutgers, E., Christiaens, M.R., Limbergen, E.V., Baaijens, M.H.A., Bogaerts, J., Bartelink, H., 2012. Breast Conserving Therapy Versus Mastectomy for Stage I–II Breast Cancer: 20-Year Follow-Up of the EORTC 10801 Phase 3 Randomized Trial. Lancet Oncology, 13, 412-419.
• Littel, H.J., Corcoran, J., Pillai, V., 2008. Systematic Reviews and Meta-Analysis. New York: Oxford University Press.
• Mullenix, P.S., Cuadrado, D.G., Steele, S.R., Martin, M.J., See, C.S., Beitler, A.L., Carter, P.L., 2004. Secondaryoperations are Frequently Required to Complete the Surgical Phase of Therapy in the Era of Breast Conservation and Sentinel Lymph Node Biopsy. The American Journal of Surgery, 187, 643–646.
• Nesvold, I., Dahl, A.A., Løkkevik, E., Mengshoel, A.M., Fossa, S.D., 2008. Arm and Shoulder Morbidity in Breast Cancer Patients After Breast-Conserving Therapy Versus Mastectomy. Acta Oncologica, 47, 835-842.
• Nold, R.J., Beamer, R.L., Helmer, S.D., McBoyle, M.F., 2000. Factors Influencing a Woman’s Choice to Undergo Breast-Conserving Surgery Versus Modified Radical Mastectomy. The American Journal of Surgery, 180, 413-418.
• Onitilo, A.A., Engel, J.M., Stankowski, R.V., Doi, S.A.R., 2015. Survival Comparisons for Breast Conserving Surgery and Mastectomy Revisited: Community Experience and The Role of Radiation Therapy. Clinical Medicine & Research, 13(2), 65-73.
• Parviz, M., Cassel, J.B., Kaplan, B.J., Karp, S.E., Neifeld, J.P., Penberthy, L.T., Bear, H.D., 2003. Breast Conservation Therapy Rates are no Different in Medically Indigent Versus Insured Patients with Early Stage Breast Cancer. Journal of Surgical Oncology, 84, 57–62.
• Pearson, K., 1904. Report on Certain Enteric Fever Inoculation Statistics. The British Medical Journal, 2(2288), 1243–46.
• Rosenthal, R., 1994. Interpersonal Expectancy Effects. A 30-Year Perspective, Current Directions in Psychological Science, 3, 176–179. Sacks, H.S., Berrier, J., Reitman, D., Ancona-Berk, V.A., Chalmers, T.C., 1987. Meta-analyses of Randomized Controlled Trails. The New England Journal of Medicine, 316, 450-455.
• Selçuk, S., Zalluhoğlu, N., Gürkan, A., Kaçar, S., Kılıç, S., Karaca, C., Varılsüha, C., 2005. Erken Meme Kanseri Tedavisinde Meme Koruyucu Cerrahinin Yeri (Geriye Dönük Analiz). Turkish Journal of Surgery, 21(3), 135-140.
• Smith, L.I., Dayal, S., Murray, J., Lannigan, A., 2016. Attitudes Towards Breast Conservation in Patients Aged Over 70 with Breast Cancer. Springerplus, 5(478), 1-9.
• Smith, M., Glass, G., 1977. Meta-Analysis of Psychotherapy Outcome Studies, American Psychologist, 32, 752–760.
• Sutton, A.J., Abrams, K.R., Jones, D.R., Sheldon, T.A., Song, F., 2000. Methods for Meta-Analysis in Medical Research, John Wiley & Sons.
• URL-1,www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breast-cancer/breast-conserving-surgery-lumpectomy.html. 24 Mart 2017
• URL-2,www.womenshealth.gov/publications/our-publications/fact-sheet/early-stage-breast-cancer.html. 24 Mart 2017.
• URL-3, www.breast-cancer.ca/8c-treatment/. 24 Mart 2017.
• Veronesi, U., Cascinelli, N., Mariani, L., Greco, M., Saccozzi, R., Luini, A., Aguilar, M., Marubini, E., 2002. Twenty-Year Follow-Up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer. The New England Journal of Medicine, 347(16), 1227-1232.
• Voogd, A.C., Nab, H.W., Crommelin, M.A., Van der Heijden, L.H., Kluck, H.M., Coebergh, J.W.W., 1996. Comparison of Breast-Conserving Therapy with Mastectomy for Treatment of Early Breast Cancer in Community Hospitals. European Journal of Surgical Oncology, 22, 13-16.
• Wan, X., Wang, W., Liu, J., Tong, T., 2014. Estimating the Sample Mean and Standart Deviation from the Sample Size, Median, Range and/or Interquartile Range. BMC Medical research Methodology, 14(135), 1-21.
• Yang, S.H., Yang, K.H., Li, Y.P., Zhang, Y.C., He, X.D., Song, A.L., Tian, J.H., Jiang, L., Bai, Z.G., He, L.F., Liu, Y.L., Ma, B., 2008. Breast Conservation Therapy for Stage I or Stage II Breast Cancer: A Meta-Analysis of Randomized Controlled Trials, Annals of Oncology, 19, 1039-1044.