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Spirulina: Properties, Benefits and Health-Nutrition Relationship

Yıl 2022, , 1654 - 1662, 22.12.2022
https://doi.org/10.37989/gumussagbil.1200004

Öz

Spirulina is a natural product that is scientifically used in many fields due to its many beneficial contents such as antioxidants, essential amino acids, high-quality proteins and essential unsaturated fats. Spirulina is known as a nutriment-dense food as it has vitamins A, C, E and B and many minerals including calcium, zinc, magnesium and selenium. In particular, selenium and vitamin C are vitamins with antioxidant properties and protect our cells and tissues against potential damage. Due to these properties, Spirulina is used in food, cosmetics and medical fields. Since it contains antioxidant properties, it is used in several diseases such as arthritis, diabetes, anemia, cancer and cardiovascular diseases. In many studies, the properties of Spirulina have been investigated and positive results have been obtained. Also, the significance of Spirulina has improved with its use in fields such as pharmacology, cosmetics, medicine and food. In this study, the importance of this microalgae, which has numerous benefits, has been tried to be emphasized with today’s approach and studies in the fields of biochemistry, biotechnology and medicine.

Kaynakça

  • 1. Yousefi, R, Saidpour, A. and Mottaghi, A. (2019). ‘‘The effects of Spirulina supplementation on metabolic syndrome components, its liver manifestation and related inflammatory markers: A systematic review’’. Complementary Therapies in Medicine, 42, 137–144.
  • 2. Pan, R, Lu, R, Zhang, Y, Zhu, M, Zhu, W, Yang, R, Zhang, E, Ying, J, Xu, T, Yi, H, Li, J, Shi, M, Zhou, L, Xu, Z, Li, P. and Bao, Q. (2015). ‘‘Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells’’. International Journal of Biological Macromolecules, 81, 951–959.
  • 3. Um, B.H. and Kim, Y.S. (2009). ‘‘Review: A chance for Korea to advance algal-biodiesel technology’’. Journal of Industrial and Engineering Chemistry, 15 (1), 1–7.
  • 4. Dubey, A. (2014). ‘‘Biochemical composition of spirulina cultivated under outdoor conditions’’. Journal Phytological Research, 27, 79–82.
  • 5. Babadzhanov, A.S, Abdusamatova, N, Yusupova, F.M, Faizullaeva, N, Mezhlumyan, L.G. and Malikova, M.K. (2004). ‘‘Chemical composition of spirulina platensis cultivated in uzbekistan’’. Chemistry of Natural Compounds, 40, 3.
  • 6. Lugara, R, Realini, L, Kreuzer, M. and Giller, K. (2022). ‘‘Effects of maternal high-energy diet and spirulina supplementation in pregnant and lactating sows on performance, quality of carcass and meat, and its fatty acid profile in male and female offspring’’. Meat Science, 187, 108769.
  • 7. Paula da Silva, S, Ferreira do Valle, A. and Perrone, D. (2021). ‘‘Microencapsulated Spirulina maxima biomass as an ingredient for the production of nutritionally enriched and sensorially well-accepted vegan biscuits’’. LWT, 142, 110997.
  • 8. Ramirez-Rodrigues, M.M, Estrada-Beristain, C, Metri-Ojeda, J, Perez-Alva, A. and Baigts-Allende, D.K. (2021). ‘‘Spirulina plantensis Protein as Sustainable Ingredient for Nutritional Food Products Development’’. Sustainability, 13, 6849.
  • 9. Hassaan, M. S, Mohammady, E. Y, Soaudy, M. R, Sabae, S. A, Mahmoud, A. M. A. and El-Haroun, E. R. (2021). ‘‘Comparative study on the effect of dietary β-carotene and phycocyanin extracted from Spirulina platensis on immune-oxidative stress biomarkers, genes expression and intestinal enzymes, serum biochemical in Nile tilapia, Oreochromis niloticus’’. Fish and Shellfish Immunology, 108, 63–72.
  • 10. Ranga Rao, A, Raghunath Reddy, R.L, Baskaran, V, Sarada, R. and Ravishankar, G.A. (2010). ‘‘Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model’’. Journal Agricultural Food Chemistry, 58 (15), 11.
  • 11. Hemlata, Afreen, S. and Fatma, T. (2018). ‘‘Extraction, purification and characterization of phycoerythrin from Michrochaete and its biological activities’’. Biocatalysis and Agricultural Biotechnology, 13, 84–89.
  • 12. Fernandes e Silva, E, Figueira, F.S, Lettnin, A.P, Carrett-Dias, M, Filgueira, D.M.V. B, Kalil, S, Trindade, G.S. and Votto, A.P.S. (2018). ‘‘C-Phycocyanin: Cellular targets, mechanisms of action and multi drug resistance in cancer’’. Pharmacological Reports, 70 (1), 75–80.
  • 13. Chethana, S, Nayak, C.A, Madhusudhan, M.C. and Raghavarao, K.S.M.S. (2015). ‘‘Single step aqueous two-phase extraction for downstream processing of C-phycocyanin from Spirulina platensis’’. Journal of Food Science and Technology, 52 (4), 2415–2421.
  • 14. Mobin, S. and Alam, F. (2017). ‘‘Some Promising Microalgal Species for Commercial Applications: A review’’. Energy Procedia, 110, 510–517.
  • 15. Yuan, D, Zhan, X, Wang, M, Wang, X, Feng, W, Gong, Y. and Hu, Q. (2018). ‘‘Biodiversity and distribution of microzooplankton in Spirulina (Arthrospira) platensis mass cultures throughout China’’. Algal Research, 30, 38–49.
  • 16. Ghanbari, A, Vafaei, A.A, Naghibi nasab, F.S, Attarmoghaddam, M, Bandegi, A.R. and Moradi- Kor, N. (2019). ‘‘Spirulina microalgae improves memory deficit induced by scopolamine in male pup rats: Role of oxidative stress’’. South African Journal of Botany, 127, 220–225.
  • 17. Abdel-Daim, M.M, Ahmed, A, Ijaz, H, Abushouk, A.I, Ahmed, H, Negida, A, Aleya, L. and Bungau, S. G. (2019). ‘‘Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits’’. Environmental Science and Pollution Research, 26 (8), 8080–8086.
  • 18. Abdel-Daim, M, El-Bialy, B.E, Rahman, H.G.A, Radi, A.M, Hefny, H.A. and Hassan, A. M. (2016). ‘‘Antagonistic effects of Spirulina platensis against sub-acute deltamethrin toxicity in mice: Biochemical and histopathological studies’’. Biomedicine and Pharmacotherapy, 77, 79–85.
  • 19. Wu, Q, Liu, L, Miron, A, Klímová, B, Wan, D. and Kuča, K. (2016). ‘‘The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview’’. Archives of Toxicology, 90 (8), 1817–1840.
  • 20. Gad, A.S, Khadrawy, Y.A, El-Nekeety, A.A, Mohamed, S.R, Hassan, N.S. and Abdel-Wahhab, M.A. (2011). ‘‘Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats’’. Nutrition, 27 (5), 582–589.
  • 21. Pinero Estrada, J.E, Bermejo Bescos, P. and Villar del Fresno, A.M. (2001). ‘‘Antioxidant activity of different fractions of Spirulina platensis protean extract’’. II. Farmaco 56, 497-500.
  • 22. Minic, S.L, Stanic-Vucinic, D, Mihailovic, J, Krstic, M, Nikolic, M.R. and Cirkovic Velickovic, T. (2016). ‘‘Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina’’. Journal of Proteomics, 147, 132–139.
  • 23. Ravi, M, Tentu, S, Baskar, G, Rohan Prasad, S, Raghavan, S, Jayaprakash, P, Jeyakanthan, J, Rayala, S. K. and Venkatraman, G. (2015). ‘‘Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells’’. BMC Cancer, 15 (1), 1–14.
  • 24. Mohammadi, H. S, Asl, A.H. and Khajenoori, M. (2020). ‘‘Experimental measurement and correlation of solubility of β-carotene in pure and ethanol-modified subcritical water’’. Chinese Journal of Chemical Engineering, 28 (10), 2620–2625.
  • 25. Haghighat, M, Iranbakhsh, A, Baharara, J, Ebadi, M. and Sotoodehnejadnematalahi, F. (2021). ‘‘Effect of β-carotene on the differentiation potential of ciliary epithelium-derived MSCs isolated from mouse eyes on alginate-based scaffolds’’. Experimental Eye Research, 202, 108346.
  • 26. Hao, S, Liu, Y, Li, S, Wang, J, Zhao, L, Wang, C. and Sun, B. (2020). ‘‘Insight into the potential antineoplastic mechanism of phycocyanin in non- small cell lung carcinoma A549 cells based on micro-RNA sequencing’’. Journal of Functional Foods, 74, 104175.
  • 27. Youn, K, Lee, J, Yun, E. Y, Ho, C.T, Karwe, M.V, Jeong, W.S. and Jun, M. (2014). ‘‘Biological evaluation and in silico docking study of γ-linolenic acid as a potential BACE1 inhibitor’’. Journal of Functional Foods, 10, 187–191.
  • 28. Sun, M, Zhou, Z, Dong, J, Zhang, J, Xia, Y. and Shu, R. (2016). ‘‘Antibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria’’. Microbial Pathogenesis, 99, 196–203.
  • 29. De Oliveira Souza, A, Couto-Lima, C.A, Catalão, C.H.R, Santos-Júnior, N.N, dos Santos, J.F, da Rocha, M.J.A. and Alberici, L.C. (2019). ‘‘Neuroprotective action of Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids on Paraquat intoxication in Drosophila melanogaster’’. NeuroToxicology, 70, 154–160.
  • 30. Abuajah, C.I, Ogbonna, A.C. and Osuji, C. M. (2015). ‘‘Functional components and medicinal properties of food: a review’’. Journal Food Science and Technology, 52, 2522-2529.
  • 31. Zehiroglu, C. and Ozturk Sarikaya, S.B. (2019). ‘‘The importance of antioxidants and place in today’s scientific and technological studies’’. Journal of Food Science and Technology, 56 (11), 4757–4774.
  • 32. Al-Qahtani, W.H. and Binobead, M.A. (2019). ‘‘Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats’’. Saudi Journal of Biological Sciences, 26 (4), 647–652.
  • 33. Vigliante, I, Mannino, G. and Maffei, M.E. (2019). ‘‘OxiCyan®, a phytocomplex of bilberry (Vaccinium myrtillus) and spirulina (Spirulina platensis), exerts both direct antioxidant activity and modulation of ARE/Nrf2 pathway in HepG2 cells’’. Journal of Functional Foods, 61.
  • 34. Abdel-Tawwab, M, El-Saadawy, H.A, El-Belbasi, H.I, Abd El-Hameed, S.A.A. and Attia, A.A. (2021). ‘‘Dietary spirulina (Arthrospira platenesis) mitigated the adverse effects of imidacloprid insecticide on the growth performance, haemato-biochemical, antioxidant, and immune responses of Nile tilapia’’. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 247, 109067.
  • 35. Pavlopoulou, A, Spandidos, D.A. and Michalopoulos, I. (2015). ‘‘Human cancer databases (Review)’’. Oncology Reports, 33 (1), 3–18.
  • 36. Kepekçi, R.A, Polat, S, Çelik, A, Bayat, N. and Saygideger, S. D. (2013). ‘‘Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4’’. Food Chemistry, 141 (3), 1972–1979.
  • 37. Czerwonka, A, Kaławaj, K, Sławińska-Brych, A, Lemieszek, M.K, Bartnik, M, Wojtanowski, K.K, Zdzisińska, B. and Rzeski, W. (2018). ‘‘Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line’’. Biomedicine and Pharmacotherapy, 106, 292–302.
  • 38. Shokri, H, Khosravi, A. and Taghavi, M. (2014). ‘‘Efficacy of Spirulina platensis on immune functions in cancer mice with systemic candidiasis’’. Journal of Mycology Research, 1 (1), 7.
  • 39. Ren, H.T, Zhao, X, Huang, Y. and Xiong, J. (2021). ‘‘Combined effect of Spirulina and ferrous fumarate on growth parameters, pigmentation, digestive enzyme activity, antioxidant enzyme activity and fatty acids composition of Yellow River carp (Cyprinus carpio)’’. Aquaculture Reports, 21.
  • 40. Batista de Oliveira, T.T, Miranda dos Reis, I, Bastos de Souza, M, da Silva Bispo, E, Fonseca Maciel, L, Druzian, J.I, Lordelo Guimarães Tavares, P.P, de Oliveira Cerqueira, A, dos Santos Boa Morte, E, Abreu Glória, M.B, Lima Deus, V. and Radomille de Santana, L. R. (2021). ‘‘Microencapsulation of Spirulina sp. LEB-18 and its incorporation in chocolate milk: Properties and functional potential’’. LWT, 148.
  • 41. Hossam El-Beltagi, S, Dhawi, F, Ihab Ashoush, S. and Khaled Ramadan, M.A. (2020). ‘‘Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4’’. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 48 (4), 1941–1956.
  • 42. Sözeri Atik, D, Gürbüz, B, Bölük, E. and Palabıyık, İ. (2021). ‘‘Development of vegan kefir fortified with Spirulina platensis’’. Food Bioscience, 42.
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  • 44. Ebrahimi, F. and Rastegar, S. (2020). ‘‘Preservation of mango fruit with guar based edible coatings enriched with Spirulina platensis and aloe vera extract during storage at ambient temperature’’. Scientia Horticulturae, 265, 109258.
  • 45. Rashwan, R.S. and Hammad, D.M. (2020). ‘‘Toxic effect of Spirulina platensis and Sargassum vulgar as natural pesticides on survival and biological characteristics of cotton leaf worm Spodoptera littoralis’’. Scientific African, 8, e00323.
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  • 47. Vázquez-Velasco, M, González-Torres, L, López-Gasco, P, Bastida, S, Benedí, J, Sánchez-Reus, M.I, González-Muñoz, M.J. and Sánchez-Muniz, F. J. (2014). ‘‘Liver oxidation and inflammation in Fa/Fa rats fed glucomannan/spirulina- surimi’’. Food Chemistry, 159, 215–221.
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Spirulina: Özellikleri, Faydaları ve Sağlık-Besin İlişkisi

Yıl 2022, , 1654 - 1662, 22.12.2022
https://doi.org/10.37989/gumussagbil.1200004

Öz

Spirulina, antioksidanlar, esansiyel amino asitler, yüksek kaliteli proteinler ve esansiyel doymamış yağlar gibi birçok faydalı içeriği nedeniyle bilimsel olarak birçok alanda kullanılan doğal bir üründür. Spirulina, A, C, E ve B vitaminleri ve kalsiyum, çinko, magnezyum ve selenyum gibi birçok mineral içeriğine sahip olduğu için besleyiciliği yoğun bir gıda olarak bilinir. Özellikle selenyum ve C vitamini antioksidan özelliklere sahip vitaminlerdir ve hücrelerimizi ve dokularımızı olası hasarlara karşı korurlar. Bu özelliklerinden dolayı Spirulina gıda, kozmetik ve tıp alanlarında kullanılmaktadır. Antioksidan özellikler içerdiğinden artrit, diyabet, anemi, kanser ve kardiyovasküler hastalıklar gibi çeşitli hastalıklarda kullanılır. Birçok çalışmada Spirulina'nın özellikleri araştırılmış ve olumlu sonuçlar elde edilmiştir. Ayrıca, Spirulina'nın farmakoloji, kozmetik, tıp ve gıda gibi alanlarda kullanımıyla da önemi artmıştır. Bu çalışmada, sayısız faydası bulunan bu mikroalglerin önemi günümüz yaklaşımlarıyla ve biyokimya, biyoteknoloji ve tıp alanlarında yapılan çalışmalarla vurgulanmaya çalışılmıştır.

Kaynakça

  • 1. Yousefi, R, Saidpour, A. and Mottaghi, A. (2019). ‘‘The effects of Spirulina supplementation on metabolic syndrome components, its liver manifestation and related inflammatory markers: A systematic review’’. Complementary Therapies in Medicine, 42, 137–144.
  • 2. Pan, R, Lu, R, Zhang, Y, Zhu, M, Zhu, W, Yang, R, Zhang, E, Ying, J, Xu, T, Yi, H, Li, J, Shi, M, Zhou, L, Xu, Z, Li, P. and Bao, Q. (2015). ‘‘Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells’’. International Journal of Biological Macromolecules, 81, 951–959.
  • 3. Um, B.H. and Kim, Y.S. (2009). ‘‘Review: A chance for Korea to advance algal-biodiesel technology’’. Journal of Industrial and Engineering Chemistry, 15 (1), 1–7.
  • 4. Dubey, A. (2014). ‘‘Biochemical composition of spirulina cultivated under outdoor conditions’’. Journal Phytological Research, 27, 79–82.
  • 5. Babadzhanov, A.S, Abdusamatova, N, Yusupova, F.M, Faizullaeva, N, Mezhlumyan, L.G. and Malikova, M.K. (2004). ‘‘Chemical composition of spirulina platensis cultivated in uzbekistan’’. Chemistry of Natural Compounds, 40, 3.
  • 6. Lugara, R, Realini, L, Kreuzer, M. and Giller, K. (2022). ‘‘Effects of maternal high-energy diet and spirulina supplementation in pregnant and lactating sows on performance, quality of carcass and meat, and its fatty acid profile in male and female offspring’’. Meat Science, 187, 108769.
  • 7. Paula da Silva, S, Ferreira do Valle, A. and Perrone, D. (2021). ‘‘Microencapsulated Spirulina maxima biomass as an ingredient for the production of nutritionally enriched and sensorially well-accepted vegan biscuits’’. LWT, 142, 110997.
  • 8. Ramirez-Rodrigues, M.M, Estrada-Beristain, C, Metri-Ojeda, J, Perez-Alva, A. and Baigts-Allende, D.K. (2021). ‘‘Spirulina plantensis Protein as Sustainable Ingredient for Nutritional Food Products Development’’. Sustainability, 13, 6849.
  • 9. Hassaan, M. S, Mohammady, E. Y, Soaudy, M. R, Sabae, S. A, Mahmoud, A. M. A. and El-Haroun, E. R. (2021). ‘‘Comparative study on the effect of dietary β-carotene and phycocyanin extracted from Spirulina platensis on immune-oxidative stress biomarkers, genes expression and intestinal enzymes, serum biochemical in Nile tilapia, Oreochromis niloticus’’. Fish and Shellfish Immunology, 108, 63–72.
  • 10. Ranga Rao, A, Raghunath Reddy, R.L, Baskaran, V, Sarada, R. and Ravishankar, G.A. (2010). ‘‘Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model’’. Journal Agricultural Food Chemistry, 58 (15), 11.
  • 11. Hemlata, Afreen, S. and Fatma, T. (2018). ‘‘Extraction, purification and characterization of phycoerythrin from Michrochaete and its biological activities’’. Biocatalysis and Agricultural Biotechnology, 13, 84–89.
  • 12. Fernandes e Silva, E, Figueira, F.S, Lettnin, A.P, Carrett-Dias, M, Filgueira, D.M.V. B, Kalil, S, Trindade, G.S. and Votto, A.P.S. (2018). ‘‘C-Phycocyanin: Cellular targets, mechanisms of action and multi drug resistance in cancer’’. Pharmacological Reports, 70 (1), 75–80.
  • 13. Chethana, S, Nayak, C.A, Madhusudhan, M.C. and Raghavarao, K.S.M.S. (2015). ‘‘Single step aqueous two-phase extraction for downstream processing of C-phycocyanin from Spirulina platensis’’. Journal of Food Science and Technology, 52 (4), 2415–2421.
  • 14. Mobin, S. and Alam, F. (2017). ‘‘Some Promising Microalgal Species for Commercial Applications: A review’’. Energy Procedia, 110, 510–517.
  • 15. Yuan, D, Zhan, X, Wang, M, Wang, X, Feng, W, Gong, Y. and Hu, Q. (2018). ‘‘Biodiversity and distribution of microzooplankton in Spirulina (Arthrospira) platensis mass cultures throughout China’’. Algal Research, 30, 38–49.
  • 16. Ghanbari, A, Vafaei, A.A, Naghibi nasab, F.S, Attarmoghaddam, M, Bandegi, A.R. and Moradi- Kor, N. (2019). ‘‘Spirulina microalgae improves memory deficit induced by scopolamine in male pup rats: Role of oxidative stress’’. South African Journal of Botany, 127, 220–225.
  • 17. Abdel-Daim, M.M, Ahmed, A, Ijaz, H, Abushouk, A.I, Ahmed, H, Negida, A, Aleya, L. and Bungau, S. G. (2019). ‘‘Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits’’. Environmental Science and Pollution Research, 26 (8), 8080–8086.
  • 18. Abdel-Daim, M, El-Bialy, B.E, Rahman, H.G.A, Radi, A.M, Hefny, H.A. and Hassan, A. M. (2016). ‘‘Antagonistic effects of Spirulina platensis against sub-acute deltamethrin toxicity in mice: Biochemical and histopathological studies’’. Biomedicine and Pharmacotherapy, 77, 79–85.
  • 19. Wu, Q, Liu, L, Miron, A, Klímová, B, Wan, D. and Kuča, K. (2016). ‘‘The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview’’. Archives of Toxicology, 90 (8), 1817–1840.
  • 20. Gad, A.S, Khadrawy, Y.A, El-Nekeety, A.A, Mohamed, S.R, Hassan, N.S. and Abdel-Wahhab, M.A. (2011). ‘‘Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats’’. Nutrition, 27 (5), 582–589.
  • 21. Pinero Estrada, J.E, Bermejo Bescos, P. and Villar del Fresno, A.M. (2001). ‘‘Antioxidant activity of different fractions of Spirulina platensis protean extract’’. II. Farmaco 56, 497-500.
  • 22. Minic, S.L, Stanic-Vucinic, D, Mihailovic, J, Krstic, M, Nikolic, M.R. and Cirkovic Velickovic, T. (2016). ‘‘Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina’’. Journal of Proteomics, 147, 132–139.
  • 23. Ravi, M, Tentu, S, Baskar, G, Rohan Prasad, S, Raghavan, S, Jayaprakash, P, Jeyakanthan, J, Rayala, S. K. and Venkatraman, G. (2015). ‘‘Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells’’. BMC Cancer, 15 (1), 1–14.
  • 24. Mohammadi, H. S, Asl, A.H. and Khajenoori, M. (2020). ‘‘Experimental measurement and correlation of solubility of β-carotene in pure and ethanol-modified subcritical water’’. Chinese Journal of Chemical Engineering, 28 (10), 2620–2625.
  • 25. Haghighat, M, Iranbakhsh, A, Baharara, J, Ebadi, M. and Sotoodehnejadnematalahi, F. (2021). ‘‘Effect of β-carotene on the differentiation potential of ciliary epithelium-derived MSCs isolated from mouse eyes on alginate-based scaffolds’’. Experimental Eye Research, 202, 108346.
  • 26. Hao, S, Liu, Y, Li, S, Wang, J, Zhao, L, Wang, C. and Sun, B. (2020). ‘‘Insight into the potential antineoplastic mechanism of phycocyanin in non- small cell lung carcinoma A549 cells based on micro-RNA sequencing’’. Journal of Functional Foods, 74, 104175.
  • 27. Youn, K, Lee, J, Yun, E. Y, Ho, C.T, Karwe, M.V, Jeong, W.S. and Jun, M. (2014). ‘‘Biological evaluation and in silico docking study of γ-linolenic acid as a potential BACE1 inhibitor’’. Journal of Functional Foods, 10, 187–191.
  • 28. Sun, M, Zhou, Z, Dong, J, Zhang, J, Xia, Y. and Shu, R. (2016). ‘‘Antibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria’’. Microbial Pathogenesis, 99, 196–203.
  • 29. De Oliveira Souza, A, Couto-Lima, C.A, Catalão, C.H.R, Santos-Júnior, N.N, dos Santos, J.F, da Rocha, M.J.A. and Alberici, L.C. (2019). ‘‘Neuroprotective action of Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids on Paraquat intoxication in Drosophila melanogaster’’. NeuroToxicology, 70, 154–160.
  • 30. Abuajah, C.I, Ogbonna, A.C. and Osuji, C. M. (2015). ‘‘Functional components and medicinal properties of food: a review’’. Journal Food Science and Technology, 52, 2522-2529.
  • 31. Zehiroglu, C. and Ozturk Sarikaya, S.B. (2019). ‘‘The importance of antioxidants and place in today’s scientific and technological studies’’. Journal of Food Science and Technology, 56 (11), 4757–4774.
  • 32. Al-Qahtani, W.H. and Binobead, M.A. (2019). ‘‘Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats’’. Saudi Journal of Biological Sciences, 26 (4), 647–652.
  • 33. Vigliante, I, Mannino, G. and Maffei, M.E. (2019). ‘‘OxiCyan®, a phytocomplex of bilberry (Vaccinium myrtillus) and spirulina (Spirulina platensis), exerts both direct antioxidant activity and modulation of ARE/Nrf2 pathway in HepG2 cells’’. Journal of Functional Foods, 61.
  • 34. Abdel-Tawwab, M, El-Saadawy, H.A, El-Belbasi, H.I, Abd El-Hameed, S.A.A. and Attia, A.A. (2021). ‘‘Dietary spirulina (Arthrospira platenesis) mitigated the adverse effects of imidacloprid insecticide on the growth performance, haemato-biochemical, antioxidant, and immune responses of Nile tilapia’’. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 247, 109067.
  • 35. Pavlopoulou, A, Spandidos, D.A. and Michalopoulos, I. (2015). ‘‘Human cancer databases (Review)’’. Oncology Reports, 33 (1), 3–18.
  • 36. Kepekçi, R.A, Polat, S, Çelik, A, Bayat, N. and Saygideger, S. D. (2013). ‘‘Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4’’. Food Chemistry, 141 (3), 1972–1979.
  • 37. Czerwonka, A, Kaławaj, K, Sławińska-Brych, A, Lemieszek, M.K, Bartnik, M, Wojtanowski, K.K, Zdzisińska, B. and Rzeski, W. (2018). ‘‘Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line’’. Biomedicine and Pharmacotherapy, 106, 292–302.
  • 38. Shokri, H, Khosravi, A. and Taghavi, M. (2014). ‘‘Efficacy of Spirulina platensis on immune functions in cancer mice with systemic candidiasis’’. Journal of Mycology Research, 1 (1), 7.
  • 39. Ren, H.T, Zhao, X, Huang, Y. and Xiong, J. (2021). ‘‘Combined effect of Spirulina and ferrous fumarate on growth parameters, pigmentation, digestive enzyme activity, antioxidant enzyme activity and fatty acids composition of Yellow River carp (Cyprinus carpio)’’. Aquaculture Reports, 21.
  • 40. Batista de Oliveira, T.T, Miranda dos Reis, I, Bastos de Souza, M, da Silva Bispo, E, Fonseca Maciel, L, Druzian, J.I, Lordelo Guimarães Tavares, P.P, de Oliveira Cerqueira, A, dos Santos Boa Morte, E, Abreu Glória, M.B, Lima Deus, V. and Radomille de Santana, L. R. (2021). ‘‘Microencapsulation of Spirulina sp. LEB-18 and its incorporation in chocolate milk: Properties and functional potential’’. LWT, 148.
  • 41. Hossam El-Beltagi, S, Dhawi, F, Ihab Ashoush, S. and Khaled Ramadan, M.A. (2020). ‘‘Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4’’. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 48 (4), 1941–1956.
  • 42. Sözeri Atik, D, Gürbüz, B, Bölük, E. and Palabıyık, İ. (2021). ‘‘Development of vegan kefir fortified with Spirulina platensis’’. Food Bioscience, 42.
  • 43. Rosas, V. T, Monserrat, J.M, Bessonart, M, Magnone, L, Romano, L.A. and Tesser, M. B. (2019). ‘‘Fish oil and meal replacement in mullet (Mugil liza) diet with Spirulina (Arthrospira platensis) and linseed oil’’. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 218, 46–54.
  • 44. Ebrahimi, F. and Rastegar, S. (2020). ‘‘Preservation of mango fruit with guar based edible coatings enriched with Spirulina platensis and aloe vera extract during storage at ambient temperature’’. Scientia Horticulturae, 265, 109258.
  • 45. Rashwan, R.S. and Hammad, D.M. (2020). ‘‘Toxic effect of Spirulina platensis and Sargassum vulgar as natural pesticides on survival and biological characteristics of cotton leaf worm Spodoptera littoralis’’. Scientific African, 8, e00323.
  • 46. Dalle Zotte, A, Cullere, M, Sartori, A, Szendro, Z, Kovàcs, M, Giaccone, V. and Dal Bosco, A. (2014). ‘‘Dietary Spirulina (Arthrospira platensis) and Thyme (Thymus vulgaris) supplementation to growing rabbits: Effects on raw and cooked meat quality, nutrient true retention and oxidative stability’’. Meat Science, 98 (2), 94–103.
  • 47. Vázquez-Velasco, M, González-Torres, L, López-Gasco, P, Bastida, S, Benedí, J, Sánchez-Reus, M.I, González-Muñoz, M.J. and Sánchez-Muniz, F. J. (2014). ‘‘Liver oxidation and inflammation in Fa/Fa rats fed glucomannan/spirulina- surimi’’. Food Chemistry, 159, 215–221.
  • 48. Balti, R, Mansour, M, Ben Sayari, N, Yacoubi, L, Rabaoui, L, Brodu, N. and Massé, A. (2017). ‘‘Development and characterization of bioactive edible films from spider crab (Maja crispata) chitosan incorporated with Spirulina extract’’. International Journal of Biological Macromolecules, 105, 1464–1472.
  • 49. Wang, Y, Chang, C.F, Chou, J, Chen, H.L, Deng, X, Harvey, B.K, Cadet, J.L. and Bickford, P. C. (2005). ‘‘Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage’’. Experimental Neurology, 193 (1), 75–84.
  • 50. Dal Bosco, A, Gerencsér, Z, Szendro, Z, Mugnai, C, Cullere, M, Kovàcs, M, Ruggeri, S, Mattioli, S, Castellini, C. and Dalle Zotte, A. (2014). ‘‘Effect of dietary supplementation of Spirulina (Arthrospira platensis) and Thyme (Thymus vulgaris) on rabbit meat appearance, oxidative stability and fatty acid profile during retail display’’. Meat Science. 96 (1), 114–119.
  • 51. Karadeniz, A, Cemek, M. and Simsek, N. (2009). ‘‘The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats’’. Ecotoxicology and Environmental Safety, 72 (1), 231–235.
  • 52. Strömberg, I, Gemma, C, Vila, J. and Bickford, P. C. (2005). ‘‘Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system’’. Experimental Neurology, 196 (2), 298–307.
Toplam 52 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Derlemeler
Yazarlar

Burhan Budak 0000-0002-3715-5861

Sevim Beyza Öztürk Sarıkaya 0000-0002-7820-4260

Yayımlanma Tarihi 22 Aralık 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Budak, B., & Öztürk Sarıkaya, S. B. (2022). Spirulina: Properties, Benefits and Health-Nutrition Relationship. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 11(4), 1654-1662. https://doi.org/10.37989/gumussagbil.1200004
AMA Budak B, Öztürk Sarıkaya SB. Spirulina: Properties, Benefits and Health-Nutrition Relationship. Gümüşhane Sağlık Bilimleri Dergisi. Aralık 2022;11(4):1654-1662. doi:10.37989/gumussagbil.1200004
Chicago Budak, Burhan, ve Sevim Beyza Öztürk Sarıkaya. “Spirulina: Properties, Benefits and Health-Nutrition Relationship”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11, sy. 4 (Aralık 2022): 1654-62. https://doi.org/10.37989/gumussagbil.1200004.
EndNote Budak B, Öztürk Sarıkaya SB (01 Aralık 2022) Spirulina: Properties, Benefits and Health-Nutrition Relationship. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11 4 1654–1662.
IEEE B. Budak ve S. B. Öztürk Sarıkaya, “Spirulina: Properties, Benefits and Health-Nutrition Relationship”, Gümüşhane Sağlık Bilimleri Dergisi, c. 11, sy. 4, ss. 1654–1662, 2022, doi: 10.37989/gumussagbil.1200004.
ISNAD Budak, Burhan - Öztürk Sarıkaya, Sevim Beyza. “Spirulina: Properties, Benefits and Health-Nutrition Relationship”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11/4 (Aralık 2022), 1654-1662. https://doi.org/10.37989/gumussagbil.1200004.
JAMA Budak B, Öztürk Sarıkaya SB. Spirulina: Properties, Benefits and Health-Nutrition Relationship. Gümüşhane Sağlık Bilimleri Dergisi. 2022;11:1654–1662.
MLA Budak, Burhan ve Sevim Beyza Öztürk Sarıkaya. “Spirulina: Properties, Benefits and Health-Nutrition Relationship”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, c. 11, sy. 4, 2022, ss. 1654-62, doi:10.37989/gumussagbil.1200004.
Vancouver Budak B, Öztürk Sarıkaya SB. Spirulina: Properties, Benefits and Health-Nutrition Relationship. Gümüşhane Sağlık Bilimleri Dergisi. 2022;11(4):1654-62.