Egzersize Bağlı Modellenen Anjiyogenez Mekanizmasında Fizyolojik Değişimler: Kalp Kası ve İskelet Kası İncelemesi

Yıl 2023, Cilt: 12 Sayı: 1, 334 - 340, 25.03.2023

Yavuz Yasul , Taner Akbulut , Muhammet Enes Yasul

https://doi.org/10.37989/gumussagbil.1224908

Cited By: 1

Öz

Kalp ve iskelet kasındaki metabolik değişimler ile anjiyogenez arasında yakın bir etkileşimin olduğu bilinmektedir. Ancak egzersizin bu iki doku üzerindeki etkisine bağlı olarak ortaya çıkaracağı anjiyojenik hareketliliğin serüveni tam anlamıyla aydınlığa kavuşturulamamıştır. Bu sebeple mevcut araştırma egzersizin fiziksel etkisine maruz kalan kalp kası ve iskelet kası dokularının fizyolojik anjiyogeneze nasıl cevaplar verdiğinin irdelenmesi amacı ile geleneksel derleme türünde hazırlanmıştır. Bu derleme yayın yılı kısıtlaması olmadan PubMed, Google Scholar, Web of Science ve ULAKBİM veri tabanlarındaki literatürden oluşturulmuştur. Literatür taramasında 4 Türkçe anahtar kelime (egzersiz, anjiyogenez, kalp kası, iskelet kası) ve bunların ingilizceleri kullanılarak ulaşılan yayınlar incelenmiştir. Egzersizin anjiyogenezi teşviki konusundaki rolü, anjiyogenez mekanizması üzerindeki etkisi ve doku yapısındaki anjiyonegez hareketliliğine olan katkısının derinlemesine tartışılması yeni terapötik hedefleri keşfetmeye rehberlik edebilir. Bu kapsamda çalışma egzersize bağlı anjiyogenezin kalp kası ve iskelet kasındaki yeniden modellenme mekanizmalarını ve fizyolojik çabasını açıklamaya yönelik sürdürülen araştırmalara odaklanmıştır. Yapılan literatür incelemesi ışığında egzersizin hem kalp kası hem de iskelet kasında fizyolojik anjiyogenezi modelleme konusundaki çabasının dikkate değer olduğu ve sporcularda sportif performans artışını önemli düzeyde etkileyebileceği ifade edilebilir.

Anahtar Kelimeler

Anjiyogenez, Egzersiz, Kalp kası, İskelet kası

Physiological Changes in the Mechanism of Angiogenesis Modeled by Exercise: A review of Cardiac and Skeletal Muscles

Öz

It is known that there is a close interaction between angiogenesis and metabolic changes in the heart and skeletal muscle. However, the adventure of angiogenic mobility, which will be revealed by the effect of exercise on these two tissues, has not been fully clarified. For this reason, the present study was prepared in a traditional review type with the aim of examining how cardiac muscle and skeletal muscle tissues, which are exposed to the physical effects of exercise, respond to physiological angiogenesis. The research was obtained from PubMed, Google Scholar, Web of Science and ULAKBİM databases without the limitation of publication year. In the literature review, the publications reached using 4 Turkish keywords (exercise, angiogenesis, heart muscle, skeletal muscle) and their English versions were examined. An in-depth discussion of the role of exercise in promoting angiogenesis, its effect on the mechanism of angiogenesis, and its contribution to angiogenesis in tissue structure may guide the discovery of new therapeutic targets. In this context, the study focused on ongoing research to explain the remodeling mechanisms and physiological effort of exercise-induced angiogenesis in cardiac and skeletal muscle. In the light of the literature review, it can be stated that the effort of exercise in modeling physiological angiogenesis in both cardiac and skeletal muscle is remarkable and can significantly affect the increase in sportive performance in athletes.

Anahtar Kelimeler

Angiogenesis, exercise, hearth muscle, skeletal muscle

Kaynakça

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