Cardioprotective Effects of Carvacrol on Sodium Arsenite-Induced Cardiac Toxicity in Rats

Yıl 2023, Cilt: 12 Sayı: 3, 1106 - 1114, 26.09.2023

Sibel Çiğdem Tuncer , Özge Kandemir , Cihan Gür

https://doi.org/10.37989/gumussagbil.1227435

Öz

Introduction: Sodium arsenite is a toxic compound affecting millions of people's health. As a result of long-term arsenite exposure, many tissues in the body are affected, especially the heart, kidney, and liver. Carvacrol (KRV) is a natural flavonoid with anti-inflammatory and antioxidant effects found in plants such as thyme and black pepper. This study aimed to investigate the use and possible consequences of KRV, a natural antioxidant, on sodium arsenite-induced heart damage.
Material-Methods: 25 or 50 mg/kg KRV was administered 30 minutes after sodium arsenite was administered at a dose of 10 mg/kg for 14 days. On the 15th day, 35 animals were decapitated and their heart tissues were taken and biochemical analyzes were performed.
Results: Sodium arsenite increased the levels of inflammation, oxidative stress, autophagy, apoptosis, and ER stress markers in heart tissue compared to the control group (P<0.05). With the application of KRV, decreases occurred in all these increases (P<0.05).
Discussion: It was concluded that KRV has potential protective properties in sodium arsenite-induced cardiotoxicity.

Anahtar Kelimeler

Carvacrol, Inflammation, Sodium Arsenite, Toxicity, Oxidative Stress

Sıçanlarda Sodyum Arsenit ile Oluşturulan Kalp Toksisitesi Üzerine Karvakrol’un Kardiyoprotektif Etkileri

Öz

Giriş: Sodyum arsenit, toksik bir bileşik olup milyonlarca insanın sağlığını etkilemektedir. Uzun süreli arsenit maruziyeti sonucunda kalp, böbrek ve karaciğer başta olmak üzere vücutta birçok doku etkilenmektedir. Karvakrol (KRV), kekik, karabiber gibi bitkilerde bulunan anti-inflamatuvar ve antioksidan etkilere sahip doğal bir flavanoidtir. Bu çalışmada sodyum arsenit kaynaklı kalp hasarı üzerine doğal bir antioksidan olan KRV’ün kullanımı ve muhtemel etkilerinin araştırılması amaçlanmıştır.
Materyal-Metot: 14 gün boyunca 10 mg/kg dozda sodyum arsenit uygulaması yapıldıktan 30 dakika sonra 25 veya 50 mg/kg KRV uygulaması yapıldı. 15. günde 35 adet hayvan dekapite edilerek kalp dokuları alındı ve biyokimyasal analizler yapıldı.
Bulgular: Sodyum arsenit kalp dokusunda inflamasyon, oksidatif stres, otofaji, apoptoz ve ER stres markırlarının düzeylerini kontrol grubuna göre arttırdı (P<0,05). KRV uygulamasıyla birlikte tüm bu artış miktarlarında azalmalar meydana gelmiştir (P<0,05).
Tartışma: Sodyum arsenit kaynaklı kardiyotoksisitede KRV'in potansiyel koruyucu özelliklere sahip olduğu sonucuna varıldı.

Anahtar Kelimeler

İnflamasyon, Karvakrol, Sodyum Arsenit, Toksisite, Oksidatif Stres

Kaynakça

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