Kanabinoid Sistem ve Epilepsi

Öz

Epilepsi tekrarlayan nöbetlerle karakterize olan en yaygın nörolojik hastalıklardan biridir. Kanabinoidlerin epilepside önemli rolü olduğu yapılan deneysel çalışmalarda gösterilmiştir. Kanabinoidlerin birçok fizyolojik süreçte düzenleyici rol oynadığı bilinmektedir ve son yıllarda, hastalıkların tedavisinde kullanılması konusunda artan bir ilgi söz konusudur. Kanabinoid sistemde CB1 ve CB2 olmak üzere iki tip reseptör bulunur. Esrarın psikoaktif bileşeni olan Δ9-Tetrahydrocannabinol (THC), kimyasal olarak üretilen sentetik kanabinoidler ve insan ve hayvanlarda doğal olarak üretilen dokanabinoidler, kanabinoid reseptörlerine bağlanarak etki gösterirler. Kanabinoidler, beyinde aynı anda birden fazla kanal ve reseptör sistemi üzerinde etkili maddeler olduğundan, epilepsi üzerine olan etkisinin hangi sistem üzerinden gerçekleştiğinin ortaya konulması zordur. Bu yazıda kanabinoid sistem ve epilepsiyle olan ilişkisi özetlenmiştir.

Anahtar Kelimeler

• Kanabinoid sietem,epilepsi,Kanabinoid,CB1,CB2

Cannabinoid System and Epilepsy

Öz

Epilepsy is one of the commonest chronic neurological disease, which is characterized by recurrent spontaneous seizures. Experimental studies show that cannabinoid system has an important role in epilepsy. The cannabinoids plays a regulatory role in a number of physiological processes and over the past decade there has been an increasing interest in using cannabinoids to in many diseased treatments. The Cannabinoids system comprises CB1 receptors, and CB2 receptors. Δ9-Tetrahidrokannabinol (THC) the psychoactive component of marihuana, chemically produced synthetic cannabinoids and naturally occurring in humans and animals, endocannabinoids bind to cannabinoid receptor. Cannabinoids are so active substances that effects multiple channel and receptors systems, simultaneously. Therefore, it is diffucult to reveal in which system cannabinoids show their effects on epilepsy.The cannabinoid system and its physiological properties are relation to epilepsy briefly summarized here.

Anahtar Kelimeler

• Canabinoid system,epilepsy,Canabinoid,CB1,CB2

Kaynakça

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