Propofol Enjeksiyon Ağrısının Önlenmesinde Deksketoprofen ve Tenoksikamın Etkileri

Öz

Amaç: Çalışmamızın amacı propofol enjeksiyon ağrısının önlenmesinde tenoksikam ve deksketoprofenin etkinliğini araştırmaktır.Metod: Çalışmaya 20-60 yaş arası 150 hastanın dahil edilmesi planlandı. Hastalar randomize olarak 3 gruba ayrıldı. Genel anestezi indüksiyonu için iv olarak propofol uygulanmasından 2 dk önce hastalara; Grup I’de 2 mL salin, Grup II’de 20 mg (2mL) tenoksikam, Grup III’te ise 50 mg (2mL) deksketoprofen uygulandı. Hesaplanan propofol dozunun 4’te 1’inin uygulanması sonrası enjeksiyon ağrısı 4 puanlı verbal derecelendirme skalası (VRS) ve nümerik değerlendirme skalası (NRS) ile değerlendirildi. Bulgular: Deksketoprofen grubu, çalışma ilacı uygulaması esnasında hastaların şiddetli ağrı duyması nedeniyle 18. hastada sonlandırıldı. Toplam 118 hastanın verileri değerlendirildi. Propofol enjeksiyon ağrısı sıklığı salin grubunda %76, tenoksikam grubunda ise %38 idi ve fark istatistiksel olarak anlamlıydı (p<0,01). NRS skorları salin grubunda 3,1±2,2, tenoksikam grubunda 1,7±1,7 ve deksketoprofen grubunda 1,9±1,5 idi ve salin grubunda tenoksikam ve deksketoprofen grubu ile karşılaştırıldığında istatistiksel olarak anlamlı şekilde yüksekti (sırasıyla p<0,01 ve p<0,05). Sonuç: Çalışmamız sonucunda 20 mg iv tenoxicam ön tedavisinin, propofol enjeksiyon ağrısını azaltmada etkili olduğunu tespit ettik.

Anahtar Kelimeler

• Deksketoprofen,enjeksiyon ağrısı,propofol,tenoksikam

The Effect of Intravenous Dexketoprofen and Tenoxicam on Propofol Injection Pain

Öz

Background and Objectives: The aim of our study is to research the efficacy of tenoxicam and dexketoprofen in preventing propofol injection pain. Methods: The study included 150 patients aged from 20 to 60 years. The patients were randomly divided into 3 groups. Two minutes before iv propofol administration for induction of general anesthesia patients in Group I were given 2 mL saline, patients in Group II were given 20 mg (2 mL) tenoxicam and patients in Group III were given 50 mg (2 mL) dexketoprofen. After administering 1 quarter of the calculated propofol dose injection pain severity was assessed using a four-point verbal rating scale (VRS) and numeric rating scale (NRS).Results: Due to pain felt during administration of the study medication in the dexketoprofen group, the study was terminated after 18 patients. The data from 118 patients were assessed. The incidence of propofol injection pain in the saline group was 76%, while this was 38% in the tenoxicam group and the difference was statistically significant (p<0.01). NRS score was 3.1±2.2 in the saline group, 1.7±1.7 in the tenoxicam group and 1.9±1.5 in the dexketoprofen group and it was statistically significantly higher in the saline group compared to the tenoxicam and dexketoprofen groups (p<0.01 and p<0.05 respectively). Conclusions: At the end of our study we identified that 20 mg iv tenoxicam pretreatment was effective in reducing propofol injection pain.

Anahtar Kelimeler

• Dexketoprofen,injection pain,propofol,tenoxicam

Kaynakça

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