Ailevi Akdeniz Ateşi Hastalarında Ataklar Arası Dönemde Ortalama Trombosit Hacmi ve Nötrofil/Lenfosit Oranı

Öz

Amaç: Ortalama trombosit hacmi (MPV) ve nötrofil/lenfosit oranı (NLR) birçok kronik hastalıkta inflamasyon varlığını gösteren basit belirteçlerdir. Ailevi Akdeniz Ateşi (AAA) hastalarında ataksız dönemlerde subklinik düşük dereceli inflamasyon devam etmektedir. Bu çalışmada AAA'lı hastalarda ataksız dönemlerdeki subklinik inflamasyonu değerlendirmede MPV ve NLR belirteçlerinin değeri incelendi. Materyal ve metot: Ocak 2017 ile Ocak 2019 tarihleri arasında Tokat Gaziosmanpaşa Üniversitesi İç Hastalıkları ve Fizik Tedavi ve Rehabilitasyon polikliniklerine başvuran ataklar arası dönemde olan 55 AAA hastasının verileri geriye dönük incelendi. Hastaların rutin kontrol laboratuar değerlerinden C-reaktif protein, sedimentasyon, trombosit sayısı, hemoglobin, nötrofil, lenfosit ve MPV seviyeleri kaydedildi. Bulgular: Çalışmaya 35 kadın 20 erkek FMF hastası ve 30 (16 kadın 14 erkek) kontrol olgusu dahil edildi (p=0,239). Hastaların yaş ortalaması AAA olgularında 30,9±8,8 kontrol olgularında ise 31,3±7,3 idi (p=0,864). Ortalama MPV değeri AAA grubunda 9,844±1,358 fL iken kontrol grubunda 9,551±1,249 fL idi (p=0,326). Ortalama NLR değeri AAA grubunda 1,85±0,69 iken kontrol grubunda 1,96±0,13 idi (p=0,501). Alt grup analizinde proteinüri mevcut olan AAA hastalarında MPV ve NLR değerleri kontrol grubundan farklı değildi. Hemoglobin, beyaz kan hücresi, trombosit sayısı ve RDW değerleri iki grupta benzerdi (p>0,05). Sonuç: Çalışmamız ataklar arası dönemde AAA hastalarında MPV ve NLR seviyelerinin hastalığın subklinik inflamasyon varlığını göstermede rolünün yetersiz olduğunu göstermektedir.

Anahtar Kelimeler

• Ailevi Akdeniz Ateşi
• ortalama trombosit hacmi
• nötrofil lenfosit oranı
• subklinik inflamasyon

Mean Platelet Volume and Neutrophil to Lymphocyte Ratio in Patient with Attack Free Period of Familial Mediterranean Fever

Öz

Objective: Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are simple predictors of inflammation in many chronic diseases. Subclinical low-grade inflammation continues in attack free period of Familial Mediterranean Fever (FMF). In this study, we evaluated the value of MPV and NLR parametres in the assessment of subclinical inflammation in patients with attack free period of FMF. Materials and methods: The data of 55 attack free period of FMF patients between January 2017 and January 2019 who were admitted to Tokat Gaziosmanpaşa University Internal Medicine and Physical Therapy and Rehabilitation outpatient clinics were analyzed retrospectively. C-reactive protein, sedimentation, platelet count, hemoglobin, neutrophil, lymphocyte and MPV levels were recorded. Results: Thirty five female and 20 male FMF patients and 30 (16 female and 14 male) control subjects were included in the study (p = 0.239). The mean age of the patients was 30.9 ± 8.8 in AAA and 31.3 ± 7.3 in the control group (p = 0.864). The mean MPV value was 9.844 ± 1,358 fL in the AAA group and 9,551 ± 1,249 fL in the control group (p = 0.326). Mean NLR value was 1.85 ± 0.69 in the AAA group and 1.96 ± 0.13 in the control group (p = 0.501). In subgroup analysis, MPV and NLR values were not different from the control group in AAA patients with proteinuria. Hemoglobin, white blood cell, platelet count and RDW values were similar in two groups (p> 0.05). Conclusion: Our study shows that MPV and NLR levels are not sufficient to show the presence of subclinical inflammation in attack free period of FMF.

Anahtar Kelimeler

• Familial Mediterranean Fever
• mean platelet volume
• neutrophil lymphocyte ratio
• subclinical inflammation

Kaynakça

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