Kemik Metastazı Bulunan Hastalara Multidisipliner Yaklaşım

Yıl 2017, Cilt: 9 Sayı: 3, 122 - 132, 01.09.2017

Gülhan Güler Avcı Zekiye Hasbek

Öz

İskelet
sistemi en sık şiddetli ağrılara yol açan metastaz lokalizasyon bölgesidir.
İleri dönem kanser hastalarında, kemoterapi, analjezikler, hormon tedavisi gibi
tedavi yöntemleri yetersiz kalabilmektedir. Kemik ağrılarının
palyasyonunda radyoterapi etkin bir tedavidir. Kemik metastazlarında radyoterapinin amacı;
ağrıyı azaltmak, patolojik fraktür gelişmesini önlemek, morbiditeyi azaltırken fonksiyonu
iyileştirmek ve yaşam kalitesini yükseltmektir. Kemikte tutulan Sr-89 Strontiumchloride,
Sm-153 Samariumlexidronam ve Re-186 Rheniumetidronate gibi radyofarmasötiklerde ağrı
palyasyonundayeni bir tedavi seçeneği olup, yaygın kemik metastazı olan
hastalarda etkinliği gösterilmiştir. Radyonüklid tedavi ağrının azaltılması,
yaşam kalitesinin artırılması ve yeni ağrı odaklanılın gelişiminin
azaltılmasında etkili bir yöntemdir.

Anahtar Kelimeler

Kemik metastazı, Radyoterapi, Radyonüklid tedavi

Multidisciplinary Approach to Patients with Bone Metastasis

Öz

Bone
metastases are very frequent causes of intractable pain in cancer patients.
Since therapeutic methods that chemotherapy, analgesics, hormonal therapy may
be insufficient in patients with advanced cancer disease.

Radiotherapy in the palliation of
bone pain is an effective treatment. Purpose of radiotherapy in bone
metastases; reducing pain, preventing pathological fractures, improving
function and improving quality of life while reducing morbidity. Bone seeking radiopharmaceuticals that
Sr-89 Strontiumchloride, Sm-153 Samariumlexidronam and Re-186 Rheniumetidronate
have provided a new option to
these management strategies and have been proven to be effective in patients
with widespread bone metastases. Radionuclide therapy is an effective method in
the reduction of bone pain, in the enhancement of life quality and in
preventing the development of new painful metastatic sites.

Anahtar Kelimeler

Bone metastasis, Radiotherapy, Radyonuclide therapy

Kaynakça

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