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İnmemiş Testis ve İnfertilite

Yıl 2020, Cilt: 12 Sayı: 4, 96 - 119, 24.04.2021

Öz

İnmemiş testis çocuklarda %3-4 oranında görülmektedir. Bu oran erken doğan çocuklarda %40’a kadar ulşabilmektedir. İnmmeiş testis tanılı çocuklarda tedavi bir yaşına kadar tamamlanmalıdır. Uygun zamanda yapılmayan tedavilere bağlı olarak infertilite ve tümör gelişim riski bulunmaktadır. Ayrıca kozmetik nedenlere bağlı olarak çocuklarda ve ailelerinde psiolojik sorunlar olabilmektedir. İnmemiş testisin ve fertilite üzerine olan etkisini inceleyen deneysel ve klinik çalışmaların oldukça sınırlı olduğu görülmektedir. Bu derlemede inmemiş testis ve infertilite ilişkisi değerlendirilmiştir.

Kaynakça

  • 1. Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. E. A. U. Guidelines on Male Infertility. 2018;6–7. https://uroweb.org/wp-content/ uploads/EAU-Guidelines-on-Male-Infertility-2018-large-text.pdf
  • 2. Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 2017;32(1):18-31.
  • 3. Fallara G, Cazzaniga W, Boeri L, Capogrosso P, Candela L, Pozz E. Male factor infertility trends throughout the last 10 years: Report from a tertiary-referral academic andrology centre. Andrology. 2020 Nov 24. doi: 10.1111/andr.12947. Online ahead of print.
  • 4. Cortes D, Holt R, de Knegt V. Hormonal aspects of the pathogenesis and treatment of cryptorchidism. Eur J Pediatr Surg. 2016;26:409‐ 17.
  • 5. Goel P, Sijstermans K, Schneuer FJ, Virtanen HE, Bjerknes R, Cortes D. Cryptorchidism: Classification, prevalence and long‐term consequences. Acta Paediatr. 2007;96:611‐6.
  • 6. Mieusset R, Bujan L, Massat G, Mansat A, Pontonnier F. Clinical and biological characteristics of infertile men with a history of cryptorchidism. Hum Reprod. 1995;10(3):613-9.
  • 7. Emad-Eldin S. Spigelian-cryptorchidism syndrome in an adult male complaining of primary infertility: Case report. Emad-Eldin S, Abdelaziz O, Shokr M. Andrologia. 2020 Oct 25:e13838. doi: 10.1111/and.13838.
  • 8. Muncey W, Dutta R, Terlecki RP, Woo LL, Scarberry K. Fertility potential in adult men treated for uncorrected bilateral cryptorchidism: A systematic literature review and analysis of case reports. Andrology. 2020 Dec 22. doi: 10.1111/andr.12964.
  • 9. Olesen IA, Andersson A‐M, Aksglaede L, et al. Clinical, genetic, biochemical, and testicular biopsy findings among 1213 men evaluated for infertility. Fertil Steril. 2017;107:74‐ 82.
  • 10. Gracia J, Sánchez Zalabardo J, Sánchez García J, García C, Ferrández A. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. BJU Int. 2000;85(9):1100-3.
  • 11. Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone and semen data. Horm Res. 2001;55:29–31.
  • 12. Wilkerson ML, Bartone FF, Fox L. Fertility potential: a comparison of intra-abdominal and intracanalicular testes by age groups in children. Horm Res. 2001;55:18-20.
  • 13. Kobayashi H, Nagao K, Nakajima K. Advanced Studies in Medical Sciences. 1. Vol. 1. HIKARI Ltd; 2013. Therapeutic Advances in the Field of Male Infertility: Stem Cell Research; pp. 39–54.
  • 14. Lee PA. Fertility after cryptorchidism: epidemiology and other outcome studies. Urology. 2005;66(2):427–31.
  • 15. Fallon B, Kennedy TJ. Long-term follow-up of fertility in cryptorchid patients. Urology. 1985;25:502–4.
  • 16. Koch T, Hansen AH, Priskorn L, Petersen JH, Carlsen E, Main KM. A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population. Hum Reprod. 2020 Aug 1;35(8):1765-80.
  • 17. Lee PA, O'Leary LA, Songer NJ, Coughlin MT, Bellinger MF, LaPorte RE. Paternity after unilateral cryptorchidism: a controlled study. Pediatrics. 1996;98(4 Pt 1):676-9.
  • 18. Braga LH, Lorenzo AJ, Romao RLP. Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism. Can Urol Assoc J. 2017;11(7):251-260.
  • 19. Kojima Y, Hayashi Y, Mizuno K, et al. Future treatment strategies for cryptorchidism to improve spermatogenesis. Hinyokika Kiyo. 2007;53(7):517–522.
  • 20. Adomaitis R, Vincel B, Eidukaite A, Ostaneviciute E, Kirka R, Bilius V, Malcius D, Verkauskas G, Hadziselimovic F. Consequences of bilateral cryptorchidism in adults. Andrologia. 2016;48(9):933-8.
  • 21. Hanson BM, Eisenberg ML, Hotaling JM. Male infertility: a biomarker of individual and familial cancer risk. Fertil Steril 2018;109:6–19.
  • 22. Lipshultz LI, Caminos-Torres R, Greenspan CS, Snyder PJ. Testicular function after orchiopexy for unilaterally undescended testis. N Engl J Med. 1976;295:15–8.
  • 23. Walsh TJ, Croughan MS, Schembri M, Chan JM, Turek PJ. Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med. 2009;169:351–6.
  • 24. internet sayfası linki: https://www.genecards.org
  • 25. Sharifi N, Sabbaghian M, Farrahi F, Almadani N, Boroujeni PB, Meybodi AM. Cytogenetic assessment of Iranian infertile men with undescended testis: A retrospective study. JBRA Assist Reprod. 2020;24(4):400-4.
  • 26. Hutson JM, Li R, Southwell BR, Petersen BL, Thorup J, Cortes D Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? Front Endocrinol (Lausanne). 2012;3:176.
  • 27. Loebenstein M, Hutson J, Li R. Gonocyte transformation in a congenitally cryptorchid rat is normal and may be similar to the situation reported in human acquired cryptorchidism. J Pediatr Surg. 2018;53(9):1770-5.
  • 28. Li R, Zhang JG, Churchill J, Sourial M, Southwell BR, Hutson JM. Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation? J Pediatr Surg. 2012;47(9):1724-9.
  • 29. Cobellis G, Noviello C, Nino F, Romano M, Mariscoli F, Martino A, Parmeggiani P, Papparella A. Spermatogenesis and cryptorchidism. Front Endocrinol (Lausanne). 2014;1;5:63.
  • 30. Radmayr C, Bogaert G, Dogan HS, Kočvara R, Nijman JM, Stein R. EAU Guidelines on Paediatric Urology 2018. Arnhem (The Netherlands): European Association of Urology: European Society for Paediatric Urology;2018;33.
  • 31. Wilson V, Thorup J, Clasen-Linde E, Cortes D, Hutson JM, Li R. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death? Pediatr Surg Int. 2019;35(11):1309-6.
  • 32. Kamisawa H, Kojima Y, Mizuno K, Imura M, Hayashi Y, Kohri K. Attenuation of spermatogonial stem cell activity in cryptorchid testes. J Urol. 2012;187(3):1047-52.
  • 33. Hadziselimovic F, Zivkovic D, Bica DT, Emmons LR. The importance of mini-puberty for fertility in cryptorchidism. J Urol. 2005;174:1536–9.
  • 34. Ong C, Hasthorpe S, Hutson JM. Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation. Pediatr Surg Int. 2005;21(4):240-54.
  • 35. Huff DS, Hadziselimovic F, Snyder HM, III, Blythe B, Ducket JW. Histologic maldevelopment of unilaterally cryptorchid testes and their descended partners. Eur J Pediatr. 1993;52(suppl 2):11–4.
  • 36. de Sanctis C, Lala R, Canavese F. Cryptorchidism, La Pediatria Medicae Chirurgica: Medical and Surgical Pediatrics. 1995;17(1):23–8.
  • 37. Su CS, Szarek M, Vooght A. Gonocyte transformation to spermatogonial stem cells occurs earlier in patients with undervirilisation syndromes J Pediatr Surg. 2014;49:323-7.
  • 38. Cortes JM, Thorup J. Visfeldt Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism Horm Res. 2001;55:21-7.
  • 39. Rocca MS, Di Nisio A, Sabovic I, Ghezzi M, Foresta C, Ferlin A. E2F1 copy number variations contribute to spermatogenic impairment and cryptorchidism by increasing susceptibility to heat stress. Andrology. 2019;7(2):251-6.
  • 40. Hutson JM, Southwell BR, Li R. The regulation of testicular descent and the effects of cryptorchidism Endocr Rev. 2013;34:725.
  • 41. Thompson ST. Preventable causes of male infertility. World J Urol. 1993;11(2):111-9.
  • 42. Vigueras-Villasenor RM, Ojeda I, Gutierrez-Perez O. Protective effect of alpha-tocopherol on damage to rat testes by experimental cryptorchidism Int J Exp Pathol. 2011;92:131.
  • 43. Mete F, Kilic E, Somay A. Effects of heat stress on endocrine functions & behaviour in the pre-pubertal rat. Indian J Med Res. 2012;135:(2).
  • 44. Danno S, Itoh K, Matsuda T. Decreased expression of mouse Rbm3, a cold-shock protein, in Sertoli cells of cryptorchid testis. Am J Pathol. 2000;156:1685.
  • 45. Nie DS, Xiang Y, Wang J. Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis Biochemical & Biophysical Research Communications. 2005;28:1010.
  • 46. KubotaH, Sasaki S, Kubota Y. Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice. J Androl. 2011;32:77.
  • 47. Huff DS, Fenig DM, Canning DA. Abnormal germ cell development in cryptorchidism. Horm Res. 2001;55:11-17.
  • 48. Hadziselimovic F, Verkauskas G, Vincel B, Krey G, Zachariou Z. Abnormal histology in testis from prepubertal boys with monorchidism. Basic Clin Androl. 2020;6;30:11.
  • 49. Verkauskas G, Malcius D, Dasevicius D, Hadziselimovic F. Histopathology of Unilateral Cryptorchidism. Pediatr Dev Pathol. 2019;22(1):53-58.
  • 50. Li R, Thorup J, Sun C, Cortes D, Southwell B, Hutson J. Immunofluorescent analysis of testicular biopsies with germ cell and Sertoli cell markers shows significant MVH negative germ cell depletion with older age at orchiopexy. J Urol. 2014;191(2):458-64.
  • 51. Thorup, K. Kvist, E. Clasen-Linde. The relation between adult dark spermatogonia and other parameters of fertility potential in cryptorchid testes. J Urol. 2013;190(4 Suppl):1566-71.
  • 52. Tomomasa H, Adachi Y, Oshio S. Germ cell apoptosis in undescended testis: the origin of its impaired spermatogenesis in the TS inbred rat. J Urol. 2002;168:343-7.
  • 53. Ge WL, Chen JN, Ji LH, Zhao J, Xian H, Xu YZ. NEK2 gene expression in mouse cryptorchidism model and its mechanism involved in apoptosis. Zhonghua Yi Xue Za Zhi. 2020;100(44):3534-8.
  • 54. Zheng Y, Zhang P, Zhang C, Zeng W. Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice Zygote. 2019;27(2):101-10.
  • 55. Vigueras-Villasenor RM, Cortes-Trujillo L, Chavez-Saldana M. Analysis of POU5F1, c-Kit, PLAP, AP2gamma and SALL4 in gonocytes of patients with cryptorchidism. Acta Histochem. 2015;117:752-761.
  • 56. Hadziselimovic F, Gegenschatz-Schmid K, Verkauskas G, Docampo-Garcia MJ, Demougin P. Gene expression changes underlying idiopathic central hypogonadism in cryptorchidism with defective mini-puberty. Sex Dev. 2016;10:136–46.
  • 57. Thorup J, Clasen-Linde E, Cortes D. Positive Oct -3/4 and D2-40 Immunohistochemical Expression in Germ Cells and Suspected Histology Pattern of Intratubular Germ Cell Neoplasia in Boys with Cryptorchidism Vanish after the Age of 2 Years. Eur J Pediatr Surg. 2017;27(4):313-8.
  • 58. Thorup J, Clasen-Linde E, Li R, Reinhardt S, Kvist K, et al. Postnatal germ cell development in the cryptorchid testis: the key to explain why early surgery decreases the risk of malignancy. Eur J Pediatr Surg. 2018;28:469–76.
  • 59. Honecker F, Stoop H, de Krijger RR, Chris Lau YF, Bokemeyer C, et al. Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol. 2004;203:849–57.
  • 60. Rivier C, Meunier H, Roberts V, Vale W. Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Biol Reprod. 1989;41(5):967-81.
  • 61. Cortes D, Clasen-Linde E, Hutson JM. The Sertoli cell hormones inhibin-B and anti Mullerian hormone have different patterns of secretion in prepubertal cryptorchid boys. J Pediatr Surg. 2016;51:475-80.
  • 62. Kato T, Mizuno K, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Maruyama T. Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model. Andrology. 2020;8(5):1398-408.
  • 63. Cinislioglu AE, Ozkaya F, Altay MS, Aksoy Y. The incidence of epididymal anomalies in the bilateral and unilateral cryptorchidism cases: A comparative study. J Pediatr Urol. J Pediatr Urol. 2020;16(6):819.e1-819.
  • 64. Zhou Y, Zhang D, Liu B, Hu D, Shen L, Long C, Yu Y. Bioinformatic identification of key genes and molecular pathways in the spermatogenic process of cryptorchidism. Genes Dis. 201814;6(4):431-40.
  • 65. Docampo MJ, Hadziselimovic F. Molecular Pathology of Cryptorchidism-Induced Infertility. Sex Dev. 2015;9(5):269-78.9.
  • 66. Gendrel D, Roger M, Job JC. Plasma gonadotropin and testosterone values in infants with cryptorchidism. J Pediatr. 1980;97:217–20.
  • 67. Kuiri-Hänninen T, Koskenniemi J, Dunkel L, Toppari J, Sankilampi U. Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism. Front Endocrinol (Lausanne). 2019 Jul 23;10:489. doi: 10.3389/fendo.2019.00489.
  • 68. Mathers MJ, Sperling H, Rübben H, Roth S. The undescended testis: diagnosis, treatment and long-term consequences. Dtsch Arztebl Int. 2009;106(33):527-32.
  • 69. Huff DS, Hadziselimović F, Snyder HM 3rd, Blyth B, Duckett JW. Early postnatal testicular maldevelopment in cryptorchidism. J Urol. 1991;146(2 ( Pt 2):624-6.
  • 70. Job JC, Toublanc JE, Chaussain JL, Gendrel D, Roger M, Canlorbe P. The pituitary-gonadal axis in cryptorchid infants and children. Eur J Pediatr. 1987;146:2–5.
  • 71. Barthold JS, Manson J, Regan V, Si X, Hassink SG, Coughlin MT, et al. Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis. J Urol. 2004;172:1736–41.
  • 72. Hadziselimovic F, Hadziselimovic NO, Demougin P, Oakeley EJ. Testicular gene expression in cryptorchid boys at risk of azoospermia. Sex Dev. 2011;5:49–59.
  • 73. Kon Y, Endoh D. Heat-shock resistance in experimental cryptorchid testis of mice. Mol Reprod Dev. 2001;58(2):216-22.
  • 74. DeFoor WR, Kuan CY, Pinkerton M, Sheldon CA, Lewis AG. Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism. J Urol. 2004;172:1731–5.
  • 75. Ishii T, Matsuki S, Iuchi Y, Okada F, Toyosaki S, Tomita Y. Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress. Free Radic Res. 2005;39:697–705.
  • 76. Ahotupa M, Huhtaniemi I. Impaired detoxification of reactive oxygen and consequent oxidative stress in experimentally cryptorchid rat testis. Biol Reprod. 1992;46:1114–8.
  • 77. Gao P, Gao J, Dou X, Peng D, Zhang Y, Li H, Zhu T. The relationship between vascular endothelial growth factor and spermatogenesis disturbance in an experimentally-induced unilateral cryptorchidism murine model. Mol Biol Rep. 2020 May;47(5):3605-13.
  • 78. Yefimova MG, Buschiazzo A, Burel A, Lavault MT, Pimentel C, Jouve G, Jaillard S, Jegou B. Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa. Asian J Androl. 2019;21(6):570-6.
  • 79. Virtanen HE, Bjerknes R, Cortes D, et al. Cryptorchidism: Classification, prevalence and long‐term consequences. Acta Paediatr. 2007;96:611‐6.
  • 80. Olesen IA, Andersson A‐M, Aksglaede L, et al. Clinical, genetic, biochemical, and testicular biopsy findings among 1213 men evaluated for infertility. Fertil Steril. 2017;107:74‐ 82.
  • 81. Rossi LM, Pereira LA, de Santis L, Pasqualotto FF, Iaconelli A Jr, Ortiz V, Borges E. Sperm retrieval techniques in rats with suppressed spermatogenesis by experimental cryptorchidism. Hum Reprod. 2005;20(2):443-7.
  • 82. Haimov‐Kochman R, Prus D, Farchat M, Bdolah Y, Hurwitz A. Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques. Int J Androl. 2010;33:139‐43.
  • 83. Cito G, Della Camera PA, Degli Innocenti S, et al. Testicular sperm extraction after laparoscopic orchiectomy for bilateral postpubertal intra‐abdominal cryptorchidism: What chance of sperm retrieval? Andrologia. 2018;50:1‐6.
  • 84. Xu T, Peng L, Lin X, Li J, Xu W. Predictors for successful sperm retrieval of salvage microdissection testicular sperm extraction (TESE) following failed TESE in nonobstructive azoospermia patients. Andrologia. 2017;49(4). doi: 10.1111/and.12642.
  • 85. Barbotin A‐L, Dauvergne A, Dumont A, et al. Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: testicular sperm extraction outcomes. Asian J Androl. 2019;21:1‐7.
  • 86. Wiser A, Raviv G, Weissenberg R, et al. Does age at orchidopexy impact on the results of testicular sperm extraction ? RBM Online. 2009;19:778‐83.
  • 87. Osaka A, Iwahata T, Kobori Y, Shimomura Y, Yoshikawa N, Onota S, Yamamoto A, Ide H, Sugimoto K, Okada H. Testicular volume in non-obstructive azoospermia with a history of bilateral cryptorchidism may predict successful sperm retrieval by testicular sperm extraction. Reprod Med Biol. 2020;19(4):372-7.
  • 88. Schneuer FJ, Milne E, Jamieson SE, Pereira G, Hansen M, Barker A, Holland AJA, Bower C, Nassar N. Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 years. Lancet Child Adolesc Health. 2018;2(10):736-743.
  • 89. Ritzen EM. Undescended testes: a consensus on management. Eur J Endocrinol. 2008;159:87–90.
  • 90. Kollin C, Hesser U, Ritzen EM, Karpe B. Testicular growth from birth to two years of age, and the effect of orchidopexy at age nine months: a randomized, control study. Acta Paediatr. 2006;95:318–24.
  • 91. Kollin C, Karpe B, Heser U, Granholm T, Ritzen EM. Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchidopexy at age 9 months or 3 years. J Urol. 2007;178:1589–93.
  • 92. Ritzen EM, Bergh A, Bjerknes R, Christiansen P, Cortes D, Haugen SE, et al. Nordic consensus on treatment of undescended testes. Acta Pediatr. 2007;96:638–43.
  • 93. Rohayem J, Luberto A, Nieschlag E, Zitzmann M, Kliesch S. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine. 2017;55:914‐ 24.
  • 94. van Brakel J, Kranse R, de Muinck Keizer‐Schrama SMPF, et al. Fertility potential in a cohort of 65 men with previously acquired undescended testes. J Pediatr Surg. 2014;49:599‐ 605.
  • 95. Lee PA, O’Leary LA, Songer NJ, Coughlin MT, Bellinger MF, LaPorte RE. Paternity after bilateral cryptorchidism: a controlled study. Arch Pediat Adol Med. 1997;151:260‐ 3.
  • 96. Hagiuda J, Nakagawa K, Oya M. Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature. Syst Biol Reprod Med. 2021 Feb 25:1-4.
  • 97. Vernaeve V, Krikilion A, Verheyen G, Van Steirteghem A, Devroey P, Tournaye H. Outcome of testicular sperm recovery and ICSI in patients with non-obstructive azoospermia with a history of orchidopexy. Hum Reprod. 2004;19(10):2307-12.
  • 98. Chung E, Brock GB. Cryptorchidism and it's impact on male fertility: a state of art review of current literature. Can Urol Assoc J. 2011;5:210–4.
  • 99. Hadziselimovic F, Herzog B. Importance of early postnatal germ cell maturation for fertility of cryptorchid males. Horm Res. 2001;55:6–10.
  • 100. Leslie SW, Sajjad H, Villanueva CA. 2020 Oct 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–PMID: 29261861.
  • 101. Chilvers C, Dudley NE, Gough MH, et al. Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg 1986;21(8):691–6.
  • 102. Virtanen HE, Bjerknes R, Cortes D, et al. Cryptorchidism: classification, prevalence and long-term consequences. Acta Paediatr. 2007;96(5):611–6.
  • 103. Taskinen S, Hovatta O, Wikstrom S. Early treatment of cryptorchidism, semen quality and testicular endocrinology. J Urol 1996;156(1):82–4.
  • 104. Gracia J, Sa´nchez Zalabardo J, Sa´nchez Garcı´a J. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. BJU Int 2000;85(9):1100–3.
  • 105. Feyles F, Peiretti V, Mussa A, et al. Improved sperm count and motility in young men surgically treated for cryptorchidism in the first year of life. Eur J Pediatr Surg 2014;24(5):376–80.
  • 106. Verkauskas G, Malcius D, Eidukaite A, Vilimas J, Dasevicius D, Bilius V, Hadziselimovic F. Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism Multicenter Study J Pediatr Urol. 2016;12(4):238.e1-6.
  • 107. Pyo¨ra¨la¨ S, Huttunen NP, Uhari M. A review and meta-analysis of hormonal treatment of cryptorchidism. J Clin Endocrinol Metab 1995;80(9):2795–9.
  • 108. Henna MR, Del Nero RG, Sampaio CZ, et al. Hormonal cryptorchidism therapy. systematic review with meta-analysis of randomized clinical trials. Pediatr Surg Int. 2004;20(5):357–9.
  • 109. Cortes D, Thorup J, Visfeldt J. Hormonal treatment may harm the germ cells in 1 to 3-year-old boys with cryptorchidism. J Urol 2000;163(4):1290–2.
  • 110. Penson D, Krishnaswami S, Jules A, McPheeters ML. Effectiveness of hormonal and surgical therapies for cryptorchidism: a systematic review. ediatrics. 2013;131(6):e1897-907.
  • 111. Gapany C, Frey P, Cachat F, et al. Management of cryptorchidism in children:guidelines. Swiss Med Wkly 2008;138(33–34):492–8.
  • 112. Kolon TF, Herndon CD, Baker LA, et al. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol 2014;192(2):337–45.
  • 113. Hjertkvist M, Bergh A, Damber JE. hCG treatment increases intratesticular pressure in the abdominal testis of unilaterally cryptorchid rats. J Androl. 1988;9:116–20.
  • 114. Bergh A, Rooth P, Widmark A, Damber JE. Treatment of rats with hCG induces inflammation-like changes in the testicular microcirculation. J Reprod Fertil. 1987;79:135–43.
  • 115. Chandrasekharam VV, Srinivas M, Das SN, Jha P, Bajpai M, Chaki SP, et al. Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology. 2003;62:571–4.
  • 116. Assmus M, Svechnikov K, von Euler M, Setchell B, Sultana T, Zeetterstrom C, et al. Single subcutaneous administration of chorionic gonadotropin to rats induces a rapid and transient increase in testicular expression of pro-inflammatory cytokines. Pediatr Res. 2005;57:896–901.
  • 117. Hjertkvist M, Lackgren G, Ploen L, Bergh A. Does hCG treatment induce inflammation-like changes in undescended testes in boys? J Pediatr Surg. 1993;29:254–8.
  • 118. Dermirbilek S, Atayurt HF, Celik N, Aydin G. Does treatment with human chorionic gonadotropin induce reversible changes in undescended testes in boys? Pediatr Surg Int. 1997;12:591–4.
  • 119. Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikstrom S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest. 1997;100:2341–6.
  • 120. Grasso M, Buonaguidi A, Lania C, Bergamaschi F, Castelli M, Rigatti P. Post-pubertal cryptorchidism: review and evaluation of the fertility. Eur Urol. 1991;20(2):126–8. 41.
  • 121. Drabik G, Józsa T, Ruzsnavszky O, Kistamás K, Dienes B, Kovacs I, Benyó M, Flaskó T. Correlation between the androgen receptor status of the appendix testis and the efficacy of human chorionic gonadotropin treatment in undescended testis. Int Urol Nephrol. 2015;47(8):1235-9.
  • 122. Hadziselimovic F. Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue. Int Braz J Urol. 2008;34(3):319–28.
  • 123. Hadziselimovic F, Huff D, Duckett J, et al. Treatment of cryptorchidism with low doses of buserelin over a 6-months period. Eur J Pediatr. 1987;146(suppl 2):56–8.
  • 124. Hadziselimovic F, Hoecht B, Herzog B, Girard J. Does long term treatment with buserein improvemthe fertility chances of cryptorchid testes? In: Labrie F, Belanger A, Dupont A, editors. LH-RH and its Analogues. Amsterdam: Elsevier; 1984. p. 457.
  • 125. Biers SM, Malone PS. A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexy. J Purol. 2010;6(3):239–46.
  • 126. Zivkovic D, Bica DT, Hadziselimovic F, Bay K, Andersson AM. Relationship between adult dark spermatogonia and secretory capacity of Leydig cells in cryptorchidism. BJU Int. 2007;100(5):1147–9.
  • 127. Kolon TF, Herndon CD, Baker LA, Baskin LS, Baxter CG, Cheng EY, Diaz M, Lee PA, Seashore CJ, Tasian GE, Barthold JS; American Urological Assocation. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol. 2014;192(2):337-45.
  • 128. Hadziselimovic F, Herzog B. Treatment with a luteinizing hormone-releasing hormone analogue after successful orchiopexy markedly improves the chance of fertility later in life. J Urol. 1997;158:1193–5.
  • 129. Biers SM, Malone PS. A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexy. J Pediatr Urol. 2010;6(3):239-46.
  • 130. Elder JS. The undescended testis. Hormonal and surgical management. Surg Clin North Am. 1988;68(5):983-1005.
  • 131. Zivkovic D, Bica DG, Hadziselimovic F. Effects of hormonal treatment on the contralateral descended testis in unilateral cryptorchidism. J Pediatr Urol. 2006;2:468–72.
  • 132. Yilmaz O, Akyol I, Özyurt M, Ateş F, Soydan H, Malkoç E. The influence of hormonal treatment with beta-human chorionic gonadotropin for cryptorchidism on future fertility in rats. Comparative Study J Pediatr Urol. 2015;11(2):92.e1-4.
  • 133. Kawada T, Yamanaka H, Hasegawa Y. Decreased immunoreactive inhibin and increased FSH levels in cryptorchidism after orchidopexy. Endocr J. 1995;42(4):577-80.
  • 134. Uijldert M, Meißner A, Kuijper CF, Repping S, de Jong TPVM, Chrzan RJ. Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques. Andrologia. 2019;51(3):e13194.
  • 135. Thorup J, Petersen BL, Kvist K, Cortes D. Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys. J Urol. 2012;188(4 suppl):1436–42.
  • 136. Jørgensen N, Rajpert-De Meyts E, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl. 2010;2010;33:298–303.
  • 137. Hadziselimovic F, Herzog B. The importance of both and early orchidopexy and germ cell maturation for fertility. Lancet. 2001;358:1156–1157.
  • 138. Kraft KH, Canning DA, Snyder HM, et al. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol 2012;188(4 Suppl):1429–35.
  • 139. Cortes D, Thorup JM, Beck BL. Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants. J Urol. 1995;154(3):1188-92.
  • 140. Cortes D. Cryptorchidism-aspects of pathogenesis, histology and treatment. Scand J Urol Nephrol. 1998;196(Suppl):1–54.
  • 141. Hadziselimovic F, Hocht B, Herzog B, Buser MW. Infertility in cryptorchidism is linked to the stage of germ cell development at orchiopexy. Horm Res. 2007;68:46–52.
  • 142. Hadziselimovic F, Hoecht B. Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism. Klin Padiatr. 2008;220:302–7.
  • 143. DeFoor WR, Kuan CY, Pinkerton M, Sheldon CA, Lewis AG. Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism. J Urol. 2004;172:1731–5.
  • 144. Viqueral-Villasenor RM, Ojeda I, Gutierrez-Perez O, Chavez-Saldana M, Cuevas O, Maria DS, et al. Protective effect of α-tocopherol on damage to rat testis by experimental cryptorchidism. Int J Exp Pathol. 2011;92:131–9.
  • 145. Yang S, Ping P, Ma M, Li P, Tian R, Yang H. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of crylptorchid patients. Stem Cell Rep. 2014;3:663–75.
  • 146. Acikgoz A, Asci R, Aydin O, Cavus H, Donmez G, Buyukalpelli R. The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral descended testes. Drug Des Devel Ther. 2014;8:2089–97.
  • 147. Munyali A, Momo AT, Fozin GRB, Defo PBD, Tchatat YP, Lieunang B, Watcho P. Rubus apetalus (Rosaceae) improves spermatozoa characteristics, antioxidant enzymes and fertility potential in unilateral cryptorchid rats. Basic Clin Androl. 2020 Jul 9;30:8.
  • 148. Tekayev M, Bostancieri N, Saadat KASM, Turker M, Yuncu M, Ulusal H, Cicek H, Arman K. Effects of Moringa oleifera Lam Extract (MOLE) in the heat shock protein 70 expression and germ cell apoptosis on experimentally induced cryptorchid testes of rats. Gene. 2019 Mar 10;688:140-50.
  • 149. Enrica Bianchi, Kim Boekelheide, Mark Sigman, Susan J Hall, Kathleen Hwang Folia Morphol (Warsz). Ghrelin modulates testicular damage in a cryptorchid mouse model. PLoS One. 2017 May 18;12(5):e0177995.
  • 150. M A Abd-El-Hafez, M D El-Shafee, S H Omar, A A Aburahma, S S Kamar. The ameliorative effect of curcumin on cryptorchid and non-cryptorchid testes in induced unilateral cryptorchidism in albino rat: histological evaluation. Folia Morphol (Warsz). 2020 Aug 4. doi: 10.5603/FM.a2020.0084.
  • 151. Kraft KH, Canning DA, Snyder HM 3rd, Kolon TF. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol. 2012;188(4 Suppl):1429-35.
  • 152. Pettersson A, Richiardi L, Nordenskjokd A, Kaijser M, Akre O. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356:1835–41.
  • 153. Hildorf S, Clasen-Linde E, Cortes D, Fossum M, Thorup J. Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism despite Orchiopexy within the First Year of Life. J Urol. 2020;203(4):832-40.
  • 154. Kraft KH, Mucksavage P, Canning DA, Snyder HM 3rd, Kolon TF. Histological findings in patients with cryptorchidism and testis-epididymis nonfusion. J Urol. 2011;186(5):2045-9.
  • 155. McAleer IM, Packer MG, Kaplan GW, Scherz HC, Krous HF, Billman GF. Fertility index analysis in cryptorchidism. J Urol. 1995;153(4):1255-8.
  • 156. Çayan S, Orhan I, Altay B, Aşcı R, Akbay E, Ayas B, Yaman O. Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction. Andrology. 2020 Sep 22. doi: 10.1111/andr.12910. Online ahead of print.
  • 157. Raman JD, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. J Urol. 2003;170:1287‐90.
  • 158. Haimov‐Kochman R, Prus D, Farchat M, Bdolah Y, Hurwitz A. Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques. Int J Androl. 2010;33:139‐43.
  • 159. Negri L, Albani E, DiRocco M, Morreale G, Novara P, Levi‐Setti PE. Testicular sperm extraction in azoospermic men submitted to bilateral orchidopexy. Hum Reprod. 2003;18:2534‐ 9.
  • 160. Ozan T, Karakeci A, Kaplancan T, Pirincci N, Firdolas F, Orhan I. Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation? Andrologia. 2019;51(11):e13430.
  • 161. Sangster P, Alnajjar HM, Ahmed K, et al. Microdissection TESE (mTESE) following adult orchidopexy for undescended intra‐abdominal and inguinal testicles‐surgical techniques and outcomes from a single‐centre cohort. Andrology. 2019;8:1‐ 5.
  • 162. Irkilata HC, Dayanc M, Yıldırım I, Cincik M, Aydur E, Peker AF. Low sperm recovery from the undescended testis with testicular sperm extraction in postpubertal crptorchids: preliminary report. Andrologia. 2005;37:65‐8.
  • 163. Dabaja AA, Schlegel PN. Microdissection testicular sperm extraction: an update. Asian J Androl. 2013;15(1):35-9.
  • 164. Anne-Laure Barbotin, Anaïs Dauvergn, Agathe Dumont, Nassima Ramdane 5, Valérie Mitchell, Jean-Marc Rigot, Florence Boitrelle, Geoffroy Robin Comparative Study.Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: Testicular sperm extraction outcomes. Asian J Androl. 2019;21(5):445-51.
  • 165. Calleja Aguayo E, Delgado Alvira R, Estors Sastre B, et al. Fertility survey of patients operated on of cryptorchidism in the pediatric age. Cir Pediatr. 2012;25(2):78–81.
  • 166. Kvist K, Thorup J, Byskov AG, Hoyer PE, Mollgard K. Cryopreservation of intact testicular tissue from boys with cryptorchidism. Hum Reprod. 2006;21:484–91.

Undescended Testis and Infertility

Yıl 2020, Cilt: 12 Sayı: 4, 96 - 119, 24.04.2021

Öz

Undescended testicle is seen in 3-4% of children. This rate can reach up to 40% in premature children. Treatment should be completed until the age of one year in children with undescended testicle. There is a risk of infertility and tumor development due to treatments that are not performed at the appropriate time. In addition, there may be psychological problems in children and their parents due to cosmetic reasons. It is seen that the number of experimental and clinical studies related to the effect of undescended testis on fertility is very limited. In this review, the relationship between undescended testis and infertility was investigated.

Kaynakça

  • 1. Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. E. A. U. Guidelines on Male Infertility. 2018;6–7. https://uroweb.org/wp-content/ uploads/EAU-Guidelines-on-Male-Infertility-2018-large-text.pdf
  • 2. Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 2017;32(1):18-31.
  • 3. Fallara G, Cazzaniga W, Boeri L, Capogrosso P, Candela L, Pozz E. Male factor infertility trends throughout the last 10 years: Report from a tertiary-referral academic andrology centre. Andrology. 2020 Nov 24. doi: 10.1111/andr.12947. Online ahead of print.
  • 4. Cortes D, Holt R, de Knegt V. Hormonal aspects of the pathogenesis and treatment of cryptorchidism. Eur J Pediatr Surg. 2016;26:409‐ 17.
  • 5. Goel P, Sijstermans K, Schneuer FJ, Virtanen HE, Bjerknes R, Cortes D. Cryptorchidism: Classification, prevalence and long‐term consequences. Acta Paediatr. 2007;96:611‐6.
  • 6. Mieusset R, Bujan L, Massat G, Mansat A, Pontonnier F. Clinical and biological characteristics of infertile men with a history of cryptorchidism. Hum Reprod. 1995;10(3):613-9.
  • 7. Emad-Eldin S. Spigelian-cryptorchidism syndrome in an adult male complaining of primary infertility: Case report. Emad-Eldin S, Abdelaziz O, Shokr M. Andrologia. 2020 Oct 25:e13838. doi: 10.1111/and.13838.
  • 8. Muncey W, Dutta R, Terlecki RP, Woo LL, Scarberry K. Fertility potential in adult men treated for uncorrected bilateral cryptorchidism: A systematic literature review and analysis of case reports. Andrology. 2020 Dec 22. doi: 10.1111/andr.12964.
  • 9. Olesen IA, Andersson A‐M, Aksglaede L, et al. Clinical, genetic, biochemical, and testicular biopsy findings among 1213 men evaluated for infertility. Fertil Steril. 2017;107:74‐ 82.
  • 10. Gracia J, Sánchez Zalabardo J, Sánchez García J, García C, Ferrández A. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. BJU Int. 2000;85(9):1100-3.
  • 11. Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone and semen data. Horm Res. 2001;55:29–31.
  • 12. Wilkerson ML, Bartone FF, Fox L. Fertility potential: a comparison of intra-abdominal and intracanalicular testes by age groups in children. Horm Res. 2001;55:18-20.
  • 13. Kobayashi H, Nagao K, Nakajima K. Advanced Studies in Medical Sciences. 1. Vol. 1. HIKARI Ltd; 2013. Therapeutic Advances in the Field of Male Infertility: Stem Cell Research; pp. 39–54.
  • 14. Lee PA. Fertility after cryptorchidism: epidemiology and other outcome studies. Urology. 2005;66(2):427–31.
  • 15. Fallon B, Kennedy TJ. Long-term follow-up of fertility in cryptorchid patients. Urology. 1985;25:502–4.
  • 16. Koch T, Hansen AH, Priskorn L, Petersen JH, Carlsen E, Main KM. A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population. Hum Reprod. 2020 Aug 1;35(8):1765-80.
  • 17. Lee PA, O'Leary LA, Songer NJ, Coughlin MT, Bellinger MF, LaPorte RE. Paternity after unilateral cryptorchidism: a controlled study. Pediatrics. 1996;98(4 Pt 1):676-9.
  • 18. Braga LH, Lorenzo AJ, Romao RLP. Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism. Can Urol Assoc J. 2017;11(7):251-260.
  • 19. Kojima Y, Hayashi Y, Mizuno K, et al. Future treatment strategies for cryptorchidism to improve spermatogenesis. Hinyokika Kiyo. 2007;53(7):517–522.
  • 20. Adomaitis R, Vincel B, Eidukaite A, Ostaneviciute E, Kirka R, Bilius V, Malcius D, Verkauskas G, Hadziselimovic F. Consequences of bilateral cryptorchidism in adults. Andrologia. 2016;48(9):933-8.
  • 21. Hanson BM, Eisenberg ML, Hotaling JM. Male infertility: a biomarker of individual and familial cancer risk. Fertil Steril 2018;109:6–19.
  • 22. Lipshultz LI, Caminos-Torres R, Greenspan CS, Snyder PJ. Testicular function after orchiopexy for unilaterally undescended testis. N Engl J Med. 1976;295:15–8.
  • 23. Walsh TJ, Croughan MS, Schembri M, Chan JM, Turek PJ. Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med. 2009;169:351–6.
  • 24. internet sayfası linki: https://www.genecards.org
  • 25. Sharifi N, Sabbaghian M, Farrahi F, Almadani N, Boroujeni PB, Meybodi AM. Cytogenetic assessment of Iranian infertile men with undescended testis: A retrospective study. JBRA Assist Reprod. 2020;24(4):400-4.
  • 26. Hutson JM, Li R, Southwell BR, Petersen BL, Thorup J, Cortes D Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? Front Endocrinol (Lausanne). 2012;3:176.
  • 27. Loebenstein M, Hutson J, Li R. Gonocyte transformation in a congenitally cryptorchid rat is normal and may be similar to the situation reported in human acquired cryptorchidism. J Pediatr Surg. 2018;53(9):1770-5.
  • 28. Li R, Zhang JG, Churchill J, Sourial M, Southwell BR, Hutson JM. Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation? J Pediatr Surg. 2012;47(9):1724-9.
  • 29. Cobellis G, Noviello C, Nino F, Romano M, Mariscoli F, Martino A, Parmeggiani P, Papparella A. Spermatogenesis and cryptorchidism. Front Endocrinol (Lausanne). 2014;1;5:63.
  • 30. Radmayr C, Bogaert G, Dogan HS, Kočvara R, Nijman JM, Stein R. EAU Guidelines on Paediatric Urology 2018. Arnhem (The Netherlands): European Association of Urology: European Society for Paediatric Urology;2018;33.
  • 31. Wilson V, Thorup J, Clasen-Linde E, Cortes D, Hutson JM, Li R. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death? Pediatr Surg Int. 2019;35(11):1309-6.
  • 32. Kamisawa H, Kojima Y, Mizuno K, Imura M, Hayashi Y, Kohri K. Attenuation of spermatogonial stem cell activity in cryptorchid testes. J Urol. 2012;187(3):1047-52.
  • 33. Hadziselimovic F, Zivkovic D, Bica DT, Emmons LR. The importance of mini-puberty for fertility in cryptorchidism. J Urol. 2005;174:1536–9.
  • 34. Ong C, Hasthorpe S, Hutson JM. Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation. Pediatr Surg Int. 2005;21(4):240-54.
  • 35. Huff DS, Hadziselimovic F, Snyder HM, III, Blythe B, Ducket JW. Histologic maldevelopment of unilaterally cryptorchid testes and their descended partners. Eur J Pediatr. 1993;52(suppl 2):11–4.
  • 36. de Sanctis C, Lala R, Canavese F. Cryptorchidism, La Pediatria Medicae Chirurgica: Medical and Surgical Pediatrics. 1995;17(1):23–8.
  • 37. Su CS, Szarek M, Vooght A. Gonocyte transformation to spermatogonial stem cells occurs earlier in patients with undervirilisation syndromes J Pediatr Surg. 2014;49:323-7.
  • 38. Cortes JM, Thorup J. Visfeldt Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism Horm Res. 2001;55:21-7.
  • 39. Rocca MS, Di Nisio A, Sabovic I, Ghezzi M, Foresta C, Ferlin A. E2F1 copy number variations contribute to spermatogenic impairment and cryptorchidism by increasing susceptibility to heat stress. Andrology. 2019;7(2):251-6.
  • 40. Hutson JM, Southwell BR, Li R. The regulation of testicular descent and the effects of cryptorchidism Endocr Rev. 2013;34:725.
  • 41. Thompson ST. Preventable causes of male infertility. World J Urol. 1993;11(2):111-9.
  • 42. Vigueras-Villasenor RM, Ojeda I, Gutierrez-Perez O. Protective effect of alpha-tocopherol on damage to rat testes by experimental cryptorchidism Int J Exp Pathol. 2011;92:131.
  • 43. Mete F, Kilic E, Somay A. Effects of heat stress on endocrine functions & behaviour in the pre-pubertal rat. Indian J Med Res. 2012;135:(2).
  • 44. Danno S, Itoh K, Matsuda T. Decreased expression of mouse Rbm3, a cold-shock protein, in Sertoli cells of cryptorchid testis. Am J Pathol. 2000;156:1685.
  • 45. Nie DS, Xiang Y, Wang J. Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis Biochemical & Biophysical Research Communications. 2005;28:1010.
  • 46. KubotaH, Sasaki S, Kubota Y. Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice. J Androl. 2011;32:77.
  • 47. Huff DS, Fenig DM, Canning DA. Abnormal germ cell development in cryptorchidism. Horm Res. 2001;55:11-17.
  • 48. Hadziselimovic F, Verkauskas G, Vincel B, Krey G, Zachariou Z. Abnormal histology in testis from prepubertal boys with monorchidism. Basic Clin Androl. 2020;6;30:11.
  • 49. Verkauskas G, Malcius D, Dasevicius D, Hadziselimovic F. Histopathology of Unilateral Cryptorchidism. Pediatr Dev Pathol. 2019;22(1):53-58.
  • 50. Li R, Thorup J, Sun C, Cortes D, Southwell B, Hutson J. Immunofluorescent analysis of testicular biopsies with germ cell and Sertoli cell markers shows significant MVH negative germ cell depletion with older age at orchiopexy. J Urol. 2014;191(2):458-64.
  • 51. Thorup, K. Kvist, E. Clasen-Linde. The relation between adult dark spermatogonia and other parameters of fertility potential in cryptorchid testes. J Urol. 2013;190(4 Suppl):1566-71.
  • 52. Tomomasa H, Adachi Y, Oshio S. Germ cell apoptosis in undescended testis: the origin of its impaired spermatogenesis in the TS inbred rat. J Urol. 2002;168:343-7.
  • 53. Ge WL, Chen JN, Ji LH, Zhao J, Xian H, Xu YZ. NEK2 gene expression in mouse cryptorchidism model and its mechanism involved in apoptosis. Zhonghua Yi Xue Za Zhi. 2020;100(44):3534-8.
  • 54. Zheng Y, Zhang P, Zhang C, Zeng W. Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice Zygote. 2019;27(2):101-10.
  • 55. Vigueras-Villasenor RM, Cortes-Trujillo L, Chavez-Saldana M. Analysis of POU5F1, c-Kit, PLAP, AP2gamma and SALL4 in gonocytes of patients with cryptorchidism. Acta Histochem. 2015;117:752-761.
  • 56. Hadziselimovic F, Gegenschatz-Schmid K, Verkauskas G, Docampo-Garcia MJ, Demougin P. Gene expression changes underlying idiopathic central hypogonadism in cryptorchidism with defective mini-puberty. Sex Dev. 2016;10:136–46.
  • 57. Thorup J, Clasen-Linde E, Cortes D. Positive Oct -3/4 and D2-40 Immunohistochemical Expression in Germ Cells and Suspected Histology Pattern of Intratubular Germ Cell Neoplasia in Boys with Cryptorchidism Vanish after the Age of 2 Years. Eur J Pediatr Surg. 2017;27(4):313-8.
  • 58. Thorup J, Clasen-Linde E, Li R, Reinhardt S, Kvist K, et al. Postnatal germ cell development in the cryptorchid testis: the key to explain why early surgery decreases the risk of malignancy. Eur J Pediatr Surg. 2018;28:469–76.
  • 59. Honecker F, Stoop H, de Krijger RR, Chris Lau YF, Bokemeyer C, et al. Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol. 2004;203:849–57.
  • 60. Rivier C, Meunier H, Roberts V, Vale W. Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Biol Reprod. 1989;41(5):967-81.
  • 61. Cortes D, Clasen-Linde E, Hutson JM. The Sertoli cell hormones inhibin-B and anti Mullerian hormone have different patterns of secretion in prepubertal cryptorchid boys. J Pediatr Surg. 2016;51:475-80.
  • 62. Kato T, Mizuno K, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Maruyama T. Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model. Andrology. 2020;8(5):1398-408.
  • 63. Cinislioglu AE, Ozkaya F, Altay MS, Aksoy Y. The incidence of epididymal anomalies in the bilateral and unilateral cryptorchidism cases: A comparative study. J Pediatr Urol. J Pediatr Urol. 2020;16(6):819.e1-819.
  • 64. Zhou Y, Zhang D, Liu B, Hu D, Shen L, Long C, Yu Y. Bioinformatic identification of key genes and molecular pathways in the spermatogenic process of cryptorchidism. Genes Dis. 201814;6(4):431-40.
  • 65. Docampo MJ, Hadziselimovic F. Molecular Pathology of Cryptorchidism-Induced Infertility. Sex Dev. 2015;9(5):269-78.9.
  • 66. Gendrel D, Roger M, Job JC. Plasma gonadotropin and testosterone values in infants with cryptorchidism. J Pediatr. 1980;97:217–20.
  • 67. Kuiri-Hänninen T, Koskenniemi J, Dunkel L, Toppari J, Sankilampi U. Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism. Front Endocrinol (Lausanne). 2019 Jul 23;10:489. doi: 10.3389/fendo.2019.00489.
  • 68. Mathers MJ, Sperling H, Rübben H, Roth S. The undescended testis: diagnosis, treatment and long-term consequences. Dtsch Arztebl Int. 2009;106(33):527-32.
  • 69. Huff DS, Hadziselimović F, Snyder HM 3rd, Blyth B, Duckett JW. Early postnatal testicular maldevelopment in cryptorchidism. J Urol. 1991;146(2 ( Pt 2):624-6.
  • 70. Job JC, Toublanc JE, Chaussain JL, Gendrel D, Roger M, Canlorbe P. The pituitary-gonadal axis in cryptorchid infants and children. Eur J Pediatr. 1987;146:2–5.
  • 71. Barthold JS, Manson J, Regan V, Si X, Hassink SG, Coughlin MT, et al. Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis. J Urol. 2004;172:1736–41.
  • 72. Hadziselimovic F, Hadziselimovic NO, Demougin P, Oakeley EJ. Testicular gene expression in cryptorchid boys at risk of azoospermia. Sex Dev. 2011;5:49–59.
  • 73. Kon Y, Endoh D. Heat-shock resistance in experimental cryptorchid testis of mice. Mol Reprod Dev. 2001;58(2):216-22.
  • 74. DeFoor WR, Kuan CY, Pinkerton M, Sheldon CA, Lewis AG. Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism. J Urol. 2004;172:1731–5.
  • 75. Ishii T, Matsuki S, Iuchi Y, Okada F, Toyosaki S, Tomita Y. Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress. Free Radic Res. 2005;39:697–705.
  • 76. Ahotupa M, Huhtaniemi I. Impaired detoxification of reactive oxygen and consequent oxidative stress in experimentally cryptorchid rat testis. Biol Reprod. 1992;46:1114–8.
  • 77. Gao P, Gao J, Dou X, Peng D, Zhang Y, Li H, Zhu T. The relationship between vascular endothelial growth factor and spermatogenesis disturbance in an experimentally-induced unilateral cryptorchidism murine model. Mol Biol Rep. 2020 May;47(5):3605-13.
  • 78. Yefimova MG, Buschiazzo A, Burel A, Lavault MT, Pimentel C, Jouve G, Jaillard S, Jegou B. Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa. Asian J Androl. 2019;21(6):570-6.
  • 79. Virtanen HE, Bjerknes R, Cortes D, et al. Cryptorchidism: Classification, prevalence and long‐term consequences. Acta Paediatr. 2007;96:611‐6.
  • 80. Olesen IA, Andersson A‐M, Aksglaede L, et al. Clinical, genetic, biochemical, and testicular biopsy findings among 1213 men evaluated for infertility. Fertil Steril. 2017;107:74‐ 82.
  • 81. Rossi LM, Pereira LA, de Santis L, Pasqualotto FF, Iaconelli A Jr, Ortiz V, Borges E. Sperm retrieval techniques in rats with suppressed spermatogenesis by experimental cryptorchidism. Hum Reprod. 2005;20(2):443-7.
  • 82. Haimov‐Kochman R, Prus D, Farchat M, Bdolah Y, Hurwitz A. Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques. Int J Androl. 2010;33:139‐43.
  • 83. Cito G, Della Camera PA, Degli Innocenti S, et al. Testicular sperm extraction after laparoscopic orchiectomy for bilateral postpubertal intra‐abdominal cryptorchidism: What chance of sperm retrieval? Andrologia. 2018;50:1‐6.
  • 84. Xu T, Peng L, Lin X, Li J, Xu W. Predictors for successful sperm retrieval of salvage microdissection testicular sperm extraction (TESE) following failed TESE in nonobstructive azoospermia patients. Andrologia. 2017;49(4). doi: 10.1111/and.12642.
  • 85. Barbotin A‐L, Dauvergne A, Dumont A, et al. Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: testicular sperm extraction outcomes. Asian J Androl. 2019;21:1‐7.
  • 86. Wiser A, Raviv G, Weissenberg R, et al. Does age at orchidopexy impact on the results of testicular sperm extraction ? RBM Online. 2009;19:778‐83.
  • 87. Osaka A, Iwahata T, Kobori Y, Shimomura Y, Yoshikawa N, Onota S, Yamamoto A, Ide H, Sugimoto K, Okada H. Testicular volume in non-obstructive azoospermia with a history of bilateral cryptorchidism may predict successful sperm retrieval by testicular sperm extraction. Reprod Med Biol. 2020;19(4):372-7.
  • 88. Schneuer FJ, Milne E, Jamieson SE, Pereira G, Hansen M, Barker A, Holland AJA, Bower C, Nassar N. Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 years. Lancet Child Adolesc Health. 2018;2(10):736-743.
  • 89. Ritzen EM. Undescended testes: a consensus on management. Eur J Endocrinol. 2008;159:87–90.
  • 90. Kollin C, Hesser U, Ritzen EM, Karpe B. Testicular growth from birth to two years of age, and the effect of orchidopexy at age nine months: a randomized, control study. Acta Paediatr. 2006;95:318–24.
  • 91. Kollin C, Karpe B, Heser U, Granholm T, Ritzen EM. Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchidopexy at age 9 months or 3 years. J Urol. 2007;178:1589–93.
  • 92. Ritzen EM, Bergh A, Bjerknes R, Christiansen P, Cortes D, Haugen SE, et al. Nordic consensus on treatment of undescended testes. Acta Pediatr. 2007;96:638–43.
  • 93. Rohayem J, Luberto A, Nieschlag E, Zitzmann M, Kliesch S. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine. 2017;55:914‐ 24.
  • 94. van Brakel J, Kranse R, de Muinck Keizer‐Schrama SMPF, et al. Fertility potential in a cohort of 65 men with previously acquired undescended testes. J Pediatr Surg. 2014;49:599‐ 605.
  • 95. Lee PA, O’Leary LA, Songer NJ, Coughlin MT, Bellinger MF, LaPorte RE. Paternity after bilateral cryptorchidism: a controlled study. Arch Pediat Adol Med. 1997;151:260‐ 3.
  • 96. Hagiuda J, Nakagawa K, Oya M. Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature. Syst Biol Reprod Med. 2021 Feb 25:1-4.
  • 97. Vernaeve V, Krikilion A, Verheyen G, Van Steirteghem A, Devroey P, Tournaye H. Outcome of testicular sperm recovery and ICSI in patients with non-obstructive azoospermia with a history of orchidopexy. Hum Reprod. 2004;19(10):2307-12.
  • 98. Chung E, Brock GB. Cryptorchidism and it's impact on male fertility: a state of art review of current literature. Can Urol Assoc J. 2011;5:210–4.
  • 99. Hadziselimovic F, Herzog B. Importance of early postnatal germ cell maturation for fertility of cryptorchid males. Horm Res. 2001;55:6–10.
  • 100. Leslie SW, Sajjad H, Villanueva CA. 2020 Oct 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–PMID: 29261861.
  • 101. Chilvers C, Dudley NE, Gough MH, et al. Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg 1986;21(8):691–6.
  • 102. Virtanen HE, Bjerknes R, Cortes D, et al. Cryptorchidism: classification, prevalence and long-term consequences. Acta Paediatr. 2007;96(5):611–6.
  • 103. Taskinen S, Hovatta O, Wikstrom S. Early treatment of cryptorchidism, semen quality and testicular endocrinology. J Urol 1996;156(1):82–4.
  • 104. Gracia J, Sa´nchez Zalabardo J, Sa´nchez Garcı´a J. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. BJU Int 2000;85(9):1100–3.
  • 105. Feyles F, Peiretti V, Mussa A, et al. Improved sperm count and motility in young men surgically treated for cryptorchidism in the first year of life. Eur J Pediatr Surg 2014;24(5):376–80.
  • 106. Verkauskas G, Malcius D, Eidukaite A, Vilimas J, Dasevicius D, Bilius V, Hadziselimovic F. Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism Multicenter Study J Pediatr Urol. 2016;12(4):238.e1-6.
  • 107. Pyo¨ra¨la¨ S, Huttunen NP, Uhari M. A review and meta-analysis of hormonal treatment of cryptorchidism. J Clin Endocrinol Metab 1995;80(9):2795–9.
  • 108. Henna MR, Del Nero RG, Sampaio CZ, et al. Hormonal cryptorchidism therapy. systematic review with meta-analysis of randomized clinical trials. Pediatr Surg Int. 2004;20(5):357–9.
  • 109. Cortes D, Thorup J, Visfeldt J. Hormonal treatment may harm the germ cells in 1 to 3-year-old boys with cryptorchidism. J Urol 2000;163(4):1290–2.
  • 110. Penson D, Krishnaswami S, Jules A, McPheeters ML. Effectiveness of hormonal and surgical therapies for cryptorchidism: a systematic review. ediatrics. 2013;131(6):e1897-907.
  • 111. Gapany C, Frey P, Cachat F, et al. Management of cryptorchidism in children:guidelines. Swiss Med Wkly 2008;138(33–34):492–8.
  • 112. Kolon TF, Herndon CD, Baker LA, et al. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol 2014;192(2):337–45.
  • 113. Hjertkvist M, Bergh A, Damber JE. hCG treatment increases intratesticular pressure in the abdominal testis of unilaterally cryptorchid rats. J Androl. 1988;9:116–20.
  • 114. Bergh A, Rooth P, Widmark A, Damber JE. Treatment of rats with hCG induces inflammation-like changes in the testicular microcirculation. J Reprod Fertil. 1987;79:135–43.
  • 115. Chandrasekharam VV, Srinivas M, Das SN, Jha P, Bajpai M, Chaki SP, et al. Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology. 2003;62:571–4.
  • 116. Assmus M, Svechnikov K, von Euler M, Setchell B, Sultana T, Zeetterstrom C, et al. Single subcutaneous administration of chorionic gonadotropin to rats induces a rapid and transient increase in testicular expression of pro-inflammatory cytokines. Pediatr Res. 2005;57:896–901.
  • 117. Hjertkvist M, Lackgren G, Ploen L, Bergh A. Does hCG treatment induce inflammation-like changes in undescended testes in boys? J Pediatr Surg. 1993;29:254–8.
  • 118. Dermirbilek S, Atayurt HF, Celik N, Aydin G. Does treatment with human chorionic gonadotropin induce reversible changes in undescended testes in boys? Pediatr Surg Int. 1997;12:591–4.
  • 119. Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikstrom S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest. 1997;100:2341–6.
  • 120. Grasso M, Buonaguidi A, Lania C, Bergamaschi F, Castelli M, Rigatti P. Post-pubertal cryptorchidism: review and evaluation of the fertility. Eur Urol. 1991;20(2):126–8. 41.
  • 121. Drabik G, Józsa T, Ruzsnavszky O, Kistamás K, Dienes B, Kovacs I, Benyó M, Flaskó T. Correlation between the androgen receptor status of the appendix testis and the efficacy of human chorionic gonadotropin treatment in undescended testis. Int Urol Nephrol. 2015;47(8):1235-9.
  • 122. Hadziselimovic F. Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue. Int Braz J Urol. 2008;34(3):319–28.
  • 123. Hadziselimovic F, Huff D, Duckett J, et al. Treatment of cryptorchidism with low doses of buserelin over a 6-months period. Eur J Pediatr. 1987;146(suppl 2):56–8.
  • 124. Hadziselimovic F, Hoecht B, Herzog B, Girard J. Does long term treatment with buserein improvemthe fertility chances of cryptorchid testes? In: Labrie F, Belanger A, Dupont A, editors. LH-RH and its Analogues. Amsterdam: Elsevier; 1984. p. 457.
  • 125. Biers SM, Malone PS. A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexy. J Purol. 2010;6(3):239–46.
  • 126. Zivkovic D, Bica DT, Hadziselimovic F, Bay K, Andersson AM. Relationship between adult dark spermatogonia and secretory capacity of Leydig cells in cryptorchidism. BJU Int. 2007;100(5):1147–9.
  • 127. Kolon TF, Herndon CD, Baker LA, Baskin LS, Baxter CG, Cheng EY, Diaz M, Lee PA, Seashore CJ, Tasian GE, Barthold JS; American Urological Assocation. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol. 2014;192(2):337-45.
  • 128. Hadziselimovic F, Herzog B. Treatment with a luteinizing hormone-releasing hormone analogue after successful orchiopexy markedly improves the chance of fertility later in life. J Urol. 1997;158:1193–5.
  • 129. Biers SM, Malone PS. A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexy. J Pediatr Urol. 2010;6(3):239-46.
  • 130. Elder JS. The undescended testis. Hormonal and surgical management. Surg Clin North Am. 1988;68(5):983-1005.
  • 131. Zivkovic D, Bica DG, Hadziselimovic F. Effects of hormonal treatment on the contralateral descended testis in unilateral cryptorchidism. J Pediatr Urol. 2006;2:468–72.
  • 132. Yilmaz O, Akyol I, Özyurt M, Ateş F, Soydan H, Malkoç E. The influence of hormonal treatment with beta-human chorionic gonadotropin for cryptorchidism on future fertility in rats. Comparative Study J Pediatr Urol. 2015;11(2):92.e1-4.
  • 133. Kawada T, Yamanaka H, Hasegawa Y. Decreased immunoreactive inhibin and increased FSH levels in cryptorchidism after orchidopexy. Endocr J. 1995;42(4):577-80.
  • 134. Uijldert M, Meißner A, Kuijper CF, Repping S, de Jong TPVM, Chrzan RJ. Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques. Andrologia. 2019;51(3):e13194.
  • 135. Thorup J, Petersen BL, Kvist K, Cortes D. Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys. J Urol. 2012;188(4 suppl):1436–42.
  • 136. Jørgensen N, Rajpert-De Meyts E, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl. 2010;2010;33:298–303.
  • 137. Hadziselimovic F, Herzog B. The importance of both and early orchidopexy and germ cell maturation for fertility. Lancet. 2001;358:1156–1157.
  • 138. Kraft KH, Canning DA, Snyder HM, et al. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol 2012;188(4 Suppl):1429–35.
  • 139. Cortes D, Thorup JM, Beck BL. Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants. J Urol. 1995;154(3):1188-92.
  • 140. Cortes D. Cryptorchidism-aspects of pathogenesis, histology and treatment. Scand J Urol Nephrol. 1998;196(Suppl):1–54.
  • 141. Hadziselimovic F, Hocht B, Herzog B, Buser MW. Infertility in cryptorchidism is linked to the stage of germ cell development at orchiopexy. Horm Res. 2007;68:46–52.
  • 142. Hadziselimovic F, Hoecht B. Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism. Klin Padiatr. 2008;220:302–7.
  • 143. DeFoor WR, Kuan CY, Pinkerton M, Sheldon CA, Lewis AG. Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism. J Urol. 2004;172:1731–5.
  • 144. Viqueral-Villasenor RM, Ojeda I, Gutierrez-Perez O, Chavez-Saldana M, Cuevas O, Maria DS, et al. Protective effect of α-tocopherol on damage to rat testis by experimental cryptorchidism. Int J Exp Pathol. 2011;92:131–9.
  • 145. Yang S, Ping P, Ma M, Li P, Tian R, Yang H. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of crylptorchid patients. Stem Cell Rep. 2014;3:663–75.
  • 146. Acikgoz A, Asci R, Aydin O, Cavus H, Donmez G, Buyukalpelli R. The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral descended testes. Drug Des Devel Ther. 2014;8:2089–97.
  • 147. Munyali A, Momo AT, Fozin GRB, Defo PBD, Tchatat YP, Lieunang B, Watcho P. Rubus apetalus (Rosaceae) improves spermatozoa characteristics, antioxidant enzymes and fertility potential in unilateral cryptorchid rats. Basic Clin Androl. 2020 Jul 9;30:8.
  • 148. Tekayev M, Bostancieri N, Saadat KASM, Turker M, Yuncu M, Ulusal H, Cicek H, Arman K. Effects of Moringa oleifera Lam Extract (MOLE) in the heat shock protein 70 expression and germ cell apoptosis on experimentally induced cryptorchid testes of rats. Gene. 2019 Mar 10;688:140-50.
  • 149. Enrica Bianchi, Kim Boekelheide, Mark Sigman, Susan J Hall, Kathleen Hwang Folia Morphol (Warsz). Ghrelin modulates testicular damage in a cryptorchid mouse model. PLoS One. 2017 May 18;12(5):e0177995.
  • 150. M A Abd-El-Hafez, M D El-Shafee, S H Omar, A A Aburahma, S S Kamar. The ameliorative effect of curcumin on cryptorchid and non-cryptorchid testes in induced unilateral cryptorchidism in albino rat: histological evaluation. Folia Morphol (Warsz). 2020 Aug 4. doi: 10.5603/FM.a2020.0084.
  • 151. Kraft KH, Canning DA, Snyder HM 3rd, Kolon TF. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol. 2012;188(4 Suppl):1429-35.
  • 152. Pettersson A, Richiardi L, Nordenskjokd A, Kaijser M, Akre O. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356:1835–41.
  • 153. Hildorf S, Clasen-Linde E, Cortes D, Fossum M, Thorup J. Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism despite Orchiopexy within the First Year of Life. J Urol. 2020;203(4):832-40.
  • 154. Kraft KH, Mucksavage P, Canning DA, Snyder HM 3rd, Kolon TF. Histological findings in patients with cryptorchidism and testis-epididymis nonfusion. J Urol. 2011;186(5):2045-9.
  • 155. McAleer IM, Packer MG, Kaplan GW, Scherz HC, Krous HF, Billman GF. Fertility index analysis in cryptorchidism. J Urol. 1995;153(4):1255-8.
  • 156. Çayan S, Orhan I, Altay B, Aşcı R, Akbay E, Ayas B, Yaman O. Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction. Andrology. 2020 Sep 22. doi: 10.1111/andr.12910. Online ahead of print.
  • 157. Raman JD, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. J Urol. 2003;170:1287‐90.
  • 158. Haimov‐Kochman R, Prus D, Farchat M, Bdolah Y, Hurwitz A. Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques. Int J Androl. 2010;33:139‐43.
  • 159. Negri L, Albani E, DiRocco M, Morreale G, Novara P, Levi‐Setti PE. Testicular sperm extraction in azoospermic men submitted to bilateral orchidopexy. Hum Reprod. 2003;18:2534‐ 9.
  • 160. Ozan T, Karakeci A, Kaplancan T, Pirincci N, Firdolas F, Orhan I. Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation? Andrologia. 2019;51(11):e13430.
  • 161. Sangster P, Alnajjar HM, Ahmed K, et al. Microdissection TESE (mTESE) following adult orchidopexy for undescended intra‐abdominal and inguinal testicles‐surgical techniques and outcomes from a single‐centre cohort. Andrology. 2019;8:1‐ 5.
  • 162. Irkilata HC, Dayanc M, Yıldırım I, Cincik M, Aydur E, Peker AF. Low sperm recovery from the undescended testis with testicular sperm extraction in postpubertal crptorchids: preliminary report. Andrologia. 2005;37:65‐8.
  • 163. Dabaja AA, Schlegel PN. Microdissection testicular sperm extraction: an update. Asian J Androl. 2013;15(1):35-9.
  • 164. Anne-Laure Barbotin, Anaïs Dauvergn, Agathe Dumont, Nassima Ramdane 5, Valérie Mitchell, Jean-Marc Rigot, Florence Boitrelle, Geoffroy Robin Comparative Study.Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: Testicular sperm extraction outcomes. Asian J Androl. 2019;21(5):445-51.
  • 165. Calleja Aguayo E, Delgado Alvira R, Estors Sastre B, et al. Fertility survey of patients operated on of cryptorchidism in the pediatric age. Cir Pediatr. 2012;25(2):78–81.
  • 166. Kvist K, Thorup J, Byskov AG, Hoyer PE, Mollgard K. Cryopreservation of intact testicular tissue from boys with cryptorchidism. Hum Reprod. 2006;21:484–91.
Toplam 166 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

Fikret Erdemir Bu kişi benim

Hatice Zoroğlu Bu kişi benim

Şahin Kılıç Bu kişi benim

Yayımlanma Tarihi 24 Nisan 2021
Yayımlandığı Sayı Yıl 2020 Cilt: 12 Sayı: 4

Kaynak Göster

APA Erdemir, F., Zoroğlu, H., & Kılıç, Ş. (2021). İnmemiş Testis ve İnfertilite. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, 12(4), 96-119.
AMA Erdemir F, Zoroğlu H, Kılıç Ş. İnmemiş Testis ve İnfertilite. Gaziosmanpaşa Tıp Dergisi. Nisan 2021;12(4):96-119.
Chicago Erdemir, Fikret, Hatice Zoroğlu, ve Şahin Kılıç. “İnmemiş Testis Ve İnfertilite”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 12, sy. 4 (Nisan 2021): 96-119.
EndNote Erdemir F, Zoroğlu H, Kılıç Ş (01 Nisan 2021) İnmemiş Testis ve İnfertilite. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 12 4 96–119.
IEEE F. Erdemir, H. Zoroğlu, ve Ş. Kılıç, “İnmemiş Testis ve İnfertilite”, Gaziosmanpaşa Tıp Dergisi, c. 12, sy. 4, ss. 96–119, 2021.
ISNAD Erdemir, Fikret vd. “İnmemiş Testis Ve İnfertilite”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 12/4 (Nisan 2021), 96-119.
JAMA Erdemir F, Zoroğlu H, Kılıç Ş. İnmemiş Testis ve İnfertilite. Gaziosmanpaşa Tıp Dergisi. 2021;12:96–119.
MLA Erdemir, Fikret vd. “İnmemiş Testis Ve İnfertilite”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, c. 12, sy. 4, 2021, ss. 96-119.
Vancouver Erdemir F, Zoroğlu H, Kılıç Ş. İnmemiş Testis ve İnfertilite. Gaziosmanpaşa Tıp Dergisi. 2021;12(4):96-119.

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