Kardiyopulmoner Baypasta Gelişebilen Böbrek Hasarında miRNA’ların Biyobelirteç Olma Rolü/ The Role of miRNAs as a Biomarker in Kidney Damage Developing in Cardiopulmonary Bypass

Yıl 2022, Cilt: 17 Sayı: 1, 21 - 28, 31.01.2022

Mahmut Padak , Reşat Dikme

https://doi.org/10.47565/ndthdt.2022.50

Öz

Son yıllarda, vücut dışı dolaşıma bağlı olarak gelişebilen akut böbrek hasarının tanı ve tedavisindeki gecikmelerden dolayı geriye dönüşümü olmayan böbrek hasarları meydana gelebilmektedir. Bu tanı ve tedavideki gecikmelerin ortadan kaldırılabilmesi için tanıya yardımcı olacak yeni biyobelirteçlerin bilinmesi gerekmektedir. Bu bağlamda özellikle mikro ribo nükleik asitler birçok uyaranın hücre tepkilerinin anahtar düzenleyicisidir ve hücre dışı ortama salgılanabilirler. Bu nedenle, mikro ribo nükleik asitler vücut sıvılarında tespit edilebilmelerinden dolayı, akut böbrek hasarı gelişebilecek olan hastalarda erken teşhis amacıyla biyobelirteç olarak kullanılabilecektir. Bu derlemede mikro ribo nükleik asitlerin vücut dışı dolaşıma bağlı olarak meydana gelebilecek olan akut böbrek hasarını erken dönemde belirlemedeki rolü tartışılmıştır.

Anahtar kelimeler: Kardiyopulmoner baypas; mikroRNA; Kardiyak Cerrahi; Akut Böbrek Hasarı.

Anahtar Kelimeler

Kardiyopulmoner Baypas, mikroRNA, Kardiyak Cerrahi, Akut Böbrek Hasarı

The Role of miRNAs as a Biomarker in Kidney Damage Developing in Cardiopulmonary Bypass

Öz

In recent years, irreversible kidney damage may occur due to delays in diagnosis and treatment of acute kidney injury which may develop due to extracorporeal circulation. In order to eliminate the delays in the diagnosis and treatment, it is necessary to know the new biomarkers that will help the diagnosis. In this context, especially micro-ribonucleic acids are key regulators of cell responses of many stimuli and can be secreted into the extracellular environment. Therefore, since micro-ribonucleic acids can be detected in body fluids, they can be used as a biomarker for early diagnosis in patients who may develop acute kidney injury. In this review, the role of micro-ribonucleic acids in the early detection of acute kidney injury which may occur due to extracorporeal circulation has been discussed.

Keywords: Cardiopulmonary Bypass; microRNA; Cardiac Surgery; Acute Kidney Injury.

Anahtar Kelimeler

Cardiopulmonary Bypass, microRNA, Cardiac Surgery, Acute Kidney Injury

Kaynakça

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