Investigation of Antimicrobial Effects of Some N-Substituted Phthalimide Derivatives

Yıl 2024, , 57 - 61, 27.10.2024

Sefa Işık , Ayşe Tan

https://doi.org/10.5281/zenodo.13996463

Öz

In this study, antimicrobial effects of some N-substituted phthalimide derivatives (2, 3, 4a-c) were investigated on Gram-negative (generic Escherichia coli, Salmonella enterica Typhimurium, Citrobacter freundii, Klebsiella pneumoniae, shiga toxin producing E. coli O157:H7 (STEC O157:H7)) and Gram-positive bacteria (Stapylococcus aureus, Listeria monocytogenes). The antifungal effects of N-substituted phthalimide derivatives were tested on yeast (Candida albicans) and mold (Aspergillus brasiliensis). In the antimicrobial analysis, vancomycin-30 µg (VA-30), rifampicin-5 µg (RA-5) and tetracycline-30 µg (TE-30) against bacteria and fluconazole-25 µg (FZ-25) against fungi were used as positive control groups. In general, N-substituted phthalimide derivatives (2, 3, 4a-c) have been observed to have important antimicrobial activities on Gram-negative, Gram-positive bacteria, yeast, and mold. Compound 4c, which contains a diethylamine group in its structure, showed the best activity on C. freundii and L. monocytogenes compared to other phthalimide derivatives and control compounds. On the other hand, compound 3 containing Br has been observed to have broad-spectrum antimicrobial properties with both antibacterial and antifungal effects, except for C. freundii. In conclusion, N-substituted phthalimide derivatives (2, 3, 4a-c) can be considered new promising antimicrobial agents.

Anahtar Kelimeler

Phthalimide, Antimicrobial, Antibacterial, Antifungal, Diethylamine

Bazı N-Sübstitüe Ftalimid Türevlerinin Antimikrobiyal Etkilerinin İncelenmesi

Öz

Bu çalışmada, bazı N-sübstitüe ftalimid türevlerinin (2, 3, 4a-c) antimikrobiyal etkileri Gram-negatif (jenerik Escherichia coli, Salmonella enterica Typhimurium, Citrobacter freundii, Klebsiella pneumoniae, şiga toksin üreten E. coli O157:H7 (STEC O157:H7)) ve Gram-pozitif bakteriler (Stapylococcus aureus, Listeria monocytogenes) üzerinde incelenmiştir. N-sübstitüe ftalimid türevlerinin antifungal etkileri ise maya (Candida albicans) ve küf (Aspergillus brasiliensis) üzerinde test edilmiştir. Antimikrobiyal analizlerde bakterilere karşı vankomisin-30 µg (VA-30), rifampisin-5 µg (RA-5) ve tetrasiklin-30 µg (TE-30), funguslara karşı ise karşı flukonazol-25 µg (FZ-25) pozitif kontrol grubu olarak kullanılmıştır. Genel olarak, N-sübstitüe ftalimid türevlerinin (2, 3, 4a-c) Gram-negatif, Gram-pozitif bakteriler, maya ve küf üzerinde önemli antimikrobiyal aktivitelere sahip olduğu gözlemlenmiştir. Yapısında dietilamin grubu ihtiva eden 4c bileşiği C. freundii ve L. monocytogenes üzerinde diğer ftalimid türevlerine ve kontrol bileşiklerine göre en iyi aktiviteyi göstermiştir. Diğer taraftan Br içeren 3 bileşiğinin, C. freundii hariç hem antibakteriyel hem de antifungal etkisi ile geniş spektrumlu antimikrobiyal özelliklere sahip olduğu görülmüştür. Sonuç olarak, N-sübstitüe ftalimid türevleri (2, 3, 4a-c) yeni ümit verici antimikrobiyal ajanlar olarak düşünülebilir.

Anahtar Kelimeler

Ftalimid, Antimikrobiyal, Antibakteriyel, Antifungal, Dietilamin

Teşekkür

Yazarlar Muş Alparslan Üniversitesi’ne teşekkür eder.

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