Can HCG MoM Ratio Predict Preeclampsia?

Yıl 2024, , 21 - 27, 26.02.2024

Betül Tokgöz , Gizem Kızılboğa Seval Yılmaz Ergani , Aykut Kından Mehmet Obut , Levent Dereli , Kadriye Yakut Yücel , Erkan Sağlam Fahri Burçin Fıratlıgil , Sadullah Özkan , Onur Kaya , Caner Çakır , Şevki Çelen , Ali Çağlar , Yaprak Ustun

https://doi.org/10.52827/hititmedj.1298037

Öz

Objective: To predict preeclampsia by the ratio of the HCG MoM value in the first and second trimester screening tests.
Material and Methods: The HCG-MoM values of 136 pregnant women with preeclampsia and 222 normatensive pregnant women used for first and second-trimester screening tests were proportioned , and the difference between the groups was examined. Numeric variables are expressed as mean ± standard deviation, median (minimum – maximum), and categorical variables as n (%).
Results: HCG MoM values were not different between the two groups and were within the accepted international values. The ratio of the free HCG MoM value in the first trimester to the intact HCG MoM value in the second trimester was significantly higher in the control group (1.06) than in the study group (0.99) (p=0.02).
Conclusion: Rating the MoM values of β-HCG, a biochemical marker used in screening tests for chromosomal anomaly, may predict preeclampsia in the later weeks of pregnancy.

Anahtar Kelimeler

Preeclampsia, HCG MoM, Screening Tests

HCG Oranı Preeklempsiyi Predikte Edermi?

Öz

Amaç: Birinci ve ikinci trimester tarama testlerindeki HCG MoM değerinin oranına göre preeklampsiyi öngörmek.
Gereç ve Yöntemler: 136 preeklampsili gebe ile 222 normal tansiyonlu gebenin birinci ve ikinci trimester tarama testleri için kullandıkları HCG-MoM değerleri oranlanarak gruplar arasındaki fark incelendi. Sayısal değişkenler ortalama ± standart sapma, medyan (minimum – maksimum), kategorik değişkenler ise n (%) olarak ifade edilmiştir.
Bulgular: İki grup arasında HCG MoM değerleri arasında fark izlenmedi ve kabul edilen uluslararası değerler içerisindeydi . Birinci trimesterdeki serbest HCG MoM değerinin, ikinci trimesterdeki intakt HCG MoM değerine oranı kontrol grubunda (1,06) çalışma grubuna göre (0,99) anlamlı olarak yüksekti (p=0,02).
Sonuç: Kromozomal anomali tarama testlerinde kullanılan biyokimyasal bir belirteç olan β-HCG'nin MoM değerlerinin derecelendirilmesi, gebeliğin ileri haftalarında preeklampsiyi öngörebilir.

Anahtar Kelimeler

Preeklempsi, ,HCG MoM, Tarama Testleri

Kaynakça

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