Retinal Ven Tıkanıklığı Risk Belirteci Olarak Aterojenik Plazma İndeksi

Öz

Abstract Objective: Atherogenic index of plasma is a relatively new index used to predict the risk of cardiovascular diseases in the general population. Our aim was to investigate association between the development of retinal vein occlusion and atherogenic index of plasma. Material and Method: A total of 24 patients with retinal vein occlusion and 24 age-sex matched healthy individuals were included in this retrospective study. The demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical records. Atherogenic index of plasma was calculated as the logarithmical ratio of molar concentrations of triglycerides to high density lipoprotein cholesterol as. The association among atherogenic index of plasma, lipid metabolism parameters, and retinal vein occlusion was analyzed. Results: The median age was 69.5 (range, 48-86 ) in the patient group and 71.5 (range, 50-84) in the control group (p=812). Although there were no significant differences in terms of total cholesterol and low-density lipoprotein cholesterol between two groups (P=0.458, 0.88), atherogenic index of plasma was significantly higher in the patient group (P<0.05). Conclusion: Elevated atherogenic index of plasma values might aid clinicians raise suspicion against a possible retinal vein occlusion attack and take precautions accordingly to prevent complications related to retinal vein occlusion. Özet Amaç: Aterojenik plazma indeksi kardiyovasküler hastalık riskini tahmin etmek için kullanılan yeni bir indekstir. Amacımız retinal ven tıkanıklığı ile aterojenik plazma indeksi arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Retinal ven tıkanıklığı olan 24 hasta ve bu hastalarla yaş-cinsiyet ile uyumlu 24 sağlıklı birey retrosepktif olarak incelendi. Hasta ve kontrol grubunun demografik özellikleri ve laboratuvar bulguları hastane veri tabanından elde edildi. Aterojenik plazma indeksi trigliseritin molar konsantrasyonunun yüksek yoğunluklu lipoprotein kolesterolüne logaritmik oranı olarak hesaplandı. Aterojenik plazma indeksi, lipid metabolizma parametreleri ve retinal ven tıkanıklığı arasındaki ilişki analiz edildi. Bulgular: Hasta grubunun yaş ortancası 69,5 (48-86 ), kontrol grubunun 71,5 (50-84) idi (p=812). İki grup arasında total kolesterol ve düşük yoğunluklu lipoprotein kolesterol açısından anlamlı fark olmamasına rağmen (P=0.458, 0.88), aterojenik plazma indeksi, hasta grubunda anlamlı olarak yüksekti (P<0.05). Sonuç: Yüksek aterojenik plazma indeksi, klinisyenlere olası retinal ven atağı ve retinal ven tıkanıklığına bağlı komplikasyonların önlenmesi için yol gösterici olabilir.

Anahtar Kelimeler

• Aterojenik plazma indeksi
• lipit parametre
• retinal ven tıkanıklığı

Atherogenic index of plasma as a Novel Biomarker to Predict Retinal Vein Occlusion

Öz

Objective: Atherogenic index of plasma is a relatively new index used to predict the risk of cardiovascular diseases in the general population. Our aim was to investigate association between the development of retinal vein occlusion and atherogenic index of plasma. Material and Method: A total of 24 patients with retinal vein occlusion and 24 age-sex matched healthy individuals were included in this retrospective study. The demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical records. Atherogenic index of plasma was calculated as the logarithmical ratio of molar concentrations of triglycerides to high density lipoprotein cholesterol as. The association among atherogenic index of plasma, lipid metabolism parameters, and retinal vein occlusion was analyzed. Results: The median age was 69.5 (range, 48-86) in the patient group and 71.5 (range, 50-84) in the control group (p=812). Although there were no significant differences in terms of total cholesterol and low-density lipoprotein cholesterol between two groups (P=0.458, 0.88), atherogenic index of plasma was significantly higher in the patient group (P<0.05). Conclusion: Elevated atherogenic index of plasma values might aid clinicians raise suspicion against a possible retinal vein occlusion attack and take precautions accordingly to prevent complications related to retinal vein occlusion.

Anahtar Kelimeler

• Atherogenic index of plasma
• lipid profile
• retinal vein occlusion.

Kaynakça

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