Value of Aquaporins in the Eyes

Öz

Aquaporins (AQPs) are small integrated membrane proteins that enable water conduction across the plasma membranes of cells as a result of osmotic gradients. AQPs have been indicated to be involved in the molecular adjustment of many biological functions such as osmolarity, cell movement, junctional adhesion, management of surface protein expression, transepithelial water transport, energy metabolism, cellular proliferation, neuroexcitation, extracellular matrix stress regulation, cellular water adjustment. In addition to regulating aqueous humor balance, it also facilitates the removal of many residuals products of the cornea, lens, ciliary body and retina while preserving clarity in the optic compartments. Studies have ascertained the value of mammalian AQPs in both pathophysiological and physiological conditions. This suggests that pharmacological modulation of aquaporin expression and tasks may provide a novel therapy for the amelioration of various vision-related pathologies that may involve water and small solute transport. This review clarifies the physiological roles of AQPs in the eye and their involvement in pathological conditions in light of previous studies and highlights the development of selective pharmacological target strategies that may be beneficial for the treatment of related conditions, mobilization.

Anahtar Kelimeler

• Aquaporin
• eye
• osmolarity

Akuaporinlerin Gözdeki Değeri

Öz

Akuaporinler (AQP’ler), ozmotik gradyanlara yanıt olarak hücrelerin plazma zarları boyunca su taşınmasını kolaylaştıran küçük, entegre zar proteinlerinin bir ailesidir. AQP’lerin; ozmolarite, hücre göçü, bağlantı adezyonu, yüzey proteini üretiminin düzenlenmesi, transepitelyal su transportu, hücresel proliferasyon, nöroeksitasyon, hücre dışı matris stres düzenlemesi, enerji metabolizması ve hücresel su düzenlemesi gibi birçok biyolojik fonksiyonun moleküler düzeyde düzenlemesinde yer aldığı belirtilmiştir. Göz yapılarının şeffaflığını korumasının yanında aköz hümör dengesinin düzenlenmesi, kornea, siliyer cisim, lens ve retina gibi dokuların metabolik ürünlerinin temizlenmesini de sağlamaktadır. Yapılan çalışmalar, memeli AQP’lerin hem fizyolojik hem de patofizyolojik ortamlardaki önemini ortaya çıkarmıştır. Bu, akuaporin ekspresyonunun ve aktivitesinin, farmakolojik modülasyonunun, su ve çözünebilen küçük maddelerin taşınmasının da dahil olabileceği çeşitli görme ile ilgili bozuklukların tedavisi için yeni araçlar sağlayabileceğini göstermektedir. Bu derleme, AQP’lerin göz organındaki fizyolojik rolünü ve patolojik durumlara katılımını yapılan çalışmalar ışığında açıklamakla birlikte ilgili durumların tedavileri için yararlı olabilecek hedefe yönelik farmakolojik stratejilerin geliştirilmesini vurgulamaktadır.

Anahtar Kelimeler

• Akuaporin
• Göz
• Ozmolarite

Kaynakça

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