Pregestasyonel Diyabetes Mellitusta Glikoz-Potasyum Oranına Dayalı Perinatal Sonuçların Tahmini

Öz

Amaç: Birinci trimester glukoz-potasyum oranı (GPR) değerinin tip 2 diyabetes mellitus tanılı gebe kadınlarda olumsuz perinatal sonuç öngörüsündeki değerini araştırmaktır. Gereç ve Yöntemler: Tip 2 diyabete sahip gebeler ve kontrol grubunun verileri retrospektif olarak değerlendirildi. Gruplar arasında demografik veriler, laboratuvar parametreleri, GPR değeri ve perinatal sonuçlar iki grup arasında karşılaştırıldı. Alıcı işletim eğrisi (ROC) analizleri ile, GPR indeksinin kompozit olumsuz perinatal sonuç (CAPO) öngörüsündeki gücü değerlendirildi. Bulgular: Tip 2 diyabete sahip 69 gebe ve sağlıklı kontrol olarak 138 gebe olmak üzere çalışmaya 207 hasta dahil edildi. Vaka grubunda kontrol grubuna göre kompozit olumsuz perinatal sonuçlar anlamlı olarak daha yüksek bulundu. Yapılan ROC eğrisi analizinde GPR indeksinin CAPO’yu öngörmede anlamlı bir performansa sahip olduğu gösterildi (AUC: 0,769, %95 CI 0,696-0,842, p<0,001; duyarlılık: %61,2, özgüllük: %87,5). Bunlara ek olarak GPR indeksinin en sık izlenen fetal, neonatal ve maternal komplikasyonları öngörme kapasitesi ROC analizleri ile değerlendirildi. (Preterm eylem için AUC: 0,763, %95 CI 0,629-0,897, p<0,001; NICU için AUC: 0,772, %95 CI 0,668 - 0,875, p<0,001; disregüle diyabet için AUC: 0,733, %95 CI 0,542 - 0,923, p=0,013). Sonuç: Mevcut çalışma, tip 2 diyabetli gebelerde birinci trimester GPR indeksinin hem perinatal hem de maternal olumsuz sonuçları öngörmek için kullanılabileceğini göstermiştir.

Anahtar Kelimeler

• perinatal sonuçlar
• tip 2 diyabet
• glukoz potasyum oranı
• pregestasyonel diyabet

Predicting Perinatal Outcomes Based on the Glucose-Potassium Ratio in Pregestational Diabetes Mellitus

Öz

Objective: The objective of the present study is to investigate first-trimester glucose-potassium ratio (GPR) values as a predictor of adverse perinatal outcomes in pregnant women with type 2 diabetes mellitus. Materials and Methods: A retrospective study was conducted comparing pregnant women with type 2 diabetes mellitus to a control group. The study analyzed demographic data, laboratory parameters, GPR values, and perinatal outcomes between the two groups. Receiver Operating Characteristic (ROC) analyses were performed to assess the predictive value of the GPR index for Composite Adverse Perinatal Outcomes (CAPO). Results: The study's sample population comprised 207 patients. The study population included 69 pregnant women with type 2 diabetes mellitus and 138 healthy pregnant controls. The composite adverse perinatal outcomes were significantly higher in the case group than in the control group. ROC curve analysis demonstrated that the GPR index had significant predictive performance for CAPO (AUC: 0.769, 95%CI 0.696-0.842, p<0.001; sensitivity: 61.2%; specificity: 87.5%). Furthermore, the predictive capacity of the GPR index for the most common fetal, neonatal, and maternal complications was also evaluated through ROC analyses (AUC for preterm labor: 0. 763, 95%CI 0.629-0.897, p<0.001; AUC for NICU: 0.772, 95%CI 0.668 - 0.875, p<0.001; AUC for dysregulated diabetes: 0.733, 95%CI 0.542 - 0.923, p=0.013). Conclusion: The present study demonstrated that the first trimester GPR index can serve as a prognostic tool for adverse perinatal and maternal outcomes in pregnant women with type 2 diabetes mellitus.

Anahtar Kelimeler

• perinatal outcomes
• type 2 diabetes
• glucose potassium ratio
• pregestational diabetes mellitus

Kaynakça

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