Evaluation of the Relationship Between Luteinizing Hormone Levels and Body Mass Index in Girls With Idiopathic Central Precocius Puberty

Yıl 2020, Cilt: 2 Sayı: 1, 1 - 6, 29.02.2020

Asan Önder , Havva Nur Peltek Kendirci , Elif Sagsak , Emre Demir

Öz

Objective: Excess  adiposity 
has  effects on various aspects of
pubertal development as  the timing  of pubertal initiation and  hormonal parameters during  puberty. We aimed to determine the effect of
BMI on peak LH (luteinizing  hormone)
levels obtained by standard GnRH (Gonadotropin 
Releasing  Hormone) stimulation  test in girls with central precicous puberty.

Materials and Methods: A total of 59  female patients who were diagnosed as
idiopathic  central precicous pubertywere
included in the study. Anthropometric measurements at the time  of  GnRH stimulation test and basal/stimulated
gonadotropin levels were evaluated. The relationship between BMI and gonadotropins
 was investigated.

Results: The  mean age 
of the  participants  was 7.11±1.01 (3.20-7.94) years. 21 cases(35
%) were overweight/obese. 67.8% (n = 40) of the cases were presented with
breast development and 64.4% (n = 38) were in stage 2, 35.6% (n = 21) were in
stage 3 puberty. There was no  significant correlation between BMI SDS and
basal/peak LH levels (p=0.531, p= 0.598 for stage  2  and  p=0.126, p=0.827  for stage 
3  puberty respectively), peak LH
/ FSH (follicle-stimulating
hormone)ratio (p=0.408
for  stage  2  and  p=0.797  for stage 
3  puberty) in patients
according  to  both puberty stages. There was not  also any correlation  between BMI /BMI SDS  and peak LH in total study  group.Basal  LH, FSH, E2 
and  peak LH levels  did not 
vary  among normal weight,
overweight  and  obese 
cases.

Conclusion: Body mass index had no effect on
basal and stimulated gonadotropin levels in girls with central precicous puberty
in  different stages of puberty.

Anahtar Kelimeler

body mass index, GnRH stimulation test

Kaynakça

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