Klinik olarak Tek Taraflı Psödoeksfoliasyon Sendromu Olanların Ön Segment Parametrelerinin Schempflug Görüntüleme Tekniği ile değerlendirilmesi

Yıl 2023, Cilt: 5 Sayı: 3, 126 - 130, 10.10.2023

Mustafa Duran , Tayfun Şahin , Selim Cevher

https://doi.org/10.52827/hititmedj.1276468

Öz

Objective: We aimed to compare the intraocular pressure (IOP), keratometry values (K) and anterior segment parameters of patients with clinically unilateral pseudoexfoliation syndrome (PEX) with the other eyes without PEX and the control group.
Material and Method: 54 patients with unilateral PEX findings and 40 people without PEX findings in both eyes were included in the study as a control group. IOP was measured by Goldmann applanation tonometry. K values and anterior segment parameters [central corneal thickness (CCT), anterior chamber depth (ACD), iridocorneal angle (ICA), anterior chamber volume (ACV)] were measured using Scheimpflug Imaging Technique.
Results: The mean age of PEX patients was 67.9± 9.2 years, while the mean age of the control group was 58.9± 5.7 years. The IOP values of the eyes with PEX were significantly higher than the other eyes (p= 0.02), and there was no significant difference between them and the control group (p= 0.59). In terms of K values and anterior segment parameters, the measurements of eyes with PEX and the other eyes, and eyes with PEX and control group were similar (p> 0.05).
Conclusion: In our study, eyes with PEX had higher IOP values than the fellow eyes and control group. In addition, thinner CCT, narrower ACD and ICA values were found in eyes with PEX than in the other eyes, but these values were not statistically significant.

Anahtar Kelimeler

Ön segment parametreleri, korneal topografi, göziçi basıncı, psödoeksfoliasyon sendromu.

Evaluation of Anterior Segment Parameters of Clinically Unilateral Pseudoexfoliation Syndrome Using Scheimpflug Imaging Technique

Öz

Objective: We aimed to compare the intraocular pressure (IOP), keratometry values (K), and anterior segment parameters of patients with clinically unilateral pseudoexfoliation syndrome (PEX) with the other eyes without PEX and the control group.
Material and Method: Fifty four patients with unilateral PEX findings and 40 participants without PEX findings in both eyes were included in the study as a control group. IOP was measured by Goldmann applanation tonometry. K values and anterior segment parameters [central corneal thickness (CCT), anterior chamber depth (ACD), iridocorneal angle (ICA), and anterior chamber volume (ACV)] were measured using Scheimpflug imaging technique.
Results: The mean age of PEX patients was 67.9±9.2 years, while the mean age of the control group was 58.9±5.7 years. The IOP values of the eyes with PEX were significantly higher than the other eyes (p=0.02), and there was no significant difference between them and the control group (p=0.59). In terms of K values and anterior segment parameters, the measurements of eyes with PEX and the other eyes, and eyes with PEX and control group were similar (p>0.05).
Conclusion: In our study, eyes with PEX had higher IOP values than the fellow eyes and control group. In addition, thinner CCT, narrower ACD, and ICA values were found in eyes with PEX than in the other eyes. However, these values were not statistically significant.

Anahtar Kelimeler

Anterior segment parameters, Corneal topography, Intraocular pressure, Pseudoexfoliation syndrome

Kaynakça

• Ritch R, Schlötzer-Schrehardt U, Konstas AG. Why is glaucoma associated with exfoliation syndrome?. Progress in retinal and eye research. 2003; 22(3):253-75.
• Ringvold A. Epidemiology of the pseudo-exfoliation syndrome. Acta Ophthalmologica Scandinavica. 1999; 77:371-5.
• Jonasson F, Damji KF, Arnarsson A, Sverrisson T, Wang L, Sasaki H, et al. Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study. Eye. 2003; 17(6):747-53.
• Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H, et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science. 2007; 317(5843):1397-1400.
• Konstas AG, Stewart WC, Stroman GA, Sine CS. Clinical presentation and initial treatment patterns in patients with exfoliation glaucoma versus primary open-angle glaucoma. Ophthalmic Surgery, Lasers and Imaging Retina. 1997; 28(2):111-7.
• Musch DC, Shimizu T, Niziol LM, Gillespie BW, Cashwell LF, Lichter PR. Clinical characteristics of newly diagnosed primary, pigmentary and pseudoexfoliative open-angle glaucoma in the Collaborative Initial Glaucoma Treatment Study. The British journal of ophthalmology. 2012; 96(9):1180–4.
• Henry JC, Krupin T, Schmitt M, Lauffer J, Miller E, Ewing MQ, et al. Long-term follow-up of pseudoexfoliation and the development of elevated intraocular pressure. Ophthalmology. 1987; 94(5):545-52.
• Jeng SM, Karger RA, Hodge DO, Burke JP, Johnson DH, Good MS. The risk of glaucoma in pseudoexfoliation syndrome. Journal of glaucoma. 2007; 16(1):117-21.
• Tekin K, Inanc M, Elgin U. Monitoring and management of the patient with pseudoexfoliation syndrome: current perspectives. Clinical Ophthalmology (Auckland, NZ). 2019; 13:453.
• Scorolli L, Scorolli L, Campos EC, Bassein L, Meduri RA. Pseudoexfoliation syndrome: a cohort study on intraoperative complications in cataract surgery. Ophthalmologica. 1998; 212(4):278-80.
• Hammer T, Schlötzer-Schrehardt U, Naumann GO. Unilateral or asymmetric pseudoexfoliation syndrome?: an ultrastructural study. Archives of ophthalmology. 2001; 119(7):1023-31.
• Kivelä,T, Hietanen J, Uusitalo M. Autopsy analysis of clinically unilateral exfoliation syndrome. Investigative ophthalmology & visual science. 1997; 38(10):2008-15.
• Vesti E, Kivelä T. Exfoliation syndrome and exfoliation glaucoma. Progress in retinal and eye research. 2000; 19(3):345-68.
• Arnarsson AM, Damji KF, Sverrisson T, Sasaki H, Jonasson F. Prevalence of Pseudoexfoliation and Association With IOP, Corneal Thickness, and Structural Optic Disc Parameters in the Reykjavik Eye Study. Investigative Ophthalmology & Visual Science. 2007; 48(13):1562.
• Mažeikaitė G, Daveckaitė A, Šiaudvytytė L, Kuzmienė L, Janulevičienė I. Comparison of anterior segment parameters, intraocular pressure and cataract surgery complications in eyes with and without pseudoexfoliation syndrome. In The International Congress of Advanced Technologies and Treatments for Glaucoma (ICATTG): 29-31 October 2015, Milan, Italy: Program [poster presentations, abstracts, poster abstracts]/Glaucoma Research Foundation.[Milan]: Glaucoma Research Foundation, 2015.
• Bozkurt B, Güzel H, Kamış Ü, Gedik Ş, Okudan S. Characteristics of the anterior segment biometry and corneal endothelium in eyes with pseudoexfoliation syndrome and senile cataract. Turkish Journal of Ophthalmology. 2015; 45(5):188.
• Doganay S, Tasar A, Cankaya C, Firat PG, Yologlu S. Evaluation of Pentacam‐Scheimpflug imaging of anterior segment parameters in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Clinical and Experimental Optometry. 2012; 95(2):218-22.
• Özcura F, Aydin S, Dayanir V. Central corneal thickness and corneal curvature in pseudoexfoliation syndrome with and without glaucoma. Journal of Glaucoma. 2011; 20(7):410-13.
• Krysik K, Dobrowolski D, Polanowska K, Lyssek-Boron A, Wylegala EA. Measurements of corneal thickness in eyes with pseudoexfoliation syndrome: comparative study of different image processing protocols. Journal of Healthcare Engineering, 2017.
• Tomaszewski BT, Zalewska R, Mariak Z. Evaluation of the endothelial cell density and the central corneal thickness in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Journal of ophthalmology. 2014; 123683.
• Arnarsson A, Damji KF, Sverrisson T, Sasaki H, Jonasson F. Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related ophthalmological variables. Acta Ophthalmologica Scandinavica. 2007; 85(8):822-27.
• Demircan S, Atas M, Yurtsever Y. Effect of torsional mode phacoemulsification on cornea in eyes with/without pseudoexfoliation. International Journal of Ophthalmology. 2015; 8(2):281.
• Sarowa S, Manoher J, Jain K, Singhal Y, Devathia D. Qualitative and quantitative changes of corneal endothelial cells and central corneal thickness in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Int J Med Sci Public Heal. 2016; 5(12):1.
• Bartholomew RS. Anterior chamber depth in eyes with pseudoexfoliation. The British Journal of Ophthalmology. 1980; 64(5):322.
• You QS, Xu L, Wang YX, Yang H, Ma K, Li JJ, et al. Pseudoexfoliation: normative data and associations: the Beijing eye study 2011. Ophthalmology. 2013; 120(8):1551–8.
• Mohammadi M, Johari M, Eslami Y, Moghimi S, Zarei R, Fakhraie G, et al. Evaluation of anterior segment parameters in pseudoexfoliation disease using anterior segment optical coherence tomography. American Journal of Ophthalmology. 2022; 234:199-204.
• Damji KF, Chialant D, Shah K, Kulkarni SV, Ross EA, Al-Ani A, et al. Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. Canadian Journal of Ophthalmology. 2009; 44(1):70-5.
• Omura T, Tanito M, Doi R, Ishida R, Yano K, Matsushige K, et al. Correlations among various ocular parameters in clinically unilateral pseudoexfoliation syndrome. Acta Ophthalmologica. 2014; 92(5):e412-13.
• Ritch R, Vessani RM, Tran HV, Ishikawa H, Tello C, Liebmann JM. Ultrasound biomicroscopic assessment of zonular appearance in exfoliation syndrome. Acta Ophthalmologica Scandinavica. 2007; 85(5):495-9.
• Sbeity Z, Dorairaj SK, Reddy S, Tello C, Liebmann JM, Ritch R. Ultrasound biomicroscopy of zonular anatomy in clinically unilateral exfoliation syndrome. Acta Ophthalmologica. 2008; 86(5):565-68.