The Frequency of HLA-B27 Antigen Positivity in Patients with Rheumatoid Arthritis and Anklylosing Spondylitis and The Relationship Between HLA-B27 Antigen and Other Autoantibodies

Yıl 2024, Cilt: 6 Sayı: 2, 136 - 142, 30.06.2024

Gülseren Demir Karakılıç Esra Şahingöz Bakırcı Ferda Büyük

https://doi.org/10.52827/hititmedj.1401533

Öz

Objective: The aim of this study was to research the frequency of Human Leukocyte Antigen (HLA)-B27 antigen positivity and relationship between HLA-B27 positivity and other autoantibodies and between HLA-B27 positivity and treatment in patients diagnosed with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).
Material and Method: The study is a retrospective study. Patients diagnosed with RA and AS as a result of the examinations performed at Physical Medicine and Rehabilitation outpatient clinic between January 2017 and September 2022 were retrospectively screened, and patients whose HLA-B27 antigen was tested were included in study.
Results: A total of 569 patients, 199 with RA and 370 with AS were included in study. While HLA-B27 was positive in 11% of patients with RA, it was 37.5% in patients with AS and there was a significant difference between the groups. When we analyzed the correlation of autoantibodies with HLA-B27, we found that HLA-B27 was not correlated with RF, Anti-cyclic citrullinated peptides (Anti-CCP) or Anti-nuclear antibody (ANA). When we analyzed the relationship between HLA-B27 and the treatment method, there was no significant relationship between HLA-B27 and treatment method.
Conclusion: While HLA-B27 was found to be 5% positive in the general population in the literature, we found 11% in 199 patients with RA. This study is important because it shows that HLA-B27 positivity is not very common in patients diagnosed with AS recently contrary to popular belief. More studies are needed to evaluate HLA-B27 frequency in RA and AS.

Anahtar Kelimeler

Ankylosing Spondylitis, correlation of autoantibodies, HLA-B27 antigen, Rheumatoid Arthritis

Etik Beyan

Before the study, the study protocol was approved by the Ankara City Hospital No. 2 Clinical Research Ethics Committee Presidency (E2-22-2356).

Destekleyen Kurum

None

Teşekkür

None

Romatoid Artritli ve Ankilozan Spondilitli Hastalarda HLA-B27 Antijen Pozitifliği Sıklığı ve HLA-B27 Antijeni ile Diğer Otoantikorlar Arasındaki İlişki

Öz

Amaç: Bu çalışmanın amacı, romatoid artrit tanılı hastalarda İnsan Lökosit Antijeni (HLA-B27) antijen pozitifliği sıklığını ve romatoid artrit (RA) ve ankilozan spondilit (AS) tanılı hastalarda HLA-B27 pozitifliği ile diğer otoantikorlar ve tedavi arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem: Ocak 2017-Eylül 2022 tarihleri arasında Fiziksel Tıp ve Rehabilitasyon polikliniğinde yapılan tetkikler sonucunda RA ve AS tanısı alan hastalar retrospektif olarak tarandı ve HLA-B27 antijeni bakılanlar çalışmaya alındı. Hastaların yaşı, cinsiyeti, HLA-B27 antijen incelemesi sırasında Sedimantasyon (SED) ve C-reaktif protein (CRP) değerleri, Romatoid Faktör (RF), Anti-CCP, Anti-nükleer antikor (ANA), HLA-B27 sonuçları, AS tanısı alan hastalarda sakroiliak Manyetik Rezonans (MR) sonuçları ve verilen ilaç tedavileri kaydedildi.
Bulgular: : Çalışmaya RA’lı 199 ve AS’li 370 olmak üzere toplam 569 hasta dahil edildi. HLA-B27 RA’lı hastaların %11’inde pozitif bulunurken AS’li hastalarda %37.5 idi ve gruplar arasında anlamlı fark vardı. Otoantikorların HLA-B27 ile korelasyonunu analiz ettiğimizde, HLA-B27’ nin RF, Anti-CCP veya ANA ile korele olmadığını bulduk. HLA-B27 ile tedavi yöntemi arasındaki ilişkiyi incelediğimizde, HLA-B27 ile tedavi yöntemi arasında anlamlı bir ilişki yoktu.
Sonuç: Literatürde genel popülasyonda HLA-B27 pozitifliği %5 iken biz 199 RA hastasında %11 pozitif bulduk. Bu çalışma, sanılanın aksine yeni AS tanısı alan hastalarda HLA-B27 pozitifliğinin çok yaygın olmadığını göstermesi açısından önemlidir. RA ve AS’de HLA-B27 sıklığını ve prognoza etkisini değerlendirmek için hasta sayısının daha çok olduğu çalışmalar gereklidir.

Anahtar Kelimeler

Ankilozan Spondilit, HLA-B27 antijeni, otoantikorların korelasyonu, Romatoid Artrit

Kaynakça

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